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1. 发明申请

US20110002994A1 METHOD OF REGULATING THE TH17 PATHWAY AND ITS ASSOCIATED METABOLIC IMPACT 审中-公开
标题翻译：调节TH17途径及其相关代谢影响的方法
公开(公告)号：US20110002994A1
公开(公告)日：2011-01-06
申请号：US12681294
申请日：2008-10-02
申请人： Josee Beaulieu , Jean-Francois Lapointe , Claude Dupont , Pierre Lemieux , Eric Simard , Eric Trottier
发明人： Josee Beaulieu , Jean-Francois Lapointe , Claude Dupont , Pierre Lemieux , Eric Simard , Eric Trottier
IPC分类号： A61K9/00 , A61K38/02 , C07K14/00 , A61K39/395 , A61K8/64 , A61P3/00 , A61P9/12 , A61P17/06 , A61P19/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/00 , A61P35/00 , A61P37/02 , A61Q90/00 , A61P1/00
CPC分类号： A61K38/018
摘要： It is disclosed a method of immunomodulating an immune response in a subject comprising administering to a subject a malleable protein matrix (MPM), from fermented whey, in an amount effective to modulate the biological activity of Th17 cells, and its associated metabolic pathway, for a preventative or a therapeutic purpose of a variety of health applications in the field of immunity or obesity related diseases.
摘要翻译：公开了一种在受试者中免疫调节免疫应答的方法，其包括以有效调节Th17细胞及其相关代谢途径的生物活性的量向受试者施用来自发酵乳清的可延展蛋白质基质（MPM）及其相关代谢途径，用于在免疫或肥胖相关疾病领域中的各种健康应用的预防或治疗目的。

2. 发明申请

US20100272676A1 CHEMOTHERAPEUTIC AGENTS AS ANTI-CANCER VACCINE ADJUVANTS AND THERAPEUTIC METHODS THEREOF 审中-公开
标题翻译：化疗药物作为抗癌剂疫苗及其治疗方法
公开(公告)号：US20100272676A1
公开(公告)日：2010-10-28
申请号：US12753173
申请日：2010-04-02
申请人： Éric Simard , Philippe Goyette , Pierre Lemieux
发明人： Éric Simard , Philippe Goyette , Pierre Lemieux
IPC分类号： A61K39/00 , A61K38/21 , A61K38/19 , A61K38/20 , A61K39/395 , A61K38/22 , A61P35/00
CPC分类号： A61K39/39 , A61K39/0011 , A61K2039/5152 , A61K2039/55511 , A61K2039/55555 , Y02A50/41
摘要： The present invention relates to an anti-cancer vaccine composition comprising an antigen in association with an effective amount of at least one immunomodulator chemotherapeutic adjuvant eliciting an immune response in a patient and a pharmaceutically acceptable carrier. It also relates to method of preventing tumor growth and reducing tumor growth using the anti-cancer vaccine composition of the present invention.
摘要翻译：本发明涉及一种抗癌疫苗组合物，其包含与有效量的至少一种在患者和药学上可接受的载体中引起免疫应答的免疫调节剂化学治疗剂的抗原。本发明还涉及使用本发明的抗癌疫苗组合物来预防肿瘤生长和减少肿瘤生长的方法。

3. 发明授权

US06656459B2 Compositions of non-ionic block copolymers to treat autoimmune and inflammatory diseases, and to reduce graft/implantation, and methods of use thereof 失效
标题翻译：用于治疗自身免疫性和炎性疾病以及减少移植物/植入的非离子嵌段共聚物的组合物及其使用方法
公开(公告)号：US06656459B2
公开(公告)日：2003-12-02
申请号：US09852533
申请日：2001-05-10
申请人： Alexander V. Kabanov , Pierre Lemieux , Nadia Guerin , Valery Alakhov
发明人： Alexander V. Kabanov , Pierre Lemieux , Nadia Guerin , Valery Alakhov
IPC分类号： A61K3174
CPC分类号： A61K31/74
摘要： Compositions comprising non-ionic block copolymers are useful for the treatment of autoimmune, inflammatory and proliferative diseases and for reducing graft/implantation rejection. The present invention also relates to methods of treating animals having various autoimmune, inflammatory and proliferative diseases. The present invention also relates to methods of reducing inflammation in an animal comprising administering the compositions of the invention. Also, the present invention relates to methods of reducing autoimmune responses and to methods of reducing graft/implantation rejection comprising administering the compositions of the inventions. A typical embodiment is a mixture of Pluronics F127 and L61.
摘要翻译：包含非离子嵌段共聚物的组合物可用于治疗自身免疫性，炎性和增殖性疾病以及减少移植物/植入物排斥反应。本发明还涉及治疗具有各种自身免疫性，炎性和增殖性疾病的动物的方法。本发明还涉及在动物中减少炎症的方法，包括施用本发明的组合物。此外，本发明还涉及降低自身免疫应答的方法以及降低移植物/植入排斥的方法，包括施用本发明的组合物。典型的实施方案是Pluronics F127和L61的混合物。

4. 发明授权

US08088605B2 Exopolysaccharides delivery system for active molecules 失效
标题翻译：活性分子的多糖递送系统
公开(公告)号：US08088605B2
公开(公告)日：2012-01-03
申请号：US10537118
申请日：2003-12-04
申请人： Nicolas Beaudet , Claude Dupont , Pierre Lemieux , Eric Simard , Philippe Goyette
发明人： Nicolas Beaudet , Claude Dupont , Pierre Lemieux , Eric Simard , Philippe Goyette
IPC分类号： C12P19/04 , A61K31/715
CPC分类号： A61K9/1075 , A61K9/0014 , A61K9/0019 , A61K9/2009 , A61K31/337 , A61K31/425 , A61K31/715 , A61K47/36
摘要： The present invention relates to a delivery system for delivery of an active molecule to a patient, the delivery system comprising a population of exopolysaccharide micelles, each micelle defining a core for containing the active molecule.
摘要翻译：本发明涉及一种用于将活性分子递送至患者的递送系统，所述递送系统包含一群外多糖胶束，每个胶束限定含有活性分子的核心。

5. 发明申请

US20100150520A1 METHOD AND SYSTEM FOR CONTROLLING PLAYBACK OF A VIDEO PROGRAM INCLUDING BY PROVIDING VISUAL FEEDBACK OF PROGRAM CONTENT AT A TARGET TIME 审中-公开
标题翻译：控制视频节目播放的方法和系统，包括在目标时间内提供程序内容的视觉反馈
公开(公告)号：US20100150520A1
公开(公告)日：2010-06-17
申请号：US12630287
申请日：2009-12-03
申请人： Shawn Hopwood , Pierre Lemieux
发明人： Shawn Hopwood , Pierre Lemieux
IPC分类号： H04N5/93 , G09G5/00 , G06F3/048
CPC分类号： H04N5/783 , G06F3/0484 , G06F3/04855 , G11B27/034 , G11B27/34 , H04N5/85 , H04N9/8227
摘要： In a class of embodiments, a method for controlling playback of a video program by a media player including by providing visual feedback (referred to as a thumbnail) indicative of content of the program at a target location, a media player configured to perform any embodiment of the method, and a computer readable medium which stores code for implementing any embodiment of the method. Preferably at least one thumbnail is displayed and updated in real-time during playback of the program. Typically each thumbnail is a compressed or reduced-scale version of a frame of the program at, or a representative image of a segment of the program including, the target location. Typically, the thumbnail is an element of a displayed timeline control also including a timeline and an icon, position of the icon along the timeline indicates the target location, and the icon is movable along the timeline in response to user selection of different target locations (typically by asserting commands to the media player using a mouse or other input device). Preferably, data determining each thumbnail are computed prior to playback of the program, and the data and the program are stored prior to playback of the program.
摘要翻译：在一类实施例中，一种用于控制由媒体播放器播放视频节目的方法，包括通过在目标位置提供指示节目内容的视觉反馈（被称为缩略图），被配置为执行任何实施例的媒体播放器的方法，以及存储用于实现该方法的任何实施例的代码的计算机可读介质。优选地，在播放节目期间实时地显示和更新至少一个缩略图。通常，每个缩略图是程序的帧的压缩或缩小版本，或者包括目标位置的程序段的代表图像。通常，缩略图是还包括时间线和图标的显示的时间线控制的元素，沿着时间线的图标的位置指示目标位置，并且响应于用户对不同目标位置的选择，图标可以沿着时间轴移动（通常通过使用鼠标或其他输入设备向媒体播放器发出命令）。优选地，在重放节目之前计算确定每个缩略图的数据，并且在播放节目之前存储数据和节目。

6. 发明申请

US20090130072A1 Use of Lactobacillus Kefiranofaciens as a Probiotic and a Synbiotic 审中-公开
标题翻译：使用乳酸杆菌作为益生菌和合生素
公开(公告)号：US20090130072A1
公开(公告)日：2009-05-21
申请号：US11884093
申请日：2006-02-10
申请人： Pierre Lemieux , Louis-Philippe Precourt , Eric Simard
发明人： Pierre Lemieux , Louis-Philippe Precourt , Eric Simard
IPC分类号： A61K35/74 , A61P29/00 , A61P37/00 , A61P3/00 , A61P19/00
CPC分类号： A61K35/747 , A23C9/1234 , A23C21/026
摘要： In accordance with the present invention, there is provided a probiotic composition comprising an effective amount of Lactobacillus kefiranofaciens in association with a suitable carrier. The probiotic composition has many probiotic effects such as intestinal adherence, intestinal persistence, positive modulation of the intestinal microflora, protection against intestinal pathogens, immunomodulation, protection against systemic inflammation, protection against intestinal inflammation, protection against allergies, protection against diarrhea, protection against diabetes, protection against hyperlipidemia and protection against colon cancer. In accordance with the present invention, there is also provided a method of treatment and/or prevention of a number of diseases for which the composition has a beneficial effect. For example, the composition is useful for fermenting a product which in turn finds utility in the treatment of hypertension, the treatment of weight disorder, the treatment of hyperlipidemia or the treatment of triglyceride disorder.
摘要翻译：根据本发明，提供一种益生菌组合物，其包含与合适的载体相关的有效量的胃酸乳杆菌（Lactobacillus kefiranafaciens）。益生菌组合物具有许多益生菌作用，例如肠粘连，肠持续性，肠道微生物群落的阳性调节，肠道病原体的保护，免疫调节，防止全身炎症，保护肠道炎症，防止过敏，防止腹泻，防止糖尿病，防止高脂血症和防止结肠癌。根据本发明，还提供了治疗和/或预防组合物具有有益效果的多种疾病的方法。例如，组合物可用于发酵产品，其又可用于治疗高血压，治疗体重紊乱，治疗高脂血症或治疗甘油三酸酯障碍。

7. 发明授权

US06374356B1 Shared intelligence automated access control system 失效
标题翻译：共享智能自动门禁系统
公开(公告)号：US06374356B1
公开(公告)日：2002-04-16
申请号：US09103637
申请日：1998-06-23
申请人： Benoit Daigneault , Pierre Lemieux
发明人： Benoit Daigneault , Pierre Lemieux
IPC分类号： G06F1130
CPC分类号： G07C9/00015 , G07C9/00103
摘要： The present invention relates to access control systems ore commonly referred to as security systems. In a preferred embodiment of the invention, the access control system uses a memory card and a network of access control subsystems. Among the specific characteristics of the invention are the loading of schedule data on the memory card and the devolution of specific functions such as schedule validation to the access control subsystem level. These characteristics of the system provide, among other advantages, a reduction of the amount of wiring, a reduction in the hardware and installation costs, a considerable memory saving for the hardware and an increase in the system's capacity and flexibility.
摘要翻译：本发明涉及通常称为安全系统的访问控制系统。在本发明的优选实施例中，访问控制系统使用存储卡和访问控制子系统的网络。在本发明的具体特征之中是将存储卡上的时间表数据加载到诸如计划验证的特定功能的下放到访问控制子系统级。该系统的这些特征除了其他优点之外还提供了布线量的减少，硬件和安装成本的降低，硬件的相当大的存储器节省以及系统的容量和灵活性的增加。

8. 发明申请

US20130029906A1 METHOD OF REGULATING PPAR, OBESITY RELATED PATHWAYS AND THEIR ASSOCIATED METABOLIC IMPACT 审中-公开
标题翻译：调节PPAR，肥胖相关途径及其相关代谢影响的方法
公开(公告)号：US20130029906A1
公开(公告)日：2013-01-31
申请号：US13513442
申请日：2010-12-03
申请人： Eric Simard , Eric Trottier , Josée Beaulieu , Jean-Francois Lapointe , Pierre Lemieux
发明人： Eric Simard , Eric Trottier , Josée Beaulieu , Jean-Francois Lapointe , Pierre Lemieux
IPC分类号： A61K38/01 , A61P3/08
CPC分类号： A61K35/20 , A61K38/018
摘要： It is disclosed a method of modulating a peroxisome proliferator activated receptor (PPAR) activity in a patient comprising administering to said subject an effective amount of a malleable protein matrix (MPM), uses thereof and pharmaceutical compositions comprising MPM for treating obesity related disorders and their associated metabolic impact by modulating PPAR activity.
摘要翻译：公开了一种调节患者过氧化物酶体增殖物激活受体（PPAR）活性的方法，包括向所述受试者施用有效量的可延展蛋白质基质（MPM），其用途和包含MPM的药物组合物，用于治疗肥胖相关病症及其通过调节PPAR活性引起的相关代谢影响。

9. 发明授权

US07256180B2 Compositions and methods for inducing activation of dendritic cells 失效
标题翻译：用于诱导树突状细胞活化的组合物和方法
公开(公告)号：US07256180B2
公开(公告)日：2007-08-14
申请号：US09845938
申请日：2001-04-30
申请人： Alexander V. Kabanov , Pierre Lemieux , Valery Alakhov , Nadia Guerin
发明人： Alexander V. Kabanov , Pierre Lemieux , Valery Alakhov , Nadia Guerin
IPC分类号： A61K48/00 , A61K9/127
CPC分类号： A61K9/0019 , A61K9/1075 , A61K47/10 , A61K48/0008 , C08L53/00 , Y02A50/412 , C08L2666/24 , C08L2666/02 , C08L2666/14
摘要： Compositions induce the activation of dendritic cells comprising a polynucleotide, such as viruses, RNA, DNA, plasmid DNA, or derivatives thereof and at least one block copolymer of alkylethers. The present invention further relates to compositions for inducing the activation of dendritic cells wherein the block copolymers are PLURONIC F127 and L61. More particular, the compositions comprise block copolymers PLURONIC F127/PLURONIC L61. The invention also relates to methods of inducing the activation of dendritic cells in animals comprising administering the compositions of the invention. Additionally, the present invention relates to methods of increasing the immune response of animals comprising administering the compositions of the present invention.
摘要翻译：组合物诱导包含多核苷酸例如病毒，RNA，DNA，质粒DNA或其衍生物和至少一种烷基醚嵌段共聚物的树突细胞的活化。本发明还涉及用于诱导树突状细胞活化的组合物，其中嵌段共聚物是PLURONIC F127和L61。更具体地，组合物包含嵌段共聚物PLURONIC F127 / PLURONIC L61。本发明还涉及诱导动物中树突状细胞活化的方法，包括施用本发明的组合物。另外，本发明涉及增加动物的免疫应答的方法，包括施用本发明的组合物。

10. 发明申请

US20060057131A1 Malleable protein matrix and uses thereof 审中-公开
标题翻译：可塑性蛋白质基质及其用途
公开(公告)号：US20060057131A1
公开(公告)日：2006-03-16
申请号：US10499313
申请日：2002-12-20
申请人： Eric Simard , Dominique Pilote , Claude DuPont , Nathalie Lajoie , Marcel Paquet , Pierre Lemieux , Philippe Goyette
发明人： Eric Simard , Dominique Pilote , Claude DuPont , Nathalie Lajoie , Marcel Paquet , Pierre Lemieux , Philippe Goyette
IPC分类号： A61K35/74 , C12N1/20
CPC分类号： A61K35/74 , A23C9/1307 , A23C9/1315 , A23C13/14 , A23C15/16 , A23J3/00 , A23J3/08 , A23J3/22 , A23L27/60 , A23L33/135 , A23V2002/00 , A23Y2220/47 , A61K8/64 , A61K8/99 , A61K9/0014 , A61K9/1658 , A61K35/20 , A61K35/742 , A61K35/744 , A61K35/745 , A61K35/747 , A61K36/064 , A61K38/00 , A61K47/42 , A61K2800/85 , A61Q1/02 , A61Q19/00 , C12N1/20 , C12N11/02 , C12N15/63 , A23V2200/242 , A23V2250/54252 , A23V2200/124
摘要： The present invention relates to a malleable protein matrice (MPM), which is the reaction product of the agglomeration of proteins after a fermentation process and is exhibiting biological activities and is suitable for the incorporation (or encapsulation) of various hydrophilic or lipophylic substances. The present invention also relates to the process for the preparation of the malleable protein matrice and its usages.
摘要翻译：本发明涉及可发育的蛋白质基质（MPM），其是发酵过程后蛋白质聚集并且具有生物活性并且适于掺入（或包封）各种亲水或亲脂物质的反应产物。本发明还涉及可塑性蛋白质基质的制备方法及其用途。

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