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    • 7. 发明申请
    • Anti-pathogen treatments
    • 抗病原体治疗
    • US20070031965A1
    • 2007-02-08
    • US11503416
    • 2006-08-11
    • Todd Rider
    • Todd Rider
    • A61K31/70C12N5/00A01N43/04C12N5/02
    • A61K47/48246A61K38/16A61K38/17A61K38/1709A61K38/4873A61K47/64G01N33/5091G01N33/56983Y02A50/481
    • Chimeric molecules that contain at least one pathogen-detection domain and at least one effector domain, and their methods of use in preventing or treating a pathogen infection in a cell or organism are described. The pathogen-detection domain and effector domain of the chimeric molecules are domains not typically found in nature to be associated together. Agents are also described herein having at least one pathogen-interacting molecular structure and at least one effector-mediating molecular structure, the agent being one that is non-naturally-occurring in a cell. The methods of prevention and treatment described herein are effective for a broad spectrum of pathogens and exhibit little or no toxic side-effects. Assays for the detection of a pathogen, pathogen component, or product produced or induced by a pathogen, are also provided.
    • 描述了含有至少一个病原体检测结构域和至少一个效应子结构域的嵌合分子及其用于预防或治疗细胞或生物体中的病原体感染的方法。 嵌合分子的病原体检测结构域和效应子结构域是自然界中通常不被结合在一起的结构域。 本文还描述了具有至少一种病原体相互作用的分子结构和至少一种效应物介导分子结构的试剂,所述试剂是在细胞中非天然存在的试剂。 本文所述的预防和治疗方法对于广谱的病原体是有效的,并且表现出很少的或没有毒性的副作用。 还提供了用于检测病原体,病原体成分​​或由病原体产生或诱导的产物的检测。
    • 9. 发明授权
    • Rocket staging system
    • 火箭分级系统
    • US4723736A
    • 1988-02-09
    • US898010
    • 1986-08-18
    • Todd Rider
    • Todd Rider
    • B64G1/00B64G1/40F02K9/44F02K9/60F42B15/36F02K9/42
    • F02K9/605B64G1/002B64G1/402F02K9/44F42B15/36B64G1/401
    • An improved rocket staging system for missiles and the like wherein a carriage borne rocket engine assembly is sequentially employed within separate, generally aligned oxidizer stages which are generally coaxially disposed about the central rocket engine and its associated carriage. A central fuel tank is surrounded by several separate, cooperating, generally ring-shaped oxidizer tanks generally coaxially disposed about the rocket periphery. A plurality of oxidizer delivery lines run through each of the outer tanks and up to the top of the fuel tank, where a flexible hose brings oxidizer down to the engine carriage. As fuel is consumed, the rocket motor carriage slides upwardly inside the fuel tank in response to thrust. When the carriage is firmly seated inside the next higher oxidizer tank and all of the propellant has been removed from the lowest tank, the lowest tank is jettisoned to discard unnecessary mass. Thus when a stage is jettisoned, its oxidizer lines disconnect from those of the next higher stage and check valves in the lower endsd of the lines in the next stage prevent significant oxidizer spillage. Oxidizer intake ports such as solenoid valves mounted on the oxidizer delivery lines in each stage are kept open in the lowermost stage and closed in all other stages to allow oxidizer to be drawn only from the lowermost tank.
    • 用于导弹等的改进的火箭分级系统,其中滑架式火箭发动机组件被顺序地用在分开的,大致对准的氧化器级中,该氧化器级大致同轴地设置在中心火箭发动机及其相关联的支架周围。 中央燃料箱被几个单独的,协作的,通常环形的氧化剂罐围绕,通常同轴地设置在火箭周边周围。 多个氧化剂输送管线穿过每个外部罐和直到燃料箱的顶部,其中柔性软管将氧化剂带到发动机支架。 当燃料消耗时,火箭发动机支架响应于推力向上滑向燃料箱内部。 当托架牢牢地安置在下一个较高的氧化剂罐内并且所有的推进剂都已从最低的罐中取出时,最低的罐被抛弃以丢弃不必要的物料。 因此,当一个阶段被抛弃时,其氧化剂管线与下一个较高阶段的氧化剂管线断开,下一阶段管线下端的止回阀可防止显着的氧化剂溢出。 安装在每个阶段的氧化剂输送管线上的电磁阀的氧化剂进气口在最下阶段保持打开,并且在所有其它阶段中保持关闭,以允许氧化剂仅从最下面的罐抽出。