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    • 4. 发明申请
    • Anti-pathogen treatments
    • 抗病原体治疗
    • US20070031965A1
    • 2007-02-08
    • US11503416
    • 2006-08-11
    • Todd Rider
    • Todd Rider
    • A61K31/70C12N5/00A01N43/04C12N5/02
    • A61K47/48246A61K38/16A61K38/17A61K38/1709A61K38/4873A61K47/64G01N33/5091G01N33/56983Y02A50/481
    • Chimeric molecules that contain at least one pathogen-detection domain and at least one effector domain, and their methods of use in preventing or treating a pathogen infection in a cell or organism are described. The pathogen-detection domain and effector domain of the chimeric molecules are domains not typically found in nature to be associated together. Agents are also described herein having at least one pathogen-interacting molecular structure and at least one effector-mediating molecular structure, the agent being one that is non-naturally-occurring in a cell. The methods of prevention and treatment described herein are effective for a broad spectrum of pathogens and exhibit little or no toxic side-effects. Assays for the detection of a pathogen, pathogen component, or product produced or induced by a pathogen, are also provided.
    • 描述了含有至少一个病原体检测结构域和至少一个效应子结构域的嵌合分子及其用于预防或治疗细胞或生物体中的病原体感染的方法。 嵌合分子的病原体检测结构域和效应子结构域是自然界中通常不被结合在一起的结构域。 本文还描述了具有至少一种病原体相互作用的分子结构和至少一种效应物介导分子结构的试剂,所述试剂是在细胞中非天然存在的试剂。 本文所述的预防和治疗方法对于广谱的病原体是有效的,并且表现出很少的或没有毒性的副作用。 还提供了用于检测病原体,病原体成分​​或由病原体产生或诱导的产物的检测。