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1. 发明授权

US09034260B2 Apparatus and method for selecting particles 有权
标题翻译：用于选择颗粒的装置和方法
公开(公告)号：US09034260B2
公开(公告)日：2015-05-19
申请号：US13379944
申请日：2010-06-24
申请人： Heiko Meyer , Raoul Amadeus Lorbeer , Alexander Heisterkamp , Detlef Rath
发明人： Heiko Meyer , Raoul Amadeus Lorbeer , Alexander Heisterkamp , Detlef Rath
IPC分类号： G01N33/00 , B41J2/135 , B41J2/02 , G01N15/14
CPC分类号： G01N15/1459 , G01N2015/149
摘要： The invention provides a device and a method for flow cytometric fractionation of particles contained in a fluid stream, wherein sections of the fluid stream, especially droplets if the fluid stream is a droplet stream, are irradiated with a laser. The laser disposed for the irradiation of the sections of the fluid stream can have a wavelength which is absorbed by the fluid and can have a sufficient radiation duration and radiation intensity to deflect sections of the fluid stream.
摘要翻译：本发明提供了流体流中所含颗粒的流式细胞分级分离装置和方法，其中如果流体流是液滴流，则流体流的部分，尤其是液滴流中的液滴被激光照射。设置用于照射流体流的部分的激光器可以具有被流体吸收的波长，并且可以具有足够的辐射持续时间和辐射强度以偏转流体流的部分。

2. 发明申请

US20120094352A1 METHOD FOR CELL IDENTIFICATION AND CELL SORTING 有权
标题翻译：细胞鉴定和细胞分选方法
公开(公告)号：US20120094352A1
公开(公告)日：2012-04-19
申请号：US13003962
申请日：2009-07-15
申请人： Detlef Rath , Wilfried Kues , Ulrike Taylor , Stephan Barcikowski , Svea Petersen
发明人： Detlef Rath , Wilfried Kues , Ulrike Taylor , Stephan Barcikowski , Svea Petersen
IPC分类号： C12N15/01 , C12N5/076 , B82Y5/00
CPC分类号： G01N33/532 , C12N5/0612 , G01N33/54313 , G01N33/54346
摘要： The present invention relates to a method and to compounds useable in the method for analysis of cells for the pre-sence of an analyte and sorting the cells on the basis of the analyte. The compounds used in the method are optically detectable because of the content of a fluorochrome and contain a binder fraction which can specifically bind an analyte, in particular an oligonucleotide.
摘要翻译：本发明涉及一种可用于分析细胞分析方法的方法和化合物，该化合物基于分析物分选细胞。该方法中使用的化合物是可光学检测的，因为荧光染料的含量并且含有可以特异性结合分析物，特别是寡核苷酸的粘合剂级分。

3. 发明申请

US20120225418A1 APPARATUS AND METHOD FOR SELECTING PARTICLES 有权
标题翻译：选择颗粒的装置和方法
公开(公告)号：US20120225418A1
公开(公告)日：2012-09-06
申请号：US13379944
申请日：2010-06-24
申请人： Heiko Meyer , Alexander Heisterkamp , Raoul Amadeus Lorbeer , Detlef Rath
发明人： Heiko Meyer , Alexander Heisterkamp , Raoul Amadeus Lorbeer , Detlef Rath
IPC分类号： A01N1/02 , B01D43/00
CPC分类号： G01N15/1459 , G01N2015/149
摘要： The invention provides a device and a method for flow cytometric fractionation of particles contained in a fluid stream, wherein sections of the fluid stream, especially droplets if the fluid stream is a droplet stream, are irradiated with a laser. The laser disposed for the irradiation of the sections of the fluid stream can have a wavelength which is absorbed by the fluid and can have a sufficient radiation duration and radiation intensity to deflect sections of the fluid stream.
摘要翻译：本发明提供了流体流中所含颗粒的流式细胞分级分离装置和方法，其中如果流体流是液滴流，则流体流的部分，尤其是液滴流中的液滴被激光照射。设置用于照射流体流的部分的激光器可以具有被流体吸收的波长，并且可以具有足够的辐射持续时间和辐射强度以偏转流体流的部分。

4. 发明授权

US5659494A Method and apparatus for determination of an approximate standard deviation in an image processor 失效
标题翻译：用于确定图像处理器中的近似标准偏差的方法和装置
公开(公告)号：US5659494A
公开(公告)日：1997-08-19
申请号：US385990
申请日：1995-02-09
申请人： Ingo Chmielewski , Detlef Rath
发明人： Ingo Chmielewski , Detlef Rath
IPC分类号： G06F17/18 , G06T5/20 , H04N5/21 , G06F7/00
CPC分类号： H04N5/21
摘要： An economical and less cumbersome method for the determination of an approximate standard deviation is implemented in hardware that does not require multipliers and root calculators. A mean value for a series of values is first calculated. Then, for each of the values in the series, the difference between the value and the mean value is calculated. Each of the differences is then classified in at least two different groups, with the classification corresponding to the size of the difference. The differences are then weighted according to the group in which they are classified. Finally, the weighted differences are summed and divided by an appropriate predetermined number. This method can be used in systems for noise suppression with a sigma filter.
摘要翻译：用于确定近似标准偏差的经济且不太麻烦的方法在不需要乘法器和根计算器的硬件中实现。首先计算一系列值的平均值。然后，对于系列中的每个值，计算值和平均值之间的差。然后将每个差异分为至少两个不同的组，其分类对应于差异的大小。然后根据其分类的组对差异进行加权。最后，将加权差值相加并除以适当的预定数量。该方法可用于使用Σ滤波器进行噪声抑制的系统。

5. 发明申请

US20160161391A1 NOZZLE AND METHOD FOR FLOW CYTOMETRY 审中-公开
标题翻译：用于流动细胞计数的喷嘴和方法
公开(公告)号：US20160161391A1
公开(公告)日：2016-06-09
申请号：US14888906
申请日：2014-05-08
申请人： Detlef RATH , MASTERRIND GMBH
发明人： Detlef Rath
IPC分类号： G01N15/14 , C12M1/00 , G01N33/487
CPC分类号： G01N15/1404 , C12M47/04 , G01N15/14 , G01N33/487 , G01N2015/1006 , G01N2015/1081 , G01N2015/1236 , G01N2015/1409 , G01N2015/1413 , G01N2015/1422 , G01N2015/149
摘要： The invention relates to a nozzle for flow cytometry, the housing of which is tapering towards an outlet and in which a feed tube is arranged for a core flow liquid, the outlet opening of which is arranged at a distance from the outlet of the housing. The outlet of the housing forms the outlet of the nozzle. The housing of the nozzle extends from its outlet, which is arranged at its first end to its opposite second end, and has an inlet for a sheath flow liquid connected with the internal volume. The nozzle is characterized in that in the housing a leading element that promotes the alignment of particles extends from both sides of the feed tube.
摘要翻译：本发明涉及一种用于流式细胞术的喷嘴，其壳体朝向出口逐渐变细，并且其中为芯流动液体设置进料管，其出口开口设置在离壳体出口一定距离处。外壳的出口形成喷嘴的出口。喷嘴的壳体从其出口延伸，其出口在其第一端设置到其相对的第二端，并具有用于与内部容积连接的护套流动液体的入口。喷嘴的特征在于，在壳体中，促进颗粒对准的引导元件从进料管的两侧延伸。

6. 发明授权

US5828791A Method for storing and playback of fixed videotexts 失效
标题翻译：固定录像带的存储和播放方法
公开(公告)号：US5828791A
公开(公告)日：1998-10-27
申请号：US650982
申请日：1996-05-21
申请人： Ingo Chmielewski , Detlef Rath , Eckart Neumann , Christian Seydel , Rolf Michael Schuller
发明人： Ingo Chmielewski , Detlef Rath , Eckart Neumann , Christian Seydel , Rolf Michael Schuller
IPC分类号： G09G5/00 , G06F3/14 , G09G5/22 , G09G5/30 , H03M7/40 , H04N5/445 , H04N7/088 , G06K9/36 , G06K9/46
CPC分类号： G06F3/14 , H04N5/44504 , H04N7/0882 , G09G2340/02 , H04N21/4856
摘要： In a method for storing and playback of a repertoire of fixed videotexts, in which the videotext is stored by characters in digital form in an electrical memory, the quantity of the data to be stored can be effectively reduced in that in addition to the characters, position characters are stored and that for recurring, identical character sequences of greater length, instead of the character sequence, a reference to the location of the already stored character sequence is stored. The playback of the thus compressed texts can take place without problems in real time, i.e., without noticeable delay.
摘要翻译：在用于存储和回放固定视频文本的全部方法中，其中视频文本以数字形式的字符存储在电存储器中，可以有效地减少要存储的数据量，因为除了字符之外，存储位置字符，对于重复的长度相同的字符序列而不是字符序列，存储对已经存储的字符序列的位置的引用。这样压缩的文本的播放可以在没有问题的情况下实时发生，即没有明显的延迟。

7. 发明授权

US08649983B2 Method for cell identification and cell sorting 有权
标题翻译：细胞鉴定和细胞分选方法
公开(公告)号：US08649983B2
公开(公告)日：2014-02-11
申请号：US13003962
申请日：2009-07-15
申请人： Detlef Rath , Wilfried Kues , Ulrike Taylor , Stephan Barcikowski , Svea Petersen
发明人： Detlef Rath , Wilfried Kues , Ulrike Taylor , Stephan Barcikowski , Svea Petersen
IPC分类号： G06F19/00 , C12Q1/68 , C12N15/11
CPC分类号： G01N33/532 , C12N5/0612 , G01N33/54313 , G01N33/54346
摘要： The present invention relates to a method and to compounds useable in the method for analysis of cells for the presence of an analyte and sorting the cells on the basis of the analyte. The compounds used in the method are optically detectable because of the content of a fluorochrome and contain a binder fraction which can specifically bind an analyte, in particular an oligonucleotide.
摘要翻译：本发明涉及一种可用于细胞分析方法的方法和化合物，用于分析物的存在并基于分析物分选细胞。该方法中使用的化合物是可光学检测的，因为荧光染料的含量并含有能够特异性结合分析物，特别是寡核苷酸的粘合剂级分。

8. 发明授权

US5841934A Method for noise suppression and noise-suppression circuit for video recorders 失效
标题翻译：视频录像机的噪声抑制和噪声抑制电路方法
公开(公告)号：US5841934A
公开(公告)日：1998-11-24
申请号：US500946
申请日：1996-03-08
申请人： Ingo Chmielewski , Detlef Rath , Hans-Peter Arnold
发明人： Ingo Chmielewski , Detlef Rath , Hans-Peter Arnold
IPC分类号： H04N9/87 , H04N9/79 , H04N9/88
CPC分类号： H04N9/7908
摘要： A noise suppression apparatus and method for recorded luminance signals in which a level of an FM signal from the recording medium is detected, and the level of the recovered chroma signal is detected, the luminance signal is bandpass filtered and limited. A subtraction signal is generated based on the filtered and limited luminance signal and having magnitude based on the detected level of at least one of the chroma signal and the FM signal. The subtraction signal is subtracted from the luminance signal to generate a noise suppressed luminance signal. The passband of the bandpass filter may be varied based on at least one of the chroma signal and the FM signal.
摘要翻译： PCT No.PCT / DE94 / 01456 Sec。 371日期：1996年3月8日 102（e）1996年3月8日PCT 1994年12月7日PCT PCT。 WO95 / 16326 PCT公开号日期：1995年6月15日一种用于记录亮度信号的噪声抑制装置和方法，其中检测到来自记录介质的FM信号的电平，并且检测到恢复的色度信号的电平，亮度信号被带通滤波和限制。基于滤波和有限的亮度信号产生减法信号，并且具有基于检测到的色度信号和FM信号中的至少一个的电平的幅度。从亮度信号中减去减法信号，生成噪声抑制亮度信号。带通滤波器的通带可以基于色度信号和FM信号中的至少一个来改变。

9. 发明授权

US10094758B2 Nozzle and method for flow cytometry 有权
公开(公告)号：US10094758B2
公开(公告)日：2018-10-09
申请号：US14888906
申请日：2014-05-08
申请人： MASTERRIND GMBH , Detlef Rath
发明人： Detlef Rath
IPC分类号： G01N21/00 , G01N15/14 , C12M1/00 , G01N33/487 , G01N15/12 , G01N15/10
摘要： The invention relates to a nozzle for flow cytometry, the housing of which is tapering towards an outlet and in which a feed tube is arranged for a core flow liquid, the outlet opening of which is arranged at a distance from the outlet of the housing. The outlet of the housing forms the outlet of the nozzle. The housing of the nozzle extends from its outlet, which is arranged at its first end to its opposite second end, and has an inlet for a sheath flow liquid connected with the internal volume. The nozzle is characterized in that in the housing a leading element that promotes the alignment of particles extends from both sides of the feed tube.

10. 发明授权

US5448304A Process for reducing the noise of a video signal 失效
标题翻译：降低视频信号噪声的过程
公开(公告)号：US5448304A
公开(公告)日：1995-09-05
申请号：US238852
申请日：1994-05-06
申请人： Ingo Chmielewski , Detlef Rath
发明人： Ingo Chmielewski , Detlef Rath
IPC分类号： H04N5/21 , H04N5/911 , H04N5/93 , H04N5/213
CPC分类号： H04N5/911 , H04N5/21
摘要： The present invention is a process for reducing the noise of a video signal (S1), in particular when reproducing a video signal stored on a video recorder, in which a window is defined around every signal value P (0,0,0) as an output signal value. A mean deviation (.sigma.) of the signal values in the window is established from the output signal values P (0,0,0), and an averaging of the output signal value is carried out with those neighboring signal values in the window which lie within limit values (So, Su) for the deviation from the output signal value P (0,0,0) dependent on the established mean deviation (.sigma.). The method is improved in its effectiveness by at least one threshold value (a1, a2) being fixed for the mean deviation (.sigma.=a/2), by the limit values (So, Su) for a mean deviation lying below the threshold value (a1, a2) being set with values (b) dependent on the established mean deviation (.sigma.) and by the limit values (So, Su) for a mean deviation (.sigma.) lying above the at least one threshold value (a1, a2 ) being determined with a substantially constant, preselected maximum value (b2).
摘要翻译：本发明是一种降低视频信号（S1）的噪声的方法，特别是当再现存储在视频记录器上的视频信号时，其中围绕每个信号值P（0,0,0）定义窗口作为输出信号值。从输出信号值P（0,0,0）建立窗口中信号值的平均偏差（sigma），并且输出信号值的平均值与在窗口中的那些相邻信号值进行对于偏离输出信号值P（0,0,0）的极限值（So，Su），取决于建立的平均偏差（sigma）。通过对于平均偏差（σ= a / 2）固定的至少一个阈值（a1，a2）通过低于阈值的平均偏差的极限值（So，Su）来提高其有效性的方法（a1，a2）被设置为取决于建立的平均偏差（sigma）的值（b）和对于高于至少一个阈值（a1，a2）的平均偏差（sigma）的限制值（So，Su））以基本恒定的预选最大值（b2）确定。

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