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1. 发明授权

US06547229B1 Stacking apparatus and method for laminated products and packaging 失效
标题翻译：堆叠设备和层压产品和包装方法
公开(公告)号：US06547229B1
公开(公告)日：2003-04-15
申请号：US09718549
申请日：2000-11-22
申请人： Eric J. Hanson , John R. Wheeler , Alan P. Miller , David B. Pritchard , Donald G. Peterson , John R. Jacobson , Jeffrey J. Missling , James N. Dobbs , David C. Kramlich
发明人： Eric J. Hanson , John R. Wheeler , Alan P. Miller , David B. Pritchard , Donald G. Peterson , John R. Jacobson , Jeffrey J. Missling , James N. Dobbs , David C. Kramlich
IPC分类号： B32B3116
CPC分类号： H01M10/0404 , B65H29/243 , B65H31/28 , B65H37/002 , B65H2801/72 , H01M6/40 , H01M8/1004 , H01M10/052 , H01M10/0565 , H01M10/058 , Y10T156/1705 , Y10T156/1707 , Y10T156/171 , Y10T156/1906
摘要： A product stacking apparatus and method employs one or more stations, each including a stationary stacking platform or a conveyor upon which spaced-apart pucks are coupled for travel thereon. A product delivery apparatus drives one or more movable webs to which segmented product sheets are removably affixed. The product delivery apparatus includes one or more rotatable lamination interfaces associated with each of the stations for transferring product sheets from the webs to the pucks on a repetitive basis to produce a stack of product sheets on the respective pucks. Each of the segmented product sheets may define all or a portion of an electrochemical cell, all or a portion of a pad including layers of film or sheet material, wherein a portion of each of the layers is provided with a bonding feature, or all or a portion of a pack comprising layers of medical dressing. A puck need not be in motion during the transfer of the product sheet from the lamination roll to the puck. The puck may or may not be attached to a conveyor, but the conveyor need not be in motion during the lamination or stack building process. In this case, a roller is moved across the puck and simultaneously rotated so a point on the surface of the roller interfaces with the puck at the same location on each pass.
摘要翻译：产品堆垛装置和方法采用一个或多个工位，每个工位都包括一个固定的堆垛平台或一个传送带，在该传送带上分开有一个分开的盘，以便在其上行进。产品输送装置驱动一个或多个可移动的网，分段的产品片可拆卸地固定到该幅片上。产品递送装置包括与每个站相关联的一个或多个可旋转的层压界面，用于将产品板从纸幅重复地传送到冰球，以在相应的冰球上产生一叠产品纸。每个分段产品片可以限定电化学电池的全部或一部分，包括膜或片材材料层的焊盘的全部或一部分，其中每个层的一部分设置有结合特征，或全部或包括医用敷料层的一部分包装。在将产品片从层压辊转移到冰球期间，圆盘不需要运动。圆盘可以或可以不附接到输送机，但是在层压或堆叠构建过程期间输送机不需要运动。在这种情况下，辊子移动穿过圆盘并同时旋转，使得辊子表面上的点与每个通道上的相同位置处的冰球接触。

2. 发明授权

US06585846B1 Rotary converting apparatus and method for laminated products and packaging 失效
标题翻译：用于层压产品和包装的旋转转换装置和方法
公开(公告)号：US06585846B1
公开(公告)日：2003-07-01
申请号：US09718584
申请日：2000-11-22
申请人： Eric J. Hanson , John R. Wheeler , Alan P. Miller , David B. Pritchard , Donald G. Peterson , John R. Jacobson , Jeffrey J. Missling , James N. Dobbs , David C. Kramlich
发明人： Eric J. Hanson , John R. Wheeler , Alan P. Miller , David B. Pritchard , Donald G. Peterson , John R. Jacobson , Jeffrey J. Missling , James N. Dobbs , David C. Kramlich
IPC分类号： B32B3100
CPC分类号： H01M10/0404 , B65H37/002 , B65H39/14 , B65H2801/72 , H01M6/188 , H01M6/40 , H01M8/1004 , H01M10/0436 , Y02P70/56 , Y10T29/49112 , Y10T29/49114 , Y10T156/1075 , Y10T156/1084 , Y10T156/1322 , Y10T156/133 , Y10T156/1343
摘要： An apparatus and method provides for rotatably cutting and/or laminating layered structures or sheet material supported by webs. A rotary converting apparatus and method of the present invention converts a web comprising a cathode layered structure and a web comprising an anode layered structure into a series of layered electrochemical cell structures supported by a release liner. Employment of a rotary converting process of the present invention provides, among other benefits, for the creation of a product having a finished size, without need for downstream or subsequent cutting.
摘要翻译：一种装置和方法提供了可旋转地切割和/或层压由纤维网支撑的层状结构或片材。本发明的旋转转换装置和方法将包括阴极层状结构的网和包含阳极层状结构的网转换成由剥离衬垫支撑的一系列层状电化学电池结构。本发明的旋转转换方法的使用除了其他的优点之外还提供了一种具有成品尺寸的产品，而不需要下游或随后的切割。

3. 发明授权

US06939383B2 Method for making electrode 有权
标题翻译：电极制作方法
公开(公告)号：US06939383B2
公开(公告)日：2005-09-06
申请号：US10138278
申请日：2002-05-03
申请人： Brian C. Eastin , Katherine A. Graham , Tony B. Hollobaugh , James A. McDonell , Jeffrey J. Missling , John R. Wheeler
发明人： Brian C. Eastin , Katherine A. Graham , Tony B. Hollobaugh , James A. McDonell , Jeffrey J. Missling , John R. Wheeler
IPC分类号： B29C47/10 , B29C47/38 , B29C47/40 , H01M4/04 , H01M4/08 , H01M4/1391 , H01M4/38 , H01M4/46 , H01M4/62 , H01M4/88 , H01M6/18 , H01M10/052 , H01M10/0565 , H01M10/36 , H01M6/00
CPC分类号： H01M4/0483 , B29C47/0011 , B29C47/10 , B29C47/1081 , B29C47/38 , B29C47/402 , B29C47/404 , B29K2023/06 , B29K2023/12 , B29K2027/16 , B29K2067/00 , B29K2105/0044 , H01M4/0404 , H01M4/0411 , H01M4/1391 , H01M10/052 , H01M10/0565 , Y10T29/49108 , Y10T29/49115
摘要： Described are methods of making electrodes for electrochemical systems, especially cathodes for lithium polymer batteries, and products prepared from the methods; the methods involve the use of a co-rotating, fully intermeshing twin screw extruder, the extrusion of essentially solvent-free systems, or both.
摘要翻译：描述了制备用于电化学系统的电极，特别是用于锂聚合物电池的阴极和由该方法制备的产品的方法; 该方法涉及使用共旋转，完全相互啮合的双螺杆挤出机，基本上无溶剂体系的挤出或两者。

4. 发明授权

US07919111B2 Biodegradable hydrophobic polysaccharide-based drug delivery implants 有权
标题翻译：可生物降解的疏水多糖类药物输送种植体
公开(公告)号：US07919111B2
公开(公告)日：2011-04-05
申请号：US11724554
申请日：2007-03-15
申请人： Stephen J. Chudzik , Signe R. Erickson , Jeffrey J. Missling
发明人： Stephen J. Chudzik , Signe R. Erickson , Jeffrey J. Missling
IPC分类号： A61F2/02
CPC分类号： A61L31/16 , A61F9/0017 , A61K9/0024 , A61K9/0051 , A61L27/20 , A61L27/54 , A61L31/10 , A61L31/148 , A61L2300/222 , A61L2300/41 , A61L2300/604 , A61L2300/606 , C08B30/18 , C08L3/02 , C08L5/16
摘要： Medical implants formed of hydrophobic derivatives of natural biodegradable polysaccharides and that include bioactive agent are described. The implants demonstrate desirable bioactive agent release profiles and can be prepared to have high drug loading. The implants can be used to treat medical conditions, such as those requiring prolonged administration of the bioactive agent at a target location in the body.
摘要翻译：描述了由天然生物可降解多糖的疏水衍生物形成的医学植入物，包括生物活性剂。植入物显示出所需的生物活性剂释放曲线并且可以被制备成具有高的药物负荷。植入物可以用于治疗医疗状况，例如需要在身体的目标位置长期施用生物活性剂的那些。

5. 发明申请

US20110159072A1 CONTROLLED RELEASE MATRIX 审中-公开
标题翻译：控制释放矩阵
公开(公告)号：US20110159072A1
公开(公告)日：2011-06-30
申请号：US12980468
申请日：2010-12-29
申请人： Jeffrey J. Missling , Nathan Lockwood , Kevin W. Burton , Beth A. Petersen
发明人： Jeffrey J. Missling , Nathan Lockwood , Kevin W. Burton , Beth A. Petersen
IPC分类号： A61K9/10 , A61K39/00
CPC分类号： A61K9/0024 , A61K9/7007 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/602 , C08L67/04
摘要： A biocompatible polymeric controlled release matrix for delivery of one or more bioactive agents from an implantable medical device is described. In one embodiment, the polymeric controlled release matrix is a complaint film that includes one or more compliant biocompatible polymers and one or more bioactive agents. In another embodiment, the polymeric controlled release matrix is an elastomeric collar that includes one or more elastomeric biocompatible polymers and one or more bioactive agents.
摘要翻译：描述了用于从可植入医疗装置递送一种或多种生物活性剂的生物相容性聚合物控释基质。在一个实施方案中，聚合物控制释放基质是包含一种或多种顺应性生物相容性聚合物和一种或多种生物活性剂的投诉膜。在另一个实施方案中，聚合物控释基质是包含一种或多种弹性体生物相容性聚合物和一种或多种生物活性剂的弹性体环。

6. 发明申请

US20110021899A1 CONDUCTIVE POLYMER COATINGS 审中-公开
标题翻译：导电聚合物涂料
公开(公告)号：US20110021899A1
公开(公告)日：2011-01-27
申请号：US12831539
申请日：2010-07-07
申请人： James H. Arps , Peter J. Barnett , Jeffrey J. Missling
发明人： James H. Arps , Peter J. Barnett , Jeffrey J. Missling
IPC分类号： A61B5/0408 , H01B1/16 , H01B1/18 , A61K47/02 , A61K47/04 , A61K47/34 , A61K47/32 , A61N1/04
CPC分类号： H01B1/124 , A61B5/0408 , A61K9/0009 , A61K9/0051 , A61N1/05 , A61N1/375 , H01B1/04
摘要： An electrically conductive coating composition that includes a polymeric mixture, an electrically conductive material dispersed within the polymeric mixture and, optionally, one or more bioactive agents is described.
摘要翻译：描述了包括聚合物混合物，分散在聚合物混合物内的导电材料和任选的一种或多种生物活性剂的导电涂料组合物。

7. 发明申请

US20120165760A1 DRUG ELUTING IMPLANT 审中-公开
标题翻译：药物植入物
公开(公告)号：US20120165760A1
公开(公告)日：2012-06-28
申请号：US13338695
申请日：2011-12-28
申请人： Jeffrey J. Missling , Bryan A. Claseman
发明人： Jeffrey J. Missling , Bryan A. Claseman
IPC分类号： A61M5/00 , B05D7/00
CPC分类号： A61K9/0024 , A61F2/30771 , A61F2/32 , A61F2/38 , A61F2/40 , A61F2002/3068 , A61F2002/30805 , A61L27/54
摘要： Described herein is an implantable medical device that has one or more surfaces that include one or more shallow recesses configured to receive a drug delivery composition comprising a polymeric matrix and one or more biologically active agents. In one embodiment, one or more surfaces comprise a frictional surface. In a more particular embodiment, the implantable medical device comprises a stem configured for insertion into a bone of a patient, wherein the stem comprises one or more surfaces that include one or more shallow recesses configured to receive a drug delivery composition comprising a matrix and one or more biologically active agents. The drug delivery composition can be a durable drug delivery matrix, a biodegradable drug delivery matrix, or a combination thereof. Methods of making such an implant are also provided.
摘要翻译：本文描述的是具有一个或多个表面的可植入医疗装置，所述表面包括一个或多个浅凹部，其构造成接收包含聚合物基质和一种或多种生物活性剂的药物递送组合物。在一个实施例中，一个或多个表面包括摩擦表面。在更具体的实施例中，可植入医疗装置包括构造成用于插入患者骨骼的杆，其中所述杆包括一个或多个表面，所述表面包括一个或多个浅凹槽，所述浅凹槽被构造成接收药物递送组合物，所述药物递送组合物包含基质和一个或更多的生物活性剂。药物递送组合物可以是耐久的药物递送基质，可生物降解的药物递送基质或其组合。还提供了制造这种植入物的方法。

8. 发明申请

US20070218102A1 Biodegradable hydrophobic polysaccharide-based coatings 审中-公开
标题翻译：可生物降解的疏水多糖类涂料
公开(公告)号：US20070218102A1
公开(公告)日：2007-09-20
申请号：US11724555
申请日：2007-03-15
申请人： Stephen J. Chudzik , Jeffrey J. Missling
发明人： Stephen J. Chudzik , Jeffrey J. Missling
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61F9/0017 , A61K9/0024 , A61K9/0051 , A61L27/20 , A61L27/54 , A61L31/10 , A61L31/148 , A61L2300/222 , A61L2300/41 , A61L2300/604 , A61L2300/606 , C08B30/18 , C08L3/02 , C08L5/16
摘要： Implantable medical articles having a coating formed of hydrophobic derivatives of natural biodegradable polysaccharides are described. The coatings can include a bioactive agent, and demonstrate desirable bioactive agent release profiles and can be prepared to have high drug loading. The coated implantable medical articles can be used to treat medical conditions, such as those requiring prolonged administration of the bioactive agent at a target location in the body.
摘要翻译：描述了具有由天然生物可降解多糖的疏水衍生物形成的涂层的可植入医疗制品。涂层可以包括生物活性剂，并且显示所需的生物活性剂释放曲线并且可以被制备成具有高的药物负载量。涂覆的可植入医疗制品可用于治疗医疗状况，例如需要在身体的目标位置延长施用生物活性剂的那些。

9. 发明授权

US06589299B2 Method for making electrode 有权
公开(公告)号：US06589299B2
公开(公告)日：2003-07-08
申请号：US09782748
申请日：2001-02-13
申请人： Jeffrey J. Missling , Brian C. Eastin , Tony B. Hollobaugh , Katherine A. Graham
发明人： Jeffrey J. Missling , Brian C. Eastin , Tony B. Hollobaugh , Katherine A. Graham
IPC分类号： H01M462
CPC分类号： H01M10/052 , H01M4/04 , H01M4/0404 , H01M4/0411 , H01M4/0483 , H01M4/13 , H01M4/131 , H01M4/139 , H01M4/485 , Y10T29/49115
摘要： Described are methods of making electrodes for electrochemical systems, especially cathodes for lithium polymer batteries, and products prepared from the methods; the methods involve the use of a reciprocating extruder, the extrusion of essentially solvent-free systems, or both.

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