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1. 发明申请

US20110166555A1 CARRIER FOR AN INSERTABLE MEDICAL DEVICE, INSERTION TOOLS, METHODS OF USE, AND KITS 审中-公开
标题翻译：插入式医疗装置的载体，插入工具，使用方法和工具
公开(公告)号：US20110166555A1
公开(公告)日：2011-07-07
申请号：US12895092
申请日：2010-09-30
申请人： Jianbo Zhou , Signe R. Erickson , Krip Punja
发明人： Jianbo Zhou , Signe R. Erickson , Krip Punja
IPC分类号： A61B17/00 , F16M13/00 , F16B2/10 , F16B2/20
CPC分类号： A61B17/064 , A61B17/068 , A61B2017/0649 , A61B2017/0688 , A61B2050/0065 , A61F9/0017 , F16B25/0005
摘要： Disclosed are device carriers for insertable medical devices. The device carrier holds an insertable medical device in a desired orientation to allow it to be grasped by an insertion tool. Additionally, the device carrier may be used to store and to protect the insertable medical device prior to the device being implanted at a target site in a patient. Also described are insertion tools that may be used with the device carrier for grasping the insertable medical device from the carrier, and inserting the medical device at the target site in the patient. Methods of using the device carriers and the insertion tools of the invention, and kits for practicing the methods of the invention are also disclosed.
摘要翻译：公开了用于可插入医疗装置的装置载体。装置载体将可插入的医疗装置保持在期望的取向以允许其通过插入工具抓住。另外，装置载体可以用于在将装置植入患者的目标部位之前存储和保护可插入的医疗装置。还描述了可以与装置载体一起使用的插入工具，用于从载体抓握可插入的医疗装置，并将医疗装置插入患者的目标部位。还公开了使用本发明的装置载体和插入工具的方法以及用于实施本发明的方法的试剂盒。

2. 发明授权

US07919111B2 Biodegradable hydrophobic polysaccharide-based drug delivery implants 有权
标题翻译：可生物降解的疏水多糖类药物输送种植体
公开(公告)号：US07919111B2
公开(公告)日：2011-04-05
申请号：US11724554
申请日：2007-03-15
申请人： Stephen J. Chudzik , Signe R. Erickson , Jeffrey J. Missling
发明人： Stephen J. Chudzik , Signe R. Erickson , Jeffrey J. Missling
IPC分类号： A61F2/02
CPC分类号： A61L31/16 , A61F9/0017 , A61K9/0024 , A61K9/0051 , A61L27/20 , A61L27/54 , A61L31/10 , A61L31/148 , A61L2300/222 , A61L2300/41 , A61L2300/604 , A61L2300/606 , C08B30/18 , C08L3/02 , C08L5/16
摘要： Medical implants formed of hydrophobic derivatives of natural biodegradable polysaccharides and that include bioactive agent are described. The implants demonstrate desirable bioactive agent release profiles and can be prepared to have high drug loading. The implants can be used to treat medical conditions, such as those requiring prolonged administration of the bioactive agent at a target location in the body.
摘要翻译：描述了由天然生物可降解多糖的疏水衍生物形成的医学植入物，包括生物活性剂。植入物显示出所需的生物活性剂释放曲线并且可以被制备成具有高的药物负荷。植入物可以用于治疗医疗状况，例如需要在身体的目标位置长期施用生物活性剂的那些。

3. 发明申请

US20110054441A1 METHODS, DEVICES, AND COMPOSITIONS FOR INTRAVITREAL INJECTION 审中-公开
标题翻译：方法，装置和组合物进行静脉注射
公开(公告)号：US20110054441A1
公开(公告)日：2011-03-03
申请号：US12853781
申请日：2010-08-10
申请人： SIGNE R. ERICKSON , Charles J. Hagemeier
发明人： SIGNE R. ERICKSON , Charles J. Hagemeier
IPC分类号： A61F9/007
CPC分类号： A61F9/0017
摘要： Methods of treating disorders of the eye are disclosed. One or more substances are injected into the vitreous humor of the eye using a syringe. A needle of the syringe is inserted into the eye such that the tip of the needle is positioned inferior to the visual axis. The needle of the syringe is inserted into the eye at an injection point that is located from 3 mm to 5 mm posterior to the limbus of the eye. The tip of the needle is positioned at a depth from 1 mm to 10 mm from the retina of the eye at the injection point.
摘要翻译：公开了治疗眼睛疾病的方法。使用注射器将一种或多种物质注射到眼睛的玻璃体液中。将注射器的针插入到眼睛中，使得针的尖端位于视轴以下。注射器的针被插入眼睛中的注射点，该注射点位于眼睛边缘后方3mm至5mm处。针尖位于注射点距离眼睛视网膜1mm至10mm的深度。

4. 发明申请

US20080057106A1 Low profile bioactive agent delivery device 审中-公开
标题翻译：薄型生物活性剂输送装置
公开(公告)号：US20080057106A1
公开(公告)日：2008-03-06
申请号：US11897238
申请日：2007-08-29
申请人： Signe R. Erickson , Laurie R. Lawin
发明人： Signe R. Erickson , Laurie R. Lawin
IPC分类号： A61M37/00 , A61F2/02 , A61F2/14
CPC分类号： A61F9/0017 , A61K9/0051
摘要： Disclosed are implantable devices that are configured for implantation through tissue or membrane and into an implantation site comprising viscoelastic fluid or non-osseous tissue. In embodiments of the invention, the implantable devices comprise: (a) a nonlinear body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal portion and a distal portion, wherein at least a portion of the body member deviates from the direction of extension, (b) a retention element at the proximal portion of the body member, the retention element configured to retain the implantable device at the implantation site, the retention element presenting an external profile of no greater than 0.5 mm when the device is implanted in a patient; and (c) a bioactive agent delivery system at the distal portion of the body member, the bioactive agent delivery system comprising one or more bioactive agents. Also disclosed are methods of delivering a bioactive agent to a patient using the devices.
摘要翻译：公开了被配置用于通过组织或膜并且进入包括粘弹性流体或非骨组织的植入位置的植入式装置。在本发明的实施例中，可植入装置包括：（a）具有延伸方向的非线性本体构件，沿着延伸方向的纵向轴线，以及近端部分和远侧部分，其中，至少一部分身体构件偏离延伸方向，（b）在主体构件的近侧部分处的保持元件，保持元件被配置为将可植入装置保持在植入位置处，保持元件呈现不大于0.5mm的外部轮廓当装置植入患者时; 和（c）生物活性剂递送系统在身体构件的远端部分，生物活性剂递送系统包含一种或多种生物活性剂。还公开了使用该装置将生物活性剂递送至患者的方法。

5. 发明申请

US20110245799A1 SYSTEM AND METHOD FOR DELIVERY OF SUSPENSIONS AND OTHER MICROPARTICLE COMPOSITIONS 审中-公开
标题翻译：用于输送悬浮液和其他微生物组合物的系统和方法
公开(公告)号：US20110245799A1
公开(公告)日：2011-10-06
申请号：US13077291
申请日：2011-03-31
申请人： SIGNE R. ERICKSON , Charles J. Hagemeier , Gary A. Winchester
发明人： SIGNE R. ERICKSON , Charles J. Hagemeier , Gary A. Winchester
IPC分类号： A61M5/31 , A61M5/315
CPC分类号： A61M5/24 , A61M5/2448 , A61M5/28 , A61M5/284
摘要： Disclosed herein are systems and methods useful for delivery of suspensions and other microparticle compositions, and, in particular, for delivering microparticles at desired dosing levels and eliminating blockages within microparticle suspensions positioned within a delivery device.
摘要翻译：本文公开了用于递送悬浮液和其它微粒组合物的系统和方法，特别是用于以期望的剂量水平递送微粒并消除位于递送装置内的微粒悬浮液内的阻塞物。

6. 发明申请

US20100189765A1 IMPLANTABLE OCULAR DRUG DELIVERY DEVICE AND METHODS 审中-公开
标题翻译：可植入的药物递送装置和方法
公开(公告)号：US20100189765A1
公开(公告)日：2010-07-29
申请号：US12625705
申请日：2009-11-25
申请人： Signe R. Erickson , Jianbo Zhou , Krip Punja , Nathan R.F. Beeley
发明人： Signe R. Erickson , Jianbo Zhou , Krip Punja , Nathan R.F. Beeley
IPC分类号： A61F2/14 , A61K31/5575 , A61P27/02
CPC分类号： A61K9/0051
摘要： The present invention provides implantable ocular drug delivery devices. Generally, the devices have a distal portion with a coil shaped body member and a proximal portion which contacts the sclera. In one aspect, the coil-shaped body member includes a unique configuration including two coiled portions with different pitches, which improves insertion of the device into the eye. In another aspect, the device has a proximal portion that includes a unique cap configuration having a concave distal face that improves stabilization of the device in the eye. In another aspect, the device includes a transitional portion between the cap and the coil-shaped body member that also improves stabilization of the device in the eye. The invention also provides methods for inserting the medical device into the eye, and methods for the treatment of an ocular condition.
摘要翻译：本发明提供可植入的眼药物递送装置。通常，这些装置具有远端部分，其具有线圈状体部件和接近巩膜的近端部分。在一个方面，线圈状主体部件包括具有不同间距的两个螺旋部分的独特结构，这改善了装置进入眼睛的插入。在另一方面，该装置具有近端部分，该近端部分包括具有凹形远端面的独特的帽构造，其改善了眼睛中装置的稳定性。在另一方面，该装置包括帽和线圈状本体构件之间的过渡部分，其还改善了眼睛中装置的稳定性。本发明还提供了将医疗装置插入眼睛中的方法以及用于治疗眼部病症的方法。

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