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1. 发明申请

US20050181398A1 Specific detection of host response protein clusters 审中-公开
标题翻译：特异性检测宿主反应蛋白簇
公开(公告)号：US20050181398A1
公开(公告)日：2005-08-18
申请号：US11031302
申请日：2005-01-07
申请人： Eric Fung , Rebecca Caffrey , Tai-Tung Yip
发明人： Eric Fung , Rebecca Caffrey , Tai-Tung Yip
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G01N33/68 , G06F19/00
CPC分类号： G01N33/6842 , G01N33/5091 , G01N33/6803 , G16B40/00
摘要： Methods of specifically detecting host response protein clusters and of correlating patterns of expression of these clusters with various clinical parameters are provided.
摘要翻译：提供了特异性检测宿主反应蛋白簇的方法以及将这些簇的表达模式与各种临床参数相关联的方法。

2. 发明授权

US08043825B2 Serum biomarkers for Chagas disease 失效
标题翻译：查加斯病血清生物标志物
公开(公告)号：US08043825B2
公开(公告)日：2011-10-25
申请号：US11006119
申请日：2004-12-06
申请人： Momar Ndao , Brian Ward , Rebecca Caffrey , Terence William Spithill , Hongshan Li , Vladimir Podust , Regis Perichon
发明人： Momar Ndao , Brian Ward , Rebecca Caffrey , Terence William Spithill , Hongshan Li , Vladimir Podust , Regis Perichon
IPC分类号： G01N33/53 , G01N33/569 , G06F19/00
CPC分类号： G01N33/56905 , C12Q1/6883 , C12Q1/6893 , G01N33/6848 , G01N33/6851 , G01N33/6893 , G01N2333/4716 , G01N2333/52 , G01N2333/775 , G01N2333/78 , G01N2333/9121 , Y02A90/26
摘要： The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying Chagas disease status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as infected with Chagas disease or non-infected. The biomarkers can be detected by SELDI mass spectrometry.
摘要翻译：本发明提供了可用于限定患者中的恰加斯病状态的基于蛋白质的生物标志物和生物标志物组合。特别地，本发明的生物标志物可用于分类感染了恰加斯病或未感染的受试者样品。生物标志物可以通过SELDI质谱检测。

3. 发明授权

US09482678B1 Method for measurement of bioavailable testosterone 有权
标题翻译：生物可利用睾丸激素测定方法
公开(公告)号：US09482678B1
公开(公告)日：2016-11-01
申请号：US14661306
申请日：2015-03-18
申请人： Rebecca Caffrey
发明人： Rebecca Caffrey
IPC分类号： G01N31/00 , G01N33/53 , G01N33/74
CPC分类号： G01N33/743
摘要： Provided are methods for determining level of bioactive testosterone in a biological sample. In one aspect, aromatase enzyme is utilized to convert free, bio-available testosterone into estradiol and the amount of estradiol is measured before and after the addition of enzyme. The difference in measurements provides the amount of bioactive testosterone in the sample. In another aspect, a competitor of testosterone binding to SHBG is utilized to displace testosterone bound to SHBG. Measurements of total testosterone in the sample before addition of competitor and afterwards are taken, such that the delta reflects the amount of testosterone that was bound on SHBG.
摘要翻译：提供了用于确定生物样品中生物活性睾酮水平的方法。在一个方面，芳香酶用于将游离的生物可用睾酮转化成雌二醇，并且在添加酶之前和之后测量雌二醇的量。测量差异提供了样品中生物活性睾酮的量。另一方面，使用与SHBG结合的睾丸激素的竞争者来置换与SHBG结合的睾丸激素。在添加竞争者之前和之后测量样品中的总睾酮，使得三角洲反映与SHBG结合的睾酮的量。

4. 发明申请

US20050260691A1 Serum biomarkers for Chagas disease 失效
标题翻译：查加斯病血清生物标志物
公开(公告)号：US20050260691A1
公开(公告)日：2005-11-24
申请号：US11006119
申请日：2004-12-06
申请人： Momar Ndao , Brian Ward , Rebecca Caffrey , Terence Spithill , Hongshan Li , Vladimir Podust , Regis Perichon
发明人： Momar Ndao , Brian Ward , Rebecca Caffrey , Terence Spithill , Hongshan Li , Vladimir Podust , Regis Perichon
IPC分类号： A61B20060101 , C12Q1/68 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/569 , G01N33/68 , G06F19/00
CPC分类号： G01N33/56905 , C12Q1/6883 , C12Q1/6893 , G01N33/6848 , G01N33/6851 , G01N33/6893 , G01N2333/4716 , G01N2333/52 , G01N2333/775 , G01N2333/78 , G01N2333/9121 , Y02A90/26
摘要： The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying Chagas disease status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as infected with Chagas disease or non-infected. The biomarkers can be detected by SELDI mass spectrometry.
摘要翻译：本发明提供了可用于限定患者中的恰加斯病状态的基于蛋白质的生物标志物和生物标志物组合。特别地，本发明的生物标志物可用于分类感染了恰加斯病或未感染的受试者样品。生物标志物可以通过SELDI质谱检测。

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