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1. 发明授权

US08452405B2 Methods and systems for mitigating the occurrence of arrhythmia during atrial pacing 有权
标题翻译：减轻心房起搏心律失常发生的方法和系统
公开(公告)号：US08452405B2
公开(公告)日：2013-05-28
申请号：US12772725
申请日：2010-05-03
申请人： Eric Enrooth , Yanting Dong , Kenneth N. Hayes , Gary T. Seim , Kevin John Stalsberg , Aaron McCabe
发明人： Eric Enrooth , Yanting Dong , Kenneth N. Hayes , Gary T. Seim , Kevin John Stalsberg , Aaron McCabe
IPC分类号： A61N1/362
CPC分类号： A61N1/3712 , A61N1/3622 , A61N1/3714
摘要： Noncaptured atrial paces can result in long-short cardiac cycles which are proarrhythmic for ventricular tachyarrhythmia. Approaches are described which are directed to avoiding proarrhythmic long-short cycles. For cardiac cycles in which the atrial pace captures the atrium, a first post ventricular refractory period (PVARP) and a first A-A interval are used. For cardiac cycles in which the atrial pace does not capture the atrium, both an extended PVARP and an extended A-A interval are used. The A-A interval following a noncaptured atrial pace is extended from an atrial depolarization sensed during the extended PVARP.
摘要翻译：非心房颤动可导致心律失常的心律失常的长时间心脏周期。描述了旨在避免心律失常长时间短周期的方法。对于心房搏动捕获心房的心脏周期，使用第一个心室后不应期（PVARP）和第一个A-A间隔。对于其中心房速度不捕获心房的心脏周期，使用延长的PVARP和延长的A-A间隔。在非扩张性PVARP期间感觉到的心房去极化之后，A-A间隔未被捕获。

2. 发明申请

US20100286743A1 Methods and Systems for Mitigating the Occurrence of Arrhythmia During Atrial Pacing 有权
标题翻译：心房起搏减轻心律失常发生的方法和系统
公开(公告)号：US20100286743A1
公开(公告)日：2010-11-11
申请号：US12772725
申请日：2010-05-03
申请人： Eric K. Enrooth , Yanting Dong , Kenneth N. Hayes , Gary T. Seim , Kevin John Stalsberg , Aaron McCabe
发明人： Eric K. Enrooth , Yanting Dong , Kenneth N. Hayes , Gary T. Seim , Kevin John Stalsberg , Aaron McCabe
IPC分类号： A61N1/37
CPC分类号： A61N1/3712 , A61N1/3622 , A61N1/3714
摘要： Noncaptured atrial paces can result in long-short cardiac cycles which are proarrhythmic for ventricular tachyarrhythmia. Approaches are described which are directed to avoiding proarrhythmic long-short cycles. For cardiac cycles in which the atrial pace captures the atrium, a first post ventricular refractory period (PVARP) and a first A-A interval are used. For cardiac cycles in which the atrial pace does not capture the atrium, both an extended PVARP and an extended A-A interval are used. The A-A interval following a noncaptured atrial pace is extended from an atrial depolarization sensed during the extended PVARP.
摘要翻译：非心房颤动可导致心律失常的心律失常的长时间心脏周期。描述了旨在避免心律失常长时间短周期的方法。对于心房搏动捕获心房的心脏周期，使用第一个心室后不应期（PVARP）和第一个A-A间隔。对于其中心房速度不捕获心房的心脏周期，使用延长的PVARP和延长的A-A间隔。在非扩张性PVARP期间感觉到的心房去极化之后，A-A间隔未被捕获。

3. 发明申请

US20100121402A1 REVERSE HYSTERESIS AND MODE SWITCHING FOR INTERMITTENT PACING THERAPY 有权
标题翻译：用于间歇性治疗的逆向滞后和模式切换
公开(公告)号：US20100121402A1
公开(公告)日：2010-05-13
申请号：US12615050
申请日：2009-11-09
申请人： Shantha Arcot-Krishnamurthy , Gary T. Seim , Kent Lee , Yanting Dong , Allan C. Shuros , David L. Whitehouse
发明人： Shantha Arcot-Krishnamurthy , Gary T. Seim , Kent Lee , Yanting Dong , Allan C. Shuros , David L. Whitehouse
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/3688
摘要： Cardioprotective pre-excitation pacing may be applied to stress or de-stress a particular myocardial region delivering of pacing pulses in a manner that causes a dyssynchronous contraction. Such dyssynchronous contractions are responsible for the desired cardioprotective effects of pre-excitation pacing. A method and device for applying reverse hysteresis and mode switching to the delivery of such cardioprotective pacing are described.
摘要翻译：心脏保护性预激发起搏可用于以导致同步收缩的方式对起搏脉冲递送的特定心肌区域应力或去应激。这种异常收缩负责预激励起搏的所需心脏保护作用。描述了一种用于将逆向滞后和模式切换应用于这种心脏保护起搏的递送的方法和装置。

4. 发明授权

US08929983B2 Reverse hysteresis and mode switching for intermittent pacing therapy 有权
标题翻译：间歇性起搏治疗的反向滞后和模式切换
公开(公告)号：US08929983B2
公开(公告)日：2015-01-06
申请号：US12615050
申请日：2009-11-09
申请人： Shantha Arcot-Krishnamurthy , Gary T. Seim , Kent Lee , Yanting Dong , Allan C. Shuros , David L. Whitehouse
发明人： Shantha Arcot-Krishnamurthy , Gary T. Seim , Kent Lee , Yanting Dong , Allan C. Shuros , David L. Whitehouse
IPC分类号： A61N1/368 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/3688
摘要： Cardioprotective pre-excitation pacing may be applied to stress or de-stress a particular myocardial region delivering of pacing pulses in a manner that causes a dyssynchronous contraction. Such dyssynchronous contractions are responsible for the desired cardioprotective effects of pre-excitation pacing. A method and device for applying reverse hysteresis and mode switching to the delivery of such cardioprotective pacing are described.
摘要翻译：心脏保护性预激发起搏可用于以导致同步收缩的方式对起搏脉冲递送的特定心肌区域应力或去应激。这种异常收缩负责预激励起搏的所需心脏保护作用。描述了一种用于将逆向滞后和模式切换应用于这种心脏保护起搏的递送的方法和装置。

5. 发明申请

US20100305643A1 VENTILATION SENSOR RATE RESPONSE NORMALIZATION AND CALCULATION 有权
标题翻译：通风传感器速率响应正常化和计算
公开(公告)号：US20100305643A1
公开(公告)日：2010-12-02
申请号：US12784151
申请日：2010-05-20
申请人： Paul F. Emerson , Gary T. Seim , Michael A. Querimit , Donald L. Hopper , Stephen R. Pitzl , Daniel O'Brien
发明人： Paul F. Emerson , Gary T. Seim , Michael A. Querimit , Donald L. Hopper , Stephen R. Pitzl , Daniel O'Brien
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61N1/362 , A61N1/365 , A61N1/37
摘要： A cardiac rhythm management (CRM) device can extract ventilation information from thoracic impedance or other information, and adjust a delivery rate of the CRM therapy. A tidal volume of a patient is measured and used to adjust a ventilation rate response factor. The measured tidal volume can optionally be adjusted using a ventilation rate dependent adjustment factor. The ventilation rate response factor can also be adjusted using a maximum voluntary ventilation (MVV), an age predicted maximum heart rate, a resting heart rate, and a resting ventilation determined for the patient. In various examples, a global ventilation sensor rate response factor (for a population) can be programmed into the CRM device, and automatically tailored to be appropriate for a particular patient.
摘要翻译：心脏节律管理（CRM）设备可以从胸部阻抗或其他信息中提取通气信息，并调整CRM治疗的输送速率。测量患者的潮气量并用于调节通气率反应因子。测量的潮气量可以任选地使用通风率依赖调节因子进行调整。通气率反应因子也可以使用最大自主通气（MVV），年龄预测最大心率，静息心率和为患者确定的休息通气进行调整。在各种示例中，可将全球通气传感器速率响应因子（对于群体）编程到CRM设备中，并且被自动调整为适合于特定患者。

6. 发明申请

US20080319494A1 System and method for preventing recurrence of atrial tachyarrhythmia 有权
标题翻译：用于预防房性快速性心律失常复发的系统和方法
公开(公告)号：US20080319494A1
公开(公告)日：2008-12-25
申请号：US12229563
申请日：2008-08-25
申请人： Victor T. Chen , Gary T. Seim , Milton M. Morris
发明人： Victor T. Chen , Gary T. Seim , Milton M. Morris
IPC分类号： A61N1/362
CPC分类号： A61N1/3962 , A61N1/3622
摘要： A system and method for providing pacing pulses after a cardioversion/defibrillation shock, where the pacing pulses have a pacing rate at an initial value. The pacing rate is decreased from the initial value until at least one intrinsic cardiac contraction is detected. In one embodiment, the pacing rate is decreased by a set amount after pacing a set number of cardiac cycles. Providing the set number of pacing pulses and decreasing the pacing rate by the set amount is then repeated until at least one intrinsic cardiac contraction is detected. An intrinsic cardiac rate is then determined from the at least one intrinsic cardiac contraction. The pacing rate is then increased and maintained to be above (i.e., greater than) the intrinsic cardiac rate.
摘要翻译：用于在心脏复律/除颤休克之后提供起搏脉冲的系统和方法，其中起搏脉冲具有初始值的起搏速率。起搏速率从初始值降低到检测到至少一个固有心脏收缩。在一个实施例中，起搏速率在起搏设定数量的心动周期后降低设定量。然后重复提供设定数量的起搏脉冲并将起搏速率降低设定量，直到检测到至少一个固有心脏收缩。然后从至少一个固有心脏收缩确定固有心率。然后起搏速率增加并保持在高于（即大于）本征心率。

7. 发明授权

US07024240B2 Delay to therapy following patient controlled atrial shock therapy request 失效
公开(公告)号：US07024240B2
公开(公告)日：2006-04-04
申请号：US10643513
申请日：2003-08-19
申请人： Victor T. Chen , Gary T. Seim , Carlos Ricci , Michael L. Favet , Hal Propp
发明人： Victor T. Chen , Gary T. Seim , Carlos Ricci , Michael L. Favet , Hal Propp
IPC分类号： A61N1/39
CPC分类号： A61N1/3956
摘要： An implantable cardiac device detects a patient therapy request originating from external to the implantable device. A shock therapy delay period is timed in response to the detection of the patient therapy request. Atrial shock therapy is provided to the patient after expiration of the shock therapy delay period (if the presence of an ongoing atrial arrhythmia is detected). The patient therapy request may be provided by a patient activator including a magnet for operating a reed switch in the implanted device to provide the request. A patient activator including an input and receiver/transmitter circuitry may be employed to request the immediate providing of atrial shock therapy, and/or to set the duration the shock therapy delay period. By allowing specific delays to therapy after a therapy request, a patient can prepare for the requested therapy and thereby mitigate therapy discomfort.

8. 发明授权

US06618617B2 Delay to therapy following patient controlled atrial shock therapy request 有权
公开(公告)号：US06618617B2
公开(公告)日：2003-09-09
申请号：US09839123
申请日：2001-04-20
申请人： Victor T. Chen , Gary T. Seim , Carlos Ricci , Michael L. Favet , Hal Propp
发明人： Victor T. Chen , Gary T. Seim , Carlos Ricci , Michael L. Favet , Hal Propp
IPC分类号： A61N139
CPC分类号： A61N1/3956
摘要： An implantable cardiac device detects a patient therapy request originating from external to the implantable device. A shock therapy delay period is timed in response to the detection of the patient therapy request. Atrial shock therapy is provided to the patient after expiration of the shock therapy delay period (if the presence of an ongoing atrial arrhythmia is detected). The patient therapy request may be provided by a patient activator including a magnet for operating a reed switch in the implanted device to provide the request. A patient activator including an input and receiver/transmitter circuitry may be employed to request the immediate providing of atrial shock therapy, and/or to set the duration of the shock therapy delay period. By allowing specific delays to therapy after a therapy request, a patient can prepare for the requested therapy and thereby mitigate therapy discomfort.

9. 发明授权

US06430438B1 Cardiac rhythm management system with atrial shock timing optimization 失效
标题翻译：心律节律管理系统与心房休克时序优化
公开(公告)号：US06430438B1
公开(公告)日：2002-08-06
申请号：US09316741
申请日：1999-05-21
申请人： Victor T. Chen , Jay A. Warren , Gary T. Seim , David B. Krig , Jesse W. Hartley , Jeffrey E. Stahmann
发明人： Victor T. Chen , Jay A. Warren , Gary T. Seim , David B. Krig , Jesse W. Hartley , Jeffrey E. Stahmann
IPC分类号： A61N139
CPC分类号： A61N1/3962 , A61N1/3621 , A61N1/3627 , A61N1/3682 , A61N1/395 , A61N1/3987
摘要： A cardiac rhythm management system includes atrial shock timing optimization. Because an atrial tachyarrhythmia, such as atrial fibrillation typically causes significant variability in the ventricular heart rate, resulting in potentially proarrhythmic conditions. The system avoids delivering atrial cardioversion/defibrillation therapy during potentially proarrhythmic conditions because doing so could result in dangerous ventricular arrhythmias. Using Ventricular Rate Regularization (“VRR”) techniques, the system actively stabilizes the ventricular heart rate to obtain less potentially proarrhythmic conditions for delivering the atrial tachyarrhythmia therapy. The intrinsic ventricular heart rate is stabilized at a variable VRR-indicated rate, computed using an infinite impulse response (IIR) filter, and based on the underlying intrinsic ventricular heart rate. The system withholds delivery of atrial cardioversion/defibrillation therapy until the intervals between ventricular beats (“V-V intervals”) meet certain criteria that decrease the chance that the atrial cardioversion/defibrillation therapy will induce a ventricular arrhythmia.
摘要翻译：心律管理系统包括心房休克时序优化。因为房性心律失常，例如心房颤动，通常会导致心室心率的显着变异，导致潜在的心律失常症状。该系统避免在潜在的心律失常症状期间进行心房复律/除颤治疗，因为这样做可能导致危险的室性心律失常。使用心室率正常化（“VRR”）技术，该系统主动地稳定心室心率以获得较少的用于递送心房快速性心律失常治疗的潜在致心律失常状况。使用无限脉冲响应（IIR）滤波器，并且基于潜在的内部心室心率计算，内在心室心率以可变的VRR指示速率被稳定。系统禁止心房复律/除颤治疗，直到心室搏动之间的间隔（“V-V间隔”）符合某些标准，可降低心房复律/除颤疗法诱发室性心律失常的机会。

10. 发明授权

US06427084B2 Multi-site hybrid hardware-based cardiac pacemaker 有权
标题翻译：多站点混合硬件心脏起搏器
公开(公告)号：US06427084B2
公开(公告)日：2002-07-30
申请号：US09514813
申请日：2000-02-28
申请人： Kenneth L. Baker , Doug M. Birkholz , David L. Perschbacher , Andrew P. Kramer , Gary T. Seim
发明人： Kenneth L. Baker , Doug M. Birkholz , David L. Perschbacher , Andrew P. Kramer , Gary T. Seim
IPC分类号： A61N1362
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3684
摘要： A hybrid cardiac pacemaker in which the operation of the device is controlled by hardware-based controller as supervised by a microprocessor-based controller. The hardware-based controller comprises a plurality of timers that expire when they reach timer limit values stored in registers updatable by the microprocessor, and a combinational logic array for causing the device to generate pace outputs in accordance with timer expirations and sense signals. The combinational logic array may operate the pacemaker in a number of programmed modes in accordance with a mode value stored in a mode control register by the microprocessor.
摘要翻译：一种混合心脏起搏器，其中由基于微处理器的控制器监控的由基于硬件的控制器控制该设备的操作。基于硬件的控制器包括多个定时器，当它们达到存储在可由微处理器更新的寄存器中的定时器限制值时，该定时器到期，以及组合逻辑阵列，用于使该设备根据定时器期满和感测信号产生步进输出。组合逻辑阵列可以根据由微处理器存储在模式控制寄存器中的模式值，以多种编程模式操作起搏器。

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