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1. 发明申请

US20100305325A1 PROCESS FOR THE PREPARATION OF AN ENANTIOMERIC TRISUBSTITUTED 3,4-DIHYDRO-ISOQUINOLINE DERIVATIVE 有权
标题翻译：制备三羟甲基丙酮衍生物的方法
公开(公告)号：US20100305325A1
公开(公告)日：2010-12-02
申请号：US12810176
申请日：2008-12-23
申请人： Erhard Bappert , Andreas Hendrikus Maria De Vries , Doris Domin , Matthias Helms , Christoph Imboden , Zarghun Nazir , Wolfgang Skranc , Felix Spindler , Michael Stanek , Wilhelm Tschebull , Gerardus Karel Maria Verzijl
发明人： Erhard Bappert , Andreas Hendrikus Maria De Vries , Doris Domin , Matthias Helms , Christoph Imboden , Zarghun Nazir , Wolfgang Skranc , Felix Spindler , Michael Stanek , Wilhelm Tschebull , Gerardus Karel Maria Verzijl
IPC分类号： C07D217/20
CPC分类号： C07D217/02
摘要： The present invention relates to a process for the preparation of the compound of formula (7) which process comprises the hydrogenation of the compound of formula (4) using bis[chloro-1,5-cyclooctadiene-iridium], (S)-i-dicyclohexylphosphino-2-[(S)-α-(dimethylamino)-2-(dicyclohexylphosphino)benzyl]-ferrocene as a catalyst.
摘要翻译：本发明涉及制备式（7）化合物的方法，该方法包括使用双[氯-1,5-环辛二烯 - 铱]，（S）-i 二环己基膦基-2 - [（S）-α-（二甲基氨基）-2-（二环己基膦基）苄基] - 二茂铁作为催化剂。

2. 发明授权

US08314238B2 Process for the preparation of an enantiomeric trisubstituted 3,4-dihydro-isoquinoline derivative 有权
标题翻译：制备对映体三取代3,4-二氢异喹啉衍生物的方法
公开(公告)号：US08314238B2
公开(公告)日：2012-11-20
申请号：US12810176
申请日：2008-12-23
申请人： Erhard Bappert , Andreas Hendrikus Maria De Vries , Doris Domin , Matthias Helms , Christoph Imboden , Zarghun Nazir , Wolfgang Skranc , Felix Spindler , Michael Stanek , Wilhelm Tschebull , Gerardus Karel Maria Verzijl
发明人： Erhard Bappert , Andreas Hendrikus Maria De Vries , Doris Domin , Matthias Helms , Christoph Imboden , Zarghun Nazir , Wolfgang Skranc , Felix Spindler , Michael Stanek , Wilhelm Tschebull , Gerardus Karel Maria Verzijl
IPC分类号： C07D217/20 , A61K31/47
CPC分类号： C07D217/02
摘要： The present invention relates to a process for the preparation of the compound of formula (7) which process comprises the hydrogenation of the compound of formula (4) using bis[chloro-1,5-cyclooctadiene-iridium], (S)-i-dicyclohexylphosphino-2-[(S)-α-(dimethylamino)-2-(dicyclohexylphosphino)benzyl]-ferrocene as a catalyst.
摘要翻译：本发明涉及制备式（7）化合物的方法，该方法包括使用双[氯-1,5-环辛二烯 - 铱]，（S）-i 二环己基膦基-2 - [（S）-α-（二甲基氨基）-2-（二环己基膦基）苄基] - 二茂铁作为催化剂。

3. 发明授权

US08247560B2 Trisubstituted 3,4-dihydro-1H-isoquinolin compound, process for its preparation, and its use 有权
标题翻译：三取代的3,4-二氢-1H-异喹啉化合物，其制备方法及其用途
公开(公告)号：US08247560B2
公开(公告)日：2012-08-21
申请号：US12497023
申请日：2009-07-02
申请人： Maria Andreas Hendrikus De Vries , Doris Domin , Matthias Helms , Christoph Imboden , Ralph Koberstein , Zarghun Nazir , Wolfgang Skranc , Michael Stanek , Wilhelm Tschebull , Maria Gerardus Karel Verzijl , Jurgen Stichler
发明人： Maria Andreas Hendrikus De Vries , Doris Domin , Matthias Helms , Christoph Imboden , Ralph Koberstein , Zarghun Nazir , Wolfgang Skranc , Michael Stanek , Wilhelm Tschebull , Maria Gerardus Karel Verzijl , Jurgen Stichler
IPC分类号： C07D217/20
CPC分类号： C07D217/18
摘要： The present invention relates to the compound of formula 7*acetate (see below), a process for its preparation, and its use
摘要翻译：本发明涉及式7 *乙酸酯化合物（见下文），其制备方法及其应用

4. 发明申请

US20100010226A1 TRISUBSTITUTED 3,4-DIHYDRO-1H-ISOQUINOLIN COMPOUND, PROCESS FOR ITS PREPARATION, AND ITS USE 有权
标题翻译：三取代3,4-二氢-1H-异喹啉化合物，其制备方法及其用途
公开(公告)号：US20100010226A1
公开(公告)日：2010-01-14
申请号：US12497023
申请日：2009-07-02
申请人： Maria Andreas Hendrikus De Vries , Doris Domin , Matthias Helms , Chistoph Imboden , Ralph Koberstein , Zarghun Nazir , Wolfgang Skranc , Michael Stanek , Wilhelm Tschebull , Maria Gerardus Karel Verzijl , Jürgen Stichler
发明人： Maria Andreas Hendrikus De Vries , Doris Domin , Matthias Helms , Chistoph Imboden , Ralph Koberstein , Zarghun Nazir , Wolfgang Skranc , Michael Stanek , Wilhelm Tschebull , Maria Gerardus Karel Verzijl , Jürgen Stichler
IPC分类号： C07D217/12
CPC分类号： C07D217/18
摘要： The present invention relates to the compound of formula 7*acetate (see below), a process for its preparation, and its use
摘要翻译：本发明涉及式7 *乙酸酯化合物（见下文），其制备方法及其用途

5. 发明申请

US20120220014A1 NOVEL POLYPEPTIDE HAVING ESTERASE ACTIVITY AND RECOMBINANT ESTERASE AND USE THEREOF 有权
标题翻译：具有蛋白酶活性的新型多肽和重组蛋白酶及其用途
公开(公告)号：US20120220014A1
公开(公告)日：2012-08-30
申请号：US13417734
申请日：2012-03-12
申请人： Gerhard Steinbauer , Michael Stanek , Peter Pojarliev , Wolfgang Skranc , Helmut Schwab , Joannes Kierkels , Marcel Wubbolts , Harald Pichler , Manuela Hermann , Christoph Zenzmaier
发明人： Gerhard Steinbauer , Michael Stanek , Peter Pojarliev , Wolfgang Skranc , Helmut Schwab , Joannes Kierkels , Marcel Wubbolts , Harald Pichler , Manuela Hermann , Christoph Zenzmaier
IPC分类号： C12N9/16 , C07H21/04
CPC分类号： C12N9/18 , C12P7/02 , C12P41/005
摘要： Polypeptide and recombinant protein having esterase activity which exhibit the amino acid sequence SEQ. ID. No. 1 and the use thereof.
摘要翻译：多肽和具有酯酶活性的重组蛋白质，其表现出氨基酸序列SEQ。 ID。 1及其用途。

6. 发明授权

US08642312B2 Polypeptide having esterase activity and recombinant esterase and use thereof 有权
标题翻译：具有酯酶活性的多肽和重组酯酶及其用途
公开(公告)号：US08642312B2
公开(公告)日：2014-02-04
申请号：US13417734
申请日：2012-03-12
申请人： Gerhard Steinbauer , Micheal Stanek , Peter Pojarliev , Wolfgang Skranc , Helmut Schwab , Joannes Kierkels , Marcel Wubbolts , Harald Pichler , Manuela Hermann , Christoph Zenzmaier
发明人： Gerhard Steinbauer , Micheal Stanek , Peter Pojarliev , Wolfgang Skranc , Helmut Schwab , Joannes Kierkels , Marcel Wubbolts , Harald Pichler , Manuela Hermann , Christoph Zenzmaier
IPC分类号： C12N9/18
CPC分类号： C12N9/18 , C12P7/02 , C12P41/005
摘要： Polypeptide and recombinant protein having esterase activity which exhibit the amino acid sequence SEQ. ID. No. 1 and the use thereof.
摘要翻译：多肽和具有酯酶活性的重组蛋白质，其表现出氨基酸序列SEQ。 ID。 1及其用途。

7. 发明授权

US06861243B2 Genes containing a DNA sequence coding for hydroxynitrile lyase, recombinant proteins derived therefrom and having hydroxynitrile lyase activity, and use thereof 有权
标题翻译：含有编码羟基腈裂解酶的DNA序列的基因，由其衍生并具有羟基腈裂解酶活性的重组蛋白质及其用途
公开(公告)号：US06861243B2
公开(公告)日：2005-03-01
申请号：US10046232
申请日：2002-01-16
申请人： Helmut Schwab , Anton Glieder , Christoph Kratky , Ingrid Dreveny , Peter Pöchlauer , Wolfgang Skranc , Herbert Mayrhofer , Irma Wirth , Rudolf Neuhofer , Rodolfo Bona
发明人： Helmut Schwab , Anton Glieder , Christoph Kratky , Ingrid Dreveny , Peter Pöchlauer , Wolfgang Skranc , Herbert Mayrhofer , Irma Wirth , Rudolf Neuhofer , Rodolfo Bona
IPC分类号： C12N15/09 , C07K19/00 , C12N9/04 , C12N9/88 , C12N15/52 , C12N15/60 , C12P13/00
CPC分类号： C12P13/004 , C12N9/88 , C12N15/52
摘要： New genes containing a DNA sequence coding for hydroxynitrile lyase, which genes can be prepared via a primer combination based on the DNA sequence of the 5′-region of the mdl genes from Prunus serotina and from Prunus amygdalus and/or a primer 2 based on the 3′-region of the DNA sequences of one of the hydroxynitrile lyase isoenzymes from Prunus serotina or from Prunus amygdalus, subsequent amplification with a DNA polymerase using a DNA from organisms, containing genes coding for hydroxynitrile lyase, as templates and cloning, and also recombinant proteins which can be prepared in suitable host cells by heterologous expression of the DNA sequence of said HNL genes, and proteins and fusion proteins derived therefrom and use of said proteins for preparing (R)- or (S)-cyanohydrins.
摘要翻译：含有编码羟基腈裂解酶的DNA序列的新基因，该基因可以通过引物组合基于来自黑麦白浆和来自杏仁核的md1基因的5'区域的DNA序列和/或基于其中一个羟基腈裂解酶同工酶的一个来自山梨果皮或杏仁杏仁的DNA序列的3'区域，随后用含有编码羟基腈裂解酶的基因的来自生物体的DNA的DNA聚合酶扩增作为模板和克隆，以及可以通过异源表达所述HNL基因的DNA序列以及从其衍生的蛋白质和融合蛋白质以及所述蛋白质用于制备（R） - 或（S） - 氰基氢化物的方法，在合适的宿主细胞中制备重组蛋白质。

8. 发明申请

US20100143981A1 WHOLE-CELL CATALYTIC SYSTEM COMPRISING A HYDANTOINASE, A RACEMASE AND A CARBAMOYLASE 审中-公开
标题翻译：包含HYDANTOINASE，RACEMASE和CARBAMOYLASE的全细胞催化体系
公开(公告)号：US20100143981A1
公开(公告)日：2010-06-10
申请号：US12517504
申请日：2007-12-04
申请人： Monika Rusnak-Müller , Oliver May , Petrus Johannes Hermsen , Henricus Martinus Maria Gerardus Straatman , Wolfgang Skranc , Wilhelmus Hubertus Joseph Boesten , Dannis Heemskerk , Ben De Lange , Georgios Sarakinos
发明人： Monika Rusnak-Müller , Oliver May , Petrus Johannes Hermsen , Henricus Martinus Maria Gerardus Straatman , Wolfgang Skranc , Wilhelmus Hubertus Joseph Boesten , Dannis Heemskerk , Ben De Lange , Georgios Sarakinos
IPC分类号： C12P13/04 , C12N1/21 , C12N15/74 , C07D233/72 , C07C205/01
CPC分类号： C12P13/04 , C07C229/30 , C07C229/32 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07D233/74 , C07D233/78 , C12P13/22 , C12P13/222 , C12P17/10 , C12P41/00 , C12P41/009
摘要： The present invention relates to a whole cell catalytic system for the preparation of an enantiomerically enriched α-amino acid from a corresponding hydantoin wherein hydantoinase, L-carbamoylase and hydantoin racemase are coexpressed in a recombinant micro-organism wherein the genes coding for these three enzymes are located on a single replicon. The present invention further relates to the use of such a whole cell catalytic system according in the preparation of an enantiomerically enriched L-α-amino acid from a corresponding hydantoin.
摘要翻译：本发明涉及一种用于从相应的乙内酰脲制备对映异构体富集的α-氨基酸的全细胞催化体系，其中将乙内酰脲酶，L-氨基甲酰基酶和乙内酰脲消旋酶共表达于重组微生物中，其中编码这三种酶的基因位于单个复制器上。本发明还涉及根据从对应的乙内酰脲制备对映体富集的L-α-氨基酸的这种全细胞催化体系的用途。

9. 发明申请

US20100113778A1 PROCESS FOR PREPARING O-CHLOROMETHYLPHENYLGLYOXYLIC ESTERS, IMPROVED PROCESS FOR PREPARING (E)-2-(2-CHLOROMETHYLPHENYL)-2-ALKOXIMINOACETIC ESTERS, AND NOVEL INTERMEDIATES FOR THEIR PREPARATION 审中-公开
标题翻译：制备O-氯代苯乙酰氧基酯的方法，（E）-2-（2-氯甲基苯基）-2-烷氧基亚胺酸酯的改进方法及其制备的新型中间体
公开(公告)号：US20100113778A1
公开(公告)日：2010-05-06
申请号：US12595113
申请日：2008-04-10
申请人： John-Matthias Wiegand , Karsten Luettgen , Wolfgang Skranc
发明人： John-Matthias Wiegand , Karsten Luettgen , Wolfgang Skranc
IPC分类号： C07D265/30 , C07C229/34 , C07C69/635 , C07C237/20
CPC分类号： C07F3/003 , C07B49/00 , C07C67/307 , C07C249/12 , C07C69/736 , C07C251/48
摘要： An improved process for preparing o-chloromethylphenylglyoxylic esters of the formula which comprises converting a compound of the formula by reaction with magnesium into the corresponding Grignard reagent which is then reacted with a compound of the formula to give the compound of the formula which is then cleaved by reaction with a chloroformic ester of the formula CICOOR4 or by reaction with phosgene to give the compound of the formula (I), followed by the isolation of the compound of the formula (I), and also an improved process for preparing (E)-2-(2-chloromethylphenyl)-2-alkoximinoacetic esters of the formula and intermediates for their preparation.
摘要翻译：一种制备下式的邻氯甲基苯基乙醛酸酯的改进方法，其包括将下式化合物与镁反应转化成相应的格氏试剂，然后与下式化合物反应，得到下式的化合物，然后将其分解通过与式CICOOR4的氯甲酸酯反应或通过与光气反应得到式（I）化合物，然后分离式（I）化合物，以及制备（E）化合物的改进方法， -2-（2-氯甲基苯基）-2-肟基乙酸酯及其制备中间体。

10. 发明授权

US07052885B2 Process for preparing heterocyclic (R)- and (S)-cyanohydrins 失效
标题翻译：制备杂环（R） - 和（S） - 氰基醇的方法
公开(公告)号：US07052885B2
公开(公告)日：2006-05-30
申请号：US10325922
申请日：2002-12-23
申请人： Peter Poechlauer , Wolfgang Skranc , Herbert Mayrhofer , Irma Wirth , Rudolf Neuhofer , Herfried Griengl , Martin Fechter
发明人： Peter Poechlauer , Wolfgang Skranc , Herbert Mayrhofer , Irma Wirth , Rudolf Neuhofer , Herfried Griengl , Martin Fechter
IPC分类号： C12P17/00 , C12P17/02 , C12P17/04 , C12P17/06 , C12P17/18
CPC分类号： C12P13/004 , C12P17/00 , C12P17/04
摘要： A process for preparing enantiomer-enriched heterocyclic (R)- and (S)-cyanohydrins of the formula (I), where R1, R2, R3, R4 independently of one another are H, an unsubstituted or substituted C1–C24-alkyl, alkenyl or alkynyl radical, where one or more carbon atoms in the chain can be replaced by an oxygen atom, a nitrogen atom, a sulfur atom, an SO or an SO2 group, an unsubstituted or substituted aryl or heteroaryl radical or heterocyclic radical or halogen, hydroxyl, NR5R6, acetyl, oxo, C1–C6-carbalkoxy, C1–C6-carbalkoxyamino, COOR7, cyano, amide, benzoylamino or NO2,R5 and R6 are H, C1–C6-alkyl radical, phenyl radical, benzyl radical or COOR7, or together form a C2–C8-alkylene or heteroalkylene radical,R7 is H or C1–C6-alkyl,n is 0, 1, 2 or 3,X, Y and Z can be an unsubstituted or substituted carbon atom or a radical selected from the group consisting of N, O, S or NR5R6, where R5 and R6 are as defined above, SO or SO2, and at least one of the radicals X, Y and Z is not a carbon atom, where the compounds of the formula (I) can have one or more double bonds in the ring, with the proviso that in a 5-membered ring the double bond is not conjugated with the —C(OH)CN-group, and/or can be anellated and/or bridged,by reacting a ketone of the formula (II), where R1, R2, R3, R4, X, Y, Z and n have the meanings above, with an (R)- or (S)-hydroxynitrile lyase in an organic, aqueous or two-phase system, or in emulsion, in the presence of a cyanide group donor.
摘要翻译：制备式（I）的对映异构体富集的杂环（R） - 和（S） - 氰基醇的方法，其中R 1，R 2，R 3，R 4彼此独立地是H，未取代或取代的C 1 - 链烯基或炔基，其中链中的一个或多个碳原子可以被氧原子，氮原子，硫原子，SO或 SO 2 2基团，未取代或取代的芳基或杂芳基或杂环基或卤素，羟基，NR 5 R 6，乙酰基，氧代C 1 -C 6 - 亚烷基氧基，C 1 -C 6 - 烷氧基氨基，COOR 7，氰基，酰胺，苯甲酰氨基或NO 2，R 5和R 6是H C 1 -C 6 - 烷基，苯基，苄基或COOR 7，或一起形成C 1 -C 6 - 8亚烷基或杂亚烷基，R 7是H或C 1 -C 6 - 烷基，n是0,1,2或3，X，Y 并且Z可以是未取代或取代的碳原子或选自它的基团由N，O，S或NR5R6组成的基团，其中R 5和R 6如上定义，SO或SO 2，并且基团X，Y和Z中的至少一个不是碳原子，其中式（I）的化合物可以在环中具有一个或多个双键，条件是在5元环中双键不与-C（OH）CN-基团共轭，并且 /或可以通过使式（II）的酮（其中R 1，R 2，R 3，R 4，X，Y，Z和n具有上述含义）与（R） - 或（ S） - 羟基腈裂解酶在有机，水相或两相体系中，或在乳液中，在氰化物基团给体存在下。

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