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1. 发明授权

US4829079A 1-benzenesulphonyl-2-oxo-5-alkoxypyrrolidines and medical methods of use thereof 失效
标题翻译： 1-苯磺酰基-2-氧代-5-烷氧基吡咯烷酮及其使用的医疗方法
公开(公告)号：US4829079A
公开(公告)日：1989-05-09
申请号：US947270
申请日：1986-12-29
申请人： Emilio Toja , Carlo Gorini , Carlo Zirotti , Fernando Barzaghi , Giulio Galliani
发明人： Emilio Toja , Carlo Gorini , Carlo Zirotti , Fernando Barzaghi , Giulio Galliani
IPC分类号： C07D333/00 , A61K20060101 , A61K31/40 , A61K31/4025 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61P25/28 , C07D207/26 , C07D207/273 , C07D207/48 , C07D401/12 , C07D405/12 , C07D409/12
CPC分类号： C07D401/12 , C07D207/48 , C07D405/12 , C07D409/12
摘要： Memory enhancing 1-(benzenesulfonyl)-2-oxo-5-alkoxy-pyrrolidines are prepared by alkylation of the corresponding pyrrolidones or pyrrolidone precursors.
摘要翻译：通过相应的吡咯烷酮或吡咯烷酮前体的烷基化制备记忆增强1-（苯磺酰基）-2-氧代-5-烷氧基 - 吡咯烷。

2. 发明授权

US4948804A Derivatives of 1-benzoyl 2-oxo 5-alkoxy pyrrolidine, their preparation, their use as medicaments and the compositions containing them 失效
标题翻译： 1-苯甲酰基2-氧代-5-烷氧基吡咯烷的衍生物，它们的制备，它们作为药物的用途以及含有它们的组合物
公开(公告)号：US4948804A
公开(公告)日：1990-08-14
申请号：US211287
申请日：1988-06-24
申请人： Giulio Galliani , Fernando Barzaghi , Carlo Zirotti , Emilio Toja
发明人： Giulio Galliani , Fernando Barzaghi , Carlo Zirotti , Emilio Toja
IPC分类号： C07D413/06 , A61K31/40 , A61K31/4015 , A61K31/4025 , A61K31/42 , A61K31/425 , A61P25/18 , A61P25/28 , A61P43/00 , C07D207/26 , C07D207/273 , C07D409/06 , C07D411/06
CPC分类号： C07D207/273
摘要： Compounds useful in the treatment of patients suffering from intellectual or nervous asthenias, memory failures, senescence or mental strain of the formula (I): ##STR1## in which R' represents hydrogen, linear, branched or cyclic alkyl containing up to 12 carbon atoms, alkenyl containing from 2 to 8 carbon atoms, acyl containing from 1 to 6 carbon atoms or aralkyl containing from 7 to 15 carbon atoms and R represents aryl containing up to 14 carbon atoms, optionally substituted, or a mono- or polycryclic heterocyclic aromatic radical, optionally substituted; also therapeutic compositions containing those compounds and method of use.
摘要翻译：用于治疗患有智力或神经失调，记忆障碍，衰老或精神紧张的患者（I）的患者的化合物：其中R'表示氢，直链，支链或环状烷基，其包含至多 12个碳原子，含有2至8个碳原子的烯基，含有1至6个碳原子的酰基或含有7至15个碳原子的芳烷基，R表示含有至多14个碳原子的芳基，任选取代的，或单或多个杂环芳族基，任选取代; 还含有这些化合物和使用方法的治疗组合物。

3. 发明授权

US4885307A Derivatives of 1-arylsulphonyl-1,5-dihydro-2H-pyrrol-2-one, and compositions containing them 失效
标题翻译： 1-芳基磺酰基-1,5-二氢-2H-吡咯-2-酮的衍生物和含有它们的组合物
公开(公告)号：US4885307A
公开(公告)日：1989-12-05
申请号：US205958
申请日：1988-06-13
申请人： Emilio Toja , Carlo Gorini , Fernando Barzaghi , Giulio Galliani
发明人： Emilio Toja , Carlo Gorini , Fernando Barzaghi , Giulio Galliani
IPC分类号： A61K31/40 , A61P25/18 , C07D207/48
CPC分类号： C07D207/48
摘要： Compounds useful in the treatment of patients suffering from intellectual or nervous asthenias, memory failures, senescence or mental strain of the formula (I) ##STR1## in which R' represents hydrogen, a linear, branched or cyclic alkyl containing up to 8 carbon atoms, alkenyl containing from 2 to 8 carbon atoms, acyl containing from 1 to 6 carbon atoms or aralkyl containing from 7 to 15 carbon atoms and R represents aryl containing up to 14 carbon atoms, possibly substituted, or a mono- or polycyclic heterocyclic aromatic radical, possibly substituted; also thereapeutic compositions containing those compounds and method of use.
摘要翻译：用于治疗患有智力或神经失调，记忆障碍，衰老或精神紧张的患者的化合物（I）其中R'表示氢，直链，支链或环状烷基，其含有至多 8个碳原子，含有2至8个碳原子的链烯基，含1至6个碳原子的酰基或含有7至15个碳原子的芳烷基，R表示可含有至多14个碳原子的芳基，或单环或多环杂环芳族基团，可能被取代; 还含有这些化合物和使用方法的治疗组合物。

4. 发明授权

US4885306A Derivatives of 1-arylsulphonyl-2-oxo-5-alkoxy-pyrrolidine and medical compositions containing them 失效
标题翻译： 1-芳基磺酰基-2-氧代-5-烷氧基 - 吡咯烷的衍生物和含有它们的医药组合物
公开(公告)号：US4885306A
公开(公告)日：1989-12-05
申请号：US203740
申请日：1988-06-02
申请人： Emilio Toja , Carlo Gorini , Fernando Barzaghi , Giulio Galliani
发明人： Emilio Toja , Carlo Gorini , Fernando Barzaghi , Giulio Galliani
IPC分类号： A61K31/40 , A61P25/28 , C07D207/48
CPC分类号： C07D207/48
摘要： Compounds useful in the treatment of patients suffering from intellectual or nervous asthenias, memory failures, senescence or mental strain of the formula (I) ##STR1## in which R' and R.sub.2, being identical or different, represent hydrogen, a linear, branched or cyclic alkyl containing up to 8 carbon atoms, alkenyl containing from 2 to 8 carbon atoms, acyl containing from 1 to 6 carbon atoms or aralkyl containing from 7 to 15 carbon atoms, R.sub.1 represents a possibly substituted aryl containing up to 14 carbon atoms, or a possibly substituted mono- or polycyclic heterocyclic aromatic radical; also therapeutic compositions containing those compounds and method of use.
摘要翻译：用于治疗患有智力或神经失调，记忆障碍，衰老或精神紧张的患者（I）的患者的化合物，其中R 1和R 2相同或不同，代表氢，直链，支链或含有至多8个碳原子的环状烷基，含有2至8个碳原子的烯基，含有1至6个碳原子的酰基或含有7至15个碳原子的芳烷基，R 1表示可能被取代的含有至多14个碳原子的芳基，或可能取代的单环或多环杂环芳族基团; 还含有这些化合物和使用方法的治疗组合物。

5. 发明授权

US4990531A Derivatives of 1-arylsulphonyl-2-pyrrolidinone and their use as medicaments 失效
标题翻译： 1-芳基磺酰基-2-吡咯烷酮的衍生物及其作为药物的用途
公开(公告)号：US4990531A
公开(公告)日：1991-02-05
申请号：US315170
申请日：1989-02-24
申请人： Giulio Galliani , Fernando Barzaghi , Michel Fortin , Carlo Gorini , Emilio Toja
发明人： Giulio Galliani , Fernando Barzaghi , Michel Fortin , Carlo Gorini , Emilio Toja
IPC分类号： C07D207/263 , A61K31/40 , A61K31/4015 , A61K31/4427 , A61K31/445 , A61K31/495 , A61K31/535 , A61P25/02 , C07D207/27 , C07D207/48 , C07D401/12
CPC分类号： C07D207/48
摘要： Compounds useful for the treatment of patients suffering from muscle spasms of the formula (I) ##STR1## in which R represents the radical ##STR2## in which R.sub.1, in any position on the phenyl nucleus, represents a linear, branched or cyclic alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, or the radical ##STR3## in which R.sub.2 and R.sub.3, identical or different each represents a hydrogen atom, a linear alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, or form together with the nitrogen atom to which they are joined, a heterocyclic radical optionally containing another heteroatom, or NO.sub.2, or OR', R' representing hydrogen, a linear, branched or cyclic alkyl containing up to 8 carbon atoms, or aryl containing up to 14 carbon atoms, or an SR.sub.4 or S(O)R.sub.5 radical, R.sub.4 and R.sub.5 representing a linear, branched or cyclic alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, or R represents naphthyl, optionally substituted by an R.sub.1 radical, as defined above; also therapeutic compositions containing the same and method of use.
摘要翻译：可用于治疗患有式（I）的肌肉痉挛的患者的化合物（I）其中R表示基团“IMAGE”，其中在苯基核上任何位置的R 1表示直链，支链或含有至多8个碳原子的环烷基，烯基或炔基，或其中R 2和R 3相同或不同各自表示氢原子，直链烷基，烯基或炔基，其含有至多8个碳原子的基团，或与其连接的氮原子一起形成任选地含有另外的杂原子的杂环基团，或代表氢的NO 2或OR'，R'，含有至多8个碳原子的直链，支链或环状烷基，或含有至多14个碳原子，或SR4或S（O）R5基团，R4和R5代表含有至多8个碳原子的直链，支链或环状烷基，烯基或炔基，或R代表萘基，任选被R1 如上所述; 还含有相同的治疗组合物和使用方法。

6. 发明授权

US4897414A Derivatives of 1-benzensulphonyl-2-oxo-5-alkylthio pyrrolidine, and compositions containing them 失效
标题翻译： 1-苯磺酰基-2-氧代-5-烷硫基吡咯烷的衍生物和含有它们的组合物
公开(公告)号：US4897414A
公开(公告)日：1990-01-30
申请号：US211720
申请日：1988-06-27
申请人： Emilio Toja , Carlo Zirotti , Fernando Barzaghi , Giulio Galliani
发明人： Emilio Toja , Carlo Zirotti , Fernando Barzaghi , Giulio Galliani
IPC分类号： A61K31/40 , A61K31/4025 , A61K31/42 , A61K31/435 , A61P25/18 , A61P25/28 , A61P43/00 , C07D207/26 , C07D207/273 , C07D207/48 , C07D409/12 , C07D411/12 , C07D413/12
CPC分类号： C07D207/273 , C07D207/48
摘要： Compounds useful in the treatment of patients suffering from intellectual or nervous asthenias, memory failures, senescence or mental strain of the formula (I) ##STR1## in which R' represents hydrogen, linear, branched or cyclic alkyl containing up to 8 carbon atoms, alkenyl containing from 2 to 8 carbon atoms, acyl containing from 1 to 6 carbon atoms or aralkyl containing from 7 to 15 carbon atoms and R represents aryl containing up to 14 carbon atoms, possibly substituted, or a mono- or polycyclic heterocyclic aromatic radical possibly substituted; also process and intermediates for their preparation, therapeutic compositions containing those compounds and method of use.
摘要翻译：用于治疗患有智力或神经性虚弱，记忆障碍，衰老或精神紧张的患者的化合物（I）其中R'表示氢，直链，支链或环状烷基含有至多8个碳原子，含有2至8个碳原子的烯基，含有1至6个碳原子的酰基或含有7至15个碳原子的芳烷基，R代表含有至多14个碳原子的芳基，可能被取代，或单环或多环杂环可能被取代的芳族基团还包括其制备方法和中间体，含有这些化合物的治疗组合物和使用方法。

7. 发明授权

US4810722A 1-styrenesulphonyl-2-oxo-5-hydroxy pyrrolidines and their use for memory restoration after electoshock treatment 失效
标题翻译： 1-苯乙烯基磺酰基-2-氧代-5-羟基吡咯烷酮及其在电击治疗后记忆恢复的用途
公开(公告)号：US4810722A
公开(公告)日：1989-03-07
申请号：US30113
申请日：1987-03-26
申请人： Emilio Toja , Carlo Zirotti , Giulio Galliani , Fernando Barzaghi
发明人： Emilio Toja , Carlo Zirotti , Giulio Galliani , Fernando Barzaghi
IPC分类号： A61K31/40 , A61P25/28 , C07D207/48
CPC分类号： C07D207/48
摘要： The therapeutic compounds useful in the treatment of patients suffering from intellectual or nervous asthenias, memory failures or old age and excessive intellectual fatigue having the formula (I): ##STR1## in which R.sub.1 represents an alkyl radical, linear or branched, containing up to 8 carbons atoms, an acyl radical containing from 1 to 6 carbon atoms or a cycloalkyl radical containing from 3 to 6 carbon atoms and R represents an aryl radical containing up to 14 carbon atoms, unsubstituted or substituted, or a mono- or polycyclic heterocyclic radical, unsubstituted or substituted. Also, therapeutic compositions containing the compound, method of preparing the compound and method of use.
摘要翻译：治疗化合物可用于治疗患有智力或神经失调，记忆障碍或老年人和过度智力疲劳的患者，其具有式（I）：其中R 1表示直链或支链的烷基，含有至多8个碳原子，含有1至6个碳原子的酰基或含有3至6个碳原子的环烷基，R表示含有至多14个碳原子的芳基，未取代或取代的，或单或多环杂环基团，未取代或取代的。此外，含有该化合物的治疗组合物，该化合物的制备方法和使用方法。

8. 发明授权

US5164514A Derivatives of 1-arylsulphonyl-2-pyrolidinone 失效
标题翻译： 1-芳基磺酰基-2-吡咯烷酮的衍生物
公开(公告)号：US5164514A
公开(公告)日：1992-11-17
申请号：US584108
申请日：1990-09-18
申请人： Giulio Galliani , Fernando Barzaghi , Michel Fortin , Carlo Gorini , Emilio Toja
发明人： Giulio Galliani , Fernando Barzaghi , Michel Fortin , Carlo Gorini , Emilio Toja
IPC分类号： C07D207/48
CPC分类号： C07D207/48
摘要： Compounds useful for the treatment of patients suffering from muscle spasms of the formula (I) ##STR1## in which R represents the radical ##STR2## in which R.sub.1, in any position on the phenyl nucleus, represents a linear, branched or cyclic alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, or the radical ##STR3## in which R.sub.2 and R.sub.3, identical or different each represents a hydrogen atom, a linear alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, or form together with the nitrogen atom to which they are joined, a heterocyclic radical optionally containing another heteroatom, or NO.sub.2, or OR', R' representing hydrogen, a linear, branched or cyclic alkyl containing up to 8 carbon atoms, or aryl containing up to 14 carbon atoms, or an SR.sub.4 or S(O)R.sub.5 radical, R.sub.4 and R.sub.5 representing a linear, branched or cyclic alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, or R represents naphthyl, optionally substituted by an R.sub.1 radical, as defined above; also therapeutic compositions containing the same and method of use.
摘要翻译：可用于治疗患有式（I）的肌肉痉挛的患者的化合物（I）其中R表示基团“IMAGE”，其中在苯基核上任何位置的R 1表示直链，支链或含有至多8个碳原子的环烷基，烯基或炔基，或其中R 2和R 3相同或不同各自表示氢原子，直链烷基，烯基或炔基，其含有至多8个碳原子的基团，或与其连接的氮原子一起形成任选地含有另外的杂原子的杂环基团，或代表氢的NO 2或OR'，R'，含有至多8个碳原子的直链，支链或环状烷基，或含有至多14个碳原子，或SR4或S（O）R5基团，R4和R5代表含有至多8个碳原子的直链，支链或环状烷基，烯基或炔基，或R代表萘基，任选被R1 如上所述; 还含有相同的治疗组合物和使用方法。

9. 发明授权

US5081130A Derivatives of 1-arylsulphonyl-2-pyrrolidinone, their preparation process, intermediates thereof, their use as medicaments and compositions containing them 失效
标题翻译： 1-芳基苯基-2-吡咯烷酮的衍生物，其制备方法及其中间体，作为药物及其组合物的用途
公开(公告)号：US5081130A
公开(公告)日：1992-01-14
申请号：US584701
申请日：1990-09-19
申请人： Giulio Galliani , Fernando Barzaghi , Michel Fortin , Carlo Gorini , Emilio Toja
发明人： Giulio Galliani , Fernando Barzaghi , Michel Fortin , Carlo Gorini , Emilio Toja
IPC分类号： C07D207/263 , A61K31/40 , A61K31/4015 , A61K31/4427 , A61K31/445 , A61K31/495 , A61K31/535 , A61P25/02 , C07D207/27 , C07D207/48 , C07D401/12
CPC分类号： C07D207/48
摘要： Compounds useful for the treatment of patients suffering from muscle spasms of the formula (I) ##STR1## in which R represents the radical ##STR2## in which R.sub.1, in any position on the phenyl nucleus, represents a linear, branched or cyclic alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, or the radical ##STR3## in which R.sub.2 and R.sub.3, identical or different each represents a hydrogen atom, a linear alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, or form together with the nitogen atom to which they are joined, a heterocyclic radical optionally containing another heteroatom, or NO.sub.2, or OR', R' representing hydrogen, a linear, branched or cyclic alkyl containing up to 8 carbon atoms, or aryl containing up to 14 carbon atoms, or an SR.sub.4 or S(O)R.sub.5 radical, R.sub.4 and R.sub.5 representing a linear, branched or cyclic alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, or R represents naphthyl, optionally substituted by an R.sub.1 radical, as defined above; also therapeutic compositions containing the same and method of use.

10. 发明授权

US4882350A Derivatives of 1-benzyl-2-oxo-5-alkoxy-pyrrolidine, and medicament compositions containing them 失效
标题翻译： 1-苄基-2-氧代-5-烷氧基 - 吡咯烷的衍生物和含有它们的药物组合物
公开(公告)号：US4882350A
公开(公告)日：1989-11-21
申请号：US211288
申请日：1988-06-24
申请人： Emilio Toja , Carlo Gorini , Fernando Barzaghi , Giulio Galliani
发明人： Emilio Toja , Carlo Gorini , Fernando Barzaghi , Giulio Galliani
IPC分类号： C07D411/06 , A61K31/40 , A61K31/4015 , A61K31/4025 , A61K31/42 , A61K31/435 , A61P25/18 , A61P25/28 , A61P43/00 , C07D207/26 , C07D207/273 , C07D409/06 , C07D413/06
CPC分类号： C07D207/273
摘要： Compounds useful in the treatment of patients suffering from intellectual or nervous asthenias, memory failures, senescence or metal strain of the formula (I) ##STR1## in which R' represents hydrogen, linear, branched or cyclic alkyl containing up to 12 carbon atoms, alkenyl containing from 2 to 8 carbon atoms, acyl containing from 1 to 6 carbon atoms or aralkyl containing from 7 to 15 carbon atoms and R represents aryl containing up to 14 carbon atoms, possibly substituted, or a mono- or polycyclic heterocyclic aromatic radical possibly substituted, provided that if R is unsubstituted phenyl, R' does not represent methyl or ethyl; also therapeutic compositions containing those compounds and method of use.
摘要翻译：用于治疗患有智力或神经失调，记忆障碍，衰老或金属应变的患者的化合物（I）其中R'表示氢，直链，支链或环状烷基，其含有至多12个碳原子，含有2至8个碳原子的烯基，含有1至6个碳原子的酰基或含有7至15个碳原子的芳烷基，R代表含有至多14个碳原子的芳基，可能被取代，或单环或多环杂环芳基可以被取代，条件是如果R是未取代的苯基，则R'不代表甲基或乙基; 还含有这些化合物和使用方法的治疗组合物。

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