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1. 发明授权

US06743944B1 Process for producing optically active aminoalcohol 失效
标题翻译：光学活性氨基醇的制备方法
公开(公告)号：US06743944B1
公开(公告)日：2004-06-01
申请号：US10070365
申请日：2002-03-06
申请人： Eiji Ozaki , Takakazu Endou , Yasumasa Yamaguchi , Mitsuharu Hamanaka
发明人： Eiji Ozaki , Takakazu Endou , Yasumasa Yamaguchi , Mitsuharu Hamanaka
IPC分类号： C07C5948
CPC分类号： C07C215/08 , C07B2200/07 , C07C51/412 , C07C213/10 , Y02P20/582 , C07C59/56 , C07C59/48 , C07C59/50
摘要： An industrially advantageous process for producing optically active 4-amino-2-methylbutane-1-ol which is useful as an intermediate in synthesizing optically active medicines and pesticides. Racemic 4-amino-2-methylbutane-1-ol is treated with an optically active organic acid. The diastereomeric salt thus obtained is crystallized out and subjected to solid-liquid separation to give optically active 4-amino-2-methylbutane-1-ol. The diastereomeric salt of optically active 4-amino-2-methylbutane-1-ol with an optically active reagent for optical resolution is decomposed by bringing into contact with a solvent and an alkali and subjected to solid-liquid separation, thereby recovering the optically active 4-amino-2-methylbutane-1-ol from the filtrate. Further, the filtration residue containing the alkali salt of the reagent for optical resolution obtained by the solid-liquid separation is brought into contact with a solvent and an acid. Then the reagent for optical resolution thus crystallized out is subjected to solid-liquid separation and recovered.
摘要翻译：用于制备光学活性4-氨基-2-甲基丁-1-醇的工业上有利的方法，其可用作合成光学活性药物和农药的中间体。外消旋4-氨基-2-甲基丁-1-醇用光学活性有机酸处理。将所得非对映体盐结晶出来，进行固液分离，得到光学活性的4-氨基-2-甲基丁-1-醇。光学活性的4-氨基-2-甲基丁烷-1-醇与光学活性剂的光学拆分的非对映盐通过与溶剂和碱接触进行分解，进行固液分离，由此回收光学活性物质 4-氨基-2-甲基丁烷-1-醇。此外，含有通过固液分离获得的用于光学拆分的试剂的碱金属盐的过滤残渣与溶剂和酸接触。然后将由此结晶的光学拆分试剂进行固液分离并回收。

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