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1. 发明授权

US4650854A Amide analogs of calcitonin 失效
标题翻译：降钙素的酰胺类似物
公开(公告)号：US4650854A
公开(公告)日：1987-03-17
申请号：US741936
申请日：1985-06-06
申请人： Edward S. Neiss , David Stevenson , Laurence L. Ho , Robert C. Liu , John T. Suh
发明人： Edward S. Neiss , David Stevenson , Laurence L. Ho , Robert C. Liu , John T. Suh
IPC分类号： A61K38/00 , C07K14/585 , C07K7/36
CPC分类号： C07K14/585 , A61K38/00
摘要： New peptides are disclosed which have biological activity of the same type as known calcitonins and which are amide analogs of natural calcitonins.
摘要翻译：公开了具有与已知降钙素相同类型的生物活性并且是天然降钙素的酰胺类似物的新肽。

2. 发明授权

US4804742A Amide analogs of calcitonin 失效
标题翻译：降钙素的酰胺类似物
公开(公告)号：US4804742A
公开(公告)日：1989-02-14
申请号：US938671
申请日：1986-12-05
申请人： Edward S. Neiss , David Stevenson , Laurence L. Ho , Robert C. Liu , John T. Suh
发明人： Edward S. Neiss , David Stevenson , Laurence L. Ho , Robert C. Liu , John T. Suh
IPC分类号： A61K38/00 , C07K14/585 , C07C103/52
CPC分类号： C07K14/585 , A61K38/00
摘要： New peptides are disclosed which have biological activity of the same type as known calcitonins and which are amide analogs of natural calcitonins.
摘要翻译：公开了具有与已知降钙素相同类型的生物活性并且是天然降钙素的酰胺类似物的新肽。

3. 发明授权

US4579866A Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents 失效
标题翻译：苯乙酰胺作为抗过敏，抗哮喘和抗炎药
公开(公告)号：US4579866A
公开(公告)日：1986-04-01
申请号：US614579
申请日：1984-05-29
申请人： David Stevenson , Robert C. Liu , Laurence L. Ho , Howard Jones , Stephen Coutts
发明人： David Stevenson , Robert C. Liu , Laurence L. Ho , Howard Jones , Stephen Coutts
IPC分类号： C07D215/14 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/22 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/47 , A61P11/08 , A61P29/00 , A61P37/08 , A61P43/00 , C07C67/00 , C07C231/00 , C07C233/11 , C07C233/17 , C07C233/45 , C07C233/65 , C07C233/68 , C07C233/81 , C07C235/32 , C07C235/48 , C07D209/20 , C07D521/00 , A61K31/24 , C07C101/04
CPC分类号： C07D209/20
摘要： Compounds of the structure ##STR1## and pharmaceutically acceptable salts thereof, wherein: R.sub.1 and R.sub.2 are independently H, OH, lower alkyl, lower alkoxy, aryloxy, heteroaryloxy, heteroaryl lower alkoxy, aryl, heteroaryl, aryl-lower alkyl, aryl-lower alkoxy, halogenated aryl-lower alkoxy, lower alkenyl, lower alkynyl, lower alkenoxy, lower alkynoxy, halogen or trifluoromethyl;A is H, aryl, lower alkyl, aryl-lower alkyl or heteroaryl; andB is ##STR2## n=0-6, wherein D is H, CONR.sub.3 R.sub.4, CO.sub.2 H, CO.sub.2 R.sub.5, CH.sub.2 OH or CH.sub.2 OR.sub.6,whereinR.sub.3, R.sub.4, R.sub.5 and R.sub.6 are independently H, lower alkyl, aryl, aryl-lower alkyl or heteroaryl;E is H, OH, lower alkyl, aryl or heteroaryl; andF is ##STR3## wherein G is the same as R.sub.1 and R.sub.2, useful for the treatment of allergy, asthma and inflammatory conditions.
摘要翻译：结构化合物及其药学上可接受的盐，其中：R 1和R 2独立地为H，OH，低级烷基，低级烷氧基，芳氧基，杂芳氧基，杂芳基低级烷氧基，芳基，杂芳基，芳基 - 低级烷基，芳基 - 低级烷氧基，卤代芳基 - 低级烷氧基，低级烯基，低级炔基，低级链烯氧基，低级炔氧基，卤素或三氟甲基; A是H，芳基，低级烷基，芳基 - 低级烷基或杂芳基; B为H，CONR 3 R 4，CO 2 H，CO 2 R 5，CH 2 OH或CH 2 OR 6，其中R 3，R 4，R 5和R 6独立地为H，低级烷基，芳基，芳基 - 低级烷基或杂芳基 ; E是H，OH，低级烷基，芳基或杂芳基; 且F为，其中G与R1和R2相同，可用于治疗过敏，哮喘和炎性病症。

4. 发明申请

US20130164828A1 OPTICAL TRANSFECTION 审中-公开
标题翻译：光学转印
公开(公告)号：US20130164828A1
公开(公告)日：2013-06-27
申请号：US13643279
申请日：2011-06-10
申请人： Kishan Dholakia , Na Ma , Praveen Cheriyan Ashok , David Stevenson , Francis James Gunn-Moore
发明人： Kishan Dholakia , Na Ma , Praveen Cheriyan Ashok , David Stevenson , Francis James Gunn-Moore
IPC分类号： C12N15/85
CPC分类号： C12M35/02 , C12N15/87 , G02B21/32
摘要： An integrated fibre based device for transfecting material into a cell comprising an optical fiber that has a lens formed at its end for directing light to a surface of the cell, and a channel for delivery of the material for transfection into the cell.
摘要翻译：一种用于将材料转染到细胞中的集成的基于纤维的装置，包括具有在其端部形成的用于将光引导到细胞表面的透镜的光纤，以及用于将所述材料输送到细胞中的通道。

5. 发明申请

US20090150244A1 COMBINED IN-STORE AND FUEL CENTER POINT-OF-SALE SYSTEM 有权
标题翻译：组合的存储和燃料中心点销售系统
公开(公告)号：US20090150244A1
公开(公告)日：2009-06-11
申请号：US12342385
申请日：2008-12-23
申请人： David Ciancio , David Stevenson
发明人： David Ciancio , David Stevenson
IPC分类号： G06Q30/00
CPC分类号： G06Q20/363 , G06Q20/20 , G06Q20/202 , G06Q30/0224 , G06Q30/0238 , G07F7/0866
摘要： A combined in-store and fuel center point-of-sale system having a first point-of-sale system, having a checkout manager and one or more checkout terminals, and a second point-of-sale system, having a fuel center and one or more fuel pumps, in communication with each other and with one or more primary databases containing marketing data, consumer data, customer data, master sales data, discount data, and merchandise product data, for generating a fuel discount at the second point-of-sale system based on first purchasing activity at the first point-of-sale system and/or second purchasing activity at said second point-of-sale system. The fuel discount is maintained for each customer in one of said primary databases and is based on a total purchase of products, a total purchase of product units, a total purchase amount of a product type, time period for total purchase of products, or a tiered spending amount.
摘要翻译：具有第一销售点系统的组合的店内和燃料中心销售点系统，具有结帐管理器和一个或多个结账终端，以及具有燃料中心和第二销售点系统的第二销售点系统，一个或多个燃料泵，彼此通信，以及一个或多个主要数据库，其包含营销数据，消费者数据，客户数据，主销售数据，折扣数据和商品产品数据，用于在第二点处产生燃料折扣，所述销售系统基于所述第一销售点系统的第一购买活动和/或所述第二销售点系统的第二购买活动。其中一个主要数据库中的每个客户维持燃料折扣，并且基于产品的总购买，产品单元的总购买量，产品类型的总购买量，总购买产品的时间段分层支出金额。

6. 发明申请

US20070067317A1 Navigating through websites and like information sources 审中-公开
标题翻译：浏览网站和信息来源
公开(公告)号：US20070067317A1
公开(公告)日：2007-03-22
申请号：US10554031
申请日：2004-04-23
申请人： David Stevenson
发明人： David Stevenson
IPC分类号： G06F7/00
CPC分类号： G06F16/954
摘要： An interactive/electronic guide for allowing navigation around a group of electronic documents, such as on internet or in an intranet site or such like, the guide being operable automatically to present a plurality of topic identifiers together with an indication of the importance of the topics identified within a site. Each topic is user selectable. Selection of a given topic provides access to information on that topic. Preferably, the guide also provides information about multiple sites that are potentially related by content as well as an indication of a degree of similarity in content between such multiple sites.
摘要翻译：一种互动/电子指南，用于允许在诸如互联网或内部网站点等的一组电子文档之间导航，该指南可自动地操作以呈现多个主题标识符以及主题的重要性的指示在网站内识别。每个主题都是用户可选择的。选择给定的主题可以访问有关该主题的信息。优选地，该指南还提供关于可能与内容有关的多个站点的信息，以及这些多个站点之间的内容的相似程度的指示。

7. 发明授权

US4623716A Process for the preparation and purification of peptides 失效
标题翻译：肽的制备和纯化方法
公开(公告)号：US4623716A
公开(公告)日：1986-11-18
申请号：US667025
申请日：1984-11-01
申请人： David Stevenson , Mohammad A. Islam
发明人： David Stevenson , Mohammad A. Islam
IPC分类号： C07K1/00 , A61K38/00 , C07K1/02 , C07K1/06 , C07K1/113 , C07K7/16 , C07K14/575 , C07K14/585 , C07K14/655
CPC分类号： C07K1/02 , C07K1/067 , C07K14/585 , A61K38/00 , Y10S930/15 , Y10S930/16
摘要： Peptides, such as calcitonin, having two cysteine residues connected by a disulfide bond are prepared by a process which includes the step of cyclizing the cysteines at a pH of 8.5 to 9.0, and a concentration of 0.4 to 1.8 mg of peptide per ml of solution. These novel conditions produce rapid cyclization with an unforeseen improvement in yield.
摘要翻译：具有通过二硫键连接的两个半胱氨酸残基的肽例如降钙素通过包括以下步骤的方法制备，所述方法包括在8.5至9.0的pH下使半胱氨酸环化，并且每ml溶液的浓度为0.4至1.8mg肽。这些新颖的条件产生快速环化，产量不可预见的提高。

8. 发明申请

US20080043050A1 COMPOSITE PRINTHEAD FIRE SIGNALS 审中-公开
公开(公告)号：US20080043050A1
公开(公告)日：2008-02-21
申请号：US11923134
申请日：2007-10-24
申请人： Lucas Barkley , David Stevenson
发明人： Lucas Barkley , David Stevenson
IPC分类号： B41J29/38
CPC分类号： B41J2/04541 , B41J2/04586 , B41J2/04588 , B41J2/04598
摘要： A method and device for providing a plurality of fire pulses in an ink jet printer, which includes a production of a plurality of fire signals. Each fire signal of the plurality of fire signals are asserted at a different timing than the other of the plurality of fire signals. The plurality of fire signals are combined to form a composite fire signal that maintains the different timing.

9. 发明申请

US20070152038A1 Combined in-store and fuel center point-of-sale system 有权
标题翻译：组合的店内和燃料中心销售点系统
公开(公告)号：US20070152038A1
公开(公告)日：2007-07-05
申请号：US11263080
申请日：2005-10-31
申请人： David Ciancio , David Stevenson
发明人： David Ciancio , David Stevenson
IPC分类号： G06F7/08 , G06K15/00 , G07B15/02
CPC分类号： G06Q20/363 , G06Q20/20 , G06Q20/202 , G06Q30/0224 , G06Q30/0238 , G07F7/0866
摘要： A combined in-store and fuel center point-of-sale system having a first point-of-sale system, having a checkout manager and one or more checkout terminals, and a second point-of-sale system, having a fuel center and one or more fuel pumps, in communication with each other and with one or more primary databases containing marketing data, consumer data, customer data, master sales data, discount data, and merchandise product data, for generating a fuel discount at the second point-of-sale system based on first purchasing activity at the first point-of-sale system and/or second purchasing activity at said second point-of-sale system. The fuel discount is maintained for each customer in one of said primary databases and is based on a total purchase of products, a total purchase of product units, a total purchase amount of a product type, time period for total purchase of products, or a tiered spending amount.
摘要翻译：具有第一销售点系统的组合的店内和燃料中心销售点系统，具有结帐管理器和一个或多个结账终端，以及具有燃料中心和第二销售点系统的第二销售点系统，一个或多个燃料泵，彼此通信，以及一个或多个主要数据库，其包含营销数据，消费者数据，客户数据，主销售数据，折扣数据和商品产品数据，用于在第二点处产生燃料折扣，所述销售系统基于所述第一销售点系统的第一购买活动和/或所述第二销售点系统的第二购买活动。其中一个主要数据库中的每个客户维持燃料折扣，并且基于产品的总购买，产品单元的总购买量，产品类型的总购买量，总购买产品的时间段分层支出金额。

10. 发明申请

US20050128233A1 Composite printhead fire signals 有权
标题翻译：复合打印头发射信号
公开(公告)号：US20050128233A1
公开(公告)日：2005-06-16
申请号：US10736183
申请日：2003-12-15
申请人： Lucas Barkley , David Stevenson
发明人： Lucas Barkley , David Stevenson
IPC分类号： B41J2/045 , B41J29/38
CPC分类号： B41J2/04541 , B41J2/04586 , B41J2/04588 , B41J2/04598
摘要： A method and device for providing a plurality of fire pulses in an ink jet printer, which includes a production of a plurality of fire signals. Each fire signal of the plurality of fire signals are asserted at a different timing than the other of the plurality of fire signals. The plurality of fire signals are combined to form a composite fire signal that maintains the different timing.
摘要翻译：一种用于在喷墨打印机中提供多个起火脉冲的方法和装置，其包括产生多个火情信号。多个火情信号的每个发射信号在与多个火情信号中另一个不同的定时被断言。多个火焰信号被组合以形成维持不同定时的复合火情信号。

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