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1. 发明授权

US08562633B2 Tissue repair device with a bioabsorbable support member 有权
标题翻译：具有生物吸收性支撑构件的组织修复装置
公开(公告)号：US08562633B2
公开(公告)日：2013-10-22
申请号：US10910501
申请日：2004-08-02
申请人： Edward H. Cully , James T. Walter , Charles F. White
发明人： Edward H. Cully , James T. Walter , Charles F. White
IPC分类号： A61B17/08
CPC分类号： A61F2/0063 , A61B17/00234 , A61B2017/00004 , A61F2250/0031 , A61L27/48 , A61L27/58 , C08L27/18
摘要： The present invention is a composite medical device having a non-bioabsorbable implantable tissue repair or reconstruction component and a resilient bioabsorbable support member component that aids in deployment and placement of the implantable component at a surgical site. Following deployment, the support member component is readily bioabsorbed and removed from the implantable component. The invention is particularly useful in laproscopic, endoluminal, and other surgical procedures.
摘要翻译：本发明是一种复合医疗装置，其具有非生物可吸收的可植入组织修复或重建组件和有助于将可植入组件部署和放置在外科手术部位的弹性生物可吸收性支撑构件部件。在部署之后，支撑构件部件容易地从可植入部件生物吸收和移除。本发明在腹腔镜，腔内和其他外科手术中特别有用。

2. 发明授权

US09005269B2 Bioabsorbable self-expanding endolumenal devices 有权
标题翻译：生物可吸收的自扩张腔内装置
公开(公告)号：US09005269B2
公开(公告)日：2015-04-14
申请号：US12181197
申请日：2008-07-28
申请人： Joseph R. Armstrong , Paul C. Begovac , Robert L. Cleek , Edward H. Cully , Charles Flynn , Byron K. Hayes , Ryan V. Peterson , Michael J. Vonesh , Charles F. White
发明人： Joseph R. Armstrong , Paul C. Begovac , Robert L. Cleek , Edward H. Cully , Charles Flynn , Byron K. Hayes , Ryan V. Peterson , Michael J. Vonesh , Charles F. White
IPC分类号： A61F2/82 , A61F2/01 , A61B17/12 , A61F2/91 , A61F2/915 , A61L31/06 , A61L31/14 , A61F2/30
CPC分类号： A61F2/01 , A61B17/12022 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/91 , A61F2/915 , A61F2002/016 , A61F2002/018 , A61F2002/30062 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2210/0004 , A61F2210/0076 , A61F2220/0016 , A61F2230/005 , A61F2230/0054 , A61F2230/0069 , A61F2230/008 , A61F2250/003 , A61L31/06 , A61L31/148 , C08L67/04
摘要： Bioabsorbable self-expanding medical devices formed of an integral framework with a multiplicity of fenestrations are provided. The framework is continuous, non-filamentous, non-braided, and non-interlaced. The devices includes a non-blended hydrolysable co-polymeric material comprising an amorphous component with a glass transition temperature that is below ambient body temperature and a crystallizable component that possesses a crystalline melting point in excess of ambient body temperature. The devices radially expand from a compressed first diameter to an uncompressed second diameter equal to or greater than 1.5 times the first diameter within two minutes in an aqueous medium at 37° C. following release of a compressive force placed on the devices. Additionally, the medical device does not change axial length significantly as the radial dimensions of the devices are changed. Further, the medical devices may be constructed of different bioabsorbable polymers, polymer ratios, and/or different geometries and portions may bioabsorb at different rates.
摘要翻译：提供由具有多个开窗的整体框架形成的生物可吸收的自扩张医疗装置。框架是连续的，非丝状的，非编织的和非隔行的。该装置包括非共混的可水解共聚物材料，其包含玻璃化转变温度低于环境体温的非晶组分和具有超过环境体温的结晶熔点的可结晶组分。在放置在装置上的压缩力释放之后，装置在37℃下在含水介质中在两分钟内从压缩的第一直径径向膨胀至等于或大于第一直径的1.5倍的未压缩的第二直径。此外，随着装置的径向尺寸改变，医疗装置不会显着改变轴向长度。此外，医疗装置可以由不同的生物可吸收聚合物，聚合物比率和/或不同的几何形状构成，并且部分可以以不同的速率生物吸收。

3. 发明授权

US07655584B2 Highly porous self-cohered web materials 有权
标题翻译：高度多孔的自粘网材料
公开(公告)号：US07655584B2
公开(公告)日：2010-02-02
申请号：US11193111
申请日：2005-07-29
申请人： Roy Biran , Edward H. Cully , Ted R. Farnsworth , Charles Flynn , Charles F. White
发明人： Roy Biran , Edward H. Cully , Ted R. Farnsworth , Charles Flynn , Charles F. White
IPC分类号： A61B17/03 , A61F13/00 , D04H3/03 , D04H3/16
CPC分类号： A61L31/148 , A61B17/07292 , A61L31/146 , A61L31/18 , Y10T442/608 , Y10T442/674 , Y10T442/677 , Y10T442/681 , Y10T442/682 , Y10T442/688
摘要： The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a very high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof. In some embodiments, the web materials exhibit significant thrombogenic properties.
摘要翻译：本发明涉及具有非常高的孔隙率的可植入的生物可吸收的非织造自粘性纤维网材料。纤维网材料非常柔软和柔软，同时在一个或多个方向上显示成比例地增加的机械强度。网页材料通常具有高度的阁楼。网状材料可以形成适合用作可植入医疗装置或其组件的各种形状和形式。在一些实施方案中，网状材料表现出显着的血栓形成性质。

4. 发明授权

US07659219B2 Highly porous self-cohered web materials having haemostatic properties 有权
标题翻译：具有止血特性的高度多孔的自粘性纤维网材料
公开(公告)号：US07659219B2
公开(公告)日：2010-02-09
申请号：US11343509
申请日：2006-01-30
申请人： Roy Biran , Edward H. Cully , Ted R. Farnsworth , Charles Flynn , Philip P. Off , Charles F. White
发明人： Roy Biran , Edward H. Cully , Ted R. Farnsworth , Charles Flynn , Philip P. Off , Charles F. White
IPC分类号： A61B17/03 , A61F13/00 , D04H3/03 , D04H3/16 , B32B27/12
CPC分类号： A61L31/148 , A61B17/07292 , A61L31/146 , A61L31/18 , Y10T442/608 , Y10T442/674 , Y10T442/677 , Y10T442/681 , Y10T442/682 , Y10T442/688
摘要： The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof. The web materials possess haemostatic properties.
摘要翻译：本发明涉及具有高孔隙率的可植入生物可吸收的非织造自粘性纤维网材料。纤维网材料非常柔软和柔软，同时在一个或多个方向上显示成比例地增加的机械强度。网页材料通常具有高度的阁楼。网状材料可以形成适合用作可植入医疗装置或其组件的各种形状和形式。网状材料具有止血性。

5. 发明申请

US20080281393A1 Bioabsorbable Self-Expanding Endolumenal Devices 有权
标题翻译：生物可吸收的自扩张腔内装置
公开(公告)号：US20080281393A1
公开(公告)日：2008-11-13
申请号：US12181197
申请日：2008-07-28
申请人： Joseph R. Armstrong , Paul C. Begovac , Robert L. Cleek , Edward H. Cully , Charles Flynn , Byron K. Hayes , Ryan V. Peterson , Michael J. Vonesh , Charles F. White
发明人： Joseph R. Armstrong , Paul C. Begovac , Robert L. Cleek , Edward H. Cully , Charles Flynn , Byron K. Hayes , Ryan V. Peterson , Michael J. Vonesh , Charles F. White
IPC分类号： A61F2/92
CPC分类号： A61F2/01 , A61B17/12022 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/91 , A61F2/915 , A61F2002/016 , A61F2002/018 , A61F2002/30062 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2210/0004 , A61F2210/0076 , A61F2220/0016 , A61F2230/005 , A61F2230/0054 , A61F2230/0069 , A61F2230/008 , A61F2250/003 , A61L31/06 , A61L31/148 , C08L67/04
摘要： The present invention is directed to bioabsorbable self-expanding medical devices for use inside or outside body conduits that self-expand at, or below, normal human body temperature without requisite for a polymeric thermal transition.
摘要翻译：本发明涉及用于在正常人体温度下或在正常人体温度下自膨胀而不在聚合物热转变条件下自身膨胀的身体导管内部或外部的生物可吸收自膨胀医疗装置。

6. 发明授权

US09642693B2 Medical apparatus and method of making the same 有权
公开(公告)号：US09642693B2
公开(公告)日：2017-05-09
申请号：US11735372
申请日：2007-04-13
申请人： Edward H. Cully , James Goepfrich , Joanne Hopmeyer , Edward E. Shaw
发明人： Edward H. Cully , James Goepfrich , Joanne Hopmeyer , Edward E. Shaw
IPC分类号： A61B17/08 , A61F2/04 , A61F5/00
CPC分类号： A61F2/04 , A61F5/0003 , A61F5/0076 , A61F5/0089 , A61F2002/044 , A61F2220/0016
摘要： The invention relates to a medical apparatus including a device used in the treatment of weight loss, obesity and potentially other associated health problems, e.g., type II diabetes. The device is used to impede absorption of nutrients within the gastrointestinal tract, i.e., bypassing a portion of the gastrointestinal tract. The medical apparatus enables implantation of the device using minimally invasive techniques, such a transesophageal approach under visualization. The device may be implanted via a working channel of a medical scope, e.g., an endoscope or in combination with a medical scope.

7. 发明授权

US09463269B2 Anastomotic devices and methods 有权
标题翻译：吻合装置和方法
公开(公告)号：US09463269B2
公开(公告)日：2016-10-11
申请号：US13229540
申请日：2011-09-09
申请人： Edward H. Cully , Jeffrey B. Duncan , Karan B. Sangha
发明人： Edward H. Cully , Jeffrey B. Duncan , Karan B. Sangha
IPC分类号： A61B17/08 , A61M1/36 , A61B17/11 , A61F2/06 , A61F2/07 , A61F2/848 , A61F2/89
CPC分类号： A61M1/3655 , A61B17/08 , A61B17/11 , A61B2017/1135 , A61B2017/1139 , A61F2/064 , A61F2/07 , A61F2/89 , A61F2002/075 , A61F2002/8486 , A61F2230/0067 , A61F2230/0069
摘要： Exemplary embodiments comprise AV fistulas and other anastomotic devices for creating new or reinforcing existing side-branch vessels, and/or bridging neighboring vessels together. An exemplary embodiment may comprise a sidewall port, such as a flanged sidewall port, and/or flow frame design, such as a partially bare, flexible stent or a whisk, for purposes of creating a transmural flow. Another exemplary embodiment may comprise a compliant vessel support to aid in the transition from device to vessel and/or vessel to device, and to promote vessel dilation.
摘要翻译：示例性实施例包括用于创建新的或加强现有侧支血管，和/或将邻近血管桥接在一起的AV瘘和其它吻合装置。为了产生透壁流，示例性实施例可以包括侧壁端口，例如法兰侧壁端口和/或流动框架设计，例如部分裸露的柔性支架或者搅拌器。另一个示例性实施例可以包括顺应容器支撑件，以帮助从装置到容器和/或容器到装置的过渡，并且促进血管扩张。

8. 发明授权

US09381018B2 Device for rapid repair of body conduits 有权
公开(公告)号：US09381018B2
公开(公告)日：2016-07-05
申请号：US13149696
申请日：2011-05-31
申请人： Edward H. Cully , Jeffrey B. Duncan , Keith M. Flury , Paul D. Goodman , Wayne D. House , Vrad W. Levering , Philip P. Off , Daniel M. O'Shea , Michael J. Vonesh , Jason M. Wiersdorf
发明人： Edward H. Cully , Jeffrey B. Duncan , Keith M. Flury , Paul D. Goodman , Wayne D. House , Vrad W. Levering , Philip P. Off , Daniel M. O'Shea , Michael J. Vonesh , Jason M. Wiersdorf
IPC分类号： A61F2/84 , A61B17/11 , A61F2/07 , A61F2/97 , A61B17/06 , A61F2/06 , A61F2/30 , A61F2/89
CPC分类号： A61F2/07 , A61B17/06166 , A61B17/11 , A61B2017/1107 , A61F2/064 , A61F2/844 , A61F2/848 , A61F2/88 , A61F2/89 , A61F2/958 , A61F2/97 , A61F2002/075 , A61F2002/30713 , A61F2220/0075 , A61F2220/0091 , A61F2250/0087
摘要： A self-expanding stent-graft provided in a diametrically compacted state for implantation and retained preferably by a constraining sheath, useful for the temporary or permanent repair of injured, partially or entirely transected body conduits including blood vessels. It may be used under direct visualization to quickly stop or substantially reduce loss of blood from such damaged vessels and to quickly re-establish perfusion distal to the injury site. The device would typically be implanted under emergency room conditions but also be used in field situations by trained medical technicians. After an end of the device is inserted into a blood vessel through the injury access, deployment preferably initiates from the device end in a direction moving toward the middle of the length of the device by directionally releasing the constraining sheath. In a preferred embodiment, the two opposing ends of the device are individually deployable from the compacted, small diameter intended for insertion into a vessel, to the larger diameter at which they fit interferably into a portion of the vessel.

9. 发明申请

US20120303112A1 STENT 有权
公开(公告)号：US20120303112A1
公开(公告)日：2012-11-29
申请号：US13298060
申请日：2011-11-16
申请人： Joseph R. Armstrong , Edward H. Cully , Michael W. Franklin , Mark Y. Hansen , Brandon A. Lurie , Craig r. McMurray , William D. Montgomery , Wendy J. Terry , Eric M. Tittelbaugh
发明人： Joseph R. Armstrong , Edward H. Cully , Michael W. Franklin , Mark Y. Hansen , Brandon A. Lurie , Craig r. McMurray , William D. Montgomery , Wendy J. Terry , Eric M. Tittelbaugh
IPC分类号： A61F2/82
CPC分类号： A61F2/88 , A61F2/07 , A61F2/915 , A61F2/966 , A61F2002/075 , A61F2002/91558 , A61F2002/91575 , A61F2002/9583 , A61F2220/005 , A61F2220/0075 , A61F2230/0054
摘要： The invention relates to a medical device and a method of using it. The device is a stent which can be percutaneously deliverable with (or on) an endovascular catheter or via other surgical or other techniques and then expanded. The stent is configured to have a central portion defined by “open” cells and at least two end portions, defined by “closed” cells, spaced apart and directly connected to the distal and proximal ends of the central portion of the stent. The stent may also optionally have a covering or a lattice with openings.
摘要翻译：本发明涉及医疗装置及其使用方法。该装置是可以通过（或在）血管内导管或经由其它手术或其它技术经皮递送的支架，然后扩张。支架被构造成具有由开放细胞限定的中心部分和由闭孔限定的至少两个端部，间隔开并且直接连接到支架的中心部分的远端和近端。支架也可任选地具有带开口的覆盖物或格子。

10. 发明申请

US20120289997A1 Embolic Filter Frame Having Looped Support Strut Elements 有权
标题翻译：具有环形支撑支柱元件的栓塞过滤器框架
公开(公告)号：US20120289997A1
公开(公告)日：2012-11-15
申请号：US13555543
申请日：2012-07-23
申请人： Edward H. Cully , Michael J. Vonesh
发明人： Edward H. Cully , Michael J. Vonesh
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , B23P11/00 , Y10T29/49826
摘要： An embolic frame having looped support struts. The frame configuration provides enhanced longitudinal compliance, improved sealing against a vessel wall, low profile delivery, and a short deployed length. The looped support struts have a high degree of “radial” stiffness with a low degree of “longitudinal” stiffness. In the deployed state, the frame exerts a relatively high stress onto a vessel wall to maintain an effective seal, yet remains compliant in the longitudinal direction. The looped support struts elongate when tensioned and assume a compressed and essentially linear form. While constrained in this linear state by a delivery catheter, the support struts exert minimal stress onto the delivery system. The overall delivery profile and stiffness are therefore reduced. When the delivery catheter constraint is removed during deployment, the struts “snap open” and assume a looped configuration which exert a high degree of force onto the vessel wall.
摘要翻译：具有环状支撑支柱的栓塞框架。框架结构提供增强的纵向顺应性，改进的针对血管壁的密封，薄型输送和短部署长度。环形支撑支柱具有高度的径向刚度，并且具有低程度的纵向刚度。在展开状态下，框架在容器壁上施加相当高的应力以保持有效的密封，但在长度方向保持柔顺。环形支撑件在张紧时伸长并呈现压缩且基本线性的形式。虽然通过输送导管在这种线性状态下被约束，但是支撑支柱对输送系统施加最小的压力。因此，总体输送轮廓和刚度降低。当在展开期间移除输送导管约束时，支柱卡扣打开并且呈现向血管壁施加高度力的环形构造。

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