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1. 发明授权

US09381018B2 Device for rapid repair of body conduits 有权
公开(公告)号：US09381018B2
公开(公告)日：2016-07-05
申请号：US13149696
申请日：2011-05-31
申请人： Edward H. Cully , Jeffrey B. Duncan , Keith M. Flury , Paul D. Goodman , Wayne D. House , Vrad W. Levering , Philip P. Off , Daniel M. O'Shea , Michael J. Vonesh , Jason M. Wiersdorf
发明人： Edward H. Cully , Jeffrey B. Duncan , Keith M. Flury , Paul D. Goodman , Wayne D. House , Vrad W. Levering , Philip P. Off , Daniel M. O'Shea , Michael J. Vonesh , Jason M. Wiersdorf
IPC分类号： A61F2/84 , A61B17/11 , A61F2/07 , A61F2/97 , A61B17/06 , A61F2/06 , A61F2/30 , A61F2/89
CPC分类号： A61F2/07 , A61B17/06166 , A61B17/11 , A61B2017/1107 , A61F2/064 , A61F2/844 , A61F2/848 , A61F2/88 , A61F2/89 , A61F2/958 , A61F2/97 , A61F2002/075 , A61F2002/30713 , A61F2220/0075 , A61F2220/0091 , A61F2250/0087
摘要： A self-expanding stent-graft provided in a diametrically compacted state for implantation and retained preferably by a constraining sheath, useful for the temporary or permanent repair of injured, partially or entirely transected body conduits including blood vessels. It may be used under direct visualization to quickly stop or substantially reduce loss of blood from such damaged vessels and to quickly re-establish perfusion distal to the injury site. The device would typically be implanted under emergency room conditions but also be used in field situations by trained medical technicians. After an end of the device is inserted into a blood vessel through the injury access, deployment preferably initiates from the device end in a direction moving toward the middle of the length of the device by directionally releasing the constraining sheath. In a preferred embodiment, the two opposing ends of the device are individually deployable from the compacted, small diameter intended for insertion into a vessel, to the larger diameter at which they fit interferably into a portion of the vessel.

2. 发明授权

US09005269B2 Bioabsorbable self-expanding endolumenal devices 有权
标题翻译：生物可吸收的自扩张腔内装置
公开(公告)号：US09005269B2
公开(公告)日：2015-04-14
申请号：US12181197
申请日：2008-07-28
申请人： Joseph R. Armstrong , Paul C. Begovac , Robert L. Cleek , Edward H. Cully , Charles Flynn , Byron K. Hayes , Ryan V. Peterson , Michael J. Vonesh , Charles F. White
发明人： Joseph R. Armstrong , Paul C. Begovac , Robert L. Cleek , Edward H. Cully , Charles Flynn , Byron K. Hayes , Ryan V. Peterson , Michael J. Vonesh , Charles F. White
IPC分类号： A61F2/82 , A61F2/01 , A61B17/12 , A61F2/91 , A61F2/915 , A61L31/06 , A61L31/14 , A61F2/30
CPC分类号： A61F2/01 , A61B17/12022 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/91 , A61F2/915 , A61F2002/016 , A61F2002/018 , A61F2002/30062 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2210/0004 , A61F2210/0076 , A61F2220/0016 , A61F2230/005 , A61F2230/0054 , A61F2230/0069 , A61F2230/008 , A61F2250/003 , A61L31/06 , A61L31/148 , C08L67/04
摘要： Bioabsorbable self-expanding medical devices formed of an integral framework with a multiplicity of fenestrations are provided. The framework is continuous, non-filamentous, non-braided, and non-interlaced. The devices includes a non-blended hydrolysable co-polymeric material comprising an amorphous component with a glass transition temperature that is below ambient body temperature and a crystallizable component that possesses a crystalline melting point in excess of ambient body temperature. The devices radially expand from a compressed first diameter to an uncompressed second diameter equal to or greater than 1.5 times the first diameter within two minutes in an aqueous medium at 37° C. following release of a compressive force placed on the devices. Additionally, the medical device does not change axial length significantly as the radial dimensions of the devices are changed. Further, the medical devices may be constructed of different bioabsorbable polymers, polymer ratios, and/or different geometries and portions may bioabsorb at different rates.
摘要翻译：提供由具有多个开窗的整体框架形成的生物可吸收的自扩张医疗装置。框架是连续的，非丝状的，非编织的和非隔行的。该装置包括非共混的可水解共聚物材料，其包含玻璃化转变温度低于环境体温的非晶组分和具有超过环境体温的结晶熔点的可结晶组分。在放置在装置上的压缩力释放之后，装置在37℃下在含水介质中在两分钟内从压缩的第一直径径向膨胀至等于或大于第一直径的1.5倍的未压缩的第二直径。此外，随着装置的径向尺寸改变，医疗装置不会显着改变轴向长度。此外，医疗装置可以由不同的生物可吸收聚合物，聚合物比率和/或不同的几何形状构成，并且部分可以以不同的速率生物吸收。

3. 发明申请

US20120289997A1 Embolic Filter Frame Having Looped Support Strut Elements 有权
标题翻译：具有环形支撑支柱元件的栓塞过滤器框架
公开(公告)号：US20120289997A1
公开(公告)日：2012-11-15
申请号：US13555543
申请日：2012-07-23
申请人： Edward H. Cully , Michael J. Vonesh
发明人： Edward H. Cully , Michael J. Vonesh
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , B23P11/00 , Y10T29/49826
摘要： An embolic frame having looped support struts. The frame configuration provides enhanced longitudinal compliance, improved sealing against a vessel wall, low profile delivery, and a short deployed length. The looped support struts have a high degree of “radial” stiffness with a low degree of “longitudinal” stiffness. In the deployed state, the frame exerts a relatively high stress onto a vessel wall to maintain an effective seal, yet remains compliant in the longitudinal direction. The looped support struts elongate when tensioned and assume a compressed and essentially linear form. While constrained in this linear state by a delivery catheter, the support struts exert minimal stress onto the delivery system. The overall delivery profile and stiffness are therefore reduced. When the delivery catheter constraint is removed during deployment, the struts “snap open” and assume a looped configuration which exert a high degree of force onto the vessel wall.
摘要翻译：具有环状支撑支柱的栓塞框架。框架结构提供增强的纵向顺应性，改进的针对血管壁的密封，薄型输送和短部署长度。环形支撑支柱具有高度的径向刚度，并且具有低程度的纵向刚度。在展开状态下，框架在容器壁上施加相当高的应力以保持有效的密封，但在长度方向保持柔顺。环形支撑件在张紧时伸长并呈现压缩且基本线性的形式。虽然通过输送导管在这种线性状态下被约束，但是支撑支柱对输送系统施加最小的压力。因此，总体输送轮廓和刚度降低。当在展开期间移除输送导管约束时，支柱卡扣打开并且呈现向血管壁施加高度力的环形构造。

4. 发明授权

US08197529B2 Removable stent-graft 有权
标题翻译：可移植支架移植物
公开(公告)号：US08197529B2
公开(公告)日：2012-06-12
申请号：US12491895
申请日：2009-06-25
申请人： Edward H. Cully , Erin B. Hutchinson , Michael J. Vonesh , Woodrow W. Watson
发明人： Edward H. Cully , Erin B. Hutchinson , Michael J. Vonesh , Woodrow W. Watson
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61B2017/22035 , A61F2/848 , A61F2/88 , A61F2/89 , A61F2002/072 , A61F2002/075 , A61F2002/9528 , A61F2220/005 , A61F2250/0071
摘要： A removable device such as a stent-graft, intended for applications where it may be desirable to remove the device at some time following implantation. The stent-graft of the present invention includes a helically-wound stent component provided with a covering of graft material. It is removable by gripping an end of the helically-wound stent component with a retrieval device and applying tension to the stent component in the direction in which it is intended to be withdrawn from the site of implantation. The use of such a retrieval device allows the stent-graft to be removed remotely, such as via a catheter inserted into the body at a different location from the implantation site. The design of the stent-graft is such that the stent component is extended axially while the adjacent portion of the graft separates between windings of the stent component. The axial extension of the stent component, with portions of the graft still joined to the stent component, allows the device to be “unraveled” (or “unwound”) and removed through a catheter of diameter adequately small to be inserted into the body cavity that contained the stent-graft. It is removed atraumatically, without incurring significant trauma to the body conduit in which it had been deployed.
摘要翻译：诸如支架移植物的可移除装置，其用于在植入后的某个时间可能需要移除装置的应用。本发明的支架移植物包括设置有移植材料覆盖物的螺旋缠绕的支架组件。通过用拾取装置抓住螺旋缠绕的支架部件的一端并且沿着其将要从植入部位取出的方向对支架部件施加张力，其可移除。使用这种检索装置允许远程地移除支架移植物，例如通过在与植入部位不同的位置插入体内的导管。支架移植物的设计使得支架部件沿轴向延伸，而移植物的相邻部分在支架部件的绕组之间分离。支架部件的轴向延伸，其中移植物的一部分仍然连接到支架部件，允许装置“解开”（或“展开”）并通过足够小的直径的导管移除以插入体腔包含支架移植物。它无创伤地去除，而不会对其部署的身体导管造成重大创伤。

5. 发明申请

US20110276012A1 PUNCTURABLE CATHETER 有权
标题翻译：可拆卸导管
公开(公告)号：US20110276012A1
公开(公告)日：2011-11-10
申请号：US13186198
申请日：2011-07-19
申请人： JOSEPH R. ARMSTRONG , Edward H. Cully , Keith M. Flury , Michael J. Vonesh
发明人： JOSEPH R. ARMSTRONG , Edward H. Cully , Keith M. Flury , Michael J. Vonesh
IPC分类号： A61M25/00
CPC分类号： A61M25/0043 , A61F2/958 , A61M25/005 , A61M25/0052 , A61M25/10 , A61M2025/0183 , A61M2025/0188 , A61M2025/1056 , A61M2025/1081
摘要： A catheter provided with a guidewire catheter lumen having a thin covering that is easily punctured by a guidewire at virtually any desired point along the catheter length. The thin covering may be integral with the catheter shaft, or may be a separate component that covers only the portion of the catheter shaft immediately adjacent the outer portion of the guidewire lumen, or may be a thin tubular construct that surrounds the entire catheter shaft. The covering is preferably relatively translucent, allowing for good visualization of the location of the end of the guidewire to enable puncturing of the covering at the desired location along the length of the catheter shaft. The covering is also preferably tear resistant at puncture sites. The catheter shaft is preferably made of a material having a color that provides good visibility against an operating field, and more preferably is phosphorescent either entirely or in part. Materials suitable for the catheter shaft are polymeric materials well known in the art; the catheter shaft may optionally be provided with metallic stiffening components such as wires or hypotubes along all or part of the catheter length.
摘要翻译：导管，其具有导线导管管腔，该导管管腔具有薄的覆盖层，其在导管长度的几乎任何所需点处被导丝容易地刺穿。薄的覆盖物可以与导管轴成一体，或者可以是仅覆盖导管轴的紧邻导丝管腔的外部的部分的单独的部件，或者可以是围绕整个导管轴的薄的管状结构。覆盖物优选地是相对半透明的，允许良好地可视化导丝端部的位置，以使得能够沿着导管轴的长度在期望的位置刺穿覆盖物。覆盖物也优选在穿刺部位具有抗撕裂性。导管轴优选由具有对操作场提供良好可见性的颜色的材料制成，更优选地，全部或部分地是磷光。适用于导管轴的材料是本领域公知的聚合材料; 导管轴可以可选地沿着导管长度的全部或部分设置有金属加强部件，例如电线或海波管。

6. 发明申请

US20110276011A1 PUNCTURABLE CATHETER 审中-公开
公开(公告)号：US20110276011A1
公开(公告)日：2011-11-10
申请号：US13186156
申请日：2011-07-19
申请人： JOSEPH R. ARMSTRONG , Edward H. Cully , Keith M. Flur , Michael J. Vonesh
发明人： JOSEPH R. ARMSTRONG , Edward H. Cully , Keith M. Flur , Michael J. Vonesh
IPC分类号： A61M25/00
CPC分类号： A61M25/0043 , A61F2/958 , A61M25/005 , A61M25/0052 , A61M25/10 , A61M2025/0183 , A61M2025/0188 , A61M2025/1056 , A61M2025/1081
摘要： A catheter provided with a guidewire catheter lumen having a thin covering that is easily punctured by a guidewire at virtually any desired point along the catheter length. The thin covering may be integral with the catheter shaft, or may be a separate component that covers only the portion of the catheter shaft immediately adjacent the outer portion of the guidewire lumen, or may be a thin tubular construct that surrounds the entire catheter shaft. The covering is preferably relatively translucent, allowing for good visualization of the location of the end of the guidewire to enable puncturing of the covering at the desired location along the length of the catheter shaft. The covering is also preferably tear resistant at puncture sites. The catheter shaft is preferably made of a material having a color that provides good visibility against an operating field, and more preferably is phosphorescent either entirely or in part. Materials suitable for the catheter shaft are polymeric materials well known in the art; the catheter shaft may optionally be provided with metallic stiffening components such as wires or hypotubes along all or part of the catheter length.

7. 发明申请

US20100069916A1 REMOVABLE STENT-GRAFT 有权
标题翻译：可拆卸的STENT-GRAFT
公开(公告)号：US20100069916A1
公开(公告)日：2010-03-18
申请号：US12621055
申请日：2009-11-18
申请人： EDWARD H. CULLY , Erin B. Hutchinson , Michael J. Vonesh , Woodrow W. Watson
发明人： EDWARD H. CULLY , Erin B. Hutchinson , Michael J. Vonesh , Woodrow W. Watson
IPC分类号： A61F11/00
CPC分类号： A61F2/07 , A61B2017/22035 , A61F2/848 , A61F2/88 , A61F2/89 , A61F2002/072 , A61F2002/075 , A61F2002/9528 , A61F2220/005 , A61F2250/0071
摘要： A removable device such as a stent-graft, intended for applications where it may be desirable to remove the device at some time following implantation. The stent-graft of the present invention includes a helically-wound stent component provided with a covering of graft material. It is removable by gripping an end of the helically-wound stent component with a retrieval device and applying tension to the stent component in the direction in which it is intended to be withdrawn from the site of implantation. The use of such a retrieval device allows the stent-graft to be removed remotely, such as via a catheter inserted into the body at a different location from the implantation site. The design of the stent-graft is such that the stent component is extended axially while the adjacent portion of the graft separates between windings of the stent component. The axial extension of the stent component, with portions of the graft still joined to the stent component, allows the device to be “unraveled” (or “unwound”) and removed through a catheter of diameter adequately small to be inserted into the body cavity that contained the stent-graft. It is removed atraumatically, without incurring significant trauma to the body conduit in which it had been deployed.
摘要翻译：诸如支架移植物的可移除装置，其用于在植入后的某个时间可能需要移除装置的应用。本发明的支架移植物包括设置有移植材料覆盖物的螺旋缠绕的支架组件。通过用拾取装置抓住螺旋缠绕的支架部件的一端并且沿着其将要从植入部位取出的方向对支架部件施加张力，其可移除。使用这种检索装置允许远程地移除支架移植物，例如通过在与植入部位不同的位置插入体内的导管。支架移植物的设计使得支架部件沿轴向延伸，而移植物的相邻部分在支架部件的绕组之间分离。支架部件的轴向延伸，其中移植物的一部分仍然连接到支架部件，允许装置“解开”（或“展开”）并通过足够小的直径的导管移除以插入体腔包含支架移植物。它无创伤地去除，而不会对其部署的身体导管造成重大创伤。

8. 发明授权

US07625337B2 Catheter assembly 有权
标题翻译：导管总成
公开(公告)号：US07625337B2
公开(公告)日：2009-12-01
申请号：US11500836
申请日：2006-08-07
申请人： Carey V. Campbell , Edward H. Cully , Sherif Eskaros , George N. Foutrakis , James William Mann , Peter J. Roeber , Benjamin M. Trapp , Michael J. Vonesh
发明人： Carey V. Campbell , Edward H. Cully , Sherif Eskaros , George N. Foutrakis , James William Mann , Peter J. Roeber , Benjamin M. Trapp , Michael J. Vonesh
IPC分类号： A61B1/12 , A61M29/00
CPC分类号： A61M25/10 , A61F2/958 , A61M25/0023 , A61M25/0029 , A61M25/0032 , A61M25/0043 , A61M25/005 , A61M25/0051 , A61M25/0052 , A61M25/0053 , A61M25/1002 , A61M25/1011 , A61M2025/0034 , A61M2025/0035 , A61M2025/0063 , A61M2025/0183 , A61M2025/0188 , A61M2025/1056 , A61M2025/1081
摘要： Novel catheter constructions comprising thin covering or wrapping materials such as polymer films. A catheter provided with a guidewire catheter lumen having a thin covering that is easily punctured by a guidewire at virtually any desired point along the catheter length. The thin covering may be integral with the catheter shaft, or may be a separate component that covers only the portion of the catheter shaft immediately adjacent the outer portion of the guidewire lumen, or may be a thin tubular construct that surrounds the entire catheter shaft. Moreover, polymer film can be used in combination with one or more elements to produce novel catheter constructions.
摘要翻译：新颖的导管结构包括薄的覆盖物或包裹材料如聚合物膜。导管，其具有导线导管管腔，该导管管腔具有薄的覆盖层，其在导管长度的几乎任何所需点处被导丝容易地刺穿。薄的覆盖物可以与导管轴成一体，或者可以是仅覆盖导管轴的紧邻导丝管腔的外部的部分的单独的部件，或者可以是围绕整个导管轴的薄的管状结构。此外，聚合物膜可以与一种或多种元素组合使用以产生新的导管结构。

9. 发明申请

US20090259294A1 REMOVABLE STENT-GRAFT 有权
标题翻译：可拆卸的STENT-GRAFT
公开(公告)号：US20090259294A1
公开(公告)日：2009-10-15
申请号：US12491895
申请日：2009-06-25
申请人： EDWARD H. CULLY , Erin B. Hutchinson , Michael J. Vonesh , Woodrow W. Watson
发明人： EDWARD H. CULLY , Erin B. Hutchinson , Michael J. Vonesh , Woodrow W. Watson
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61B2017/22035 , A61F2/848 , A61F2/88 , A61F2/89 , A61F2002/072 , A61F2002/075 , A61F2002/9528 , A61F2220/005 , A61F2250/0071
摘要： A removable device such as a stent-graft, intended for applications where it may be desirable to remove the device at some time following implantation. The stent-graft of the present invention includes a helically-wound stent component provided with a covering of graft material. It is removable by gripping an end of the helically-wound stent component with a retrieval device and applying tension to the stent component in the direction in which it is intended to be withdrawn from the site of implantation. The use of such a retrieval device allows the stent-graft to be removed remotely, such as via a catheter inserted into the body at a different location from the implantation site. The design of the stent-graft is such that the stent component is extended axially while the adjacent portion of the graft separates between windings of the stent component. The axial extension of the stent component, with portions of the graft still joined to the stent component, allows the device to be “unraveled” (or “unwound”) and removed through a catheter of diameter adequately small to be inserted into the body cavity that contained the stent-graft. It is removed atraumatically, without incurring significant trauma to the body conduit in which it had been deployed.
摘要翻译：诸如支架移植物的可移除装置，其用于在植入后的某个时间可能需要移除装置的应用。本发明的支架移植物包括设置有移植材料覆盖物的螺旋缠绕的支架组件。通过用拾取装置抓住螺旋缠绕的支架部件的一端并且沿着其将要从植入部位取出的方向对支架部件施加张力，其可移除。使用这种检索装置允许远程地移除支架移植物，例如通过在与植入部位不同的位置插入体内的导管。支架移植物的设计使得支架部件沿轴向延伸，而移植物的相邻部分在支架部件的绕组之间分离。支架部件的轴向延伸，其中移植物的一部分仍然连接到支架部件，允许装置“解开”（或“展开”）并通过足够小的直径的导管移除以插入体腔包含支架移植物。它无创伤地去除，而不会对其部署的身体导管造成重大创伤。

10. 发明授权

US07556641B2 Deployment system for an expandable device 有权
标题翻译：可扩展设备的部署系统
公开(公告)号：US07556641B2
公开(公告)日：2009-07-07
申请号：US10892934
申请日：2004-07-16
申请人： Edward H. Cully , Keith M. Flury , Michael J. Vonesh
发明人： Edward H. Cully , Keith M. Flury , Michael J. Vonesh
IPC分类号： A61F2/06
CPC分类号： A61F2/966 , A61F2/95 , A61F2/958 , A61F2/97 , A61F2002/9511
摘要： The present invention is directed to a deployment system for an endoluminal device. The deployment system includes a confining sheath placed around a compacted endoluminal device. A deployment line is provided in the system that is an integral extension of the sheath. As the deployment line is actuated, the sheath retracts from around the compacted endoluminal device. As the sheath retracts from around the endoluminal device, material from the sheath may be converted into deployment line. Once the sheath is retracted from around the compacted endoluminal device, the endoluminal device expands in configuration and repairs vascular or cardiac structures of an implant recipient. Any remaining sheath material is removed from the implantation site along with the deployment line. The deployment system also includes an endo-prosthesis mounting member placed between the endoluminal device and an underlying catheter. The endo-prosthesis mounting member serves to cushion and retain the endoluminal device when constrained by the sheath and may assist in expansion of the endoluminal device when unconstrained by the sheath.The present invention is also directed to a deployment system having a deployment assembly that simultaneously expands an endo-prosthesis mounting member while removing a sheath from an expandable medical device.
摘要翻译：本发明涉及一种用于腔内装置的部署系统。部署系统包括围绕压实的腔内装置放置的限制鞘。在系统中提供了一个部署线，该线是护套的整体延伸。随着部署线被致动，护套从紧凑的腔内装置周围缩回。当护套从内腔装置周围缩回时，来自护套的材料可以被转换成展开线。一旦护套从紧凑的腔内装置周围缩回，腔内装置在构型上扩张并修复植入物接受者的血管或心脏结构。任何剩余的护套材料与植入线一起从植入部位移除。所述展开系统还包括放置在腔内装置和下面的导管之间的内腔假体安装构件。假体内固定构件用于在被护套约束时缓冲和保持内腔装置，并且可以在不受护套约束时有助于内腔装置的膨胀。本发明还涉及一种具有展开组件的展开系统，所述展开组件在从可扩张医疗装置移除护套的同时同时展开内衣假体安装构件。

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