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1. 发明申请

US20120116195A1 METHOD AND DEVICE FOR DETECTION OF BIOAVAILABLE DRUG CONCENTRATION IN A FLUID SAMPLE 有权
标题翻译：用于检测流体样品中生物可利用药物浓度的方法和装置
公开(公告)号：US20120116195A1
公开(公告)日：2012-05-10
申请号：US13124036
申请日：2009-10-15
申请人： Edward Chaum , Erno Lindner , Kenneth C. Curley , Jidong Guo
发明人： Edward Chaum , Erno Lindner , Kenneth C. Curley , Jidong Guo
IPC分类号： A61B5/1473 , G01N33/50 , G01N27/327 , A61M5/168 , B82Y30/00 , B82Y99/00 , B82Y5/00
CPC分类号： A61B5/14546 , A61B5/14539 , A61B5/1468 , A61B5/4839 , A61B5/6852 , A61L29/16 , A61L2300/402 , A61L2300/602 , A61M25/0017 , A61M31/00 , A61M2205/3303
摘要： The invention relates to a method for the controlled delivery of a drug as a function of bioavailable drug concentration, a sensor device for detecting bioavailable drug concentration, and a delivery device that controls delivery of the drug based on the real-time detection of bioavailable drug concentration.
摘要翻译：本发明涉及作为生物可利用药物浓度的函数的药物的受控递送方法，用于检测生物可利用药物浓度的传感器装置，以及基于生物可利用药物的实时检测来控制药物递送的递送装置浓度。

2. 发明授权

US09700246B2 Method and device for detection of bioavailable drug concentration in a fluid sample 有权
公开(公告)号：US09700246B2
公开(公告)日：2017-07-11
申请号：US13124036
申请日：2009-10-15
申请人： Edward Chaum , Erno Lindner , Jidong Guo
发明人： Edward Chaum , Erno Lindner , Jidong Guo
IPC分类号： A61B5/05 , A61B5/145 , A61B5/00 , A61L29/16 , A61B5/1468 , A61M25/00 , A61M31/00
CPC分类号： A61B5/14546 , A61B5/14539 , A61B5/1468 , A61B5/4839 , A61B5/6852 , A61L29/16 , A61L2300/402 , A61L2300/602 , A61M25/0017 , A61M31/00 , A61M2205/3303
摘要： The invention relates to a method for the controlled delivery of a drug as a function of bioavailable drug concentration, a sensor device for detecting bioavailable drug concentration, and a delivery device that controls delivery of the drug based on the real-time detection of bioavailable drug concentration.

3. 发明授权

US08425596B2 Retinal instrument 有权
标题翻译：视网膜仪
公开(公告)号：US08425596B2
公开(公告)日：2013-04-23
申请号：US12052992
申请日：2008-03-21
申请人： Charles L. Britton , Brian R. D'Urso , Edward Chaum , John T. Simpson , Justin S. Baba , M. Nance Ericson , Robert J. Warmack
发明人： Charles L. Britton , Brian R. D'Urso , Edward Chaum , John T. Simpson , Justin S. Baba , M. Nance Ericson , Robert J. Warmack
IPC分类号： A61F2/16
CPC分类号： A61F9/00736 , A61B17/205 , A61F9/007 , A61F9/00727
摘要： In one embodiment, the present invention provides a method of removing scar tissue from an eye that includes inserting a device including an array of micro-rods into an eye, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature; contacting a scar tissue with the array of micro-rods; and removing the array of micro-rods and the scar tissue from the eye. In another embodiment, the present invention provides a medical device for engaging a tissue including and an array of glass micro-rods, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature opposite a base of the array of glass micro-rods that is connected to the cannula, wherein the sharp feature of the at least one micro-rod is angled from a plane that is normal to a face of the base of the array of glass micro-rods.
摘要翻译：在一个实施方案中，本发明提供了一种从眼睛去除疤痕组织的方法，包括将包括微棒阵列的装置插入到眼睛中，其中玻璃微棒阵列的至少一个玻璃微棒包括一个尖锐的特征; 使疤痕组织与微杆阵列接触; 并从眼睛中移除微杆阵列和瘢痕组织。在另一个实施方案中，本发明提供了一种用于接合包括玻璃微棒和玻璃微棒的阵列的组织的医疗装置，其中所述玻璃微棒阵列的至少一个玻璃微棒包括与所述玻璃微棒的基底相对的尖锐特征连接到插管的玻璃微杆的阵列，其中所述至少一个微杆的尖锐特征从与所述玻璃微棒阵列的基部的面垂直的平面成角度。

4. 发明授权

US08218838B2 Method and system for assigning a confidence metric for automated determination of optic disc location 有权
标题翻译：为自动确定视盘位置分配置信度量的方法和系统
公开(公告)号：US08218838B2
公开(公告)日：2012-07-10
申请号：US12263876
申请日：2008-11-03
申请人： Thomas P. Karnowski , Kenneth W. Tobin, Jr. , Vijaya Priya Muthusamy Govindasamy , Edward Chaum
发明人： Thomas P. Karnowski , Kenneth W. Tobin, Jr. , Vijaya Priya Muthusamy Govindasamy , Edward Chaum
IPC分类号： G06K9/60
CPC分类号： G06K9/0061 , G06F19/00 , G06F19/321 , G06T7/0012 , G06T7/70 , G06T2207/30041 , G16H50/20
摘要： A method for assigning a confidence metric for automated determination of optic disc location that includes analyzing a retinal image and determining at least two sets of coordinates locating an optic disc in the retinal image. The sets of coordinates can be determined using first and second image analysis techniques that are different from one another. An accuracy parameter can be calculated and compared to a primary risk cut-off value. A high confidence level can be assigned to the retinal image if the accuracy parameter is less than the primary risk cut-off value and a low confidence level can be assigned to the retinal image if the accuracy parameter is greater than the primary risk cut-off value. The primary risk cut-off value being selected to represent an acceptable risk of misdiagnosis of a disease having retinal manifestations by the automated technique.
摘要翻译：一种用于分配用于自动确定视盘位置的置信度量的方法，包括分析视网膜图像并且确定定位视网膜图像中的视盘的至少两组坐标。可以使用彼此不同的第一和第二图像分析技术来确定坐标集合。可以计算精度参数并将其与主要风险截止值进行比较。如果精度参数小于主要风险截止值，则可以将高置信度分配给视网膜图像，如果精度参数大于主要风险截止值，则可将低置信度水平分配给视网膜图像值。选择主要风险截止值以通过自动化技术代表具有视网膜表现的疾病的误诊的可接受风险。

5. 发明申请

US20070258630A1 Method and system for the diagnosis of disease using retinal image content and an archive of diagnosed human patient data 有权
标题翻译：用于使用视网膜图像内容诊断疾病的诊断方法和系统以及诊断的人类患者数据的归档
公开(公告)号：US20070258630A1
公开(公告)日：2007-11-08
申请号：US11416834
申请日：2006-05-03
申请人： Kenneth Tobin , Thomas Karnowski , Edward Chaum
发明人： Kenneth Tobin , Thomas Karnowski , Edward Chaum
IPC分类号： G06K9/00 , A61B3/00
CPC分类号： G06K9/0061 , A61B3/12 , G06K9/00617
摘要： A method for diagnosing diseases having retinal manifestations including retinal pathologies includes the steps of providing a CBIR system including an archive of stored digital retinal photography images and diagnosed patient data corresponding to the retinal photography images, the stored images each indexed in a CBIR database using a plurality of feature vectors, the feature vectors corresponding to distinct descriptive characteristics of the stored images. A query image of the retina of a patient is obtained. Using image processing, regions or structures in the query image are identified. The regions or structures are then described using the plurality of feature vectors. At least one relevant stored image from the archive based on similarity to the regions or structures is retrieved, and an eye disease or a disease having retinal manifestations in the patient is diagnosed based on the diagnosed patient data associated with the relevant stored image(s).
摘要翻译：用于诊断具有视网膜表现的疾病（包括视网膜病变）的方法包括以下步骤：提供CBIR系统，其包括存储的数字视网膜摄影图像的存档和与视网膜摄影图像相对应的诊断的患者数据，所存储的图像每个索引在CBIR数据库中，使用多个特征向量，对应于所存储图像的不同描述特征的特征向量。获得患者视网膜的查询图像。使用图像处理，识别查询图像中的区域或结构。然后使用多个特征向量来描述区域或结构。基于与区域或结构的相似性，归档归档中的至少一个相关的存储图像，并且基于与相关的存储图像相关联的诊断的患者数据来诊断眼病或患者中具有视网膜表现的疾病，。

6. 发明申请

US20090240271A1 RETINAL INSTRUMENT 有权
标题翻译：离子仪器
公开(公告)号：US20090240271A1
公开(公告)日：2009-09-24
申请号：US12052992
申请日：2008-03-21
申请人： Charles L. Britton , Brian R. D'Urso , Edward Chaum , John T. Simpson , Justin S. Baba , M. Nance Ericson , Robert J. Warmack
发明人： Charles L. Britton , Brian R. D'Urso , Edward Chaum , John T. Simpson , Justin S. Baba , M. Nance Ericson , Robert J. Warmack
IPC分类号： A61F9/00
CPC分类号： A61F9/00736 , A61B17/205 , A61F9/007 , A61F9/00727
摘要： In one embodiment, the present invention provides a method of removing scar tissue from an eye that includes inserting a device including an array of micro-rods into an eye, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature; contacting a scar tissue with the array of micro-rods; and removing the array of micro-rods and the scar tissue from the eye. In another embodiment, the present invention provides a medical device for engaging a tissue including and an array of glass micro-rods, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature opposite a base of the array of glass micro-rods that is connected to the cannula, wherein the sharp feature of the at least one micro-rod is angled from a plane that is normal to a face of the base of the array of glass micro-rods.
摘要翻译：在一个实施方案中，本发明提供了一种从眼睛去除疤痕组织的方法，包括将包括微棒阵列的装置插入到眼睛中，其中玻璃微棒阵列的至少一个玻璃微棒包括一个尖锐的特征; 使疤痕组织与微杆阵列接触; 并从眼睛中移除微杆阵列和瘢痕组织。在另一个实施方案中，本发明提供了一种用于接合包括玻璃微棒和玻璃微棒的阵列的组织的医疗装置，其中所述玻璃微棒阵列的至少一个玻璃微棒包括与所述玻璃微棒的基底相对的尖锐特征连接到插管的玻璃微杆的阵列，其中所述至少一个微杆的尖锐特征从与所述玻璃微棒阵列的基部的面垂直的平面成角度。

7. 发明授权

US08243999B2 Method and system for the diagnosis of disease using retinal image content and an archive of diagnosed human patient data 有权
标题翻译：用于使用视网膜图像内容诊断疾病的诊断方法和系统以及诊断的人类患者数据的归档
公开(公告)号：US08243999B2
公开(公告)日：2012-08-14
申请号：US11416834
申请日：2006-05-03
申请人： Kenneth William Tobin, Jr. , Thomas P. Karnowski , Edward Chaum
发明人： Kenneth William Tobin, Jr. , Thomas P. Karnowski , Edward Chaum
IPC分类号： G06K9/00
CPC分类号： G06K9/0061 , A61B3/12 , G06K9/00617
摘要： A method for diagnosing diseases having retinal manifestations including retinal pathologies includes the steps of providing a CBIR system including an archive of stored digital retinal photography images and diagnosed patient data corresponding to the retinal photography images, the stored images each indexed in a CBIR database using a plurality of feature vectors, the feature vectors corresponding to distinct descriptive characteristics of the stored images. A query image of the retina of a patient is obtained. Using image processing, regions or structures in the query image are identified. The regions or structures are then described using the plurality of feature vectors. At least one relevant stored image from the archive based on similarity to the regions or structures is retrieved, and an eye disease or a disease having retinal manifestations in the patient is diagnosed based on the diagnosed patient data associated with the relevant stored image(s).
摘要翻译：用于诊断具有视网膜表现的疾病（包括视网膜病变）的方法包括以下步骤：提供CBIR系统，其包括存储的数字视网膜摄影图像的存档和与视网膜摄影图像相对应的诊断的患者数据，所存储的图像每个索引在CBIR数据库中，使用多个特征向量，对应于所存储图像的不同描述特征的特征向量。获得患者视网膜的查询图像。使用图像处理，识别查询图像中的区域或结构。然后使用多个特征向量来描述区域或结构。基于与区域或结构的相似性，归档归档中的至少一个相关的存储图像，并且基于与相关的存储图像相关联的诊断的患者数据来诊断眼病或患者中具有视网膜表现的疾病，。

8. 发明申请

US20080312128A1 Cellular Biomarker Antioxidant Assay and Uses Thereof 审中-公开
标题翻译：细胞生物标志物抗氧化测定及其用途
公开(公告)号：US20080312128A1
公开(公告)日：2008-12-18
申请号：US11912446
申请日：2006-04-28
申请人： Edward Chaum , John Lang
发明人： Edward Chaum , John Lang
IPC分类号： A61K38/02 , C12Q1/02 , C12Q1/26 , C12Q1/68 , A61K31/375
CPC分类号： G01N33/5044 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/5091 , G01N2800/16
摘要： The invention encompasses cell-based systems comprising biomarkers that respond to oxidative stress (OS) in a quantitative manner, and methods of use thereof. The systems are useful for screening, identifying and testing antioxidant agents, combinations, and formulations thereof for preventing, treating, or reducing symptoms of conditions associated with oxidative damage to cells. The cell-based systems are useful for identifying effective new antioxidant agents and for optimizing antioxidant formulations for targeted therapeutic applications. One cell-based system utilizes RPE cells of the eye for identifying and optimizing antioxidant compositions effective for treatment of age-related conditions such as macular degeneration. The cell-based systems provide a convenient, inexpensive and physiologically relevant in vitro alternative to human population-based methods for testing efficacy of nutritional and pharmaceutical compositions comprising antioxidants. The invention further encompasses nutritional or pharmaceutical compositions targeting particular diseases such as AMD, formulated using methods as disclosed herein.
摘要翻译：本发明包括基于细胞的系统，其包括以定量方式响应于氧化应激（OS）的生物标志物及其使用方法。该系统可用于筛选，鉴定和测试用于预防，治疗或减少与细胞氧化损伤相关的病症症状的抗氧化剂，组合和制剂。基于细胞的系统可用于鉴定有效的新抗氧化剂并优化用于靶向治疗应用的抗氧化剂制剂。一个基于细胞的系统利用眼睛的RPE细胞来鉴定和优化有效治疗年龄相关病症如黄斑变性的抗氧化剂组合物。基于细胞的系统提供方便，便宜和生理上相关的体外替代人群基于方法，用于测试包含抗氧化剂的营养和药物组合物的功效。本发明还包括使用本文公开的方法配制的靶向特定疾病例如AMD的营养或药物组合物。

9. 发明授权

US08591481B2 Microfabricated instruments and methods to treat recurrent corneal erosion 有权
标题翻译：微量手术和治疗复发性角膜糜烂的方法
公开(公告)号：US08591481B2
公开(公告)日：2013-11-26
申请号：US12052971
申请日：2008-03-21
申请人： Charles L. Britton , Brian R. D'Urso , Edward Chaum , John T. Simpson , Justin S. Baba , M. Nance Ericson , Robert J. Warmack
发明人： Charles L. Britton , Brian R. D'Urso , Edward Chaum , John T. Simpson , Justin S. Baba , M. Nance Ericson , Robert J. Warmack
IPC分类号： A61M5/158
CPC分类号： A61F9/007 , A61B2017/320004 , A61F9/0017
摘要： In one embodiment, the present invention provides a device and method for treating recurrent corneal erosion. In one embodiment, the method includes the steps of contacting an epithelium layer of a cornea with an array of glass micro-rods including a plurality of sharp features having a length that penetrates a Bowman's layer of the eye, wherein the plurality of sharp features of the array of glass micro-rods produces a plurality of punctures in the Bowman's layer of the eye that are of micro-scale or less. In another embodiment, the present invention provides a method and device for drug delivery. In one embodiment, the device includes an array of glass micro-rods, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature opposite a base of the array of glass micro-rods, wherein the sharp feature includes a treated surface for delivering a chemical compound to the eye.
摘要翻译：在一个实施方案中，本发明提供了用于治疗复发性角膜侵蚀的装置和方法。在一个实施例中，该方法包括以下步骤：使角膜的上皮层与玻璃微杆阵列接触，所述玻璃微杆包括具有穿透眼睛Bowman层的长度的多个尖锐特征，其中多个尖锐特征玻璃微棒的阵列在眼睛的Bowman层中产生微量级或更小的多个穿刺。在另一个实施方案中，本发明提供用于药物递送的方法和装置。在一个实施例中，该装置包括玻璃微棒阵列，其中玻璃微棒阵列的至少一个玻璃微棒包括与玻璃微棒阵列相对的尖锐特征，其中尖锐特征包括用于将化学化合物递送至眼睛的处理表面。

10. 发明授权

US08503749B2 Method and system for the diagnosis of disease using retinal image content and an archive of diagnosed human patient data 有权
标题翻译：用于使用视网膜图像内容诊断疾病的诊断方法和系统以及诊断的人类患者数据的归档
公开(公告)号：US08503749B2
公开(公告)日：2013-08-06
申请号：US13471720
申请日：2012-05-15
申请人： Kenneth W. Tobin , Thomas P. Karnowski , Edward Chaum
发明人： Kenneth W. Tobin , Thomas P. Karnowski , Edward Chaum
IPC分类号： G06K9/00
CPC分类号： G06K9/0061 , A61B3/12 , G06K9/00617
摘要： A method for diagnosing diseases having retinal manifestations including retinal pathologies includes the steps of providing a CBIR system including an archive of stored digital retinal photography images and diagnosed patient data corresponding to the retinal photography images, the stored images each indexed in a CBIR database using a plurality of feature vectors, the feature vectors corresponding to distinct descriptive characteristics of the stored images. A query image of the retina of a patient is obtained. Using image processing, regions or structures in the query image are identified. The regions or structures are then described using the plurality of feature vectors. At least one relevant stored image from the archive based on similarity to the regions or structures is retrieved, and an eye disease or a disease having retinal manifestations in the patient is diagnosed based on the diagnosed patient data associated with the relevant stored image(s).
摘要翻译：用于诊断具有视网膜表现的疾病（包括视网膜病变）的方法包括以下步骤：提供CBIR系统，其包括存储的数字视网膜摄影图像的存档和与视网膜摄影图像相对应的诊断的患者数据，所存储的图像每个索引在CBIR数据库中，使用多个特征向量，对应于所存储图像的不同描述特征的特征向量。获得患者视网膜的查询图像。使用图像处理，识别查询图像中的区域或结构。然后使用多个特征向量来描述区域或结构。基于与区域或结构的相似性，归档归档中的至少一个相关的存储图像，并且基于与相关的存储图像相关联的诊断的患者数据来诊断眼病或患者中具有视网膜表现的疾病，。

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