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1. 发明授权

US07824399B2 Ablation system and method of use 有权
标题翻译：消融系统和使用方法
公开(公告)号：US07824399B2
公开(公告)日：2010-11-02
申请号：US11355465
申请日：2006-02-16
申请人： David E. Francischelli , Eduardo N. Warman , Rahul Mehra , Mark T. Stewart , James R. Skarda , Harry Puryear , David Schwartzman
发明人： David E. Francischelli , Eduardo N. Warman , Rahul Mehra , Mark T. Stewart , James R. Skarda , Harry Puryear , David Schwartzman
IPC分类号： A61B18/18
CPC分类号： A61B18/1445 , A61B5/04 , A61B18/12 , A61B2018/00065 , A61B2018/00363 , A61B2018/00577 , A61B2018/00654 , A61B2018/00702 , A61B2018/00755 , A61B2018/00779 , A61B2018/00791 , A61B2018/00839 , A61B2018/00875 , A61B2018/1226 , A61B2018/1253 , A61B2018/126 , A61B2018/1467 , A61B2018/1472 , A61B2218/002 , A61N1/403
摘要： A system and method for creating lesions and assessing their completeness or transmurality. Assessment of transmurality of a lesion is accomplished by monitoring the depolarization signal in a local electrogram taken using electrodes located adjacent the tissue to be ablated. Following onset of application of ablation energy to heart tissue, the local electrogram is measured with electrodes located adjacent tissue to be ablated so that the ablation energy to ablation elements can be selectively reduced or terminated when transmurality is detected.
摘要翻译：用于创建病变并评估其完整性或透视性的系统和方法。病变透壁度的评估是通过使用邻近待消融组织的电极拍摄的局部电描记图来监测去极化信号来实现的。在开始将消融能量施加到心脏组织之后，用邻近待组织的组织的电极测量局部电描记图，以便当检测到透视时，消融元件的消融能量可被选择性地减少或终止。

2. 发明授权

US06876880B2 Automated reapplication of atrial pacing therapies 有权
标题翻译：心房起搏治疗的自动再次应用
公开(公告)号：US06876880B2
公开(公告)日：2005-04-05
申请号：US10034060
申请日：2001-12-20
申请人： Michael F. Hess , Rahul Mehra , Eduardo N. Warman , Nirav V. Sheth , Mark L. Brown , David Ritscher
发明人： Michael F. Hess , Rahul Mehra , Eduardo N. Warman , Nirav V. Sheth , Mark L. Brown , David Ritscher
IPC分类号： A61N1/365 , A61N1/362 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/3624
摘要： The invention relates to the use of atrial pacing therapies to treat atrial tachycardia (AT). When an AT episode is detected, an implantable medical device applies an ATP therapy. If the AT episode persists, the ATP therapy may be automatically reapplied at a later time during the course of the same AT episode. In particular, previously used ATP therapies are reapplied when episodic conditions, such as cycle length or cycle regularity, change. Although a particular ATP therapy initially may be unsuccessful in terminating the AT, it may prove successful when the cycle length or regularity of the atrial rhythm changes. As the rhythm slows down, the AT may be more responsive to ATP therapies that were previously unsuccessful. As a result, potentially efficacious ATP therapies can be reapplied to terminate AT episodes, and reduce the number of episodes that require more aggressive termination by painful, atrial shocks.
摘要翻译：本发明涉及心房起搏疗法用于治疗房性心动过速（AT）的用途。当检测到AT发作时，可植入医疗装置应用ATP疗法。如果AT发作持续存在，ATP疗法可能会在相同的AT发作过程中的较晚时间自动重新应用。特别是，当诸如循环长度或循环规律性等情况时，先前使用的ATP疗法将被重新应用。尽管特定的ATP疗法最初可能不能终止AT，但是当心房节律的周期长度或规律性发生变化时，可能会成功。随着节奏减慢，AT可能对以前不成功的ATP疗法更有反应。因此，可以重新应用潜在有效的ATP疗法来终止AT发作，并通过痛苦的心房休克减少需要更积极终止的发作次数。

3. 发明授权

US06663627B2 Ablation system and method of use 有权
公开(公告)号：US06663627B2
公开(公告)日：2003-12-16
申请号：US10132392
申请日：2002-04-24
申请人： David E. Francischelli , Eduardo N. Warman , Rahul Mehra , Mark T. Stewart , James R. Skarda , Harry Puryear , David Schwartzman
发明人： David E. Francischelli , Eduardo N. Warman , Rahul Mehra , Mark T. Stewart , James R. Skarda , Harry Puryear , David Schwartzman
IPC分类号： A61B1818
CPC分类号： A61B18/1445 , A61B5/04 , A61B18/12 , A61B2018/00065 , A61B2018/00363 , A61B2018/00577 , A61B2018/00654 , A61B2018/00702 , A61B2018/00755 , A61B2018/00779 , A61B2018/00791 , A61B2018/00839 , A61B2018/00875 , A61B2018/1226 , A61B2018/1253 , A61B2018/126 , A61B2018/1467 , A61B2018/1472 , A61B2218/002 , A61N1/403
摘要： A system and method for creating lesions and assessing their completeness or transmurality. Assessment of transmurality of a lesion is accomplished by monitoring the depolarization signal amplitude in a local electrogram taken using electrodes located adjacent the tissue to be ablated. Following onset of application of ablation energy to heart tissue, the amplitude of a local electrogram measured with electrodes located adjacent tissue to be ablated first gradually drops and then stabilizes, indicating that the tissue being monitored has ceased making any contribution to the sensed electrogram. The amplitude drop and/or the following amplitude plateau may be used alone or together as indicators of transmurality. Detection of a rapid drop in amplitude may be employed as an indicator that the ablation process is proceeding too quickly and may be employed to trigger a reduction in the power of applied ablation energy. Detection of an insufficiently rapid drop in amplitude may be employed as an indicator that the ablation process is proceeding too slowly and may be employed to trigger an increase in the power of applied ablation energy.

4. 发明授权

US06272380B1 Apparatus for treating atrial tachy arrhythmias with synchronized shocks 失效
标题翻译：用同步冲击治疗心房速度性心律失常的装置
公开(公告)号：US06272380B1
公开(公告)日：2001-08-07
申请号：US09377514
申请日：1999-08-19
申请人： Eduardo N. Warman , Michael R. S. Hill , David K. L. Peterson , Rahul Mehra , Luc R. Mongeon
发明人： Eduardo N. Warman , Michael R. S. Hill , David K. L. Peterson , Rahul Mehra , Luc R. Mongeon
IPC分类号： A61N139
CPC分类号： A61N1/3987 , A61N1/3956
摘要： An implantable anti-tachyarrhythmia device which delivers atrial cardioversion or defibrillation pulses heart in response to detection of atrial tachyarrhythmias. The pulses are synchronized to atrial and ventricular events in such a fashion as to assure they occur outside of the vulnerable periods associated with both chambers.
摘要翻译：一种可植入的抗快速性心律失常装置，其响应于心房快速性心律失常的检测而传送心房心脏复律或除颤脉冲心脏。这些脉冲以这样的方式与心房和心室事件同步，以确保它们发生在与两个腔室相关联的脆弱周期之外。

5. 发明授权

US6091988A Apparatus for treating atrial tachyarrhythmias with synchronized shocks 失效
标题翻译：用同步冲击治疗房性快速性心律失常的装置
公开(公告)号：US6091988A
公开(公告)日：2000-07-18
申请号：US70690
申请日：1998-04-30
申请人： Eduardo N. Warman , Michael R. S. Hill , David K. L. Peterson , Rahul Mehra , Luc R. Mongeon
发明人： Eduardo N. Warman , Michael R. S. Hill , David K. L. Peterson , Rahul Mehra , Luc R. Mongeon
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3956 , A61N1/3622 , A61N1/3987
摘要： An implantable anti-tachyarrhythmia device which delivers atrial cardioversion or defibrillation pulses heart in response to detection of atrial tachyarrhythmias. The pulses are synchronized to atrial and ventricular events in such a fashion as to assure they occur outside of the vulnerable periods associated with both chambers. The device is provided with a pulse synchronizer which defines a first synchronization interval initiated following a sensed atrial event and a second synchronization interval initiated responsive to a sensed ventricular event and a pulse triggerer which triggers delivery of a cardioversion or defibrillation pulse responsive to the first and second synchronization intervals simultaneously being underway. In particular, the pulse triggerer may be responsive to initiation of the first synchronization interval during the second synchronization interval. In addition, the synchronizer may also define minimum time intervals following ventricular events and the triggerer may additionally be responsive to expiration of a defined minimum time interval following a ventricular event preceding the sensed ventricular event which initiated the second synchronization interval currently underway.
摘要翻译：一种可植入的抗快速性心律失常装置，其响应于心房快速性心律失常的检测而传送心房心脏复律或除颤脉冲心脏。这些脉冲以这样的方式与心房和心室事件同步，以确保它们发生在与两个腔室相关联的脆弱周期之外。该装置设置有脉冲同步器，该脉冲同步器限定在感测的心房事件之后启动的第一同步间隔和响应于感测到的心室事件而发起的第二同步间隔和脉冲触发器，其响应于第一和第二同步间隔触发心脏复律或除颤脉冲的传递第二同步间隔同时进行。特别地，脉冲触发器可以响应于在第二同步间隔期间启动第一同步间隔。此外，同步器还可以定义心室事件之后的最小时间间隔，并且触发器可以另外响应于起始于当前正在进行的第二同步区间的感测的心室事件之前的心室事件之后的限定的最小时间间隔的到期。

6. 发明授权

US5968079A Method and apparatus for diagnosis and treatment of arrhythmias 失效
标题翻译：用于诊断和治疗心律失常的方法和装置
公开(公告)号：US5968079A
公开(公告)日：1999-10-19
申请号：US40544
申请日：1998-03-18
申请人： Eduardo N. Warman , Rahul Mehra
发明人： Eduardo N. Warman , Rahul Mehra
IPC分类号： A61N1/39 , A61N1/368
CPC分类号： A61N1/3962 , A61N1/395
摘要： An implantable medical device which senses atrial electrograms, detects atrial tachyarrhythmias and delivers atrial cardioversion/defibrillation pulses in response thereto, which employ a correlation analysis to assist in detection of arrhythmias and/or timing of delivery of cardioversion/defibrillation shocks. The device includes an electrogram recorder which stores atrial electrogram segments associated with R--R intervals extending over multiple atrial depolarizations and a correlator which measures correlation of successive stored atrial electrogram segments. The device may use the measured corellation meeting a defined threshold value to detect the occurrence of a defined tachyarrhythmia such as atrial fibrillation or allow delivery of a cardioversion/defibrillation pulse.
摘要翻译：感测心房电图的可植入医疗装置，检测心房快速性心律失常并响应于此传递心房复律/除颤脉冲，其使用相关分析来辅助检测心律不齐和/或转发/除颤电击的递送时机。该装置包括电描记录记录器，其存储与跨多个心房去极化延伸的R-R间隔相关联的心房电描绘片段，以及测量连续存储的心房电描记图片段的相关性的相关器。该装置可以使用满足定义的阈值的测量的核心数来检测定义的心律失常的发生，例如心房颤动或允许递送心脏复律/除颤脉冲。

7. 发明授权

US08333764B2 Device and method for determining tissue thickness and creating cardiac ablation lesions 失效
标题翻译：用于确定组织厚度并产生心脏消融病变的装置和方法
公开(公告)号：US08333764B2
公开(公告)日：2012-12-18
申请号：US10844213
申请日：2004-05-12
申请人： David E. Francischelli , Eduardo N. Warman , Rahul Mehra
发明人： David E. Francischelli , Eduardo N. Warman , Rahul Mehra
IPC分类号： A61B18/14
CPC分类号： A61B18/1442 , A61B2018/00666 , A61B2018/1861 , A61B2090/061 , A61B2090/064
摘要： A tissue ablation device has a handle and an ablation head coupled to the handle. The ablation head has a first jaw, a second jaw, and an ablative element coupled to at least one of the first and second jaws. A thickness measurement device may be coupled to the ablation device to indicate the distance separating the first and second jaws. Further, a force measurement device may be coupled to the ablation device to measure the force being applied by the first and second jaws to a piece of tissue. Further, a strain measurement device may be coupled to the ablation device to indicate the strain resulting in a piece of tissue disposed between the first and second jaws when a stress is applied to the tissue.
摘要翻译：组织消融装置具有手柄和联接到手柄的消融头。消融头具有联接到第一和第二钳口中的至少一个的第一钳口，第二钳口和消融元件。厚度测量装置可以联接到消融装置以指示分离第一和第二钳口的距离。此外，力测量装置可以联接到消融装置以测量由第一和第二钳口施加到一片组织上的力。此外，当应力施加到组织时，应变测量装置可以联接到消融装置以指示当应力施加到组织上时产生设置在第一和第二钳口之间的一片组织的应变。

8. 发明授权

US07336994B2 Control of atrial defibrillation therapy based on hemodynamic sensor feedback 有权
标题翻译：基于血流动力学传感器反馈控制心房除颤治疗
公开(公告)号：US07336994B2
公开(公告)日：2008-02-26
申请号：US10760155
申请日：2004-01-16
申请人： Douglas A. Hettrick , David E. Euler , Eduardo N. Warman , Michael R. Ujhelyi , Rahul Mehra , Paul D. Ziegler , Shailesh Kumar V. Musley , Charles E. Distad , David E. Ritscher
发明人： Douglas A. Hettrick , David E. Euler , Eduardo N. Warman , Michael R. Ujhelyi , Rahul Mehra , Paul D. Ziegler , Shailesh Kumar V. Musley , Charles E. Distad , David E. Ritscher
IPC分类号： A61N1/39
CPC分类号： A61N1/3702 , A61N1/3621 , A61N1/365 , A61N1/36564 , A61N1/395 , A61N1/3962
摘要： Control of defibrillation therapy delivered by implantable medical devices (IMDs) using hemodynamic sensor feedback is disclosed. The hemodynamic sensor feedback allows for increased control over application of atrial defibrillation therapy. Specifically, the therapy is delivered when a fibrillation episode results in a discrete loss of hemodynamic function. Defibrillation therapy is thus withheld for hemodynamically benign arrhythmias.
摘要翻译：公开了使用血液动力学传感器反馈控制由可植入医疗装置（IMD）递送的除颤疗法。血液动力学传感器反馈允许增加对心房除颤治疗的应用的控制。具体来说，当纤维性颤动发作导致血液动力学功能的离散损失时，进行治疗。因此，对于血液动力学良性心律失常，禁止使用除颤疗法。

9. 发明授权

US07029470B2 Ablation system and method of use 有权
标题翻译：消融系统和使用方法
公开(公告)号：US07029470B2
公开(公告)日：2006-04-18
申请号：US10685236
申请日：2003-10-14
申请人： David E. Francischelli , Eduardo N. Warman , Rahul Mehra , Mark T. Stewart , James R. Skarda , Harry Puryear , David Schwartzman
发明人： David E. Francischelli , Eduardo N. Warman , Rahul Mehra , Mark T. Stewart , James R. Skarda , Harry Puryear , David Schwartzman
IPC分类号： A61B18/18 , A61B5/02 , A61N1/00
CPC分类号： A61B18/1445 , A61B5/04 , A61B18/12 , A61B2018/00065 , A61B2018/00363 , A61B2018/00577 , A61B2018/00654 , A61B2018/00702 , A61B2018/00755 , A61B2018/00779 , A61B2018/00791 , A61B2018/00839 , A61B2018/00875 , A61B2018/1226 , A61B2018/1253 , A61B2018/126 , A61B2018/1467 , A61B2018/1472 , A61B2218/002 , A61N1/403
摘要： A system and method for creating lesions and assessing their completeness or transmurality. Assessment of transmurality of a lesion is accomplished by monitoring the depolarization signal in a local electrogram taken using electrodes located adjacent the tissue to be ablated. Following onset of application of ablation energy to heart tissue, the local electrogram is measured with electrodes located adjacent tissue to be ablated so that the ablation energy to ablation elements can be selectively reduced or terminated when transmurality is detected.
摘要翻译：用于创建病变并评估其完整性或透视性的系统和方法。病变透壁度的评估是通过使用邻近待消融组织的电极拍摄的局部电描记图来监测去极化信号来实现的。在开始将消融能量施加到心脏组织之后，用邻近待组织的组织的电极测量局部电描记图，以便当检测到透视时，消融元件的消融能量可被选择性地减少或终止。

10. 发明授权

US10542887B2 Heart failure monitoring 有权
公开(公告)号：US10542887B2
公开(公告)日：2020-01-28
申请号：US13436408
申请日：2012-03-30
申请人： Shantanu Sarkar , Jodi L. Redemske , Eduardo N. Warman , Douglas A. Hettrick , Kevin T. Ousdigian
发明人： Shantanu Sarkar , Jodi L. Redemske , Eduardo N. Warman , Douglas A. Hettrick , Kevin T. Ousdigian
IPC分类号： A61B5/02 , A61B5/00
摘要： Techniques for transmitting diagnostic information stored in an implantable medical device (IMD) based on patient hospitalization are described. For example, the IMD may transmit higher resolution diagnostic information to a clinician and/or an external device during a hospitalization period to aid the clinician in evaluating heart failure treatment and when discharge is proper. This higher resolution diagnostic information may include one or more patient metrics automatically generated and transmitted by the IMD at least once every two hours. During a post-hospitalization period, the IMD may transmit lower resolution diagnostic information to a clinician that indicates a risk level of re-hospitalization. The lower resolution diagnostic information may include the risk level and/or patient metrics once a day, for example. In this manner, the IMD transmitted diagnostic information may be tailored to the specific heart failure monitoring needed by the patient.

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