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1. 发明申请

US20120253207A1 HEART FAILURE MONITORING 审中-公开
标题翻译：心力衰竭监测
公开(公告)号：US20120253207A1
公开(公告)日：2012-10-04
申请号：US13436408
申请日：2012-03-30
申请人： Shantanu Sarkar , Jodi L. Redemske , Eduardo N. Warman , Douglas A. Hettrick , Kevin T. Ousdigian
发明人： Shantanu Sarkar , Jodi L. Redemske , Eduardo N. Warman , Douglas A. Hettrick , Kevin T. Ousdigian
IPC分类号： A61B5/0205
CPC分类号： A61B5/0006 , A61B5/0004 , A61B5/7275 , G06F19/3418 , G16H40/40 , G16H50/30
摘要： Techniques for transmitting diagnostic information stored in an implantable medical device (IMD) based on patient hospitalization are described. For example, the IMD may transmit higher resolution diagnostic information to a clinician and/or an external device during a hospitalization period to aid the clinician in evaluating heart failure treatment and when discharge is proper. This higher resolution diagnostic information may include one or more patient metrics automatically generated and transmitted by the IMD at least once every two hours. During a post-hospitalization period, the IMD may transmit lower resolution diagnostic information to a clinician that indicates a risk level of re-hospitalization. The lower resolution diagnostic information may include the risk level and/or patient metrics once a day, for example. In this manner, the IMD transmitted diagnostic information may be tailored to the specific heart failure monitoring needed by the patient.
摘要翻译：描述了基于患者住院时间传送存储在可植入医疗装置（IMD）中的诊断信息的技术。例如，IMD可以在住院期间向临床医师和/或外部设备传送更高分辨率的诊断信息，以帮助临床医师评价心力衰竭治疗以及放电是否合适。该更高分辨率的诊断信息可以包括由IMD自动生成和发送的至少每两小时一次的一个或多个患者度量。在住院后期间，IMD可以向临床医生传递较低分辨率的诊断信息，指示重新住院的风险水平。例如，较低分辨率诊断信息可以包括一天一次的风险水平和/或患者度量。以这种方式，IMD传输的诊断信息可以针对患者所需的特定心力衰竭监测。

2. 发明授权

US10542887B2 Heart failure monitoring 有权
公开(公告)号：US10542887B2
公开(公告)日：2020-01-28
申请号：US13436408
申请日：2012-03-30
申请人： Shantanu Sarkar , Jodi L. Redemske , Eduardo N. Warman , Douglas A. Hettrick , Kevin T. Ousdigian
发明人： Shantanu Sarkar , Jodi L. Redemske , Eduardo N. Warman , Douglas A. Hettrick , Kevin T. Ousdigian
IPC分类号： A61B5/02 , A61B5/00
摘要： Techniques for transmitting diagnostic information stored in an implantable medical device (IMD) based on patient hospitalization are described. For example, the IMD may transmit higher resolution diagnostic information to a clinician and/or an external device during a hospitalization period to aid the clinician in evaluating heart failure treatment and when discharge is proper. This higher resolution diagnostic information may include one or more patient metrics automatically generated and transmitted by the IMD at least once every two hours. During a post-hospitalization period, the IMD may transmit lower resolution diagnostic information to a clinician that indicates a risk level of re-hospitalization. The lower resolution diagnostic information may include the risk level and/or patient metrics once a day, for example. In this manner, the IMD transmitted diagnostic information may be tailored to the specific heart failure monitoring needed by the patient.

3. 发明授权

US07127292B2 Addressing recurrent atrial fibrillation 有权
标题翻译：解决复发性房颤
公开(公告)号：US07127292B2
公开(公告)日：2006-10-24
申请号：US10284873
申请日：2002-10-31
申请人： Eduardo N. Warman , Stefan Holzer , Helmut Puererfellner , Douglas A. Hettrick , Paul D. Ziegler
发明人： Eduardo N. Warman , Stefan Holzer , Helmut Puererfellner , Douglas A. Hettrick , Paul D. Ziegler
IPC分类号： A61N1/36 , A61N1/365
CPC分类号： A61N1/3962 , A61N1/395
摘要： An implantable medical device is directed to techniques for applying overdrive pacing to one or both atria following termination of an AF episode, to prevent a recurrent AF episode. The implantable medical device such as a pacemaker applies overdrive pacing according to overdrive pacing parameters, and sets the parameters as a function of the response of the patient to overdrive pacing. The parameters may be adjusted upward or downward, so that overdrive pacing may be applied effectively but not over-applied.
摘要翻译：可植入式医疗装置涉及用于在AF发作终止后向一个或两个心房施加超速起搏的技术，以防止复发性AF发作。诸如起搏器的可植入医疗装置根据超速起搏参数应用过驱动起搏，并且将参数设置为患者对超速起搏的响应的函数。可以向上或向下调节参数，从而可以有效地施加过度起搏，但不会过度施加。

4. 发明授权

US07647107B2 Addressing recurrent atrial fibrillation 失效
标题翻译：解决复发性房颤
公开(公告)号：US07647107B2
公开(公告)日：2010-01-12
申请号：US11532741
申请日：2006-09-18
申请人： Eduardo N. Warman , Stefan Holzer , Helmut Puererfellner , Douglas A. Hettrick , Paul D. Ziegler
发明人： Eduardo N. Warman , Stefan Holzer , Helmut Puererfellner , Douglas A. Hettrick , Paul D. Ziegler
IPC分类号： A61N1/36 , A61N1/365
CPC分类号： A61N1/3962 , A61N1/395
摘要： Techniques for applying overdrive pacing to one or both atria following termination of an AF episode, to prevent a recurrent AF episode. An implantable medical device such as a pacemaker applies overdrive pacing according to overdrive pacing parameters, and sets the parameters as a function of the response of the patient to overdrive pacing. The parameters may be adjusted upward or downward, so that overdrive pacing may be applied effectively but not over-applied.
摘要翻译：在AF事件终止后将超速起搏应用于一个或两个心房的技术，以防止复发性AF发作。诸如起搏器的可植入医疗装置根据超速起搏参数应用过速起搏，并且将参数设置为患者对超速起搏的响应的函数。可以向上或向下调节参数，从而可以有效地施加过度起搏，但不会过度施加。

5. 发明申请

US20100204716A1 METHODS AND DEVICES FOR OCCLUSION OF AN ATRIAL APPENDAGE 审中-公开
标题翻译：方法和装置用于消除ATRIAL附件
公开(公告)号：US20100204716A1
公开(公告)日：2010-08-12
申请号：US12768200
申请日：2010-04-27
申请人： Mark T. Stewart , Alison Lutterman , David E. Francischelli , Leonard H. Leuer , Daneil C. Haeg , Marie T. Steinbrink , Roderick E. Briscoe , Tom P. Daigel , Eduardo N. Warman , Paul T. Rothstein , Phillip C. Falkner , Douglas A. Hettrick , David J.S. Kim , Steven C. Christian
发明人： Mark T. Stewart , Alison Lutterman , David E. Francischelli , Leonard H. Leuer , Daneil C. Haeg , Marie T. Steinbrink , Roderick E. Briscoe , Tom P. Daigel , Eduardo N. Warman , Paul T. Rothstein , Phillip C. Falkner , Douglas A. Hettrick , David J.S. Kim , Steven C. Christian
IPC分类号： A61B17/128 , A61B17/122
CPC分类号： A61B17/12 , A61B17/0057 , A61B17/12009 , A61B17/12013 , A61B17/122 , A61B17/128 , A61B17/1285 , A61B90/39 , A61B2017/00243 , A61B2017/00575 , A61B2017/12018 , A61B2017/306
摘要： Some embodiments of the invention provide a system for occluding a left atrial appendage of a patient. Some embodiments of the system can include a ring occluder that can be positioned around the left atrial appendage and a ring applicator to position the ring occluder with respect to the left atrial appendage. One embodiment discloses a method of accessing endocardial surfaces of the heart through the atrial appendage. Additional embodiments of the invention provide a clip occluder that can be positioned around the left atrial appendage. A clip applicator can position the clip occluder with respect to the left atrial appendage.
摘要翻译：本发明的一些实施例提供一种用于闭塞患者左心耳的系统。该系统的一些实施例可以包括可以围绕左心耳定位的环封闭器和环施加器来相对于左心耳定位环封闭器。一个实施例公开了通过心房接近心脏心脏表面的方法。本发明的另外的实施例提供了可以围绕左心耳定位的夹子封堵器。夹子施放器可以相对于左心耳定位夹子封堵器。

6. 发明申请

US20090275854A1 SYSTEM AND METHOD OF MONITORING PHYSIOLOGIC PARAMETERS BASED ON COMPLEX IMPEDANCE WAVEFORM MORPHOLOGY 审中-公开
标题翻译：基于复杂阻抗波形形态监测生理参数的系统和方法
公开(公告)号：US20090275854A1
公开(公告)日：2009-11-05
申请号：US12112655
申请日：2008-04-30
申请人： Todd M. Zielinski , Douglas A. Hettrick , Eduardo N. Warman
发明人： Todd M. Zielinski , Douglas A. Hettrick , Eduardo N. Warman
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/029 , A61B5/0538 , A61N1/36521
摘要： Changes in physiologic parameters may be detected in a patient by measuring the impedance of a tissue segment located in a selected electrode vector field, storing baseline impedance information based on the measured impedance, detecting changes in impedance characteristics from the baseline impedance information, and providing alerts for changes in the physiologic parameters based on the detected changes in impedance characteristics. In some situations, detecting the changes in impedance characteristics involves detecting changes in morphology of an impedance waveform, such as a cardiac component of an impedance waveform, a respiratory component of an impedance waveform, and the phase angle of the complex impedance.
摘要翻译：可以通过测量位于所选择的电极向量场中的组织段的阻抗，基于所测量的阻抗存储基线阻抗信息，从基线阻抗信息检测阻抗特性的变化，并提供警报来检测患者生理参数的变化基于检测到的阻抗特性变化对生理参数进行变化。在某些情况下，检测阻抗特性的变化涉及检测阻抗波形的形态变化，例如阻抗波形的心脏分量，阻抗波形的呼吸成分和复阻抗的相位角。

7. 发明授权

US07336994B2 Control of atrial defibrillation therapy based on hemodynamic sensor feedback 有权
标题翻译：基于血流动力学传感器反馈控制心房除颤治疗
公开(公告)号：US07336994B2
公开(公告)日：2008-02-26
申请号：US10760155
申请日：2004-01-16
申请人： Douglas A. Hettrick , David E. Euler , Eduardo N. Warman , Michael R. Ujhelyi , Rahul Mehra , Paul D. Ziegler , Shailesh Kumar V. Musley , Charles E. Distad , David E. Ritscher
发明人： Douglas A. Hettrick , David E. Euler , Eduardo N. Warman , Michael R. Ujhelyi , Rahul Mehra , Paul D. Ziegler , Shailesh Kumar V. Musley , Charles E. Distad , David E. Ritscher
IPC分类号： A61N1/39
CPC分类号： A61N1/3702 , A61N1/3621 , A61N1/365 , A61N1/36564 , A61N1/395 , A61N1/3962
摘要： Control of defibrillation therapy delivered by implantable medical devices (IMDs) using hemodynamic sensor feedback is disclosed. The hemodynamic sensor feedback allows for increased control over application of atrial defibrillation therapy. Specifically, the therapy is delivered when a fibrillation episode results in a discrete loss of hemodynamic function. Defibrillation therapy is thus withheld for hemodynamically benign arrhythmias.
摘要翻译：公开了使用血液动力学传感器反馈控制由可植入医疗装置（IMD）递送的除颤疗法。血液动力学传感器反馈允许增加对心房除颤治疗的应用的控制。具体来说，当纤维性颤动发作导致血液动力学功能的离散损失时，进行治疗。因此，对于血液动力学良性心律失常，禁止使用除颤疗法。

8. 发明申请

US20120238891A1 METHODS FOR ECTOPY REJECTION FOR ATRIAL FIBRILLATION DETECTION BASED ON VENTRICULAR CYCLE LENGTHS 有权
标题翻译：基于静脉循环长度的急性心肌梗死检测方法
公开(公告)号：US20120238891A1
公开(公告)日：2012-09-20
申请号：US13050091
申请日：2011-03-17
申请人： Shantanu Sarkar , Eduardo N. Warman
发明人： Shantanu Sarkar , Eduardo N. Warman
IPC分类号： A61B5/0452
CPC分类号： A61B5/0468 , A61B5/7282 , A61N1/3624 , A61N1/395
摘要： A medical device performs a method to classify a cardiac rhythm. Differences between cycle lengths in a first heart chamber are determined during an established time interval. Evidence of ectopy associated with irregular coupling intervals is detected from the signal during the established time interval. A rhythm classification output corresponding to a second heart chamber at the expiration of the established time interval is provided in response to the consecutive cycle length differences and the evidence of ectopy associated with irregular coupling intervals.
摘要翻译：医疗器械执行心律的分类方法。在建立的时间间隔期间确定第一心室中的循环长度之间的差异。在建立的时间间隔期间从信号中检测到与不规则耦合间隔相关的异常的证据。响应于连续循环长度差异和与不规则耦合间隔相关联的异常的证据，提供对应于在建立的时间间隔期满时的第二心室的节律分类输出。

9. 发明授权

US08977350B2 Methods for ectopy rejection for atrial fibrillation detection based on ventricular cycle lengths 有权
标题翻译：基于心室周期长度的心房颤动检测的异位排除方法
公开(公告)号：US08977350B2
公开(公告)日：2015-03-10
申请号：US13050091
申请日：2011-03-17
申请人： Shantanu Sarkar , Eduardo N. Warman
发明人： Shantanu Sarkar , Eduardo N. Warman
IPC分类号： A61B5/04 , A61B5/02 , A61B5/0468 , A61N1/362 , A61N1/39 , A61B5/00
CPC分类号： A61B5/0468 , A61B5/7282 , A61N1/3624 , A61N1/395
摘要： A medical device performs a method to classify a cardiac rhythm. Differences between cycle lengths in a first heart chamber are determined during an established time interval. Evidence of ectopy associated with irregular coupling intervals is detected from the signal during the established time interval. A rhythm classification output corresponding to a second heart chamber at the expiration of the established time interval is provided in response to the consecutive cycle length differences and the evidence of ectopy associated with irregular coupling intervals.
摘要翻译：医疗器械执行心律的分类方法。在建立的时间间隔期间确定第一心室中的循环长度之间的差异。在建立的时间间隔期间从信号中检测到与不规则耦合间隔相关的异常的证据。响应于连续循环长度差异和与不规则耦合间隔相关联的异常的证据，提供对应于在建立的时间间隔期满时的第二心室的节律分类输出。

10. 发明授权

US08843189B2 Interference blocking and frequency selection 有权
标题翻译：干扰阻塞和频率选择
公开(公告)号：US08843189B2
公开(公告)日：2014-09-23
申请号：US12423487
申请日：2009-04-14
申请人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
发明人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
IPC分类号： A61B5/04 , A61B19/00 , A61B5/042 , A61B5/053 , A61B17/00 , A61B5/06 , A61B8/00 , A61B5/05 , A61B8/06
CPC分类号： A61B5/061 , A61B5/0422 , A61B5/04288 , A61B5/0432 , A61B5/044 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/066 , A61B5/4836 , A61B5/742 , A61B8/06 , A61B8/4472 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/00336 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378 , A61B2090/3983
摘要： A volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以利用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

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