专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4303660A Pyrazolo[1,5-c]quinazoline derivatives and analgesic compositions containing them 失效
标题翻译：吡唑并[1,5-c]喹唑啉衍生物和含有它们的镇痛组合物
公开(公告)号：US4303660A
公开(公告)日：1981-12-01
申请号：US150349
申请日：1980-05-16
申请人： Edit Berenyi nee Poldermann , Eniko Szirt nee Kiszelly , Peter Gorog , Lujza Petocz , Ibolya Kosoczky , Agnes Kovacs nee Palotai , Gabriella rmos nee Lassu
发明人： Edit Berenyi nee Poldermann , Eniko Szirt nee Kiszelly , Peter Gorog , Lujza Petocz , Ibolya Kosoczky , Agnes Kovacs nee Palotai , Gabriella rmos nee Lassu
IPC分类号： A61K31/4162 , A61K31/4745 , A61K31/505 , A61K31/519 , A61P1/00 , A61P1/04 , A61P25/04 , A61P29/00 , C07D231/16 , C07D487/04
CPC分类号： C07D487/04 , C07D231/16
摘要： The invention relates to novel pyrazolo[1,5-c]quinazoline derivatives of the general formula I ##STR1## wherein R represents a hydrogen atom, a C.sub.1-4 alkyl group or an acyl group,R.sub.1 represents a hydrogen atom, a C.sub.1-12 alkyl group, a C.sub.3-8 cycloalkyl group, a C.sub.2-4 alkenyl group, an aralkyl group, wherein the alkyl group has 1 to 4 carbon atoms, a phenylalkenyl group, wherein the alkenyl group has 2 to 4 carbon atoms, furthermore a carboxy group or a phenyl group optionally substituted by one or more substituents selected from the group consisting of halogen, hydroxy, C.sub.1-4 alkoxy, nitro or di(C.sub.1-4 alkyl)amino groups, orR and R.sub.1 may form together a valence bond,R.sub.2 represents a hydrogen atom, a C.sub.1-4 alkyl or a phenyl group, orR.sub.1 and R.sub.2 may form together a C.sub.2-7 alkylene group,R.sub.3 represents a nitro group, an amino group, an alkylamino group, a dialkylamino group, wherein the alkyl groups have 1 to 4 carbon atoms, an alkylideneimino group, wherein the alkylidene group has 1 to 4 carbon atoms, a benzylideneimino group or an acylamino group,and pharmaceutically acceptable acid addition salts thereof.The novel compounds of the general formula I can be employed primarily as analgesic agents.
摘要翻译：本发明涉及通式I（XIX）的新颖的吡唑并[1,5-c]喹唑啉衍生物，其中R表示氢原子，C1-4烷基或酰基，R1表示氢原子， C1-12烷基，C3-8环烷基，C2-4烯基，其中烷基具有1至4个碳原子的芳烷基，苯基烯基，其中烯基具有2至4个碳原子此外，羧基或任选被一个或多个选自卤素，羟基，C 1-4烷氧基，硝基或二（C 1-4烷基）氨基的取代基取代的苯基，或R和R 1可以一起形成价键，R2表示氢原子，C1-4烷基或苯基，或R1和R2可以一起形成C2-7亚烷基，R3表示硝基，氨基，烷基氨基，二烷基氨基基团，其中烷基具有1至4个碳原子，亚烷基亚氨基，其中亚烷基具有1至4个碳 n原子，亚苄基亚氨基或酰氨基，及其药学上可接受的酸加成盐。通式I的新化合物可以主要用作止痛剂。

2. 发明授权

US4395413A Oxime ethers and pharmaceutical compositions containing the same 失效
标题翻译：肟醚和含有它的药物组合物
公开(公告)号：US4395413A
公开(公告)日：1983-07-26
申请号：US162674
申请日：1980-06-24
申请人： Zoltan Budai , Aranka Lay nee Konya , Tibor Mezei , Lujza Petocz , Katalin Grasser , Ibolya Kosoczky , Eniko Szirt nee Kiszelly , Peter Gorog
发明人： Zoltan Budai , Aranka Lay nee Konya , Tibor Mezei , Lujza Petocz , Katalin Grasser , Ibolya Kosoczky , Eniko Szirt nee Kiszelly , Peter Gorog
IPC分类号： A61K31/15 , A61K31/495 , A61P25/04 , C07C67/00 , C07C239/00 , C07C249/10 , C07C251/58 , C07D295/02 , C07D295/088 , C07D295/08
CPC分类号： C07D295/088 , Y10S514/926 , Y10S514/927
摘要： The invention relates to novel oxime ethers of the general formula /I/ and acid addition salts and quaternary ammonium derivatives thereof, ##STR1## wherein A represents a C.sub.2-6 straight or branched alkylene chain,R and R.sup.1 each represent a C.sub.1-6 alkyl group or they form together with the adjacent nitrogen atom a heterocyclic ring containing 4 to 7 carbon atoms and optionally a further hetero atom, i.e. an oxygen, sulfur or nitrogen atom, and said ring may be optionally substituted by a C.sub.1-3 alkyl, phenyl or benzyl group,R.sup.2 and R.sup.3 each denote a hydrogen atom or together form a valency bond,R.sup.4 denotes a C.sub.1-10 alkyl or C.sub.2-10 alkenyl group, andn denotes an integer from 3 to 7.The compounds of the general formula /I/ are prepared according to the invention by reacting a cycloalkane derivative of the general formula /II/ ##STR2## wherein R.sup.2, R.sup.3, R.sup.4 and n have the same meaning as above, whereasY denotes an oxygen or sulphur atom or a .dbd.N--OH group with an aminoalkyl derivative of the general formula /III/ ##STR3## wherein R, R.sup.1 and A have the same meaning as stated above andZ means a halogen atom or a H.sub.2 N--O-- group or a salt thereof in the presence of a basic condensing agent.The new compounds of the general formula /I/ possess valuable nicotine-lethality inhibiting, local anaesthetic, analgesic effects, which are, in case of certain compounds, complemented by anti-hypertensive, maximum electroshock and tetracorspasm inhibiting, ulcus inhibiting and motility inhibiting effects, and can be applied to advantage in the therapy.
摘要翻译：本发明涉及通式I I的新型肟醚及其酸加成盐和季铵衍生物，其中A表示C2-6直链或支链亚烷基链，R和R1各自表示C1 -6烷基，或者它们与相邻的氮原子一起与含有4至7个碳原子的杂环和任选的另外的杂原子（即氧，硫或氮原子）一起形成，并且所述环可以任选地被C 1-3 烷基，苯基或苄基，R2和R3各自表示氢原子或一起形成价键，R4表示C1-10烷基或C2-10烯基，n表示3至7的整数。根据本发明通过使通式/ II / IMAGE / II /的环烷烃衍生物与其中R2，R3，R4和n具有与上述相同的含义反应制备通式/ I / I，而Y表示氧或硫原子或a =具有氨基烷基衍生物的N-OH基团通式/ III / / III /其中R，R 1和A具有与上述相同的含义，Z表示在碱性缩合剂存在下的卤素原子或H 2 N-O-基或其盐。新型化合物/ I /具有有价值的尼古丁杀伤力抑制，局部麻醉，止痛作用，在某些化合物的情况下，补充有抗高血压，最大电休克和四疣抑制作用，抑制溃疡和运动抑制作用，并且可以在治疗中有利地应用。

3. 发明授权

US4342766A Novel dihydro-as-triazino[5,6-c]quinoline derivatives and a process for the preparation thereof 失效
标题翻译：新型二氢 - 三嗪并[5,6-c]喹啉衍生物及其制备方法
公开(公告)号：US4342766A
公开(公告)日：1982-08-03
申请号：US254763
申请日：1981-04-16
申请人： Edit Berenyi nee Poldermann , Peter Gorog , Katalin Grasser , Ibolya Kosoczky , Agnes Koracs nee Palotay , Lujza Petocz
发明人： Edit Berenyi nee Poldermann , Peter Gorog , Katalin Grasser , Ibolya Kosoczky , Agnes Koracs nee Palotay , Lujza Petocz
IPC分类号： A61K31/4745 , A61K31/53 , A61P23/00 , A61P25/04 , A61P25/08 , A61P25/20 , A61P29/00 , C07D471/04 , A61K31/395
CPC分类号： C07D471/04
摘要： New compounds are disclosed of the formulae ##STR1## or pharmaceutically effective salts thereof, wherein R is hydrogen, C.sub.1-12 alkyl, or R is phenyl or phenyl-C.sub.1 to C.sub.4 alkyl wherein the phenyl can be substituted with 1 to 3 halogen, C.sub.1 to C.sub.4 alkyl, or C.sub.1 to C.sub.4 alkoxy substituents; andX.sub.1, X.sub.2 and X.sub.3 are hydrogen, C.sub.1 to C.sub.6 alkanoyl, or C.sub.1 to C.sub.6 haloalkanoyl; and where X.sub.1 is hydrogen, X.sub.2 and X.sub.3 are not simultaneously hydrogen. The compounds possess antiphlogistic, analgesic, anticonvulsive, or tranquilizing properties.
摘要翻译：公开了新的化合物或其药学有效盐，其中R是氢，C 1-12烷基或R是苯基或苯基-C 1至C 4烷基，其中苯基可被1至3个卤素取代，C 1 至C 4烷基或C 1至C 4烷氧基取代基; 且X 1，X 2和X 3为氢，C 1至C 6烷酰基或C 1至C 6卤代烷酰基; 并且其中X1为氢，X2和X3不同时为氢。该化合物具有消炎，镇痛，抗惊厥或镇静作用。

4. 发明授权

US4324894A Aminoisoquinoline derivatives 失效
标题翻译：氨基异喹啉衍生物
公开(公告)号：US4324894A
公开(公告)日：1982-04-13
申请号：US138843
申请日：1980-04-10
申请人： Pal Benko , Andras Gelleri , Gyorgy Hajos , Andras Messmer , Laszlo Pallos , Lujza Petocz , Ibolya Kosoczky , Katalin Grasser , Peter Gorog , Eniko Szirt nee Kiszelly
发明人： Pal Benko , Andras Gelleri , Gyorgy Hajos , Andras Messmer , Laszlo Pallos , Lujza Petocz , Ibolya Kosoczky , Katalin Grasser , Peter Gorog , Eniko Szirt nee Kiszelly
IPC分类号： A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/495 , A61P25/00 , A61P25/04 , C07D217/22 , C07D217/24 , C07D401/12 , C07D413/04 , C07D403/14
CPC分类号： C07D217/22 , C07D217/24
摘要： Novel aminoisoquinoline derivatives of the general formula (I) ##STR1## wherein R.sub.1 represents a hydrogen atom or a C.sub.1-4 alkyl group,R.sub.2 represents a hydrogen atom,R.sub.3 represents a hydrogen atom,R.sub.4 represents a morpholinyl group or a piperazinyl group substituted with a pyridyl group, andpharmaceutically acceptable acid addition salts and quaternary derivatives thereof have been prepared. The novel compounds exert narcosis potentiating effects.
摘要翻译：通式（I）的新型氨基异喹啉衍生物其中R 1表示氢原子或C 1-4烷基，R 2表示氢原子，R 3表示氢原子，R 4表示吗啉基或哌嗪基已经制备了被吡啶基取代的基团，以及其药学上可接受的酸加成盐和其季衍生物。新型化合物发挥麻醉加强作用。

5. 发明授权

US4324786A Pyrido[2,3-e]-as-triazine derivatives and pharmaceutical compositions 失效
标题翻译：吡啶并[2,3-e] -as-三嗪衍生物和药物组合物
公开(公告)号：US4324786A
公开(公告)日：1982-04-13
申请号：US143778
申请日：1980-04-25
申请人： Andras Messmer , Pal Benko , Gyorgy Hajos , Lujza Petocz , Ibolya Kosoczky , Peter Gorog
发明人： Andras Messmer , Pal Benko , Gyorgy Hajos , Lujza Petocz , Ibolya Kosoczky , Peter Gorog
IPC分类号： A61K31/53 , A61K31/535 , A61P25/00 , A61P25/04 , A61P25/20 , A61P29/00 , C07D221/04 , C07D253/10 , C07D471/04 , C07D471/14
CPC分类号： C07D471/04
摘要： New pyrido[2,3-e]-as-triazine derivatives of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.2 each stand for a C.sub.1-20 alkylcarbonyl, halogenated (C.sub.1-4 alkyl)-carbonyl, C.sub.1-4 alkoxycarbonyl, benzoyl, phenyl-(C.sub.1-4 alkyl)-carbonyl or phenyl-(C.sub.2-4 alkenyl)-carbonyl group or a 5-10-membered mono- or bicyclic nitrogen-containing heterocyclic acid residue (preferably a pyridylcarbonyl group) containing optionally one or more additional nitrogen, oxygen and/or sulfur atoms in the heterocyclic ring, and optionally one or more identical or different substituents selected from the group consisting of halogen, C.sub.1-4 alkoxy, nitro and hydroxy are attached to the aromatic or heterocyclic rings, furthermore one of R.sup.1 and R.sup.2 may also stand for hydrogen atom, orR.sup.1 and R.sup.2 may form, together with the adjacent nitrogen atoms, a pyrazole-2,4 ring having optionally a C.sub.1-6 alkyl substituent in position 3, andR.sup.3 stands for hydrogen, halogen, C.sub.1-4 alkoxy, amino, mono-(C.sub.1-6 alkyl)-amino, di-(C.sub.1-6 alkyl)-amino, hydroxy, alkylated or acylated hydroxy, morpholino, piperazino, N-(C.sub.1-6 alkyl)-piperazino, N-benzylpiperazino or N-pyridylpiperazino group,and pharmaceutically acceptable acid addition salts thereof are prepared by acylating the respective 1,2-unsubstituted 1,2-dihydro-pyrido[2,3-e]-as-triazine derivatives.The new compounds according to the invention act on the central nervous system and exert sedative, analgesic, narcosis potentiating, tetrabenazine antagonizing and antiphlogistic effects. The new compounds according to the invention can be applied to advantage in the therapy.
摘要翻译：通式（I）的新的吡啶并[2,3-e] -as-三嗪衍生物，其中R 1和R 2各自代表C 1-20烷基羰基，卤代（C 1-4烷基） - 羰基，C 1-4烷氧基羰基，苯甲酰基，苯基 - （C 1-4烷基） - 羰基或苯基 - （C 2-4烯基） - 羰基或5-10元单环或双环含氮杂环酸残基（优选含有任选的一个或多个杂环中的一个或多个另外的氮，氧和/或硫原子，以及任选地一个或多个相同或不同的选自卤素，C 1-4烷氧基，硝基和羟基的取代基被连接到芳族或杂环，此外，R 1和R 2中的一个也可以代表氢原子，或者R 1和R 2可以与相邻的氮原子一起形成具有任选地C 1-6烷基取代基的吡唑-2,4环的位置 3，R3代表氢，卤素，C1-4烷氧基，氨基，单 - （C1-6烷基） - 氨基，二 - （C1-6烷基） - 氨羟基，烷基化或酰化羟基，吗啉代，哌嗪子基，N-（C 1-6烷基） - 哌嗪基，N-苄基哌嗪子基或N-吡啶基哌嗪子基及其药学上可接受的酸加成盐，未取代的1,2-二氢 - 吡啶并[2,3-e] -as-三嗪衍生物。根据本发明的新化合物作用于中枢神经系统，并施加镇静，止痛，麻醉增强，丁苯那嗪拮抗和消炎作用。根据本发明的新化合物可以在治疗中有利地应用。

6. 发明授权

US4320127A Pyrido[3,2-e]-as-triazines 失效
标题翻译：吡啶并[3,2-e] -as-三嗪
公开(公告)号：US4320127A
公开(公告)日：1982-03-16
申请号：US152833
申请日：1980-05-23
申请人： Pal Benko , Andras Messmer , Gyorgy Hajos , Sandor Batori , Lujza Petocz , Iboly Kosoczky , Peter Gorog
发明人： Pal Benko , Andras Messmer , Gyorgy Hajos , Sandor Batori , Lujza Petocz , Iboly Kosoczky , Peter Gorog
IPC分类号： A61K31/53 , A61P25/00 , A61P25/04 , A61P25/20 , A61P29/00 , C07D471/04 , C07D471/14
CPC分类号： C07D471/04 , C07D471/14
摘要： The invention relates to new pyrido[3,2-e]-as-triazine derivatives of the formula I and pharmaceutically acceptable acid addition salts thereof, ##STR1## wherein R.sub.1 stands for a C.sub.1-20 alkyl-carbonyl group, halogen-C.sub.1-4 alkyl-carbonyl, benzoyl, phenyl-C.sub.1-4 alkyl-carbonyl, or pyridyl-carbonyl group;R.sub.2 is a hydrogen atom or a C.sub.1-4 alkyl-carbonyl group; or R.sub.1 and R.sub.2 form together with the adjacent nitrogen atoms a pyrazole-2,4-dione ring which carries a C.sub.1-6 alkyl substituent in position 3;R.sub.3 is a hydrogen atom, a C.sub.1-20 alkyl, phenyl, phenyl-C.sub.1-3 alkyl, furyl or pyridyl group or a phenyl group optionally substituted by one to three C.sub.1-4 alkoxy-groups.The compounds of the formula I are prepared by acylating the respective 1,2-un-substituted 1,2-dihydropyrido [3,2-e]-as-triazine derivatives. The new compounds exert valuable effects on the central nervous system and possess analgesic, antiphlogistic effects, and can be applied to advantage in therapy.
摘要翻译：本发明涉及式I的新的吡啶并[3,2-e] -as-三嗪衍生物及其药学上可接受的酸加成盐，其中R1代表C1-20烷基羰基，卤素C1 -4-烷基 - 羰基，苯甲酰基，苯基-C 1-4烷基 - 羰基或吡啶基 - 羰基; R2是氢原子或C1-4烷基 - 羰基; 或R 1和R 2与相邻的氮原子一起形成在3位上带有C1-6烷基取代基的吡唑-2,4-二酮环; R 3是氢原子，C 1-20烷基，苯基，苯基-C 1-3烷基，呋喃基或吡啶基或任选被一至三个C 1-4烷氧基取代的苯基。通过酰化相应的1,2-未取代的1,2-二氢吡啶并[3,2-e] -as-三嗪衍生物制备式I化合物。新化合物对中枢神经系统起重要作用，具有镇痛，消炎作用，可用于治疗。

7. 发明授权

US4316022A Benzo-as-triazine derivatives 失效
标题翻译：苯并三嗪衍生物
公开(公告)号：US4316022A
公开(公告)日：1982-02-16
申请号：US135143
申请日：1980-03-28
申请人： Gyorgy Hajos , Andras Messmer , Pal Benko , Lujza Petocz , Peter Gorog , Ibolya Kasoczky
发明人： Gyorgy Hajos , Andras Messmer , Pal Benko , Lujza Petocz , Peter Gorog , Ibolya Kasoczky
IPC分类号： A61K31/53 , A61K31/5513 , A61P23/00 , A61P29/00 , C07D249/08 , C07D253/10 , C07D487/04 , C07D487/14 , C07D401/14 , C07D403/14
CPC分类号： C07D487/04 , C07D487/14
摘要： The invention relates to new benzo-as-triazine derivatives of the formulae (I) and (Ia) and pharmaceutically acceptable acid addition salts thereof, ##STR1## wherein R.sub.1 and R.sub.2 each represent hydrogen, a C.sub.1-20 alkylcarbonyl group, a phenylcarbonyl or phenyl-(C.sub.1-4 alkyl)-carbonyl group having optionally one or more halogen, hydroxy or C.sub.1-3 alkoxy substituents which may be the same or different, furthermore a pyridylcarbonyl, a pyrazinylcarbonyl, a furylcarbonyl, a chloroacetyl or a C.sub.1-4 alkoxycarbonyl group, orR.sub.1 and R.sub.2 may form, together with the adjacent nitrogen atoms, a pyrazole ring having optionally a C.sub.1-6 alkyl substituent in position 4,with the proviso that one of R.sub.1 and R.sub.2 is always different from hydrogen,R.sub.3 stands for hydrogen, mercapto group, a C.sub.1-4 alkylmercapto group, amino group, a C.sub.1-4 alkylamino group, a piperazino group having optionally an N-alkyl or 2-pyridyl substituent, a morpholino group or a piperidino group, andR.sub.4 stands for hydrogen, halogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy group.The compounds of the formulae (I) and (Ia) are prepared by acylating the respective 2,4,5-unsubstituted 4,5-dihydro-benzo-as-triazine derivatives.The new compounds of the formulae (I) and (Ia) possess analgesic, antiphlogistic and narcosis-potentiating effects.
摘要翻译：本发明涉及式（I）和（Ia）的新的苯并三嗪衍生物及其药学上可接受的酸加成盐，其中R 1和R 2各自代表氢， C1-20烷基羰基，具有任选一个或多个卤素的苯基羰基或苯基 - （C 1-4烷基） - 羰基，可以相同或不同的羟基或C 1-3烷氧基取代基，此外，吡啶基羰基，吡嗪基羰基，呋喃基羰基，氯乙酰基或C 1-4烷氧基羰基，或者R 1和R 2可以与相邻的氮原子一起形成在4位具有任选的C 1-6烷基取代基的吡唑环，条件是R1和R2之一总是不同于氢，R3代表氢，巯基，C1-4烷基巯基，氨基，C1-4烷基氨基，任选具有N-烷基或2-吡啶基取代基的哌嗪基，吗啉代基或哌啶子基，R4代表氢，卤素， C 1-4烷基或C 1-4烷氧基。式（I）和（Ia）的化合物通过酰化各自的2,4,5-未取代的4,5-二氢 - 苯并 - 三嗪衍生物来制备。式（I）和（Ia）的新化合物具有镇痛，消炎和麻醉增效作用。

8. 发明授权

US5296379A Apparatus and method for modeling arterial thrombus formations 失效
标题翻译：用于建模动脉血栓形成的装置和方法
公开(公告)号：US5296379A
公开(公告)日：1994-03-22
申请号：US927284
申请日：1992-09-22
申请人： Peter Gorog , Iren Kovacs
发明人： Peter Gorog , Iren Kovacs
IPC分类号： A61B17/22 , G01N33/49 , G09B23/28 , G01N33/86
CPC分类号： A61B17/22 , G01N33/4905 , G09B23/285
摘要： Apparatus and method for modeling of thrombogenesis using haemostasis measuring devices. A sleeve member is provided on a blood-carrying tube to simulate an environment of a human artery. When punctured with a small needle, bleeding is simulated, permitting blood to be trapped between the sleeve and blood-carrying tube. The trapped blood communicates with the blood flowing in the tube, resulting in thrombus formation.
摘要翻译： PCT No.PCT / GB91 / 00438 Sec。 371日期：1992年9月22日 102（e）日期1992年9月22日PCT 1991年3月22日PCT公布。公开号WO91 / 14943 日期1991年10月3日。使用止血测量装置建模血栓形成的装置和方法。在血液输送管上设置套筒构件以模拟人动脉的环境。当用小针穿刺时，模拟出血，允许血液被捕获在套管和携带血管之间。被困的血液与在管中流动的血液通信，导致血栓形成。

9. 发明授权

US6004819A Blood testing device 失效
标题翻译：血液检测装置
公开(公告)号：US6004819A
公开(公告)日：1999-12-21
申请号：US78506
申请日：1998-05-14
申请人： Peter Gorog , Iren Kovacs
发明人： Peter Gorog , Iren Kovacs
IPC分类号： G01N33/49
CPC分类号： G01N33/4905
摘要： This invention relates to the measurement of various haemostatis, clotting, and the like properties of blood.
摘要翻译：本发明涉及血液的各种血液透析，凝血等的测定。

10. 发明授权

US5925569A Blood testing device and method 失效
标题翻译：血液检测装置及方法
公开(公告)号：US5925569A
公开(公告)日：1999-07-20
申请号：US743911
申请日：1996-11-04
申请人： Peter Gorog , Iren Kovacs
发明人： Peter Gorog , Iren Kovacs
IPC分类号： A61B5/145 , G01N33/49 , G01N33/86
CPC分类号： G01N33/4905
摘要： This invention relates to the measurement of various haemostatis, clotting, and the like properties of blood.
摘要翻译：本发明涉及血液的各种血液透析，凝血等的测定。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式