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1. 发明申请

WO2016102316A1 PROCESS FOR INCREASING THE STABILITY OF A COMPOSITION COMPRISING POLYUNSATURATED OMEGA-6 FATTY ACIDS 审中-公开
标题翻译：增加包含多元醇OMEGA-6脂肪酸的组合物稳定性的方法
公开(公告)号：WO2016102316A1
公开(公告)日：2016-06-30
申请号：PCT/EP2015/080293
申请日：2015-12-17
申请人： EVONIK DEGUSSA GMBH , KNAUP, Günter , LATINOVIC, Milan , SCHWARM, Michael
发明人： KNAUP, Günter , LATINOVIC, Milan , SCHWARM, Michael
IPC分类号： A23L33/115 , A23L33/105 , A23D7/005 , A23D9/007 , C07C279/02 , C07C279/26 , C07C57/03 , C11B5/00 , A23L33/12 , A23L33/175
CPC分类号： A23L33/12 , A23L33/115 , A23L33/175 , A23V2002/00 , C11B5/0021 , C11B5/0085
摘要： The present invention relates to processes for increasing the stability of compositions comprising polyunsaturated omega-6 fatty acids against oxidation. The processes comprise the following steps: (i) providing a starting composition comprising at least one polyunsaturated omega-6 fatty acid component; (ii) providing a lysine composition; (iii) admixing aqueous, aqueous-alcoholic or alcoholic solutions of starting composition and lysine composition, and subjecting resulting admixture to spray drying conditions subsequently, thus forming a solid product composition comprising at least one salt of a cation derived from lysine with an anion derived from a polyunsaturated omega-6 fatty acid; the product composition exhibiting a solvent content SC selected from the following: SC
摘要翻译：本发明涉及增加包含多不饱和ω-6脂肪酸的组合物对氧化的稳定性的方法。该方法包括以下步骤：（i）提供包含至少一种多不饱和ω-6脂肪酸组分的起始组合物; （ii）提供赖氨酸组合物; （iii）混合起始组合物和赖氨酸组合物的水性，水性醇或醇溶液，并随后对所得混合物进行喷雾干燥条件，从而形成包含至少一种衍生自赖氨酸的阳离子的固体产物组合物和衍生自来自多不饱和ω-6脂肪酸; 该产品组合物显示出选自以下的溶剂含量SC：SC <5wt％，SC <3wt％，SC <1wt％，SC <0.5wt％。通过这种喷雾干燥方法获得的组合物和用于制造食品，营养和药物产品的这种组合物的用途还包括本发明。

2. 发明申请

WO2016102323A1 PROCESS FOR INCREASING THE STABILITY OF A COMPOSITION COMPRISING POLYUNSATURATED OMEGA-3 FATTY ACIDS 审中-公开
标题翻译：增加包含聚氧乙烯醚-3脂肪酸的组合物稳定性的方法
公开(公告)号：WO2016102323A1
公开(公告)日：2016-06-30
申请号：PCT/EP2015/080311
申请日：2015-12-17
申请人： EVONIK DEGUSSA GMBH , KNAUP, Günter , LATINOVIC, Milan , SCHWARM, Michael
发明人： KNAUP, Günter , LATINOVIC, Milan , SCHWARM, Michael
IPC分类号： A23L33/105 , A23L33/115 , A23D7/005 , A23D9/007 , C07C279/02 , C07C279/26 , C07C57/03 , C11B5/00 , A23L33/12 , A23L33/175
CPC分类号： A23L33/12 , A23D9/02 , A23L5/30 , A23L33/115 , A23L33/18 , A61K9/16 , A61K31/202 , A61K47/183 , A61K2300/00
摘要： The present invention relates to processes for increasing the stability of compositions comprising polyunsaturated omega-3 fatty acids against oxidation. The processes comprise the following steps: (i) providing a starting composition comprising at least one polyunsaturated omega-3 fatty acid component; (ii) providing a lysine composition; (iii) admixing aqueous, aqueous-alcoholic or alcoholic solutions of starting composition and lysine composition, and subjecting resulting admixture to spray drying conditions subsequently, thus forming a solid product composition comprising at least one salt of a cation derived from lysine with an anion derived from a polyunsaturated omega-3 fatty acid; the product composition exhibiting a solvent content SC selected from the following: SC
摘要翻译：本发明涉及增加包含多不饱和ω-3脂肪酸的组合物对氧化的稳定性的方法。该方法包括以下步骤：（i）提供包含至少一种多不饱和ω-3脂肪酸组分的起始组合物; （ii）提供赖氨酸组合物; （iii）混合起始组合物和赖氨酸组合物的水性，水性醇或醇溶液，并随后对所得混合物进行喷雾干燥条件，从而形成包含至少一种衍生自赖氨酸的阳离子的固体产物组合物和衍生自来自多不饱和ω-3脂肪酸; 所述产品组合物显示选自以下的溶剂含量SC：SC <5wt％，SC <3wt％，SC <1wt％，SC <0.5wt％。通过这种喷雾干燥方法获得的组合物和用于制造食品，营养和药物产品的这种组合物的用途还包括本发明。

3. 发明申请

WO2015121156A1 METHOD FOR PRODUCING VITAMINE E-ENRICHED, ESPECIALLY TOCOTRIENOL-ENRICHED, COMPOSITIONS FROM NATURAL OILS 审中-公开
标题翻译：生产富含维生素E，特别是植物油的富马酸的方法，天然油组合物
公开(公告)号：WO2015121156A1
公开(公告)日：2015-08-20
申请号：PCT/EP2015/052462
申请日：2015-02-06
申请人： EVONIK MEMBRANE EXTRACTION TECHNOLOGY LTD. , EVONIK DEGUSSA GMBH , BOAM, Andrew , BOUWHUIS, Yuri , KOLEVA, Velichka Yordanova , ROCHA, Maria Ines Fontes , SCHWARM, Michael
发明人： BOAM, Andrew , BOUWHUIS, Yuri , KOLEVA, Velichka Yordanova , ROCHA, Maria Ines Fontes , SCHWARM, Michael
IPC分类号： C11B1/10 , C11B3/00 , C11B11/00
CPC分类号： C11B11/00 , C11B1/10 , C11B3/006 , C11B3/008
摘要： The present disclosure relates generally to a process for manufacturing products enriched in the content of at least one vitamin E component, preferably tocotrienol, using solvent extraction and membrane filtration.
摘要翻译：本公开一般涉及使用溶剂萃取和膜过滤来制造富含至少一种维生素E组分（优选生育三烯酚）含量的产物的方法。

4. 发明申请

WO2019206820A1 SYNBIOTIC COMPOSITIONS 审中-公开
公开(公告)号：WO2019206820A1
公开(公告)日：2019-10-31
申请号：PCT/EP2019/060158
申请日：2019-04-18
申请人： EVONIK DEGUSSA GMBH
发明人： OCHROMBEL, Ines , SPECKMANN, Bodo , PELZER, Stefan , SCHWARM, Michael , PFEFFERLE, Walter
IPC分类号： C12R1/07 , C12R1/125 , C12R1/10 , A61K35/742 , A61K35/741 , C12N1/20 , A23K10/18 , A23K20/147 , A23K20/142 , A23L33/135 , A23L33/175 , A23L33/18 , A23K20/158 , A23K20/163
摘要： The current invention concerns a synbiotic preparation containing at least one probiotic strain and at least one amino acid or derivative thereof selected from glutamine, glutamic acid or salts thereof, conjugated glutamine, or oligopeptides of 2-10 amino acid units in length, said amino acid units being natural amino acids, and at least one amino acid unit being a glutamine or glutamic acid unit.

5. 发明申请

WO2003040439A2 A PROCESS FOR CRYSTALLISING OXONORLEUCINACETAL 审中-公开
标题翻译：一种结晶过氧化物的方法
公开(公告)号：WO2003040439A2
公开(公告)日：2003-05-15
申请号：PCT/EP2002/010568
申请日：2002-09-20
申请人： DEGUSSA AG , SCHWARM, Michael , ROOS, Jürgen , GRÖGER, Harald , WERNER, Helge , RIPPEL, Corinna
发明人： SCHWARM, Michael , ROOS, Jürgen , GRÖGER, Harald , WERNER, Helge , RIPPEL, Corinna
IPC分类号： C30B
CPC分类号： C07C227/42 , C07C229/22
摘要： The present invention provides a process for crystallising oxonorleucinacetals (Ona) of the general formula (I). In particular, precipitation is performed from an aqueous medium with the addition of organic solvents which do not possess any free hydroxyl groups. This leads, after filtration etc., to a crystalline material with little residual moisture.
摘要翻译：本发明提供了使通式（I）的氧杂亮氨酸缩醛（Ona）结晶的方法。特别地，通过添加不具有任何游离羟基的有机溶剂，从水性介质进行沉淀。这在过滤等之后导致具有很少残留水分的结晶材料。

6. 发明申请

WO2004042047A1 MUTANTS FOR THE PREPARATION OF D-AMINO ACIDS 审中-公开
标题翻译：用于制备D-氨基酸的突变体
公开(公告)号：WO2004042047A1
公开(公告)日：2004-05-21
申请号：PCT/EP2003/011432
申请日：2003-10-15
申请人： DEGUSSA AG , MAY, Oliver , BUCHHOLZ, Stefan , SCHWARM, Michael , DRAUZ, Karlheinz , TURNER, Robert J. , FOTHERINGHAM, Ian
发明人： MAY, Oliver , BUCHHOLZ, Stefan , SCHWARM, Michael , DRAUZ, Karlheinz , TURNER, Robert J. , FOTHERINGHAM, Ian
IPC分类号： C12N9/06
CPC分类号： C12R1/19 , C12N9/0024 , C12N9/86 , C12N9/90 , C12P13/04 , C12P41/009
摘要： The present invention relates to specific E. coli mutants which can be used for the synthesis of D-amino acids, and to such a process. The mutants are distinguished by deficiencies in particular enzymes which break down D-amino acids.
摘要翻译：本发明涉及可用于合成D-氨基酸的特异性大肠杆菌突变体，以及这种方法。突变体的特征在于分解D-氨基酸的特定酶的缺陷。

7. 发明申请

WO2003070720A1 PREPARATION OF N-METHYL-3-HYDROXY- 3-(2-THIENYL)PROPYLAMINE VIA NOVEL THIOPHENE DERIVATIVES CONTAINING CARBAMATE GROUPS AS INTERMEDIATES 审中-公开
标题翻译：通过含有作为中间体的碳酸酯组的新型硫代衍生物制备N-甲基-3-羟基-3-（2-苯乙基）丙氨酸
公开(公告)号：WO2003070720A1
公开(公告)日：2003-08-28
申请号：PCT/EP2003/000910
申请日：2003-01-30
申请人： DEGUSSA AG , REICHERT, Dietmar , ALMENA PEREA, Juan, José , SCHWARM, Michael , DRAUZ, Karlheinz , KRIMMER, Hans-Peter
发明人： REICHERT, Dietmar , ALMENA PEREA, Juan, José , SCHWARM, Michael , DRAUZ, Karlheinz , KRIMMER, Hans-Peter
IPC分类号： C07D333/20
CPC分类号： C07D333/20 , C07D333/22
摘要： A novel route is described for the synthesis of N-methyl-3-hydroxy-3-(2-thienyl)propylamine IV, which can be used as a starting compound for the preparation of duloxetine. N-methyl-3-hydroxy-3-(2-thienyl)propylamine is synthesized via novel thiophene derivatives containing carbamate groups, I and IIa, as intermediates.
摘要翻译：描述了用于合成N-甲基-3-羟基-3-（2-噻吩基）丙胺IV的新途径，其可用作制备度洛西汀的起始化合物。 N-甲基-3-羟基-3-（2-噻吩基）丙胺通过含有氨基甲酸酯基团I和IIa的新型噻吩衍生物作为中间体合成。

8. 发明申请

WO2003016245A1 CHROMATOGRAPHIC SEPARATION OF ENANTIOMERS OF PROTECTED AMINO ACIDS VIA SMB-METHOD 审中-公开
标题翻译：通过SMB方法对被保护的氨基酸的成膜剂进行色谱分离
公开(公告)号：WO2003016245A1
公开(公告)日：2003-02-27
申请号：PCT/EP2002/007345
申请日：2002-07-03
申请人： DEGUSSA AG , GÜNTHER, Kurt , MERGET, Stefan , DRAUZ, Karlheinz , KRIMMER, Hans-Peter , SCHWARM, Michael
发明人： GÜNTHER, Kurt , MERGET, Stefan , DRAUZ, Karlheinz , KRIMMER, Hans-Peter , SCHWARM, Michael
IPC分类号： C07B57/00
CPC分类号： C07C269/08 , C07B2200/07 , C07C227/34 , C07C229/00 , C07C271/22
摘要： The present invention is directed to the separation of enantiomers of racemates of formula (I). The separation proceeds by applying deemed racemates to continuos enantioselective chromatography like SMB. The methods predominantly is performed for industrial scale production of pure enantiomers of deemed amino acids which are useful intermediates in organic synthesis.
摘要翻译：本发明涉及分离式（I）的外消旋体的对映异构体。通过将视觉外消旋物应用于像SMB这样的连续对映选择性色谱法进行分离。主要用于工业规模生产在有机合成中有用的中间体的被认为是氨基酸的纯对映异构体的方法。

9. 发明申请

WO2006007976A1 RESOLUTION OF P-HYDROXYPHENYL-2-ALKOXYPROPIONIC ACIDS 审中-公开
标题翻译：对羟基苯基-2-羟基丙酸的分解
公开(公告)号：WO2006007976A1
公开(公告)日：2006-01-26
申请号：PCT/EP2005/007273
申请日：2005-07-06
申请人： DEGUSSA AG , MOST, Dieter , ROSSEN, Kai , SCHWARM, Michael
发明人： MOST, Dieter , ROSSEN, Kai , SCHWARM, Michael
IPC分类号： C07C51/41
CPC分类号： C07C215/08 , C07C51/412 , C07C51/487 , C07C59/64
摘要： The present invention is aimed at a process for the preparation of enantiomerically enriched compounds of general formula (I). These are obtained by classical resolution of the corresponding acid using a chiral amino base in organic solvents.
摘要翻译：本发明的目的在于制备通式（I）的对映异构体富集的化合物的方法。这些是通过在有机溶剂中使用手性氨基的相应酸的经典拆分获得的。

10. 发明公开

EP3236783A1 PROCESS FOR INCREASING THE STABILITY OF A COMPOSITION COMPRISING POLYUNSATURATED OMEGA-6 FATTY ACIDS 有权转让
标题翻译：提高包含多不饱和OMEGA-6脂肪酸的组合物稳定性的方法
公开(公告)号：EP3236783A1
公开(公告)日：2017-11-01
申请号：EP15820481.8
申请日：2015-12-17
申请人： Evonik Degussa GmbH
发明人： KNAUP, Günter , LATINOVIC, Milan , SCHWARM, Michael
IPC分类号： A23L33/115 , A23L33/105 , A23D7/005 , A23D9/007 , C07C279/02 , C07C279/26 , C07C57/03 , C11B5/00 , A23L33/12 , A23L33/175
摘要： A processes for increasing the stability of a composition containing polyunsaturated an omega-6 fatty acid against oxidation proceeds by (i) providing a starting composition containing at least one polyunsaturated omega-6 fatty acid component; (ii) providing a lysine composition; (iii) admixing an aqueous, an aqueous-alcoholic or an alcoholic solution of starting composition and lysine composition, and subjecting a resulting admixture to spray drying conditions subsequently, thus forming a solid product composition containing at least one salt of a cation derived from lysine with an anion derived from the polyunsaturated omega-6 fatty acid; the product composition exhibiting a solvent content SC selected from the following; SC
摘要翻译：本发明涉及用于增加包含多不饱和ω-6脂肪酸的组合物抗氧化的稳定性的方法。该方法包括以下步骤：（i）提供包含至少一种多不饱和ω-6脂肪酸组分的起始组合物; （ii）提供赖氨酸组合物; （iii）混合起始组合物和赖氨酸组合物的水性，含水 - 醇或醇溶液，并随后使所得混合物经受喷雾干燥条件，由此形成固体产物组合物，所述固体产物组合物包含至少一种衍生自赖氨酸的阳离子与阴离子衍生物来自多不饱和ω-6脂肪酸; 所述产品组合物显示选自以下的溶剂含量SC：SC <5重量％，SC <3重量％，SC <1重量％，SC <0.5重量％。本发明进一步包括通过这种喷雾干燥方法可获得的组合物和这种组合物用于制造食品，营养和药物产品的用途。

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