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1. 发明申请

WO2019206820A1 SYNBIOTIC COMPOSITIONS 审中-公开
公开(公告)号：WO2019206820A1
公开(公告)日：2019-10-31
申请号：PCT/EP2019/060158
申请日：2019-04-18
申请人： EVONIK DEGUSSA GMBH
发明人： OCHROMBEL, Ines , SPECKMANN, Bodo , PELZER, Stefan , SCHWARM, Michael , PFEFFERLE, Walter
IPC分类号： C12R1/07 , C12R1/125 , C12R1/10 , A61K35/742 , A61K35/741 , C12N1/20 , A23K10/18 , A23K20/147 , A23K20/142 , A23L33/135 , A23L33/175 , A23L33/18 , A23K20/158 , A23K20/163
摘要： The current invention concerns a synbiotic preparation containing at least one probiotic strain and at least one amino acid or derivative thereof selected from glutamine, glutamic acid or salts thereof, conjugated glutamine, or oligopeptides of 2-10 amino acid units in length, said amino acid units being natural amino acids, and at least one amino acid unit being a glutamine or glutamic acid unit.

2. 发明申请

WO2019068571A1 IN-PROCESS METHOD FOR GUIDING MEASURES AGAINST THE PROPAGATION OF SALMONELLA AND/OR AGAINST THE PROPAGATION OF CAMPYLOBACTER IN AN ANIMAL FLOCK 审中-公开
公开(公告)号：WO2019068571A1
公开(公告)日：2019-04-11
申请号：PCT/EP2018/076393
申请日：2018-09-28
申请人： EVONIK DEGUSSA GMBH
发明人： KAPPEL, Andreas , BÖHL, Florian , PFEFFERLE, Walter , PELZER, Stefan , IGWE, Emeka Ignatius , THIEMANN, Frank
IPC分类号： C12Q1/68
摘要： The present invention relates to an in vitro method for guiding measures against the propagation of Salmonella and/or against the propagation Campylobacter in an animal flock,the method comprising i.) determining the amount of at least one marker gene being specific for Salmonella or Campylobacter in a test sample and ii.) comparing the amount of said at least one marker gene being specific for Salmonella or Campylobacter determined in the test sample with a control sample, wherein an increase in the amount of said at least one marker gene being specific for Salmonella or Campylobacter in the test sample vs. the control sample by at least a factor of two, indicates the necessity of initiating or enhancing measures against the propagation of Salmonella and/or against the propagation Campylobacter .

3. 发明授权

EP1317550B2 NUCLEOTIDE SEQUENCES WHICH CODE FOR THE PPSA GENE 有权
标题翻译： FOR THE PPSA基因编码核苷酸
公开(公告)号：EP1317550B2
公开(公告)日：2010-08-11
申请号：EP01983438.1
申请日：2001-08-16
申请人： Evonik Degussa GmbH
发明人： MÖCKEL, Bettina , MARX, Achim , BASTUCK, Christine , BUCHHOLZ, Michael , PFEFFERLE, Walter
IPC分类号： C12N15/54 , C12N1/21 , C12P13/08
CPC分类号： C12N9/1205 , C12P13/08
摘要： The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the ppsA gene is present in enhanced form, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.

4. 发明授权

EP1319084B1 NUCLEOTIDE SEQUENCES WHICH CODE FOR THE MENE GENE 有权
标题翻译：为MENE基因编码的核苷酸序列
公开(公告)号：EP1319084B1
公开(公告)日：2008-06-18
申请号：EP01958064.6
申请日：2001-08-09
申请人： Evonik Degussa GmbH
发明人： FARWICK, Mike , HUTHMACHER, Klaus , PFEFFERLE, Walter , MARX, Achim
IPC分类号： C12P13/08 , C07K14/34 , C12N9/00 , C12N1/21 , C12N15/10 , C12N15/63 , C12Q1/68
CPC分类号： C12N9/93 , C12P13/08 , C12Y602/01026
摘要： The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70 % to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70 % to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the menE gene coding for an O-succinylbenzoic acid C0A ligase is present in attenuated form, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码包含SEQ ID No.的氨基酸序列的多肽的多核苷酸至少70％相同的程度的多核苷酸 2的多核苷酸，b）编码包含与SEQ ID No.2的氨基酸序列的至少70％的同一性的氨基酸序列的多肽的多核苷酸，c）与SEQ ID No.2的多核苷酸互补的多核苷酸，）或b），和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少所述menE 编码O-琥珀酰基苯甲酸C0A连接酶的基因以减毒形式存在，并且使用包含根据本发明的序列的多核苷酸作为杂交探针。

5. 发明授权

EP1320593B1 Process for the preparation of L-lysine using CYSD, CYSN, CYSK, CYSE AND/or CYSH OF C. GLUTAMICUM 有权
标题翻译：一种用于生产使用CYSD，CYSN，CYSK，谷氨酸棒杆菌的的cysE和/或cysH L-赖氨酸过程
公开(公告)号：EP1320593B1
公开(公告)日：2008-04-23
申请号：EP01978296.0
申请日：2001-08-23
申请人： Evonik Degussa GmbH
发明人： FARWICK, Mike , HUTHMACHER, Klaus , SCHISCHKA, Natalie , BATHE, Brigitte , PFEFFERLE, Walter , BINDER, Michael , GREISSINGER, Dieter , THIERBACH, Georg
IPC分类号： C12N15/00
CPC分类号： C12N9/0051 , A23K10/12 , A23K20/142 , A23K40/10 , C12N9/1029 , C12N9/1241 , C12N9/88 , C12P13/08 , C12P13/12
摘要： The invention provides nucleotide sequences from coryneform bacteria which code for the cysD, cysN, cysK, cysE and cysH genes and a process for the fermentative preparation of amino acids using bacteria in which the genes mentioned are enhanced, a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the cysD gene, the cysN gene, the cysK gene, the cysE gene and/or the cysH gene is present in enhanced form, and the use of polynucleotides which contain the sequences according to the invention as hybridization probes and a process for the preparation of an L-methionine-containing animal feedstuffs additive from fermentation broths.

6. 发明授权

EP1313760B1 NUCLEOTIDE SEQUENCES WHICH CODE FOR THE CITA GENE 有权
标题翻译： NULEOTIDSEQUENZEN FOR THE CITA-GEN CODE
公开(公告)号：EP1313760B1
公开(公告)日：2008-01-02
申请号：EP01974079.4
申请日：2001-07-06
申请人： Evonik Degussa GmbH
发明人： MÖCKEL, Bettina , FARWICK, Mike , HERMANN, Thomas , MARX, Achim , PFEFFERLE, Walter
IPC分类号： C07K14/34
CPC分类号： C12N9/1205 , C07K14/34 , C12N9/10 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/222 , C12P13/225 , C12P13/227 , C12P13/24
摘要： The invention relates to isolated polynucleotides comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70 % to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70 % to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the citA gene is present in attenuated form, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.

7. 发明授权

EP1303624B1 ALANINE RACEMASE (ALR) OF CORYNEBACTERIUM GLUTAMICUM 有权
标题翻译：丙氨酸消旋酶（ALR）从谷氨酸棒杆菌
公开(公告)号：EP1303624B1
公开(公告)日：2007-11-21
申请号：EP01951668.1
申请日：2001-07-11
申请人： Evonik Degussa GmbH
发明人： TAUCH, Andreas , BINDER, Michael , PFEFFERLE, Walter , THIERBACH, Georg , KALINOWSKI, Jörn , PÜHLER, Alfred
IPC分类号： C12N15/61 , C12N1/21 , C12N15/70 , C12N15/77 , C12P13/06 , C12P13/08 , C12Q1/68
CPC分类号： C12P13/08 , C12N9/90 , C12P13/06 , C12Y501/01001
摘要： The invention relates to nucleotidic sequences from corynebacteria which code for the alanine-racemase Alr, a host-vector system comprising a coryneform host bacterium in which the alr gene is present in attenuated form, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.

8. 发明授权

EP1313871B1 NUCLEOTIDE SEQUENCES WHICH CODE FOR THE metY GENE 有权
标题翻译：核苷酸，对于metY GEN CODE
公开(公告)号：EP1313871B1
公开(公告)日：2009-07-08
申请号：EP01969400.9
申请日：2001-07-17
申请人： Evonik Degussa GmbH
发明人： MÖCKEL, Bettina , PFEFFERLE, Walter , HUTHMACHER, Klaus , RÜCKERT, Christian , KALINOWSKI, Jörn , PÜHLER, Alfred , BINDER, Michael , GREISSINGER, Dieter , THIERBACH, Georg
IPC分类号： C12P13/12 , C07K14/34 , C12N9/00 , C12N1/21 , C12N15/10 , C12N15/63 , C12Q1/68 , A23L1/305
CPC分类号： C12P13/08 , C12N9/88 , C12P13/12
摘要： The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70 % to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70 % to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the metY gene coding for O-acetyl-L-homoserine sulfhydrylase (EC 4.2.99.10) is present in enhanced form, and the use of the polynucleotides which comprise the polynucleotide sequences according to the invention as hybridization probes.

9. 发明授权

EP1390504B1 NUCLEOTIDE SEQUENCES WHICH CODE FOR THE METD GENE 有权
标题翻译： METD编码核苷酸
公开(公告)号：EP1390504B1
公开(公告)日：2011-04-13
申请号：EP02740582.8
申请日：2002-05-10
申请人： Evonik Degussa GmbH
发明人： REY, Daniel , RÜCKERT, Christian , KALINOWSKI, Jörn , PÜHLER, Alfred , BATHE, Brigitte , HUTHMACHER, Klaus , PFEFFERLE, Walter
IPC分类号： C12N15/31 , C07K14/34 , C12P13/12 , C12R1/15 , C12Q1/68 , A23K1/16
CPC分类号： C07K14/34 , A23K10/12 , A23K20/142 , A23K40/10 , C12P13/12
摘要： The invention relates to nucleotide sequences from coryneform bacteria which code for the metD gene and to a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the metD gene is present in attenuated form, as well as to the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.

10. 发明授权

EP1725672B1 PROCESS FOR THE PRODUCTION OF L-LYSINE USING CORYNEFORM BACTERIA 有权
标题翻译：方法L-赖氨酸生产中使用棒状杆菌
公开(公告)号：EP1725672B1
公开(公告)日：2010-05-05
申请号：EP05716004.6
申请日：2005-03-11
申请人： Evonik Degussa GmbH
发明人： BATHE, Brigitte , SCHISCHKA, Natalie , PFEFFERLE, Walter
IPC分类号： C12P13/08
CPC分类号： C12P13/08 , C07K14/34 , C12P13/12

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