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1. 发明申请

WO2007138022A3 LIPOIC ACID PELLETS 审中-公开
公开(公告)号：WO2007138022A3
公开(公告)日：2008-01-31
申请号：PCT/EP2007055124
申请日：2007-05-25
申请人： EURAND PHARMACEUTICALS LTD , LABORATORIO CHIMICO INT SPA , BOLTRI LUIGI , FABIANI FLAVIO , MAPELLI LUIGI , SALVI ANNIBALE , MAGRI PAOLO , NARDI ANTONIO , VILLANI FLAVIO
发明人： BOLTRI LUIGI , FABIANI FLAVIO , MAPELLI LUIGI , SALVI ANNIBALE , MAGRI PAOLO , NARDI ANTONIO , VILLANI FLAVIO
IPC分类号： A61K9/50 , A23L1/30 , A61K31/385
CPC分类号： C07D339/04 , A23L33/10 , A61K9/1652 , A61K9/5042 , A61K9/5047 , A61K9/5078 , A61K31/385
摘要： Lipoic acid pellets are described, obtained from inert cores externally coated with lipoic acid. The so obtained active cores are coated with a first layer of insulating polymeric material and then with a polymeric coat that is insoluble at the gastric pH. Pellet are then formulated pharmaceutically, for instance in jelly capsules or controlled release capsules or as oral suspensions, dispersible powders, sachets, etc.
摘要翻译：描述了由外部涂覆有硫辛酸的惰性核获得的硫辛酸颗粒。如此获得的活性核心涂覆有第一层绝缘聚合物材料，然后用不溶于胃pH的聚合物涂层涂覆。然后将丸剂药物配制，例如在果冻胶囊或控释胶囊中，或作为口服悬浮液，可分散粉末，小药膏等。

2. 发明申请

WO2011067667A3 FEXOFENADINE MICROCAPSULES AND COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译： FEXOFENADINE MICROCAPSULES及其组合物
公开(公告)号：WO2011067667A3
公开(公告)日：2012-01-05
申请号：PCT/IB2010003196
申请日：2010-12-01
申请人： EURAND PHARMACEUTICALS LTD , MAPELLI LUIGI , FABIANI FLAVIO , BOLTRI LUIGI , GATTI PAOLO , SERRATONI MAURO , CASSANMAGNAGO ROBERTO
发明人： MAPELLI LUIGI , FABIANI FLAVIO , BOLTRI LUIGI , GATTI PAOLO , SERRATONI MAURO , CASSANMAGNAGO ROBERTO
IPC分类号： A61K9/50 , A61K31/445
CPC分类号： A61K31/445 , A61K9/5026 , A61K9/5042 , A61K9/5047 , A61K9/5089
摘要： The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.
摘要翻译：本发明提供一种药物组合物，其包含含有非索非那定和水不溶性聚合物涂层的味道掩蔽的立即释放微胶囊。这些微胶囊和包含它们的药物组合物具有合适的药物含量和期望的药学性质，包括非索非那定的快速溶解速率与味道掩蔽效果相结合。

3. 发明专利

CA2653403A1 LIPOIC ACID PELLETS 未知
公开(公告)号：CA2653403A1
公开(公告)日：2007-12-06
申请号：CA2653403
申请日：2007-05-25
申请人： EURAND PHARMACEUTICALS LTD , LABORATORIO CHIMICO INT SPA
发明人： SALVI ANNIBALE , MAGRI PAOLO , VILLANI FLAVIO , NARDI ANTONIO , BOLTRI LUIGI , MAPELLI LUIGI , FABIANI FLAVIO
IPC分类号： A61K9/50 , A23L1/30 , A23L33/00 , A61K31/385
摘要： Lipoic acid pellets are described, obtained from inert cores externally c oated with lipoic acid. The so obtained active cores are coated with a first layer of insulating polymeric material and then with a polymeric coat that is insoluble at the gastric pH. Pellet are then formulated pharmaceutically, for instance in jelly capsules or controlled release capsules or as oral su spensions, dispersible powders, sachets, etc.

4. 发明专利

NZ573756A 1,2-dithiolan-3-pentanoic acid or thioctic acid pellets 未知
公开(公告)号：NZ573756A
公开(公告)日：2011-04-29
申请号：NZ57375607
申请日：2007-05-25
申请人： EURAND PHARMACEUTICALS LTD , LABORATORIO CHIMICO INT SPA
发明人： MAPELLI LUIGI GIOVANNI , BOLTRI LUIGI , FABIANI FLAVIO , SALVI ANNIBALE , MAGRI PAOLO , NARDI ANTONIO , VILLANI FLAVIO
IPC分类号： A61K9/50 , A23L1/30 , A23L33/00 , A61K31/385
摘要： Disclosed are lipoic acid pellets, composed of inert cores coated with lipoic acid (active cores) and further coated with a first polymeric coat with insulating function and then with a second polymeric coat that is insoluble at the gastric pH; wherein said first polymeric coat comprises one or several polymers selected from the group consisting of hydroxypropyl methylcellulose (HPMC), hydroxypropylcellulose (HPC), polyvinylalcohol, gum arabic, polyvinylpirrolidone, copolyvidone, and polyethylene-glycol.

5. 发明专利

CA2653403C LIPOIC ACID PELLETS 未知
公开(公告)号：CA2653403C
公开(公告)日：2014-12-09
申请号：CA2653403
申请日：2007-05-25
申请人： EURAND PHARMACEUTICALS LTD , LABORATORIO CHIMICO INT SPA
发明人： BOLTRI LUIGI , FABIANI FLAVIO , MAPELLI LUIGI , SALVI ANNIBALE , MAGRI PAOLO , NARDI ANTONIO , VILLANI FLAVIO
IPC分类号： A61K9/50 , A23L1/30 , A23L33/00 , A61K31/385
摘要： Lipoic acid pellets are described, obtained from inert cores externally coated with lipoic acid. The so obtained active cores are coated with a first layer of insulating polymeric material and then with a polymeric coat that is insoluble at the gastric pH. Pellet are then formulated pharmaceutically, for instance in jelly capsules or controlled release capsules or as oral suspensions, dispersible powders, sachets, etc.

6. 发明专利

AU2007267159A1 Lipoic acid pellets 未知
公开(公告)号：AU2007267159A1
公开(公告)日：2007-12-06
申请号：AU2007267159
申请日：2007-05-25
申请人： EURAND PHARMACEUTICALS LTD , LABORATORIO CHIMICO INT SPA
发明人： NARDI ANTONIO , VILLANI FLAVIO , MAGRI PAOLO , SALVI ANNIBALE , FABIANI FLAVIO , MAPELLI LUIGI , BOLTRI LUIGI
IPC分类号： A23L1/30 , A23L33/00 , A61K9/50 , A61K31/385
摘要： Lipoic acid pellets are described, obtained from inert cores externally coated with lipoic acid. The so obtained active cores are coated with a first layer of insulating polymeric material and then with a polymeric coat that is insoluble at the gastric pH. Pellet are then formulated pharmaceutically, for instance in jelly capsules or controlled release capsules or as oral suspensions, dispersible powders, sachets, etc.

7. 发明申请

WO2008027993A2 DRUG DELIVERY SYSTEMS COMPRISING SOLID SOLUTIONS OF WEAKLY BASIC DRUGS 审中-公开
标题翻译：包含弱碱性药物固体溶液的药物递送系统
公开(公告)号：WO2008027993A2
公开(公告)日：2008-03-06
申请号：PCT/US2007077153
申请日：2007-08-29
申请人： EURAND INC , VENKATESH GOPI , BOLTRI LUIGI , COLOMBO ITALO , LAI JIN-WANG , FLABIANI FLAVIO , MAPELLI LUIGI
发明人： VENKATESH GOPI , BOLTRI LUIGI , COLOMBO ITALO , LAI JIN-WANG , FLABIANI FLAVIO , MAPELLI LUIGI
IPC分类号： A61K31/4406 , A61K9/14 , A61K9/22 , A61K31/4422 , A61K31/454 , A61K31/5513 , A61K47/30 , A61K47/38
CPC分类号： A61K9/5026 , A61K9/5005 , A61K9/5042 , A61K9/5047 , A61K9/5078 , A61K9/5089 , A61K31/4406 , A61K31/4422 , A61K31/454 , A61K31/5513
摘要： The present invention is directed to pharmaceutical compositions and dosage forms comprising TPR beads, wherein said TPR beads comprise a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer, and a TPR coating comprising a water insoluble polymer and an enteric polymer, wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 µg/mL at pH 6.8.
摘要翻译：本发明涉及包含TPR珠的药物组合物和剂型，其中所述TPR珠包含至少一种活性药物成分在至少一种溶解度增强聚合物中的固体分散体，和包含水不溶性聚合物和肠溶聚合物，其中活性药物成分包含在pH6.8时溶解度不超过100μg/ mL的弱碱性活性药物成分。

8. 发明专利

EA021501B1 ГРАНУЛЫ ЛИПОЕВОЙ КИСЛОТЫ 未知
公开(公告)号：EA021501B1
公开(公告)日：2015-07-30
申请号：EA200802398
申请日：2007-05-25
申请人： APTALIS PHARMA LTD , LABORATORIO CHIMICO INT SPA
发明人： BOLTRI LUIGI , FABIANI FLAVIO , MAPELLI LUIGI , SALVI ANNIBALE , MAGRI PAOLO , NARDI ANTONIO , VILLANI FLAVIO
IPC分类号： A61K9/50 , A23L1/30 , A23L33/00 , A61K31/385
摘要： Настоящееизобретениеотноситсяк средствам, основаннымналипоевойкислотеилиееаналогах. 1,2-Дитиолан-3-пентиноваякислота (обычноизвестнаякаклипоеваяилитиоктиноваякислота) являетсяактивнымкомпонентомс антиоксидантнойактивностью, которыйиспользуетсядлялечениярядазаболеваний, включаяболезнипечении желчнойсистемы, полинейропатии, диабетическиеполинейропатии, вирусныеинфекции, гиперхолистеринемию, дислипидемию, болезнипочек, болезньАльцгеймера, онкологиюи др. Этосоединениеулучшаетобменвеществи используетсяв качествеподдерживающеголеченияв некоторыхфармакологическихспособахлеченияилитерапии, как, например, вхимиотерапииилиу пациентов, подверженныхцикламгемодиализа, илиу пациентов, проходящихдетоксикационноелечение (детоксикацию). Цельнастоящегоизобретения - использованиегранулы (pellet) дляприготовлениялекарства, применимогоприлечениипатологическихзаболеваний, реагирующихналечениелипоевойкислотой, атакжеиспользованиеэтихгранулв качествепитательных (пищевых) добавоки дляихприготовления. Внастоящемизобретенииописываютсягранулылипоевойкислоты, состоящиеизинертныхядер, покрытыхлипоевойкислотой (активныеядра) идалеепокрытыхсначалаполимернымпокрытиемс изолирующейфункциейи затемвторымполимернымпокрытием, атакжеразличныевариантыихприготовленияи подготовки. Формулы (составы) дляпищевогоиспользованиятакжеявляютсяцельюэтогоизобретения. Гранулылипоевойкислотыможноиспользоватьв пищевойпромышленностикакпитательныедобавкидляконкретногопищевогопродукта, напримердляпищевогопродуктас кислымрН.

9. 发明公开

EP3003360A4 HIGH POTENCY PANCREATIN PHARMACEUTICAL COMPOSITIONS 无效转让
标题翻译： HOCHWIRKSAME PHARMAZEUTISCHE PANKREATINZUSAMMENSETZUNGEN
公开(公告)号：EP3003360A4
公开(公告)日：2017-04-26
申请号：EP14859866
申请日：2014-11-05
申请人： APTALIS PHARMA LTD , PERRETT STEPHEN , BECKER ROBERT , BOLTRI LUIGI , GHIDORSI LUIGI , ARZUFFI PAOLA , PIRONTI VINCENZA , TOTA MICHAEL , WARD WILLIAM W
发明人： PERRETT STEPHEN , BECKER ROBERT , BOLTRI LUIGI , GHIDORSI LUIGI , ARZUFFI PAOLA , PIRONTI VINCENZA , TOTA MICHAEL , WARD WILLIAM
IPC分类号： A61K38/54 , C12N9/94
CPC分类号： C12N9/94 , A61K38/00
摘要： The present disclosure provides high potency pharmaceutical compositions comprising high activity pancreatin enzymes. The invention is also directed to a process of producing HA-pancreatin enzymes and its compositions or dosage forms, and methods for their use.
摘要翻译：本公开提供了包含高活性胰酶的高效药物组合物。本发明还涉及生产HA-胰酶蛋白酶及其组合物或剂型的方法及其使用方法。

10. 发明申请

WO2012052853A2 ORAL DOSING DEVICE FOR ADMINISTRATION OF MEDICATION 审中-公开
标题翻译：用于行政管理的口服剂量装置
公开(公告)号：WO2012052853A2
公开(公告)日：2012-04-26
申请号：PCT/IB2011003228
申请日：2011-10-20
申请人： APTALIS PHARMA LTD , BOLTRI LUIGI , UBIGLIA LETIZIA , BECKER ROBERT
发明人： BOLTRI LUIGI , UBIGLIA LETIZIA , BECKER ROBERT
IPC分类号： A61J7/00 , A61J11/00
CPC分类号： A61J7/0046 , A61J1/067 , A61J1/2027 , A61J11/0005 , B65D81/3211
摘要： A device for administering orally particles of medication and a liquid to a patient. In a first embodiment, the device has a medicine chamber and a liquid chamber. In a second embodiment, the device has a package and an ampoule. The device assures safe and relatively long-term storage of a medicinal product; provides an administration vehicle; prepares particles of medication suspended in a liquid; and improves patient compliance. A method of administering the medication entails using the disclosed devices.
摘要翻译：用于向患者施用口服药物和液体颗粒的装置。在第一实施例中，该装置具有药剂室和液体室。在第二实施例中，该装置具有包装和安瓿。该装置确保药用产品的安全和相对长期的储存; 提供管理工具; 准备悬浮在液体中的药物颗粒; 并提高患者的依从性。施用药物的方法需要使用所公开的装置。

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