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1. 发明专利

EA021501B1 ГРАНУЛЫ ЛИПОЕВОЙ КИСЛОТЫ 未知
公开(公告)号：EA021501B1
公开(公告)日：2015-07-30
申请号：EA200802398
申请日：2007-05-25
申请人： APTALIS PHARMA LTD , LABORATORIO CHIMICO INT SPA
发明人： BOLTRI LUIGI , FABIANI FLAVIO , MAPELLI LUIGI , SALVI ANNIBALE , MAGRI PAOLO , NARDI ANTONIO , VILLANI FLAVIO
IPC分类号： A61K9/50 , A23L1/30 , A23L33/00 , A61K31/385
摘要： Настоящееизобретениеотноситсяк средствам, основаннымналипоевойкислотеилиееаналогах. 1,2-Дитиолан-3-пентиноваякислота (обычноизвестнаякаклипоеваяилитиоктиноваякислота) являетсяактивнымкомпонентомс антиоксидантнойактивностью, которыйиспользуетсядлялечениярядазаболеваний, включаяболезнипечении желчнойсистемы, полинейропатии, диабетическиеполинейропатии, вирусныеинфекции, гиперхолистеринемию, дислипидемию, болезнипочек, болезньАльцгеймера, онкологиюи др. Этосоединениеулучшаетобменвеществи используетсяв качествеподдерживающеголеченияв некоторыхфармакологическихспособахлеченияилитерапии, как, например, вхимиотерапииилиу пациентов, подверженныхцикламгемодиализа, илиу пациентов, проходящихдетоксикационноелечение (детоксикацию). Цельнастоящегоизобретения - использованиегранулы (pellet) дляприготовлениялекарства, применимогоприлечениипатологическихзаболеваний, реагирующихналечениелипоевойкислотой, атакжеиспользованиеэтихгранулв качествепитательных (пищевых) добавоки дляихприготовления. Внастоящемизобретенииописываютсягранулылипоевойкислоты, состоящиеизинертныхядер, покрытыхлипоевойкислотой (активныеядра) идалеепокрытыхсначалаполимернымпокрытиемс изолирующейфункциейи затемвторымполимернымпокрытием, атакжеразличныевариантыихприготовленияи подготовки. Формулы (составы) дляпищевогоиспользованиятакжеявляютсяцельюэтогоизобретения. Гранулылипоевойкислотыможноиспользоватьв пищевойпромышленностикакпитательныедобавкидляконкретногопищевогопродукта, напримердляпищевогопродуктас кислымрН.

2. 发明申请

WO2007138022A3 LIPOIC ACID PELLETS 审中-公开
公开(公告)号：WO2007138022A3
公开(公告)日：2008-01-31
申请号：PCT/EP2007055124
申请日：2007-05-25
申请人： EURAND PHARMACEUTICALS LTD , LABORATORIO CHIMICO INT SPA , BOLTRI LUIGI , FABIANI FLAVIO , MAPELLI LUIGI , SALVI ANNIBALE , MAGRI PAOLO , NARDI ANTONIO , VILLANI FLAVIO
发明人： BOLTRI LUIGI , FABIANI FLAVIO , MAPELLI LUIGI , SALVI ANNIBALE , MAGRI PAOLO , NARDI ANTONIO , VILLANI FLAVIO
IPC分类号： A61K9/50 , A23L1/30 , A61K31/385
CPC分类号： C07D339/04 , A23L33/10 , A61K9/1652 , A61K9/5042 , A61K9/5047 , A61K9/5078 , A61K31/385
摘要： Lipoic acid pellets are described, obtained from inert cores externally coated with lipoic acid. The so obtained active cores are coated with a first layer of insulating polymeric material and then with a polymeric coat that is insoluble at the gastric pH. Pellet are then formulated pharmaceutically, for instance in jelly capsules or controlled release capsules or as oral suspensions, dispersible powders, sachets, etc.
摘要翻译：描述了由外部涂覆有硫辛酸的惰性核获得的硫辛酸颗粒。如此获得的活性核心涂覆有第一层绝缘聚合物材料，然后用不溶于胃pH的聚合物涂层涂覆。然后将丸剂药物配制，例如在果冻胶囊或控释胶囊中，或作为口服悬浮液，可分散粉末，小药膏等。

3. 发明专利

CA2653403A1 LIPOIC ACID PELLETS 未知
公开(公告)号：CA2653403A1
公开(公告)日：2007-12-06
申请号：CA2653403
申请日：2007-05-25
申请人： EURAND PHARMACEUTICALS LTD , LABORATORIO CHIMICO INT SPA
发明人： SALVI ANNIBALE , MAGRI PAOLO , VILLANI FLAVIO , NARDI ANTONIO , BOLTRI LUIGI , MAPELLI LUIGI , FABIANI FLAVIO
IPC分类号： A61K9/50 , A23L1/30 , A23L33/00 , A61K31/385
摘要： Lipoic acid pellets are described, obtained from inert cores externally c oated with lipoic acid. The so obtained active cores are coated with a first layer of insulating polymeric material and then with a polymeric coat that is insoluble at the gastric pH. Pellet are then formulated pharmaceutically, for instance in jelly capsules or controlled release capsules or as oral su spensions, dispersible powders, sachets, etc.

4. 发明专利

NZ573756A 1,2-dithiolan-3-pentanoic acid or thioctic acid pellets 未知
公开(公告)号：NZ573756A
公开(公告)日：2011-04-29
申请号：NZ57375607
申请日：2007-05-25
申请人： EURAND PHARMACEUTICALS LTD , LABORATORIO CHIMICO INT SPA
发明人： MAPELLI LUIGI GIOVANNI , BOLTRI LUIGI , FABIANI FLAVIO , SALVI ANNIBALE , MAGRI PAOLO , NARDI ANTONIO , VILLANI FLAVIO
IPC分类号： A61K9/50 , A23L1/30 , A23L33/00 , A61K31/385
摘要： Disclosed are lipoic acid pellets, composed of inert cores coated with lipoic acid (active cores) and further coated with a first polymeric coat with insulating function and then with a second polymeric coat that is insoluble at the gastric pH; wherein said first polymeric coat comprises one or several polymers selected from the group consisting of hydroxypropyl methylcellulose (HPMC), hydroxypropylcellulose (HPC), polyvinylalcohol, gum arabic, polyvinylpirrolidone, copolyvidone, and polyethylene-glycol.

5. 发明专利

CA2653403C LIPOIC ACID PELLETS 未知
公开(公告)号：CA2653403C
公开(公告)日：2014-12-09
申请号：CA2653403
申请日：2007-05-25
申请人： EURAND PHARMACEUTICALS LTD , LABORATORIO CHIMICO INT SPA
发明人： BOLTRI LUIGI , FABIANI FLAVIO , MAPELLI LUIGI , SALVI ANNIBALE , MAGRI PAOLO , NARDI ANTONIO , VILLANI FLAVIO
IPC分类号： A61K9/50 , A23L1/30 , A23L33/00 , A61K31/385
摘要： Lipoic acid pellets are described, obtained from inert cores externally coated with lipoic acid. The so obtained active cores are coated with a first layer of insulating polymeric material and then with a polymeric coat that is insoluble at the gastric pH. Pellet are then formulated pharmaceutically, for instance in jelly capsules or controlled release capsules or as oral suspensions, dispersible powders, sachets, etc.

6. 发明专利

AU2007267159A1 Lipoic acid pellets 未知
公开(公告)号：AU2007267159A1
公开(公告)日：2007-12-06
申请号：AU2007267159
申请日：2007-05-25
申请人： EURAND PHARMACEUTICALS LTD , LABORATORIO CHIMICO INT SPA
发明人： NARDI ANTONIO , VILLANI FLAVIO , MAGRI PAOLO , SALVI ANNIBALE , FABIANI FLAVIO , MAPELLI LUIGI , BOLTRI LUIGI
IPC分类号： A23L1/30 , A23L33/00 , A61K9/50 , A61K31/385
摘要： Lipoic acid pellets are described, obtained from inert cores externally coated with lipoic acid. The so obtained active cores are coated with a first layer of insulating polymeric material and then with a polymeric coat that is insoluble at the gastric pH. Pellet are then formulated pharmaceutically, for instance in jelly capsules or controlled release capsules or as oral suspensions, dispersible powders, sachets, etc.

7. 发明申请

WO2015019198A3 HIGH POTENCY PANCREATIN PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：高水平胰蛋白酶药物组合物
公开(公告)号：WO2015019198A3
公开(公告)日：2015-05-28
申请号：PCT/IB2014002583
申请日：2014-07-15
申请人： APTALIS PHARMA LTD
发明人： PIRONTI VINCENZA , BECKER ROBERT , BOLTRI LUIGI , GHIDORSI LUIGI , ARZUFFI PAOLA
IPC分类号： A61K38/46 , A61K38/48 , A61P1/18 , C12N9/94
CPC分类号： C12N9/94 , A61K9/50 , A61K38/465 , A61K38/48 , A61K38/54
摘要： The present invention provides high potency pharmaceutical compositions comprising high activity pancreatin enzymes. The invention is also directed to a process of producing HA- pancreatin enzymes and its compositions or dosage forms, and methods for their use.
摘要翻译：本发明提供包含高活性胰酶的高效药物组合物。本发明还涉及生产HA-胰酶蛋白酶及其组合物或剂型的方法及其使用方法。

8. 发明专利

JP2013231051A Method for producing taste-masked immediate release fexofenadine microcapsule 有权
标题翻译：生产立体释放快速释放微生物的方法
公开(公告)号：JP2013231051A
公开(公告)日：2013-11-14
申请号：JP2013138080
申请日：2013-07-01
申请人： Aptalis Pharma Ltd , アプタリスファーマリミテッド
发明人： MAPELLI LUIGI , FABIANI FLAVIO , BOLTRI LUIGI , GATTI PAOLO , SERRATONI MAURO , CASSANMAGNAGO ROBERTO
IPC分类号： A61K31/445 , A61K9/10 , A61K9/16 , A61K9/26 , A61K9/32 , A61K9/50 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61P11/02 , A61P17/04 , A61P37/08 , A61P43/00
CPC分类号： A61K31/445 , A61K9/5026 , A61K9/5042 , A61K9/5047 , A61K9/5089
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a plurality of microencapsulated fexofenadine particles, by a simple process, having taste-masked immediate release properties.SOLUTION: A method for producing microcapsules includes: (a) a dissolution step of dissolving a water-insoluble polymer in an organic solvent; (b) a suspension step of suspending fexofenadine in the organic solvent as an active component; (c) a covering step of applying a coating of the water-insoluble polymer onto the fexofenadine by phase separation to thereby obtain a plurality of microcapsules, in each of which the fexofenadine is coated with the water-insoluble polymer; (d) a separation step of separating the obtained plurality of microcapsules from the organic solvent; and (e) a wetting step of wetting the separated plurality of microcapsules using a surfactant so that these plurality of microcapsules thereby have suspendability in water, thereby obtaining the plurality of particles.
摘要翻译：要解决的问题：提供一种通过简单的方法生产多个微胶囊化非索非那定颗粒的方法，其具有掩味的立即释放特性。解决方案：一种生产微胶囊的方法包括：（a）溶解水不溶性聚合物在有机溶剂中; （b）将非索非那定悬浮在有机溶剂中作为活性成分的悬浮步骤; （c）通过相分离将非水解聚合物的涂层施加到非索非那定的覆盖步骤，从而获得多个微胶囊，其中每个微胶囊中的非索非那那均涂覆有不溶于水的聚合物; （d）从所述有机溶剂中分离得到的多个微胶囊的分离步骤; 和（e）使用表面活性剂润湿分离的多个微胶囊的润湿步骤，使得这些微胶囊因此在水中具有悬浮性，从而获得多个颗粒。

9. 发明申请

WO2012052853A2 ORAL DOSING DEVICE FOR ADMINISTRATION OF MEDICATION 审中-公开
标题翻译：用于行政管理的口服剂量装置
公开(公告)号：WO2012052853A2
公开(公告)日：2012-04-26
申请号：PCT/IB2011003228
申请日：2011-10-20
申请人： APTALIS PHARMA LTD , BOLTRI LUIGI , UBIGLIA LETIZIA , BECKER ROBERT
发明人： BOLTRI LUIGI , UBIGLIA LETIZIA , BECKER ROBERT
IPC分类号： A61J7/00 , A61J11/00
CPC分类号： A61J7/0046 , A61J1/067 , A61J1/2027 , A61J11/0005 , B65D81/3211
摘要： A device for administering orally particles of medication and a liquid to a patient. In a first embodiment, the device has a medicine chamber and a liquid chamber. In a second embodiment, the device has a package and an ampoule. The device assures safe and relatively long-term storage of a medicinal product; provides an administration vehicle; prepares particles of medication suspended in a liquid; and improves patient compliance. A method of administering the medication entails using the disclosed devices.
摘要翻译：用于向患者施用口服药物和液体颗粒的装置。在第一实施例中，该装置具有药剂室和液体室。在第二实施例中，该装置具有包装和安瓿。该装置确保药用产品的安全和相对长期的储存; 提供管理工具; 准备悬浮在液体中的药物颗粒; 并提高患者的依从性。施用药物的方法需要使用所公开的装置。

10. 发明申请

WO2015020943A3 DIGESTIVE ENZYME COMPOSITION SUITABLE FOR ENTERAL ADMINISTRATION 审中-公开
标题翻译：适用于肠胃管理的消化酶组合物
公开(公告)号：WO2015020943A3
公开(公告)日：2015-10-29
申请号：PCT/US2014049569
申请日：2014-08-04
申请人： APTALIS PHARMA LTD , EREN DEVRIM , EKERDT RUTH , PIRONTI VINCENZA , UBIGLIA LETIZIA , BOLTRI LUIGI
发明人： EREN DEVRIM , EKERDT RUTH , BOLTRI LUIGI
IPC分类号： A61K38/43 , A61K9/16 , A61K9/48 , A61K38/54
CPC分类号： A61K38/54 , A23L27/60 , A23L33/17 , A23L33/195 , A23L33/40 , A23V2002/00 , A61K9/0029 , A61K9/0053 , A61K9/167 , A61K9/1682 , A61K9/5026 , A61K38/465 , C12Y301/01003 , C12Y302/01 , C12Y304/21001
摘要： The present invention is directed to a digestive enzyme composition comprising an enterically coated digestive enzyme product, administrable nutritional medium, and a pharmaceutically acceptable low viscosity oily ingredient. The process for the preparation of the digestive enzyme composition comprises adding an enterically coated digestive enzyme product to a administrable nutritional medium and pharmaceutically acceptable low viscosity oily ingredient. The invention further provides a method for treating a patient suffering from exocrine pancreatic insufficiency related condition comprising administering to the patient a therapeutically effective dose of the digestive enzyme composition by means of a feeding tube.
摘要翻译：本发明涉及消化酶组合物，其包含肠溶包衣的消化酶产物，可施用的营养培养基和药学上可接受的低粘度油性成分。用于制备消化酶组合物的方法包括向可施用的营养培养基和药学上可接受的低粘度油性成分中加入肠溶包衣消化酶产物。本发明还提供了一种治疗患有外分泌胰腺功能不全相关病症的患者的方法，包括通过进料管向患者施用治疗有效剂量的消化酶组合物。

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