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1. 发明申请

WO2008098056A2 HIGH RELAXIVITY CHELATES 审中-公开
标题翻译：高度放松的螯合物
公开(公告)号：WO2008098056A2
公开(公告)日：2008-08-14
申请号：PCT/US2008053186
申请日：2008-02-06
申请人： EPIX PHARM INC , BAYER SCHERING PHARMA AG , CARAVAN PETER D , JACQUES VINCENT , DUMAS STEPHANE , SUN WEI-CHUAN , ZHOU KEVIN L , SCHMITT-WILLICH HERIBERT
发明人： CARAVAN PETER D , JACQUES VINCENT , DUMAS STEPHANE , SUN WEI-CHUAN , ZHOU KEVIN L , SCHMITT-WILLICH HERIBERT
CPC分类号： C07F9/6524 , A61K49/085 , A61K49/10 , A61K49/14 , C07D257/02 , C07F9/12 , C07F9/242 , C07F9/65583 , C07F9/6561
摘要： This disclosure relates to metal chelating ligands, and more particularly to metal chelating ligands having high relaxivity when in a metal chelate form.
摘要翻译：本公开涉及金属螯合配体，并且更具体地涉及当处于金属螯合物形式时具有高弛豫度的金属螯合配体。

2. 发明申请

WO2006121889A3 CHEMICAL EXCHANGE SATURATION TRANSFER CONTRAST AGENTS 审中-公开
标题翻译：化学交换饱和转移反应剂
公开(公告)号：WO2006121889A3
公开(公告)日：2008-05-02
申请号：PCT/US2006017474
申请日：2006-05-05
申请人： EPIX PHARM INC , SCHERING AG , CARAVAN PETER D , JACQUES VINCENT , LAUFFER RANDALL B , SCHMITT-WILLICH HERIBERT
发明人： CARAVAN PETER D , JACQUES VINCENT , LAUFFER RANDALL B , SCHMITT-WILLICH HERIBERT
IPC分类号： A61K49/00
CPC分类号： A61K49/085 , A61K49/10 , A61K49/103 , A61K49/106 , A61K49/122 , A61K49/124 , A61K49/128 , A61K49/146 , C07D257/02 , C07D401/06
摘要： Chelating ligands and metal chelates useful as CEST MR contrast agents are disclosed. The CEST agents can be used to evaluate blood volume changes in the heart and brain.
摘要翻译：公开了可用作CEST MR造影剂的螯合配体和金属螯合物。 CEST剂可用于评估心脏和脑中的血容量变化。

3. 发明申请

WO2008087017A3 NOVEL CASCADE POLYMER COMPLEXES, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THE SAME 审中-公开
标题翻译：新CASCADE聚合物复合，方法用于生产和制药含
公开(公告)号：WO2008087017A3
公开(公告)日：2009-01-22
申请号：PCT/EP2008000285
申请日：2008-01-16
申请人： BAYER SCHERING PHARMA AG , EPIX PHARM INC , SCHMITT-WILLICH HERIBERT , SCHIRMER HEIKO , MISSELWITZ BERND , WEINMANN HANNS-JOACHIM , CARAVAN PETER
发明人： SCHMITT-WILLICH HERIBERT , SCHIRMER HEIKO , MISSELWITZ BERND , WEINMANN HANNS-JOACHIM , CARAVAN PETER
IPC分类号： A61K49/12 , A61K47/48
CPC分类号： A61K49/085 , A61K49/124
摘要： The invention relates to novel cascade polymer complexes, to agents containing said compounds, to the use of said complexes in NMR diagnostics and to methods for producing said compounds and agents. The complex forming cascade polymer complexes according to the invention can be described by the following general formula (I): R - L - A -{ X - [ Y - ( Z - { W - Kw }z )y ]x}a-1, in which R represents an HSA binding unit, L represents a linker or a bond, A represents a cascade core of base multiplicity a containing nitrogen, X and Y independently of one another represent a direct bond or a cascade reproduction unit of reproduction multiplicity x or y, Z and W independently of one another represent a direct bond or a cascade reproduction unit of reproduction multiplicity z or w, K represents the group of a complex former, a represents the numbers 2 to 12, and x, y, z and w represent independently of one another the numbers 1 to 4, with the proviso that exactly one multiplicity of base multiplicity a of the cascade core A represents exactly one bond site to L and with the proviso that the cascade polymer complexes in the complex former groups K contain in total at least 4 ions of an element of the atomic number 20 to 29, 39, 42 to 44 or 57 to 83 and optionally comprise cations of inorganic and/or organic bases, amino acids or amino acid amides.
摘要翻译：本发明涉及新的级联聚合物络合物，含有这些化合物，在NMR诊断使用复合物和制备这些化合物和药剂的方法的试剂。本发明的络合级联聚合物复合物可以用通式（I）表示描述：R t - L - A - {X - [Y - （Z - {W - 千瓦} Z）Y] x}α-1，其中R =的HSA结合单元，L =连接子或键，基多重A，X和的=含氮级联核Y =彼此独立地为直接键或再现多重x或y，Z和W的级联再现单元 =彼此独立地是直接键或再现多重Z或W的级联再现单元的，K =自由基络合剂，A =是数字2〜12，X，Y，Z和W彼此独立地数字1至是如图4所示，与基体的多个中的正好一个多重级联核a表示恰好一个结合位点到L条件，并且条件是在配位剂的基团总共K个级联聚合物络合物包含至少4个离子原子序数20的元件的以29，39，含有42至44或57至83和无机和/或有机碱，氨基酸或氨基酸酰胺任选阳离子。

4. 发明申请

WO2010028776A8 PIPERAZINE DERIVATIVES FOR BINDING AND IMAGING AMYLOID PLAQUES AND THEIR USE 审中-公开
标题翻译：用于结合和成像淀粉样蛋白的哌嗪衍生物及其用途
公开(公告)号：WO2010028776A8
公开(公告)日：2011-03-17
申请号：PCT/EP2009006406
申请日：2009-09-04
申请人： BAYER SCHERING PHARMA AG , SCHMITT-WILLICH HERIBERT , ROEHN ULRIKE , FRIEBE MATTHIAS , LEHMANN LUTZ , FITZNER ANSGAR , KRAUSE SABINE , BROCKSCHNIEDER DAMIAN , DYRKS THOMAS , THIELE ANDREA , BOEMER ULF , MOENNING URSULA , HEINRICH TOBIAS
发明人： SCHMITT-WILLICH HERIBERT , ROEHN ULRIKE , FRIEBE MATTHIAS , LEHMANN LUTZ , FITZNER ANSGAR , KRAUSE SABINE , BROCKSCHNIEDER DAMIAN , DYRKS THOMAS , THIELE ANDREA , BOEMER ULF , MOENNING URSULA , HEINRICH TOBIAS
IPC分类号： C07D209/24 , A61K31/496 , A61K51/04 , A61P25/00 , C07D213/81 , C07D213/82 , C07D239/42 , C07D295/185 , C07D405/12
CPC分类号： C07D239/42 , C07D209/24 , C07D213/81 , C07D213/82 , C07D295/185 , C07D405/12
摘要： The invention relates to compounds of formula (I), their synthesis and their use, in particular for detecting amyloid deposits in a patient.
摘要翻译：本发明涉及式（I）化合物，其合成及其用途，特别是用于检测患者中的淀粉样沉积物。

5. 发明申请

WO2009141079A8 NOVEL [F-18]-LABELLED L-GLUTAMIC ACID AND L-GLUTAMINE DERIVATIVES (II), USE THEREOF AND METHOD FOR THEIR PRODUCTION 审中-公开
标题翻译： NEW [F-18]一种用于制备标记的L-谷氨酸和L- GLUTAMINDERIVATIVE（II）的用途和方法
公开(公告)号：WO2009141079A8
公开(公告)日：2010-11-18
申请号：PCT/EP2009003384
申请日：2009-05-13
申请人： BAYER SCHERING PHARMA AG , DINKELBORG LUDGER , GRAHAM KEITH , BERNDT MATHIAS , KOGLIN NORMAN , SCHMITT-WILLICH HERIBERT , FRIEBE MATTHIAS , LEHMANN LUTZ
发明人： DINKELBORG LUDGER , GRAHAM KEITH , BERNDT MATHIAS , KOGLIN NORMAN , SCHMITT-WILLICH HERIBERT , FRIEBE MATTHIAS , LEHMANN LUTZ
IPC分类号： C07B59/00 , A61K31/225 , A61K51/04 , A61P35/00 , C07C229/24 , C07C271/22 , C07D207/28
CPC分类号： C07D207/28 , A61K51/0402 , C07B59/00 , C07C229/24 , C07C229/28 , C07C229/36 , C07C271/22 , C07C2601/04 , Y02P20/55
摘要： The invention relates to compounds and the synthesis of [F-18] labelled L-glutamic acid and [F- 18] labelled L-glutamate, to their derivatives according to formula (I) and to the uses thereof.
摘要翻译：有化合物和[F-18]标记的L-谷氨酸的合成，[F-18]标记的L-谷氨酸，其中所述的通式（I）和它们的用途的衍生物。

6. 发明申请

WO2009141091A8 NOVEL [F-18] -LABELLED L-GLUTAMIC ACID- AND L-GLUTAMINE DERIVATIVES (I), USE THEREOF AND METHOD FOR THEIR PRODUCTION 审中-公开
标题翻译： NEW [F-18]一种用于制备标记的L-谷氨酸和L-谷氨酰胺（I）的用途和方法
公开(公告)号：WO2009141091A8
公开(公告)日：2010-11-11
申请号：PCT/EP2009003420
申请日：2009-05-14
申请人： BAYER SCHERING PHARMA AG , DINKELBORG LUDGER , BERNDT MATHIAS , FRIEBE MATTHIAS , SCHMITT-WILLICH HERIBERT , SUELZLE DETLEV , KOGLIN NORMAN
发明人： DINKELBORG LUDGER , BERNDT MATHIAS , FRIEBE MATTHIAS , SCHMITT-WILLICH HERIBERT , SUELZLE DETLEV , KOGLIN NORMAN
IPC分类号： C07B59/00 , A61K31/04 , A61K31/195 , A61K51/04 , C07C229/24 , C07C237/06
CPC分类号： A61K49/0433 , A61K51/0402 , C07B59/001 , C07C227/16 , C07C229/24 , C07C231/12 , C07C237/06 , C07C269/06 , C07C271/22 , C07C309/66 , C07D207/16 , C07D207/28
摘要： The invention relates to compounds and the synthesis of [F-18] labelled L-glutamic acid, [F-18] labelled L-glutamate, to their derivatives according to formula (I) and to their uses.
摘要翻译：有化合物和[F-18]标记的L-谷氨酸的合成，[F-18]标记的L-谷氨酸，其中所述的通式（I）和它们的用途的衍生物。

7. 发明申请

WO2010000409A3 COMPOUNDS AND PROCESSES FOR PRODUCTION OF RADIOPHARMACEUTICALS 审中-公开
标题翻译：用于生产放射性药物的化合物和工艺
公开(公告)号：WO2010000409A3
公开(公告)日：2010-03-04
申请号：PCT/EP2009004537
申请日：2009-06-24
申请人： BAYER SCHERING PHARMA AG , SRINIVASAN ANANTH , BERNDT MATHIAS , GRAHAM KEITH , FRIEBE MATTHIAS , SCHMITT-WILLICH HERIBERT
发明人： SRINIVASAN ANANTH , BERNDT MATHIAS , GRAHAM KEITH , FRIEBE MATTHIAS , SCHMITT-WILLICH HERIBERT
IPC分类号： C07B59/00 , C07C309/65 , C07C309/73 , C07C309/80 , C07C309/86
CPC分类号： C07B59/00 , C07B2200/05 , C07C309/65 , C07C309/73
摘要： The present invention relates to novel perfluorinated precursors for the production of F- 18 labeled radiotracers for Positron Emission Tomography (PET) and processes for radiolabeling and purification using these precursors. The invention also comprises radiopharmaceutical kits using these precursors and processes.
摘要翻译：本发明涉及用于生产用于正电子发射断层扫描术（PET）的F-18标记的放射性示踪剂的新型全氟化前体和使用这些前体进行放射性标记和纯化的方法。本发明还包括使用这些前体和过程的放射性药物试剂盒。

8. 发明申请

WO2007009638A3 COMPLEXES CONTAINING PERFLUOROALKYL, METHOD FOR THE PRODUCTION AND USE THEREOF 审中-公开
标题翻译：全氟烷基复合物，方法生产及其用途
公开(公告)号：WO2007009638A3
公开(公告)日：2007-04-26
申请号：PCT/EP2006006777
申请日：2006-07-11
申请人： SCHERING AG , EPIX PHARM INC , SCHIRMER HEIKO , WEINMANN HANNS-JOACHIM , PLATZEK JOHANNES , ZORN LUDWIG , MISSELWITZ BERND , MEDING JOERG , SCHMITT-WILLICH HERIBERT , BRUMBY THOMAS
发明人： SCHIRMER HEIKO , WEINMANN HANNS-JOACHIM , PLATZEK JOHANNES , ZORN LUDWIG , MISSELWITZ BERND , MEDING JOERG , SCHMITT-WILLICH HERIBERT , BRUMBY THOMAS
IPC分类号： C07D257/02 , A61K49/06
CPC分类号： C07D257/02
摘要： The invention relates to objects which are characterised in the claims, that is, metal complexes containing perfluoroalky, comprising radicals of general formula I containing nitrogen, to a method for the production and use thereof in the NMR field and x-ray diagnosis, radiodiagnosis and radiotherapy, in addition to lymphography in the MRT field and for blood pool imaging.
摘要翻译：本发明涉及一种特征在于在权利要求中，即含有全氟烷金属络合物与通式I的含氮基团的主题，其制备方法以及它们在NMR和X射线诊断，放射诊断和放射治疗，使用过程以及在MRT-淋巴和血液池显像，

9. 发明申请

WO2007009637A3 COMPLEXES CONTAINING PERFLUOROALKYL, THEIR USE AS CONTRAST MEDIA FOR NMR, X-RAY AND RADIO DIAGNOSIS AND RADIOTHERAPY 审中-公开
标题翻译：它们作为造影剂使用核磁共振，X射线和无线电和诊断RADIOTHERAPHIE
公开(公告)号：WO2007009637A3
公开(公告)日：2007-05-10
申请号：PCT/EP2006006775
申请日：2006-07-11
申请人： SCHERING AG , EPIX PHARM INC , SCHIRMER HEIKO , WEINMANN HANNS-JOACHIM , PLATZEK JOHANNES , ZORN LUDWIG , MISSELWITZ BERND , MEDING JOERG , SCHMITT-WILLICH HERIBERT , BRUMBY THOMAS
发明人： SCHIRMER HEIKO , WEINMANN HANNS-JOACHIM , PLATZEK JOHANNES , ZORN LUDWIG , MISSELWITZ BERND , MEDING JOERG , SCHMITT-WILLICH HERIBERT , BRUMBY THOMAS
IPC分类号： C07D257/02 , A61B5/055 , A61K31/555 , A61K49/04 , A61K49/10 , A61P43/00 , C07D405/12 , C07H15/00
CPC分类号： A61K49/0002 , A61K49/10 , A61K49/103 , A61K49/106 , A61K51/0482 , A61K51/0497 , C07D257/02 , C07D405/06
摘要： The invention relates to the objects which are characterised in the patent claims, that is, metal complexes which contain perfluoroalkyl having N-alkyl groups of general formula (I), to a method for the production thereof and to the use thereof in NMR and X-ray diagnosis, radiodiagnosis and radiotherapy, and in MRT lymphography.
摘要翻译：本发明涉及一种特征在于在权利要求中，即含有全氟烷 - 金属配合物与N-烷基的通式（I）的主题，其制备方法以及它们在NMR和X射线诊断，放射诊断和放射治疗的使用，以及在MRT淋巴流程，

10. 发明专利

CR9645A COMPLEJOS CON CONTENIDO DE PERFLUOROALQUILO, PROCEDIMIENTOS PARA SU PREPARACION ASI COMO SU USO 未知
公开(公告)号：CR9645A
公开(公告)日：2008-05-21
申请号：CR9645
申请日：2008-01-08
申请人： BAYER SCHERING PHARMA AG , EPIX PHARM INC
发明人： SCHIRMER HEIKO , WEINMANN HANNS-JOACHIM , PLATZEK JOHANNES , ZORN LUDWING , MISSELWITZ , MEDING JORG , SCHMITT-WILLICH HERIBERT , BRUMBY THOMAS
IPC分类号： A61K49/06 , C07D257/02
摘要： La invencion se refiere a los objetos caracterizados en las reivindicaciones, a saber, complejos metalicos con contenido de perfluoroalquilo con radicales con nitrogeno de la formula general I, a procedimientos para su preparacion y a su uso en el diagnostico por RMN y rayos X, en el radiodiagnostico y la radioterapia, asi como en la linfografia MRT y para la representacion de la acumulacion de sangre por imagenes.

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