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1. 发明申请

WO2012074693A1 SELF-IMMOLATIVE PROBES FOR ENZYME ACTIVITY DETECTION 审中-公开
标题翻译：用于酶活性检测的自我检测
公开(公告)号：WO2012074693A1
公开(公告)日：2012-06-07
申请号：PCT/US2011/059884
申请日：2011-11-09
申请人： ENZO BIOCHEM, INC. , SZCZEPANIK, Maciej , LEBEDEVA, Irina, V. , XIANG, Yuejun , PANDE, Praveen , PATTON, Wayne, Forrest
发明人： SZCZEPANIK, Maciej , LEBEDEVA, Irina, V. , XIANG, Yuejun , PANDE, Praveen , PATTON, Wayne, Forrest
IPC分类号： C09K11/06 , C12Q1/26 , G01N21/64
CPC分类号： C12Q1/26 , C07D311/08 , C07D491/052 , C07D491/20 , C07D493/10 , C09K11/06 , C09K2211/1022 , C09K2211/1088 , C12Q1/37 , C12Q1/44 , C12Q1/485 , G01N2333/902 , G01N2500/00 , Y10T436/18
摘要： Provided is a compound comprising the structure: (SIG)-(SI-MOD) m . In this compound, SIG is a signaling molecule, SI is a self-immolative structure bound to SIG such that SIG has a reduced signal relative to the signal of SIG without SI, MOD is a moiety bound to SI that is subject to modification by an activator, and in is an integer from 1 to about 10. With this compound, when MOD is modified by an activator, SI is destabilized and self- cleaved from SIG such that SIG generates an increased signal. Also provided is a method of determining whether a sample comprises an activator, using the above-described compound. Additionally provided is a method of determining whether a cell comprises a nitroreductase using the above-described compound where nitroreductase is the activator. Further provided is a method of determining whether a mammalian cell is hypoxic using the above-described compound where nitroreductase is the activator. A method of detecting a microorganism that comprises a nitroreductase, using the above-described compound where nitroreductase is the activator, is also provided. Also provided is a method of identifying nitroreductase in a sample, using the above-described compound where nitroreductase is the activator.
摘要翻译：提供了包含以下结构的化合物：（SIG） - （SI-MOD）m。在该化合物中，SIG是信号分子，SI是与SIG结合的自消除结构，使得SIG相对于没有SI的SIG的信号具有降低的信号，MOD是与SI结合的部分，其经受并且in为1至约10的整数。利用该化合物，当MOD被活化剂修饰时，SI是不稳定的并且从SIG自裂解，使得SIG产生增加的信号。还提供了使用上述化合物来确定样品是否包含活化剂的方法。另外提供了使用上述硝基还原酶是活化剂的化合物来确定细胞是否包含硝基还原酶的方法。还提供了使用上述硝基还原酶是活化剂的化合物来确定哺乳动物细胞是否缺氧的方法。还提供了使用上述硝基还原酶为活化剂的化合物检测包含硝基还原酶的微生物的方法。还提供了使用上述硝酸还原酶是活化剂的化合物来鉴定样品中的硝基还原酶的方法。

2. 发明申请

WO2011034623A3 FLUORESCENT DYES AND COMPOUNDS, METHODS AND KITS USEFUL FOR IDENTIFYING SPECIFIC ORGANELLES AND REGIONS IN CELLS OF INTEREST 审中-公开
公开(公告)号：WO2011034623A3
公开(公告)日：2011-03-24
申请号：PCT/US2010/002572
申请日：2010-09-21
申请人： ENZO BIOCHEM, INC. , PANDE, Praveen , COX, Hilary , XIANG, Yuejun , PATTON, Wayne, Forrest
发明人： PANDE, Praveen , COX, Hilary , XIANG, Yuejun , PATTON, Wayne, Forrest
IPC分类号： C09B23/14 , G01N33/533 , G01N33/58
摘要： The present invention provides dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids, or cellular organelles or regions. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule, cellular organelle or cellular region provides signal generation. Dyes provided in this invention can comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The dyes of the present invention can also be substituted with specific groups to provide beneficial properties.

3. 发明申请

WO2010028349A3 FLUOROCHROMES FOR ORGANELLE TRACING AND MULTI-COLOR IMAGING 审中-公开
公开(公告)号：WO2010028349A3
公开(公告)日：2010-03-11
申请号：PCT/US2009/056198
申请日：2009-09-08
申请人： ENZO LIFE SCIENCES, INC. , PATTON, Wayne, Forrest , PANDE, Praveen , XIANG, Yuejun , LI, Zaiguo , DONEGAN, James, J. , RABBANI, Elazar
发明人： PATTON, Wayne, Forrest , PANDE, Praveen , XIANG, Yuejun , LI, Zaiguo , DONEGAN, James, J. , RABBANI, Elazar
IPC分类号： C09K19/60 , C09B1/20 , C09B1/54
摘要： Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location or position or quantity of organelles and even for distinguishing between organelles in cells of interest.

4. 发明申请

WO2011031330A1 AUTOPHAGY AND PHOSPHOLIPIDOSIS PATHWAY ASSAYS 审中-公开
标题翻译：自动和磷化物途径测定
公开(公告)号：WO2011031330A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/002494
申请日：2010-09-14
申请人： ENZO LIFE SCIENCES, INC. , PATTON, Wayne, Forrest , COLEMAN, Jack , XIANG, Yuejun , PANDE, Praveen , LI, Zaiguo , SHEN, Dee
发明人： PATTON, Wayne, Forrest , COLEMAN, Jack , XIANG, Yuejun , PANDE, Praveen , LI, Zaiguo , SHEN, Dee
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/5076 , G01N33/582 , G01N33/94 , G01N2500/10 , G01N2800/02 , G01N2800/04 , G01N2800/52
摘要： Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.
摘要翻译：提供用于检测和监测自噬和磷脂病的测定，包括溶酶体贮积病的进展。可以监测溶酶体储存疾病的药物和治疗溶酶体贮积病条件的有效性。药物候选人和疑似毒素也可以筛选对细胞，组织和器官的毒性。还提供了区分磷脂肪激活剂和自噬途径扰动剂的方法。

5. 发明公开

EP2567233A1 PROCESSES AND KITS FOR DETERMINING MULTI-DRUG RESISTANCE OF CELLS 有权转让
标题翻译：方法用于确定传感器的电阻对多个ACTIVE
公开(公告)号：EP2567233A1
公开(公告)日：2013-03-13
申请号：EP11777876.1
申请日：2011-04-25
申请人： Enzo Life Sciences, Inc. , Lebedeva, Irina , Pande, Praveen , Patton, Wayne Forrest
发明人： LEBEDEVA, Irina , PANDE, Praveen , PATTON, Wayne, Forrest
IPC分类号： G01N33/536 , G01N33/533
CPC分类号： G01N21/6486 , G01N33/502 , G01N2800/44
摘要： This invention relates to multi-drug resistance (MDR) in cells, and the use of certain xanthene compounds for determining drug resistance in cells and the effect of test compounds on cell membrane transport by the membrane transporters MDRl, MRP and BCRP. Processes and kits for making these determinations and measuring these effects are described and provided.

6. 发明申请

WO2011065980A3 DYES FOR ANALYSIS OF PROTEIN AGGREGATION 审中-公开
公开(公告)号：WO2011065980A3
公开(公告)日：2011-06-03
申请号：PCT/US2010/003061
申请日：2010-11-30
申请人： ENZO LIFE SCIENCES, INC. , PATTON, Wayne, Forrest , YARMOLUK, Sergiy, M. , PANDE, Praveen , KOVALSKA, Vladyslava , DAI, Lijun , VOLKOVA, Kateryna , COLEMAN, Jack , LOSYTSKYY, Mykhaylo , LUDLAM, Anthony , BALANDA, Anatoliy , SHEN, Dee
发明人： PATTON, Wayne, Forrest , YARMOLUK, Sergiy, M. , PANDE, Praveen , KOVALSKA, Vladyslava , DAI, Lijun , VOLKOVA, Kateryna , COLEMAN, Jack , LOSYTSKYY, Mykhaylo , LUDLAM, Anthony , BALANDA, Anatoliy , SHEN, Dee
IPC分类号： C09B23/14 , G01N33/68
摘要： Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, and analysis of molecular chaperone activity.

7. 发明申请

WO2011139634A1 PROCESSES AND KITS FOR DETERMINING MULTI-DRUG RESISTANCE OF CELLS 审中-公开
标题翻译：用于确定细胞多药耐药性的方法和试剂盒
公开(公告)号：WO2011139634A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/033776
申请日：2011-04-25
申请人： ENZO LIFE SCIENCES, INC. , LEBEDEVA, Irina , PANDE, Praveen , PATTON, Wayne, Forrest
发明人： LEBEDEVA, Irina , PANDE, Praveen , PATTON, Wayne, Forrest
IPC分类号： G01N33/536 , G01N33/533
CPC分类号： G01N21/6486 , G01N33/502 , G01N2800/44
摘要： This invention relates to multi-drug resistance (MDR) in cells, and the use of certain xanthene compounds for determining drug resistance in cells and the effect of test compounds on cell membrane transport by the membrane transporters MDRl, MRP and BCRP. Processes and kits for making these determinations and measuring these effects are described and provided.
摘要翻译：本发明涉及细胞中的多重耐药性（MDR），以及某些呫吨化合物用于测定细胞耐药性的用途以及由膜转运体MDR1，MRP和BCRP测试化合物对细胞膜转运的影响。描述和提供了用于进行这些测定和测量这些影响的方法和试剂盒。

8. 发明申请

WO2010065918A1 LABELING OF TARGET MOLECULES, IDENTIFICATION OF ORGANELLES AND OTHER APPLICATIONS, NOVEL COMPOSITIONS, METHODS AND KITS 审中-公开
标题翻译：靶标分子的标记，有机体的鉴定和其他应用，新型组合物，方法和试剂盒
公开(公告)号：WO2010065918A1
公开(公告)日：2010-06-10
申请号：PCT/US2009/066857
申请日：2009-12-04
申请人： ENZO LIFE SCIENCES, INC. , PANDE, Praveen , LI, Zaiguo , SZCZEPANIK, Maciej , PATTON, Wayne, F.
发明人： PANDE, Praveen , LI, Zaiguo , SZCZEPANIK, Maciej , PATTON, Wayne, F.
IPC分类号： A01N43/78 , A61K31/425
CPC分类号： C09B23/164 , C09B23/0066 , C09B23/0075 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/145 , C09B23/146 , C12Q1/68 , G01N33/583
摘要： The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties.
摘要翻译：本发明提供可用于检测或定量所需靶分子（例如蛋白质，核酸和细胞器器）的染料，活性染料和标记试剂。提供可以在染料与靶分子的结合提供信号产生的溶液中游离的染料。还提供了包含可用于将染料连接到将与所需靶分子结合的探针的反应性基团的染料。已经对本发明的新型染料进行了改进以提供有益的性质。

9. 发明申请

WO2009014513A1 NOVEL DYES FOR THE DETECTION OR QUANTIFICATION OF DESIRABLE TARGET MOLECULES 审中-公开
标题翻译：用于检测或定量分析目标分子的新型染料
公开(公告)号：WO2009014513A1
公开(公告)日：2009-01-29
申请号：PCT/US2007/016581
申请日：2007-07-24
申请人： ENZO LIFE SCIENCES, INC. , PANDE, Praveen , SZCZEPANIK, Maciej , XIANG, Yiu-jun
发明人： PANDE, Praveen , SZCZEPANIK, Maciej , XIANG, Yiu-jun
IPC分类号： C07D209/24
CPC分类号： C07D209/10 , C07D209/12 , C07D403/14
摘要： The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties.
摘要翻译：本发明提供可用于检测或定量所需靶分子例如蛋白质和核酸的染料，活性染料和标记试剂。提供可以在染料与靶分子的结合提供信号产生的溶液中游离的染料。还提供了包含可用于将染料连接到将与所需靶分子结合的探针的反应性基团的染料。已经对本发明的新型染料进行了改进以提供有益的性质。

10. 发明申请

WO2012027195A1 ASSAYS FOR DETECTING MODIFIED COMPOUNDS 审中-公开
标题翻译：用于检测改性化合物的测定
公开(公告)号：WO2012027195A1
公开(公告)日：2012-03-01
申请号：PCT/US2011/048243
申请日：2011-08-18
申请人： ENZO BIOCHEM, INC. , RABBANI, Elazar , RABBANI, Joshua , PANDE, Praveen , STAVRIANOPOULOS, Jannis, G.
发明人： RABBANI, Elazar , RABBANI, Joshua , PANDE, Praveen , STAVRIANOPOULOS, Jannis, G.
IPC分类号： C12Q1/48 , C12Q1/527 , G01N33/58 , G01N33/542
CPC分类号： G01N33/6803 , C12Q1/485 , C12Y207/01091 , C12Y207/11001 , G01N33/92 , G01N2405/08 , G01N2410/00 , G01N2440/14 , G01N2440/30
摘要： Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified. The modifications may take the form of functional groups which are gained, lost or retained by the compounds of interest.
摘要翻译：提供的方法和组合物可用于分离，分离，检测和定量已经由尚未被这样修饰的其它化合物化学，酶促或催化改性的化合物。这些修饰可以采取由感兴趣的化合物获得，丢失或保留的官能团的形式。

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