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1. 发明申请

WO2008112470A1 INCREASED EFFECTIVENESS OF MDA-7 WITH MDR-1 OVER-EXPRESSION 审中-公开
标题翻译： MDA-7与MDR-1超表达的有效性提高
公开(公告)号：WO2008112470A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/055877
申请日：2008-03-05
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , FISHER, Paul , EMDAD, Luni , SARKAR, Devanand , LEBEDEVA, Irina
发明人： FISHER, Paul , EMDAD, Luni , SARKAR, Devanand , LEBEDEVA, Irina
IPC分类号： C12N5/00
CPC分类号： A61K48/005 , A61K38/2066 , C12N15/86 , C12N2710/10343
摘要： The present invention relates to the use of melanoma differentiation associated gene-7, its encoded protein, and related molecules (Collectively, "Mda-7 Molecules") for improving the response of a subject to chemotherapy and the particular benefit of Mda-7 treatment in a subject resistant to chemotherapy. It is based, at least in part, on the discovery that mda-7 expression increases the response of hitherto resistant cells to chemotherapeutic agent, as well as on the discovery that mda-7 expression is itself enhanced in the context of over- expression of the multidrug resistance gene (mdr-l).
摘要翻译：本发明涉及黑素瘤分化相关基因-7，其编码的蛋白质和相关分子（统称为“Mda-7分子”）用于改善受试者对化学疗法的反应和Mda-7治疗的特殊益处的用途在化疗耐药的个体。至少部分是基于mda-7表达增加迄今为止抗性细胞对化学治疗剂的反应的发现，以及发现mda-7表达本身在过表达的背景下增强多药耐药基因（mdr-1）。

2. 发明申请

WO2011139634A1 PROCESSES AND KITS FOR DETERMINING MULTI-DRUG RESISTANCE OF CELLS 审中-公开
标题翻译：用于确定细胞多药耐药性的方法和试剂盒
公开(公告)号：WO2011139634A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/033776
申请日：2011-04-25
申请人： ENZO LIFE SCIENCES, INC. , LEBEDEVA, Irina , PANDE, Praveen , PATTON, Wayne, Forrest
发明人： LEBEDEVA, Irina , PANDE, Praveen , PATTON, Wayne, Forrest
IPC分类号： G01N33/536 , G01N33/533
CPC分类号： G01N21/6486 , G01N33/502 , G01N2800/44
摘要： This invention relates to multi-drug resistance (MDR) in cells, and the use of certain xanthene compounds for determining drug resistance in cells and the effect of test compounds on cell membrane transport by the membrane transporters MDRl, MRP and BCRP. Processes and kits for making these determinations and measuring these effects are described and provided.
摘要翻译：本发明涉及细胞中的多重耐药性（MDR），以及某些呫吨化合物用于测定细胞耐药性的用途以及由膜转运体MDR1，MRP和BCRP测试化合物对细胞膜转运的影响。描述和提供了用于进行这些测定和测量这些影响的方法和试剂盒。

3. 发明公开

EP2567233A4 PROCESSES AND KITS FOR DETERMINING MULTI-DRUG RESISTANCE OF CELLS 有权转让
标题翻译：方法和试剂盒用于确定传感器的电阻对多个ACTIVE
公开(公告)号：EP2567233A4
公开(公告)日：2013-09-11
申请号：EP11777876
申请日：2011-04-25
申请人： ENZO LIFE SCIENCES INC , LEBEDEVA IRINA , PANDE PRAVEEN , PATTON WAYNE FORREST
发明人： LEBEDEVA IRINA , PANDE PRAVEEN , PATTON WAYNE FORREST
IPC分类号： G01N33/536 , G01N33/50 , G01N33/533
CPC分类号： G01N21/6486 , G01N33/502 , G01N2800/44

4. 发明公开

EP2567233A1 PROCESSES AND KITS FOR DETERMINING MULTI-DRUG RESISTANCE OF CELLS 有权转让
标题翻译：方法用于确定传感器的电阻对多个ACTIVE
公开(公告)号：EP2567233A1
公开(公告)日：2013-03-13
申请号：EP11777876.1
申请日：2011-04-25
申请人： Enzo Life Sciences, Inc. , Lebedeva, Irina , Pande, Praveen , Patton, Wayne Forrest
发明人： LEBEDEVA, Irina , PANDE, Praveen , PATTON, Wayne, Forrest
IPC分类号： G01N33/536 , G01N33/533
CPC分类号： G01N21/6486 , G01N33/502 , G01N2800/44
摘要： This invention relates to multi-drug resistance (MDR) in cells, and the use of certain xanthene compounds for determining drug resistance in cells and the effect of test compounds on cell membrane transport by the membrane transporters MDRl, MRP and BCRP. Processes and kits for making these determinations and measuring these effects are described and provided.

5. 发明申请

WO2012074693A1 SELF-IMMOLATIVE PROBES FOR ENZYME ACTIVITY DETECTION 审中-公开
标题翻译：用于酶活性检测的自我检测
公开(公告)号：WO2012074693A1
公开(公告)日：2012-06-07
申请号：PCT/US2011/059884
申请日：2011-11-09
申请人： ENZO BIOCHEM, INC. , SZCZEPANIK, Maciej , LEBEDEVA, Irina, V. , XIANG, Yuejun , PANDE, Praveen , PATTON, Wayne, Forrest
发明人： SZCZEPANIK, Maciej , LEBEDEVA, Irina, V. , XIANG, Yuejun , PANDE, Praveen , PATTON, Wayne, Forrest
IPC分类号： C09K11/06 , C12Q1/26 , G01N21/64
CPC分类号： C12Q1/26 , C07D311/08 , C07D491/052 , C07D491/20 , C07D493/10 , C09K11/06 , C09K2211/1022 , C09K2211/1088 , C12Q1/37 , C12Q1/44 , C12Q1/485 , G01N2333/902 , G01N2500/00 , Y10T436/18
摘要： Provided is a compound comprising the structure: (SIG)-(SI-MOD) m . In this compound, SIG is a signaling molecule, SI is a self-immolative structure bound to SIG such that SIG has a reduced signal relative to the signal of SIG without SI, MOD is a moiety bound to SI that is subject to modification by an activator, and in is an integer from 1 to about 10. With this compound, when MOD is modified by an activator, SI is destabilized and self- cleaved from SIG such that SIG generates an increased signal. Also provided is a method of determining whether a sample comprises an activator, using the above-described compound. Additionally provided is a method of determining whether a cell comprises a nitroreductase using the above-described compound where nitroreductase is the activator. Further provided is a method of determining whether a mammalian cell is hypoxic using the above-described compound where nitroreductase is the activator. A method of detecting a microorganism that comprises a nitroreductase, using the above-described compound where nitroreductase is the activator, is also provided. Also provided is a method of identifying nitroreductase in a sample, using the above-described compound where nitroreductase is the activator.
摘要翻译：提供了包含以下结构的化合物：（SIG） - （SI-MOD）m。在该化合物中，SIG是信号分子，SI是与SIG结合的自消除结构，使得SIG相对于没有SI的SIG的信号具有降低的信号，MOD是与SI结合的部分，其经受并且in为1至约10的整数。利用该化合物，当MOD被活化剂修饰时，SI是不稳定的并且从SIG自裂解，使得SIG产生增加的信号。还提供了使用上述化合物来确定样品是否包含活化剂的方法。另外提供了使用上述硝基还原酶是活化剂的化合物来确定细胞是否包含硝基还原酶的方法。还提供了使用上述硝基还原酶是活化剂的化合物来确定哺乳动物细胞是否缺氧的方法。还提供了使用上述硝基还原酶为活化剂的化合物检测包含硝基还原酶的微生物的方法。还提供了使用上述硝酸还原酶是活化剂的化合物来鉴定样品中的硝基还原酶的方法。

6. 发明申请

WO2004060269A3 MDA-7 AND FREE RADICALS IN THE TREATMENT OF CANCER 审中-公开
标题翻译： MDA-7和自由基在治疗癌症中的作用
公开(公告)号：WO2004060269A3
公开(公告)日：2004-10-14
申请号：PCT/US0328512
申请日：2003-09-09
申请人： UNIV COLUMBIA , UNIV VIRGINIA COMMONWEALTH , FISHER PAUL B , GOPALKRISHNAN RAHUL , LEBEDEVA IRINA , GRANT STEVEN , YACOUB ADLY , DENT PAUL
发明人： FISHER PAUL B , GOPALKRISHNAN RAHUL , LEBEDEVA IRINA , GRANT STEVEN , YACOUB ADLY , DENT PAUL
IPC分类号： A61K38/17 , A61K48/00 , C07K14/47 , C12N15/861 , A01N37/18 , A01N43/04 , C07H21/04 , C07K1/00 , C12N15/00 , C12N15/63
CPC分类号： C12N15/86 , A61K38/1709 , A61K48/00 , C07K14/47 , C07K2319/23 , C12N2710/10343 , C12N2810/00
摘要： The present invention relates to methods of treating a cancer in a subject comprising generating within one or more cancer cells of a subject an effective amount of MDA-7 and an effective amount of one or more free radicals. The present invention further relates to methods of inhibiting proliferation or promoting death in a cancer cell of a subject comprising generating within one or more cancer cells of a subject an effective amount of MDA-7 and an effective amount of one or more free radicals. Generation of an effective amount of MDA-7 can occur by administering to the cancer cell an effective amount of an mda-7 nucleic acid, MDA-7 protein, functional equivalents of either of these molecules, by upregulation of the endogenous mda-7 gene, or by stabilization of the mda-7 mRNA. Generation of one or more free radicals in a cancer cell can occur by exposing the cancer cell to an effective amount of ionizing radiation, a free radical, a generator of a free radical, a ROS, a generator of a ROS, or a disruptor of mitochondrial membrane potential.
摘要翻译：本发明涉及治疗受试者的癌症的方法，其包括在受试者的一个或多个癌细胞内产生有效量的MDA-7和有效量的一种或多种自由基。本发明进一步涉及抑制受试者癌细胞增殖或促进死亡的方法，包括在受试者的一个或多个癌细胞内产生有效量的MDA-7和有效量的一种或多种自由基。通过向癌细胞施用有效量的mda-7核酸，MDA-7蛋白，这些分子中的任一个的功能等价物，通过上调内源性mda-7基因，可以产生有效量的MDA-7 ，或通过稳定mda-7 mRNA。通过将癌细胞暴露于有效量的电离辐射，自由基，自由基的生成物，ROS，ROS的生成物或干扰物的干扰物，可以发生癌细胞中的一种或多种自由基线粒体膜电位。

7. 发明申请

WO2004060269A2 MDA-7 AND FREE RADICALS IN THE TREATMENT OF CANCER 审中-公开
标题翻译： MDA-7和免费治疗癌症的RADICAL
公开(公告)号：WO2004060269A2
公开(公告)日：2004-07-22
申请号：PCT/US2003/028512
申请日：2003-09-09
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , VIRGINIA COMMONWEALTH UNIVERSITY , FISHER, Paul, B. , GOPALKRISHNAN, Rahul , LEBEDEVA, Irina , GRANT, Steven , YACOUB, Adly , DENT, Paul
发明人： FISHER, Paul, B. , GOPALKRISHNAN, Rahul , LEBEDEVA, Irina , GRANT, Steven , YACOUB, Adly , DENT, Paul
IPC分类号： A61K
CPC分类号： C12N15/86 , A61K38/1709 , A61K48/00 , C07K14/47 , C07K2319/23 , C12N2710/10343 , C12N2810/00
摘要： The present invention relates to methods of treating a cancer in a subject comprising generating within one or more cancer cells of a subject an effective amount of MDA-7 and an effective amount of one or more free radicals. The present invention further relates to methods of inhibiting proliferation or promoting death in a cancer cell of a subject comprising generating within one or more cancer cells of a subject an effective amount of MDA-7 and an effective amount of one or more free radicals. Generation of an effective amount of MDA-7 can occur by administering to the cancer cell an effective amount of an mda -7 nucleic acid, MDA-7 protein, functional equivalents of either of these molecules, by upregulation of the endogenous mda -7 gene, or by stabilization of the mda -7 mRNA. Generation of one or more free radicals in a cancer cell can occur by exposing the cancer cell to an effective amount of ionizing radiation, a free radical, a generator of a free radical, a ROS, a generator of a ROS, or a disruptor of mitochondrial membrane potential.
摘要翻译：本发明涉及治疗受试者的癌症的方法，包括在受试者的一个或多个癌细胞内产生有效量的MDA-7和有效量的一种或多种自由基。本发明还涉及在受试者的癌细胞中抑制增殖或促进死亡的方法，包括在受试者的一个或多个癌细胞内产生有效量的MDA-7和有效量的一种或多种自由基。有效量的MDA-7的产生可通过向癌细胞施用有效量的mda-7核酸，MDA-7蛋白，这些分子的功能等同物，通过上调内源性mda-7基因，或通过稳定mda-7mRNA。通过将癌细胞暴露于有效量的电离辐射，自由基，自由基的发生剂，ROS，ROS的产生剂或破坏剂的破坏剂，可以发生癌细胞中的一种或多种自由基的产生线粒体膜电位。

8. 发明申请

WO2010036922A1 PROFILING REACTIVE OXYGEN, NITROGEN AND HALOGEN SPECIES 审中-公开
标题翻译：配制反应性氧，氮和卤素物种
公开(公告)号：WO2010036922A1
公开(公告)日：2010-04-01
申请号：PCT/US2009/058423
申请日：2009-09-25
申请人： ENZO LIFE SCIENCES, INC. , LEBEDEVA, Irina, V. , PATTON, Wayne
发明人： LEBEDEVA, Irina, V. , PATTON, Wayne
IPC分类号： G01N21/62 , G01N33/48
CPC分类号： G01N33/582 , C12Q1/02 , G01N15/14 , G01N33/5005
摘要： This invention provides methods, kits and systems which permit simultaneous profiling of multiple reactive oxygen species (ROS), reactive nitrogen species (RNS) and/or reactive halogen species (RHS) including reactive chlorine species (RCS) and/or reactive bromine species (RBS) through multiplexed fluorescence detection of three or more indicator probes in live cells or subcellular organelles.
摘要翻译：本发明提供方法，试剂盒和系统，其允许包括反应性氯物质（RCS）和/或反应性溴物质（RCS）和/或反应性溴物质的多种活性氧（ROS），活性氮物质（RNS）和/或反应性卤素物质（RHS） RBS）通过在活细胞或亚细胞器中的三个或更多个指示物探针的多重荧光检测。

9. 发明专利

RU2107479C1 METHOD FOR PREDICTING EFFECTIVENESS OF TRANSCUTANEOUS EYE ELECTROSTIMULATION IN CASES OF AMBLYOPIA 未知
公开(公告)号：RU2107479C1
公开(公告)日：1998-03-27
申请号：RU95111456
申请日：1995-07-03
申请人： LEBEDEVA IRINA SERGEEVNA , GORBACHEVSKAJA NATAL JA LEONID , SIDORENKO EVGENIJ IVANOVICH , DUBOVSKAJA LJUDMILA ALEKSEEVNA , KHATSENKO IGOR EVGEN EVICH
发明人： LEBEDEVA IRINA SERGEEVNA , GORBACHEVSKAJA NATAL JA LEONID , SIDORENKO EVGENIJ IVANOVICH , DUBOVSKAJA LJUDMILA ALEKSEEVNA , KHATSENKO IGOR EVGEN EVICH
IPC分类号： A61F9/00 , A61B5/0476
摘要： FIELD: medicine. SUBSTANCE: method involves recording electroencephalogram and determining density in various regions of cerebral cortex. The value being equal to 6.72-8.52 mcV6,72-8,52 mkW at 1.5 Hz frequency in the right central region, 3.45-5.15 3,45-5,15 mkW at 6.5 Hz frequency in the left central region, 5.01-9.63 5,01-9,63 mkW at 9 Hz frequency in the right posteroparietal region of the cortex, positive electrostimulation effectiveness is to be predicted. EFFECT: enhanced accuracy and reliability of prediction.

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