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1. 发明申请

WO2008151059A3 IMPLANTABLE THERAPY SYSTEM 审中-公开
标题翻译：可植入治疗系统
公开(公告)号：WO2008151059A3
公开(公告)日：2009-01-29
申请号：PCT/US2008065386
申请日：2008-05-30
申请人： ENTEROMEDICS INC , DONDERS ADRIANUS P , WEIJAND KOEN J , LAMBERT SCOTT ANTHONY , SPAR GREGORY PAT , STULTZ MARK RAYMOND , VALLAPUREDDY VINEEL , LAUGHLIN JOHN CHARLES
发明人： DONDERS ADRIANUS P , WEIJAND KOEN J , LAMBERT SCOTT ANTHONY , SPAR GREGORY PAT , STULTZ MARK RAYMOND , VALLAPUREDDY VINEEL , LAUGHLIN JOHN CHARLES
IPC分类号： A61N1/36 , A61N1/372
CPC分类号： A61N1/36007 , A61N1/0556 , A61N1/0558 , A61N1/37229 , A61N1/3752 , A61N1/3787
摘要： Example embodiments of therapy systems may include an implantable component and an external component that can be configured into one of multiple selectable operating modes. Plugging an external antenna into the external component can automatically configure the external component into one of the operating modes. Initial values for the parameters of a therapy program can be incremented or decremented after a predetermined period of time by a predetermined amount to obtain a subsequent value of the parameter and therapy can be applied using the subsequent value. The implantable component can be adapted to be selectively configured into one of a training mode and a delivery mode. The implantable component is configured to simulate application of therapy when configured in the training mode.
摘要翻译：治疗系统的示例性实施例可以包括可植入组件和可以配置成多种可选操作模式之一的外部组件。将外部天线插入外部组件可以将外部组件自动配置为其中一种工作模式。治疗程序的参数的初始值可以在预定时间段之后增加或减少预定量，以获得参数的后续值，并且可以使用随后的值来应用治疗。可植入部件可以适于选择性地配置成训练模式和递送模式之一。可植入组件被配置为在训练模式下配置时模拟治疗的应用。

2. 发明申请

WO2008112430A2 REMOTE MONITORING AND CONTROL OF IMPLANTABLE DEVICES 审中-公开
标题翻译：可移植设备的远程监控和控制
公开(公告)号：WO2008112430A2
公开(公告)日：2008-09-18
申请号：PCT/US2008055098
申请日：2008-02-27
申请人： ENTEROMEDICS INC , VALLAPUREDDY VINEEL , DONDERS ADRIANUS P , RAMADHYANI SATISH , WANG WU , CHAN HANG
发明人： VALLAPUREDDY VINEEL , DONDERS ADRIANUS P , RAMADHYANI SATISH , WANG WU , CHAN HANG
IPC分类号： A61N1/372
CPC分类号： A61N1/37235 , A61N1/37247 , A61N1/37282 , G06F19/3418 , Y10S128/92
摘要： A treatment system includes a regulator implanted within a patient, a computing device storing at least one patient database associated with the patient in whom the regulator is implanted, and a data transfer device. The data transfer device provides bi-directional communication (e.g., voice communication) and a data exchange (e.g., a treatment history, a patient database, and operational instructions) between the regulator and the computing device. A programmer can obtain patient reports and/or default treatment values from the computing device based on the data exchange.
摘要翻译：治疗系统包括植入在患者体内的调节器，存储至少一个患者数据库的计算装置，所述至少一个患者数据库与其中植入调节器的患者相关联，以及数据传送装置。数据传输设备在调节器和计算设备之间提供双向通信（例如，语音通信）和数据交换（例如，治疗历史，患者数据库和操作指令）。程序员可以基于数据交换从计算设备获得患者报告和/或默认治疗值。

3. 发明申请

WO2011156439A3 NEURAL MODULATION DEVICES AND METHODS 审中-公开
标题翻译：神经调制装置及方法
公开(公告)号：WO2011156439A3
公开(公告)日：2012-02-02
申请号：PCT/US2011039540
申请日：2011-06-08
申请人： ENTEROMEDICS INC , TWEDEN KATHERINE S , WAATAJA JONATHAN J , DONDERS ADRIANUS P , KNUDSON MARK B
发明人： TWEDEN KATHERINE S , WAATAJA JONATHAN J , DONDERS ADRIANUS P , KNUDSON MARK B
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/0509 , A61N1/0551 , A61N1/36053 , A61N1/36085 , A61N1/36117 , A61N1/36171 , A61N1/36178 , A61N1/37235 , A61N1/3787
摘要： A system for designing a therapy or for treating a gastrointestinal disorder or a condition associated with excess weight in a subject comprising at least one electrode configured to be implanted within a body of the patient and placed at a vagus nerve, the electrode also configured to apply therapy to the vagus nerve upon application of a therapy cycle to the electrode; an implantable neuroregulator for placement in the body of the patient beneath the skin layer, the implantable neuroregulator being configured to generate a therapy cycle, wherein the therapy cycle comprises an on time during which an electrical signal is delivered, the electrical signal comprising: a) a set of pulses applied at a first selected frequency of about 150-10,000 Hz, wherein each pulse of the set of pulses has a pulse width of at least 0.01 milliseconds and less than the period of the first selected frequency.
摘要翻译：一种用于设计用于治疗或治疗与受试者相关的胃肠疾病或与体重过重相关的病症的系统，所述系统包括被配置为植入患者体内并置于迷走神经的至少一个电极，所述电极还被配置为施加在向电极施加治疗周期时对迷走神经进行治疗; 可植入神经调节器，用于放置在皮肤层下面的患者体内，所述可植入神经调节器被配置为产生治疗周期，其中所述治疗周期包括传递电信号的导通时间，所述电信号包括：a）以大约150-10,000Hz的第一选定频率施加的一组脉冲，其中脉冲组的每个脉冲具有至少0.01毫秒且小于第一选定频率的周期的脉冲宽度。

4. 发明申请

WO2004096344A3 IMPLANTABLE LEAD-BASED SENSOR POWERED BY PIEZOELECTRIC TRANSFORMER 审中-公开
标题翻译：由压电变压器驱动的基于导线的传感器
公开(公告)号：WO2004096344A3
公开(公告)日：2005-01-27
申请号：PCT/US2004009842
申请日：2004-03-31
申请人： MEDTRONIC INC , HOUBEN RICHARD P M , CHRISTOPHERSON MARK A , DONDERS ADRIANUS P , LEINDERS ROBERT , DENO CURTIS D
发明人： HOUBEN RICHARD P M , CHRISTOPHERSON MARK A , DONDERS ADRIANUS P , LEINDERS ROBERT , DENO CURTIS D
IPC分类号： A61N1/08 , A61N1/365 , A61N1/362 , A61N1/05
CPC分类号： A61N1/08 , A61N1/36542
摘要： In general, the invention is directed to an IMD having a piezoelectric transformer to power a lead-based sensor. The IMD powers the piezoelectric transformer with a low amplitude signal. The piezoelectric transformer serves to convert the voltage level of the low amplitude signal to a higher voltage level to drive the sensor. produced by a battery in the IMD to voltage levels appropriate for IMD operation. A piezoelectric transformer offers small size and low profile, as well as operational efficiency, and permits the IMD to transmit a low amplitude signal to a remote sensor deployed within an implantable lead. In addition, the piezoelectric transformer provides electrical isolation that reduces electromagnetic interference among different sensors.
摘要翻译：通常，本发明涉及具有压电变压器以为基于铅的传感器供电的IMD。 IMD用低幅度信号为压电变压器供电。压电变压器用于将低振幅信号的电压电平转换为更高的电压电平以驱动传感器。由IMD中的电池产生的电压水平适合于IMD操作。压电变压器提供小尺寸和低轮廓以及操作效率，并允许IMD将低振幅信号传输到部署在可植入导线内的远程传感器。此外，压电变压器提供电隔离，减少不同传感器之间的电磁干扰。

5. 发明申请

WO2004034997A3 MEDICAL DEVICE SYSTEM WITH RELAYING MODULE FOR TREATMENT OF NERVOUS SYSTEM DISORDERS 审中-公开
标题翻译：具有用于治疗神经系统疾病的继电器模块的医疗装置系统
公开(公告)号：WO2004034997A3
公开(公告)日：2004-10-14
申请号：PCT/US0332867
申请日：2003-10-15
申请人： MEDTRONIC INC , RISE MARK T , DONDERS ADRIANUS P , SCHAFFNER SCOTT F
发明人： RISE MARK T , DONDERS ADRIANUS P , SCHAFFNER SCOTT F
IPC分类号： A61B17/52 , A61F7/00 , A61N1/00 , A61N1/08 , A61N1/32 , A61N1/36 , A61N1/372 , A61N2/00 , A61L9/22 , A61N1/01
CPC分类号： A61N2/00 , A61N1/08 , A61N1/32 , A61N1/36082 , A61N1/36135 , A61N1/37229 , A61N1/37252
摘要： Apparatus and method facilitates communications between an implanted component (1405) and an external component (950) of a medical device system through a relaying module (1415). The medical device system provides treatment to a patient for a nervous system disorder. The relaying module (1415) (which may be worn by the patient) provides telemetry channels between the implanted component (1405) and the relaying module (1415) and between the telemetry module (1421) and the external component (950). With an implantable configuration the implanted component (1405) comprises a monitoring (20) componet, a treatment therapy unit (30), an interfacing unit (22), and a processing unit (24), and the external component comprises a programmer (23). With a hybrid configuration the implanted component (953) comprises a monitoring element (952), a treatment delivery unit (955), and an interfacing unit (951), and the external component comprises a processing unit (950). With an external configuration, the implanted component comprises a monitoring element (101) and a treatment delivery unit (107), and the external component comprises an interfacing unit (103) and a processing unit (105).
摘要翻译：装置和方法通过中继模块（1415）有助于植入部件（1405）和医疗装置系统的外部部件（950）之间的通信。医疗装置系统为患者提供神经系统障碍的治疗。中继模块（1415）（其可以由患者佩戴）在植入部件（1405）和中继模块（1415）之间以及遥测模块（1421）和外部组件（950）之间提供遥测通道。通过植入式构造，植入部件（1405）包括监控（20）部件，治疗治疗单元（30），接口单元（22）和处理单元（24），并且外部部件包括编程器（23 ）。通过混合配置，植入部件（953）包括监视元件（952），处理传送单元（955）和接口单元（951），并且外部部件包括处理单元（950）。利用外部配置，植入部件包括监视元件（101）和处理传送单元（107），并且外部部件包括接口单元（103）和处理单元（105）。

6. 发明专利

AU2013202803B2 Devices for regulation of blood pressure and heart rate 未知
公开(公告)号：AU2013202803B2
公开(公告)日：2016-03-17
申请号：AU2013202803
申请日：2013-03-04
申请人： ENTEROMEDICS INC
发明人： DONDERS ADRIANUS P , TWEDEN KATHERINE S , KNUDSON MARK B , THORNTON ARNOLD W
IPC分类号： A61N1/00 , A61B5/296
摘要： A method and apparatus for treating a condition associated with impaired blood pressure and/or heart rate in a subject comprising applying an electrical 5 treatment signal, wherein the electrical treatment signal is selected to at least partially block nerve impulses, or in some embodiments, to augment nerve impulses. In embodiments, the apparatus provides a first therapy program to provide a downregulating signal to one or more nerves including renal artery, renal nerve, vagus nerve, celiac plexus, a splanchnic nerve, cardiac sympathetic nerves, spinal 10 nerves originating between Ti to L5. In embodiments, the apparatus provides a third therapy program to provide an upregulating signal to one or more nerves including a glossopharyngeal nerve and/ or a tissue containing baroreceptors.

7. 发明专利

AU2014201907A1 Implantable therapy system 未知
公开(公告)号：AU2014201907A1
公开(公告)日：2014-04-17
申请号：AU2014201907
申请日：2014-04-02
申请人： ENTEROMEDICS INC
发明人： DONDERS ADRIANUS P , WEIJAND KOEN J , LAMBERT SCOTT ANTHONY , SPAR GREGORY PAT , STULTZ MARK RAYMOND , VALLAPUREDDY VINEEL , LAUGHLIN JOHN CHARLES
IPC分类号： A61N1/36 , A61N1/372
摘要： Abstract A system for applying therapy to an internal anatomical feature of a body of a patient comprising, an external component including an external antenna configured to be placed 5 above a skin layer of a patient, the external component including a memory configured to store therapy programs and therapy schedules, the external component also including a user interface configured to receive input from a user and to display output to the user, the input including a selection of one of the therapy programs and one of the therapy schedules and an implantable component for placement in the body of the patient beneath 10 the skin layer, the implantable component including an implanted antenna configured to communicate with the external antenna across the skin layer through radiofrequency communication, the implantable component being configured to receive the selected therapy program and the selected therapy schedule from the external component via the external and implanted antennas, the implantable component being adapted to be 15 selectively configured into one of a training mode, a placebo mode, and a delivery mode, the implantable component being configured to apply therapy to the internal anatomical feature in accordance with the selected therapy program and the selected therapy schedule when configured in the delivery mode, and the implantable component being configured to refrain from generating electrical therapy signals when configured in the 20 training mode, and the implantable component being configured to supply therapy signals to a resistor located within the implantable component to drain an internal power source of the implantable component when configured in the placebo mode, wherein an external charger interacts with the patient as if therapy is being applied when the therapy signals are applied to the resistor during the placebo mode. 52587751 (GHMalters) P82937AU I

8. 发明专利

AU2006280277A1 Neural electrode treatment 未知
公开(公告)号：AU2006280277A1
公开(公告)日：2007-02-22
申请号：AU2006280277
申请日：2006-08-01
申请人： ENTEROMEDICS INC
发明人： DONDERS ADRIANUS P , WEIJAND KOEN J , KNUDSON MARK B
IPC分类号： A61N1/36
摘要： An apparatus for applying a signal to a nerve for the treatment of a disorder includes a first electrode and a second electrode. Each of the electrodes is adapted to be secured to a nerve of a patient. A signal generator is electrically connected to each of the first and second electrodes. The signal generator is adapted to create a signal having a first waveform at the first electrode and a second waveform at the second electrode. The waveforms have parameters selected to block propagation of neural action potentials. The waveforms have a repeating pattern of cycles of pulses with a delay period between at least selected ones of said pulses. In one embodiment, the first and second waveforms are out of phase for a cycle of one of the waveforms to occur during a delay period of the other of the waveforms.

9. 发明专利

CA2899634A1 ENERGY EFFICIENT NEUROMODULATION 未知
公开(公告)号：CA2899634A1
公开(公告)日：2014-07-31
申请号：CA2899634
申请日：2014-01-24
申请人： ENTEROMEDICS INC
发明人： WAATAJA JONATHAN J , DONDERS ADRIANUS P , SPAR GREGORY P
IPC分类号： A61N1/36
摘要： A therapy system for applying an electrical signal to a target nerve includes an electrode, an implantable component and an external component. The electrode has an impedance of at least about 2000 ohms. The electrical signal is applied using constant current or constant voltage.

10. 发明专利

AU2014201907B2 Implantable therapy system 未知
公开(公告)号：AU2014201907B2
公开(公告)日：2015-06-18
申请号：AU2014201907
申请日：2014-04-02
申请人： ENTEROMEDICS INC
发明人： DONDERS ADRIANUS P , WEIJAND KOEN J , LAMBERT SCOTT ANTHONY , SPAR GREGORY PAT , STULTZ MARK RAYMOND , VALLAPUREDDY VINEEL , LAUGHLIN JOHN CHARLES
IPC分类号： A61N1/36 , A61N1/372
摘要： Abstract A system for applying therapy to an internal anatomical feature of a body of a patient comprising, an external component including an external antenna configured to be placed 5 above a skin layer of a patient, the external component including a memory configured to store therapy programs and therapy schedules, the external component also including a user interface configured to receive input from a user and to display output to the user, the input including a selection of one of the therapy programs and one of the therapy schedules and an implantable component for placement in the body of the patient beneath 10 the skin layer, the implantable component including an implanted antenna configured to communicate with the external antenna across the skin layer through radiofrequency communication, the implantable component being configured to receive the selected therapy program and the selected therapy schedule from the external component via the external and implanted antennas, the implantable component being adapted to be 15 selectively configured into one of a training mode, a placebo mode, and a delivery mode, the implantable component being configured to apply therapy to the internal anatomical feature in accordance with the selected therapy program and the selected therapy schedule when configured in the delivery mode, and the implantable component being configured to refrain from generating electrical therapy signals when configured in the 20 training mode, and the implantable component being configured to supply therapy signals to a resistor located within the implantable component to drain an internal power source of the implantable component when configured in the placebo mode, wherein an external charger interacts with the patient as if therapy is being applied when the therapy signals are applied to the resistor during the placebo mode. 52587751 (GHMalters) P82937AU I

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