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1. 发明申请

WO2009075923A3 6, 11-BRIDGED BIARYL MACROLIDES 审中-公开
标题翻译： 6，11-BRIDGED BIARYL MACROLIDES
公开(公告)号：WO2009075923A3
公开(公告)日：2009-09-24
申请号：PCT/US2008076731
申请日：2008-09-17
申请人： ENANTA PHARM INC , KIM IN JONG , LIU TONGZHU , LONG JIANG , WANG GUOQIANG , QUI YAO-LING , KIM HEEJIN , WANG YANCHUN , PHAN LY TAM , OR YAT SUN
发明人： KIM IN JONG , LIU TONGZHU , LONG JIANG , WANG GUOQIANG , QUI YAO-LING , KIM HEEJIN , WANG YANCHUN , PHAN LY TAM , OR YAT SUN
IPC分类号： C07D401/00
CPC分类号： C07H17/08 , C07D213/69 , C07D213/80 , C07D309/40 , C07D498/12
摘要： The present invention discloses compounds of formula I, II or, or pharmaceutically acceptable salts, esters, or prodrugs thereof: (formulas) which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译：本发明公开了式I，II或其药学上可接受的盐，酯或前药的化合物：具有抗菌性质的（式）。本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。本发明还包括制备本发明化合物的方法。

2. 发明申请

WO2008014221A3 BRIDGED CARBAMATE MACROLIDES 审中-公开
公开(公告)号：WO2008014221A3
公开(公告)日：2008-11-20
申请号：PCT/US2007074157
申请日：2007-07-24
申请人： ENANTA PHARM INC , KIM HEEJIN , PHAN LY TAM , OR YAT SUN
发明人： KIM HEEJIN , PHAN LY TAM , OR YAT SUN
IPC分类号： A61K31/70 , C07H17/08
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formulae (I) and (II) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译：本发明公开了式（I）和（II）的化合物或其药学上可接受的盐，酯或前药：它们表现出抗菌特性。本发明还涉及包含前述化合物的药物组合物，用于向需要抗生素治疗的受试者施用。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。本发明还包括制备本发明化合物的方法。

3. 发明公开

EP2203435A4 6, 11-BRIDGED BIARYL MACROLIDES 失效
标题翻译： 6,11-桥联芳基大环内酯类
公开(公告)号：EP2203435A4
公开(公告)日：2011-03-02
申请号：EP08859833
申请日：2008-09-17
申请人： ENANTA PHARM INC
发明人： KIM IN JONG , LIU TONGZHU , LONG JIANG , WANG GUOQIANG , QIU YAO-LING , KIM HEEJIN , WANG YANCHUN , PHAN LY TAM , OR YAT SUN
IPC分类号： C07D401/00 , A61K31/7004 , A61P29/00 , A61P31/00 , C07H17/08
CPC分类号： C07H17/08 , C07D213/69 , C07D213/80 , C07D309/40 , C07D498/12
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

4. 发明专利

AU2008335668B2 6, 11-bridged biaryl macrolides 未知
公开(公告)号：AU2008335668B2
公开(公告)日：2012-07-26
申请号：AU2008335668
申请日：2008-09-17
申请人： ENANTA PHARM INC
发明人： OR YAT SUN , WANG YANCHUN , LIU TONGZHU , WANG GUOQIANG , KIM IN JONG , QUI YAO-LING , KIM HEEJIN , LONG JIANG , PHAN LY TAM
IPC分类号： C07D401/00 , A61K31/7052 , C07H17/08
摘要： The present invention discloses compounds of formula I, II or, or pharmaceutically acceptable salts, esters, or prodrugs thereof: (formulas) which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

5. 发明专利

PT1506214E DERIVADOS DE CETÓLIDO 6-11 BICÍCLICOS 未知
公开(公告)号：PT1506214E
公开(公告)日：2010-04-27
申请号：PT03733983
申请日：2003-05-09
申请人： ENANTA PHARM INC
发明人： OR YAT SUN , WANG GUOQIANG , PHAN LY TAM , NIU DEQIANG , VO NHA HUU , QIU YAO-LING , BUSUYEK MARINA , WANG YANCHUN , HOU YING , PENG YULIN , KIM HEEJIN , LIU TONGZHU , FARMER JAY JUDSON , XU GUOYOU
IPC分类号： C07H17/08 , A61K31/7048 , A61P31/04

6. 发明申请

WO2011059185A2 PRODUCTION METHOD FOR A NANOCOMPOSITE HAVING IMPROVED THERMOELECTRIC EFFICIENCY, AND NANOCOMPOSITES PRODUCED THEREBY 审中-公开
标题翻译：具有改进的热电效率的纳米复合材料的生产方法和生产的纳米复合材料
公开(公告)号：WO2011059185A2
公开(公告)日：2011-05-19
申请号：PCT/KR2010007244
申请日：2010-10-21
申请人： UNIV EWHA IND COLLABORATION , KIM SUNG-JIN , HAN MI-KYUNG , KIM HEEJIN
发明人： KIM SUNG-JIN , HAN MI-KYUNG , KIM HEEJIN
CPC分类号： H01L35/16
摘要： The present invention relates to a production method for a nanocomposite having improved thermoelectric efficiency and to nanocomposites produced thereby, and more specifically relates to a production method for a nanocomposite having improved thermoelectric efficiency, comprising the steps of: producing a MTe (M = Cd or Zn) by adding a surfactant to a surface-treated MO having a coordinating ligand, and then injecting Te metal powder at high-temperature (Step 1); producing an MTe-NTe (N = Pb or Sn) having a core-shell structure by injecting an N precursor into the MTe produced in Step 1 (Step 2); and mixing bulk Nte with the nanoparticulate MTe-NTe produced in Step 2 and carrying out a preliminary heat treatment and then a heat treatment (Step 3); and also relates to nanocomposites obtained by the mixing of bulk NTe (N = Pb or Sn) with MTe-NTe nanoparticles (M = Cd or Zn) having a core-shell structure of a form in which the NTe forms a sphere surrounding the circumference of spherical nanoparticulate MTe. The production method for a nanocomposite having improved thermoelectric efficiency according to the present invention can be used to advantage for thermoelectric materials in the fields of thermoelectric cooling and thermoelectric electrical power generation since it allows the high-temperature injection method to be used in order to produce core-shell nanoparticles of uniform size, and PbTe or SnTe of bulk size is mixed in to produce a nanocomposite, thereby simultaneously controlling both the thermal and the electrical properties and so exhibiting improved thermoelectric efficiency.
摘要翻译：本发明涉及具有改善的热电效率的纳米复合材料的制造方法和由此制备的纳米复合材料的制造方法，更具体地说涉及一种具有改进的热电效率的纳米复合材料的制造方法，包括以下步骤：制备MTe（M = Cd或 Zn），然后在高温下注入Te金属粉末（步骤1），将表面活性剂添加到具有配位配体的表面处理的MO中。通过将N前体注入到步骤1（步骤2）中制备的MTe中来生产具有核 - 壳结构的MTe-NTe（N = Pb或Sn）; 并将大块Nte与步骤2中生产的纳米颗粒MTe-NTe混合并进行预热处理，然后进行热处理（步骤3）; 并且还涉及通过将本体NTe（N = Pb或Sn）与具有核壳结构的MTe-NTe纳米颗粒（M = Cd或Zn）混合而获得的纳米复合材料，其中NTe形成围绕圆周的球体球形纳米颗粒MTe。根据本发明的具有改进的热电效率的纳米复合材料的制造方法可以用于热电冷却和热电发电领域的热电材料，因为它允许使用高温注射方法来生产将尺寸均匀的核 - 壳纳米粒子和体积尺寸的PbTe或SnTe混合以制备纳米复合材料，从而同时控制热和电性质，并且因此表现出改善的热电效率。

7. 发明专利

CA2699733C 6,11-BRIDGED BIARYL MACROLIDES 未知
公开(公告)号：CA2699733C
公开(公告)日：2013-01-22
申请号：CA2699733
申请日：2008-09-17
申请人： ENANTA PHARM INC
发明人： KIM IN JONG , LIU TONGZHU , LONG JIANG , WANG GUOQIANG , QIU YAO-LING , KIM HEEJIN , WANG YANCHUN , PHAN LY TAM , OR YAT SUN
IPC分类号： C07H17/08 , A61K31/4439 , A61K31/506 , A61K31/706 , A61P29/00 , A61P31/04 , A61P43/00
摘要： The present invention discloses compounds of formula I, II or, or pharmaceutically acceptable salts, esters, or prodrugs thereof: (formulas) which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

8. 发明专利

DK1506214T3 6-11 bicykliske ketolidderivater 未知
公开(公告)号：DK1506214T3
公开(公告)日：2010-05-25
申请号：DK03733983
申请日：2003-05-09
申请人： ENANTA PHARM INC
发明人： WANG YANCHUN , PENG YULIN , OR YAT SUN , WANG GUOQIANG , NIU DEQIANG , QIU YAO-LING , BUSUYEK MARINA , HOU YING , LIU TONGZHU , XU GUOYOU , PHAN LY TAM , KIM HEEJIN , VO NHA HUU , FARMER JAY JUDSON
IPC分类号： C07H17/08 , A61K31/7048 , A61P31/04

9. 发明专利

CA2699733A1 6, 11-BRIDGED BIARYL MACROLIDES 未知
公开(公告)号：CA2699733A1
公开(公告)日：2009-06-18
申请号：CA2699733
申请日：2008-09-17
申请人： ENANTA PHARM INC
发明人： KIM IN JONG , LIU TONGZHU , LONG JIANG , WANG GUOQIANG , QUI YAO-LING , KIM HEEJIN , WANG YANCHUN , PHAN LY TAM , OR YAT SUN
IPC分类号： C07H17/08 , A61K31/7048 , A61K31/7052
摘要： The present invention discloses compounds of formula I, II or, or pharmaceutically acceptable salts, esters, or prodrugs thereof: (formulas) which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

10. 发明专利

AU2008335668A1 6, 11-bridged biaryl macrolides 未知
公开(公告)号：AU2008335668A1
公开(公告)日：2009-06-18
申请号：AU2008335668
申请日：2008-09-17
申请人： ENANTA PHARM INC
发明人： KIM IN JONG , WANG YANCHUN , WANG GUOQIANG , KIM HEEJIN , LONG JIANG , QUI YAO-LING , OR YAT SUN , PHAN LY TAM , LIU TONGZHU
IPC分类号： C07D401/00 , A61K31/7052 , C07H17/08
摘要： The present invention discloses compounds of formula I, II or, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

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