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1. 发明专利

IL269859D0 Process for preparations of sulfonyl carbamate bile acid derivatives 未知
公开(公告)号：IL269859D0
公开(公告)日：2019-11-28
申请号：IL26985919
申请日：2019-10-07
申请人： ENANTA PHARM INC , WANG GUOQIANG , HE YONG , GRANGER BRETT , XING XUECHAO , OR YAT SUN
发明人： WANG GUOQIANG , HE YONG , GRANGER BRETT , XING XUECHAO , OR YAT SUN
IPC分类号： C07J20060101
摘要： The present invention relates to processes for preparing compounds of Formula (I) and compounds of Formula (II) or a pharmaceutically acceptable salt or solvate thereof. These compounds and pharmaceutical compositions are useful as FXR or TGR5 modulators. Specifically, the present invention relates to bile acid derivatives and methods for their preparation and use. The present invention relates to a process for the preparation of the compounds of Formula (III), Formula (IV), Formula (V), and Formula (VI), The present invention also relates to a process for the preparation of compounds (VII), (VIII) and (IX).

2. 发明申请

WO2013007208A1 METHOD AND APPARATUS FOR SEAMLESS MOBILITY TECHNIQUES IN CONTENT-CENTRIC NETWORK 审中-公开
标题翻译：内容中心网络中无缝移动技术的方法与装置
公开(公告)号：WO2013007208A1
公开(公告)日：2013-01-17
申请号：PCT/CN2012/078574
申请日：2012-07-12
申请人： HUAWEI TECHNOLOGIES CO., LTD. , RAVINDRAN, Ravishankar , ZHANG, Xinwen , WANG, Guoqiang , LO, Sau Man
发明人： RAVINDRAN, Ravishankar , ZHANG, Xinwen , WANG, Guoqiang , LO, Sau Man
IPC分类号： H04L29/06
CPC分类号： H04L67/327
摘要： A networking system for a content-centric-network (CCN)/named-data networking (NDN) comprising a first point of attachment (PoA) configured to communicate with a mobile node (MN) and maintain a forwarding state for the MN to support seamless mobility for the MN, and a second PoA configured to communicate with the MN and obtain the forwarding state for the MN from the first PoA after a handoff of the MN from the first PoA to the second PoA, wherein the forwarding state is used to exchange a plurality of interests and a plurality of data responses between the MN and the CCN/NDN.
摘要翻译：一种用于以内容为中心的网络（CCN）/命名数据网络（NDN））的网络系统，包括配置成与移动节点（MN）进行通信并维护MN的转发状态以支持的第一附着点（PoA） MN的无缝移动性，以及第二PoA，被配置为与MN通信，并且在MN从第一PoA切换到第二PoA之后从第一PoA获得MN的转发状态，其中转发状态被用于在MN和CCN / NDN之间交换多个兴趣和多个数据响应。

3. 发明申请

WO2012167746A1 METHOD FOR FLEXIBLE DATA PROTECTION WITH DYNAMICALLY AUTHORIZED DATA RECEIVERS IN A CONTENT NETWORK OR IN CLOUD STORAGE AND CONTENT DELIVERY SERVICES 审中-公开
标题翻译：在内容网络或云存储和内容交付服务中具有动态授权数据接收器的灵活数据保护方法
公开(公告)号：WO2012167746A1
公开(公告)日：2012-12-13
申请号：PCT/CN2012/076691
申请日：2012-06-11
申请人： HUAWEI TECHNOLOGIES CO., LTD. , ZHANG, Xinwen , XIONG, Huijun , WANG, Guoqiang
发明人： ZHANG, Xinwen , XIONG, Huijun , WANG, Guoqiang
IPC分类号： H04L9/14
CPC分类号： G06F21/6218 , H04L9/0833 , H04L63/0464 , H04L63/0478 , H04L63/104 , H04L67/10 , H04L2209/601
摘要： A networking system comprising an application service that runs on a cloud infrastructure and is configured to receive dual encrypted content from a content provider and re- encrypt the dual encrypted content to enable dynamic user group control for group-based user authorization, and a cloud storage service coupled to the application service and configured to store the dual encrypted content from the content provider and the re-encrypted dual encrypted content from the application service, wherein the application service and the storage service are configured to communicate and operate with a content delivery service that uses a content delivery network (CDN) to deliver the re-encrypted content to one or more users in a group authorized by the content provider.
摘要翻译：一种网络系统，包括在云基础设施上运行的应用服务，并且被配置为从内容提供商接收双加密内容，并重新加密双加密内容，以实现基于组的用户授权的动态用户组控制，以及云存储服务，其被配置为存储来自内容提供商的双加密内容和来自应用服务的重新加密的双加密内容，其中应用服务和存储服务被配置为与内容传递服务进行通信和操作其使用内容递送网络（CDN）将重新加密的内容递送到由内容提供商授权的组中的一个或多个用户。

4. 发明申请

WO2012158861A2 PROCESSES FOR THE PREPARATION OF 5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID AND ITS DERIVATIVES 审中-公开
标题翻译：制备5-亚苄基[2.4]庚-6-烯羧酸及其衍生物的方法
公开(公告)号：WO2012158861A2
公开(公告)日：2012-11-22
申请号：PCT/US2012038240
申请日：2012-05-17
申请人： ENANTA PHARM INC , QIU YAO-LING , PENG XIAOWEN , KIM IN JONG , CAO HUI , TANG DATONG , OR YAT SUN , WANG GUOQIANG , XU GUOYOU
发明人： QIU YAO-LING , PENG XIAOWEN , KIM IN JONG , CAO HUI , TANG DATONG , OR YAT SUN , WANG GUOQIANG , XU GUOYOU
IPC分类号： C07D209/54
CPC分类号： C07D209/54
摘要： The present invention relates generally to an improved process for the preparation of 5-azaspiro[2.4]heptane-6-carboxylic acid and its derivatives which are useful intermediates in the synthesis of biologically active molecules, especially in the synthesis of hepatits C virus NS5A inhibitors. In particular, the present invention relates to processes and intermediates for the preparation of compounds of formulae (la), (lb) and (Ic):
摘要翻译：本发明一般涉及一种制备5-氮杂螺[2.4]庚烷-6-羧酸及其衍生物的改进方法，其在合成生物活性分子中是有用的中间体，特别是在合成肝素C病毒NS5A抑制剂。特别地，本发明涉及制备式（Ia），（Ib）和（Ic）化合物的方法和中间体：

5. 发明申请

WO2012003759A1 System and Method for Content and Application Acceleration in a Wireless Communications System 审中-公开
标题翻译：无线通信系统中内容和应用加速的系统与方法
公开(公告)号：WO2012003759A1
公开(公告)日：2012-01-12
申请号：PCT/CN2011/075593
申请日：2011-06-10
申请人： HUAWEI TECHNOLOGIES CO., LTD. , JIM, Zhao , WANG, Guoqiang
发明人： JIM, Zhao , WANG, Guoqiang
IPC分类号： H04L12/56
CPC分类号： H04L67/2847 , H04L67/02 , H04L67/2842 , H04L69/16 , H04W4/18
摘要： A system and method for content and application acceleration in a wireless communications system are provided. A method for transmitting data includes receiving a block of data from a content provider, generating a signature from the block of data, and determining if the signature exists in a content cache. The content cache includes previously transmitted signatures and blocks of data associated with the previously transmitted signatures. The method also includes if the signature exists in the content cache, saving the signature but not the block of data in a buffer. The method further includes if the signature does not exist in the content cache, saving the block of data in the buffer. The method additionally includes transmitting contents of the buffer over a backhaul link.
摘要翻译：提供了一种用于无线通信系统中的内容和应用加速的系统和方法。用于发送数据的方法包括从内容提供者接收数据块，从数据块生成签名，以及确定签名是否存在于内容高速缓存中。内容缓存包括先前发送的签名和与先前发送的签名相关联的数据块。该方法还包括如果签名存在于内容高速缓存中，则在缓冲器中保存签名而不是数据块。该方法还包括如果签名不存在于内容高速缓存中，则将数据块保存在缓冲器中。该方法还包括通过回程链路发送缓冲器的内容。

6. 发明申请

WO2010132163A1 MACROCYCLIC COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS 审中-公开
标题翻译：大环化合物作为丙型肝炎病毒抑制剂
公开(公告)号：WO2010132163A1
公开(公告)日：2010-11-18
申请号：PCT/US2010/030850
申请日：2010-04-13
申请人： ENANTA PHARMACEUTICALS, INC. , GAI, Yonghua , OR, Yat Sun , WANG, Guoqiang
发明人： GAI, Yonghua , OR, Yat Sun , WANG, Guoqiang
IPC分类号： A61K38/21
CPC分类号： A61K38/21 , A61K45/06 , C07K5/06034 , C07K5/0808 , C07K5/0812 , A61K2300/00
摘要： The present invention discloses compounds of formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

7. 发明申请

WO2015054604A1 FRAMEWORK FOR SCREEN CONTENT SHARING SYSTEM WITH GENERALIZED SCREEN DESCRIPTIONS 审中-公开
标题翻译：用于屏幕内容共享系统的框架，具有通用的屏幕描述
公开(公告)号：WO2015054604A1
公开(公告)日：2015-04-16
申请号：PCT/US2014/060086
申请日：2014-10-10
申请人： FUTUREWEI TECHNOLOGIES, INC. , HUAWEI TECHNOLOGIES CO., LTD. , WANG, Xin , GUAN, Xinjie , WANG, Guoqiang , YU, Haoping
发明人： WANG, Xin , GUAN, Xinjie , WANG, Guoqiang , YU, Haoping
IPC分类号： G06F3/048
CPC分类号： H04L12/1822 , G06F9/44 , G06F9/452
摘要： A framework for a screen content sharing system with generalized screen descriptions is described. In one approach, a screen content update message is sent from a client device to a control plane where the client device wishes to share its screen content with a remote device. The remote device sends a message indicating an interest in receiving said update. The control plane subsequently retrieves a detailed description from the client device. Based on the computational context of the remote device, the detailed description may be trimmed to a more compatible format. In some embodiments, the detailed description is sent to the remote device and includes a screen description and a content description. The content of the shared screen is described and the content is subsequently retrieved from a service router. A shared screen content is assembled based on the screen description and the content retrieved from the service router.
摘要翻译：描述了具有广义屏幕描述的屏幕内容共享系统的框架。在一种方法中，屏幕内容更新消息从客户端设备发送到控制平面，在该控制平面上，客户端设备希望与远程设备共享其屏幕内容。远程设备发送指示接收所述更新的兴趣的消息。控制平面随后从客户端设备检索详细描述。基于远程设备的计算上下文，可以将详细描述修剪成更兼容的格式。在一些实施例中，详细描述被发送到远程设备，并且包括屏幕描述和内容描述。描述共享屏幕的内容，随后从服务路由器检索内容。基于屏幕描述和从服务路由器检索的内容来组合共享屏幕内容。

8. 发明申请

WO2012092867A1 METHOD AND APPARATUS TO CREATE AND MANAGE A DIFFERENTIATED SECURITY FRAMEWORK FOR CONTENT ORIENTED NETWORKS 审中-公开
标题翻译：用于创建和管理面向内容网络的差异化安全框架的方法和设备
公开(公告)号：WO2012092867A1
公开(公告)日：2012-07-12
申请号：PCT/CN2012/070060
申请日：2012-01-05
申请人： HUAWEI TECHNOLOGIES CO., LTD. , ZHANG, Xinwen , RAVINDRAN, Ravishankar , WANG, Guoqiang , SHI, Guangyu
发明人： ZHANG, Xinwen , RAVINDRAN, Ravishankar , WANG, Guoqiang , SHI, Guangyu
IPC分类号： H04L9/32
CPC分类号： G06F21/10 , G06F2221/2141 , H04L9/0833 , H04L9/3247 , H04L63/104 , H04L63/123 , H04L2209/60
摘要： A network component comprising a receiver configured to receive a signed content item and an associated security information from a publisher, wherein the security information indicates which group from a plurality of groups is allowed to access the signed content item, a storage unit configured to cache the content item and the associated security information, a processor to implement procedures to enforce security policies defined by the security information, and a transmitter configured to send the signed content item from the cache to a subscriber when the subscriber is a member of a group indicated by the security information as authorized to access the signed content item.
摘要翻译：一种网络组件，包括被配置为从发布者接收已签名的内容项和相关联的安全信息的接收器，其中，所述安全信息指示来自多个组的哪个组被允许访问所签署的内容项，存储单元，内容项目和相关联的安全信息;处理器，用于实施用于执行由所述安全信息定义的安全策略的过程;以及发射机，被配置为当所述用户是由所述用户组成的群组的成员时，将所签署的内容项目从所述高速缓存发送到订户授权访问签名的内容项的安全信息。

9. 发明申请

WO2009075923A3 6, 11-BRIDGED BIARYL MACROLIDES 审中-公开
标题翻译： 6，11-BRIDGED BIARYL MACROLIDES
公开(公告)号：WO2009075923A3
公开(公告)日：2009-09-24
申请号：PCT/US2008076731
申请日：2008-09-17
申请人： ENANTA PHARM INC , KIM IN JONG , LIU TONGZHU , LONG JIANG , WANG GUOQIANG , QUI YAO-LING , KIM HEEJIN , WANG YANCHUN , PHAN LY TAM , OR YAT SUN
发明人： KIM IN JONG , LIU TONGZHU , LONG JIANG , WANG GUOQIANG , QUI YAO-LING , KIM HEEJIN , WANG YANCHUN , PHAN LY TAM , OR YAT SUN
IPC分类号： C07D401/00
CPC分类号： C07H17/08 , C07D213/69 , C07D213/80 , C07D309/40 , C07D498/12
摘要： The present invention discloses compounds of formula I, II or, or pharmaceutically acceptable salts, esters, or prodrugs thereof: (formulas) which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译：本发明公开了式I，II或其药学上可接受的盐，酯或前药的化合物：具有抗菌性质的（式）。本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。本发明还包括制备本发明化合物的方法。

10. 发明申请

WO2007044927A2 6, 11-BRIDGED TRICYCLIC MACROLIDES 审中-公开
标题翻译： 6,11-桥三环宏观
公开(公告)号：WO2007044927A2
公开(公告)日：2007-04-19
申请号：PCT/US2006/040243
申请日：2006-10-12
申请人： ENANTA PHARMACEUTICALS, INC. , OR, Yat, Sun , WANG, Guoqiang , LIU, Tongzhu , PHAN, Ly, Tam
发明人： OR, Yat, Sun , WANG, Guoqiang , LIU, Tongzhu , PHAN, Ly, Tam
IPC分类号： C07H17/08 , A61K31/7052
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译：本发明公开了式（I）的化合物或其药学上可接受的盐，酯或前药：其表现出抗菌特性。本发明还涉及包含前述化合物的药物组合物，用于向需要抗生素治疗的受试者施用。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。本发明还包括制备本发明化合物的方法。

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