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1. 发明公开

EP2879572A2 DEVICES AND METHODS FOR WEARABLE INJECTION GUIDES 审中-公开
标题翻译：用于可佩戴注射指导的装置和方法
公开(公告)号：EP2879572A2
公开(公告)日：2015-06-10
申请号：EP13828529.1
申请日：2013-08-05
申请人： Elwha LLC
发明人： BANGERA, Mahalaxmi Gita , BOYDEN, Edward S. , CHIN, Hon Wah , DELLA ROCCA, Gregory J. , HAWKINS, Daniel , HYDE, Roderick A. , ISHIKAWA, Muriel Y. , KARE, Jordin T. , LANGER, Robert , LEUTHARDT, Eric C. , MALASKA, Stephen L. , MYCKATYN, Terence , PARIKH, Parag Jitendra , RIVET, Dennis J. , SHIMONY, Joshua S. , SMITH, Michael A. , SWEENEY, Elizabeth A. , TEGREENE, Clarence T. , WOLDA, Sharon L. , WOOD, Lowell L., Jr.
IPC分类号： A61B5/00
CPC分类号： A61B34/10 , A61B17/3403 , A61B2017/3411 , A61B2034/108 , A61B2090/363 , A61M5/422 , A61M5/427 , A61M5/46 , A61M2205/13 , A61M2207/00 , A61M2210/0606 , B29C64/386 , B29C67/0088 , B33Y50/02 , B33Y80/00 , G05B19/4099 , G05B2219/35134 , G05B2219/49007 , G06F17/5086
摘要： Wearable injection guides and manufacture and use thereof are described, which include: a rigid material formed to substantially conform in shape to a topography of a body region of an individual, the rigid material substantially impenetrable to an injection needle, and the rigid material including one or more injection needle access regions arranged in a treatment pattern.
摘要翻译：描述了可佩戴注射导向器及其制造和使用，其包括：刚性材料，其形成为基本上符合个体身体区域的形状，所述刚性材料基本上不可渗透到注射针，并且所述刚性材料包括一个或以更多的注射针进入区域布置在治疗模式中。

2. 发明公开

EP3036338A1 SYSTEMS, METHODS, AND DEVICES FOR ASSESSING MICROBIOTA OF SKIN 审中-公开
标题翻译： SYSTEME，VERFAHREN UND VORRICHTUNG ZUR BEURTEILUNG DER MIKROBIATA VON HAUT
公开(公告)号：EP3036338A1
公开(公告)日：2016-06-29
申请号：EP14837532.2
申请日：2014-08-20
申请人： ELWHA, LLC
发明人： BANGERA, Mahalaxmi Gita , BAYM, Michael H. , HYDE, Roderick A. , KARE, Jordin T. , LEUTHARDT, Eric C. , MCKNIGHT, Gary L. , PAN, Tony S. , SHARADIN, Katherine E. , SWEENEY, Elizabeth A. , TEGREENE, Clarence T. , WOOD, Lowell L. Jr.
IPC分类号： C12Q1/04 , G01N33/53
CPC分类号： G01N33/569 , A61B10/02 , G01N15/0612 , G01N2001/028 , G16H30/40 , G16H50/20 , Y02A90/26
摘要： Devices, systems, and methods for assessing microbiota of skin are described which include: a skin-covering material with an inner surface conforming in shape to a topography of a skin surface and including a microbe-capture region; an image-capture device to capture a least one image of the inner surface of the skin-covering material and to transform the captured at least one image into a digital output including information associated with at least one property and a spatial distribution of at least one type of microbe bound to the microbe-capture region; and a computing device including circuitry configured to receive the digital output from the image-capture device, compare the at least one property of the at least one type of microbe with a database of reference microbe properties, and generate a digital profile including the at least one property and the spatial distribution of the at least one type of microbe bound to the microbe-capture region of the skin-covering material.
摘要翻译：描述了用于评估皮肤微生物的装置，系统和方法，其包括：皮肤覆盖材料，其内表面的形状符合皮肤表面的形貌并且包括微生物捕获区域; 用于捕获皮肤覆盖材料的内表面的至少一个图像并且将所捕获的至少一个图像转换为数字输出的图像捕获装置，所述数字输出包括与至少一个属性和空间分布有关的信息与微生物捕获区结合的微生物类型; 以及计算设备，其包括被配置为从所述图像捕获设备接收所述数字输出的电路，将所述至少一种类型的微生物的所述至少一种性质与参考微生物属性的数据库进行比较，并且生成包括至少所述至少一种类型的微生物的一种性质和与所述皮肤覆盖材料的微生物捕捉区域结合的空间分布。

3. 发明申请

WO2015026973A1 SYSTEMS, METHODS AND DEVICES FOR ASSESSING MICROBIOTA OF SKIN 审中-公开
标题翻译：用于评估皮肤微生物的系统，方法和装置
公开(公告)号：WO2015026973A1
公开(公告)日：2015-02-26
申请号：PCT/US2014/051934
申请日：2014-08-20
申请人： ELWHA LLC
发明人： BANGERA, Mahalaxmi Gita , BAYM, Michael H. , HYDE, Roderick A. , KARE, Jordin T. , LEUTHARDT, Eric C. , MCKNIGHT, Gary L. , PAN, Tony S. , SHARADIN, Katherine E. , SWEENEY, Elizabeth A. , TEGREENE, Clarence T. , WOOD, Lowell L., Jr.
IPC分类号： C12Q1/04 , G01N33/52
CPC分类号： A61B10/02 , A61F13/15 , G01N33/56911 , G01N33/56938 , H04N5/23229
摘要： Devices, systems, and methods for assessing microbiota of skin are described, including: a skin-covering material including an inner surface and an outer surface, the inner surface substantially conforming to a topography of a skin surface of an individual and including a plurality of signal-generating complexes, one or more of the plurality of signal-generating complexes configured to emit one or more signals in response to at least one type of microbe; an image capture device to capture an image of the inner surface of the skin-covering material, the image including one or more signals emitted from the plurality of signal-generating complexes, and to transform the image into a digital output; and a computing device including circuitry configured to receive the digital output, compare the properties of the imaged one or more signals with a database of reference signal-generating complexes, and generate a digital spatial profile of microbes on the skin-covering material.
摘要翻译：描述了用于评估皮肤的微生物群的装置，系统和方法，包括：包括内表面和外表面的皮肤覆盖材料，所述内表面基本上符合个体的皮肤表面的形貌并且包括多个信号产生复合体，多个信号发生复合体中的一个或多个被配置为响应于至少一种类型的微生物发射一个或多个信号; 用于捕获皮肤覆盖材料的内表面的图像的图像捕获装置，所述图像包括从所述多个信号生成复合体发射的一个或多个信号，并将图像变换为数字输出; 以及包括被配置为接收数字输出的电路的计算设备，将成像的一个或多个信号的属性与参考信号生成复合体的数据库进行比较，并且在皮肤覆盖材料上生成微生物的数字空间分布。

4. 发明申请

WO2014205042A1 RAPID BREEDING OF ANIMALS 审中-公开
标题翻译：动物快速繁殖
公开(公告)号：WO2014205042A1
公开(公告)日：2014-12-24
申请号：PCT/US2014/042880
申请日：2014-06-18
申请人： ELWHA LLC
发明人： BANGERA, Mahalaxmi Gita , ECKHOFF, Philip A. , HYDE, Roderick A. , JUNG, Edward K.Y. , KINDSVOGEL, Wayne R. , WOOD, Lowell L., Jr.
IPC分类号： C12Q1/04 , C12Q1/68 , C12N5/00 , C12N5/073
CPC分类号： A01K67/02 , A01K67/027 , A01K2227/101 , A01K2267/02 , A61D19/04 , C12N15/873
摘要： Various embodiments disclosed herein include systems, methods, compositions, and products by process for in vitro cycling of gametes for rapid breeding of animals. In certain embodiments, the systems and/or methods are at least partially automated.
摘要翻译：本文公开的各种实施方案包括通过用于动物快速繁殖的配子的体外循环的方法的系统，方法，组合物和产物。在某些实施例中，系统和/或方法至少部分自动化。

5. 发明授权

EP3036339B1 SYSTEMS, METHODS AND DEVICES FOR ASSESSING MICROBIOTA OF SKIN 失效
公开(公告)号：EP3036339B1
公开(公告)日：2018-07-11
申请号：EP14837854.0
申请日：2014-08-20
申请人： ELWHA, LLC
发明人： BANGERA, Mahalaxmi Gita , BAYM, Michael H. , HYDE, Roderick A. , KARE, Jordin T. , LEUTHARDT, Eric C. , MCKNIGHT, Gary L. , PAN, Tony S. , SHARADIN, Katherine E. , SWEENEY, Elizabeth A. , TEGREENE, Clarence T. , WOOD, Lowell L. Jr.
IPC分类号： G01N33/569 , C12Q1/04 , G01N33/52 , H04N5/232 , A61B10/02 , A61F13/15
CPC分类号： A61B10/02 , A61F13/15 , G01N33/56911 , G01N33/56938 , H04N5/23229
摘要： Devices, systems, and methods for assessing microbiota of skin are described, including: a skin-covering material including an inner surface and an outer surface, the inner surface substantially conforming to a topography of a skin surface of an individual and including a plurality of signal-generating complexes, one or more of the plurality of signal-generating complexes configured to emit one or more signals in response to at least one type of microbe; an image capture device to capture an image of the inner surface of the skin-covering material, the image including one or more signals emitted from the plurality of signal-generating complexes, and to transform the image into a digital output; and a computing device including circuitry configured to receive the digital output, compare the properties of the imaged one or more signals with a database of reference signal-generating complexes, and generate a digital spatial profile of microbes on the skin-covering material.

6. 发明公开

EP3185816A1 GASTROINTESTINAL DEVICE WITH ASSOCIATED COMMENSAL MICROBES 无效
标题翻译：具有相关常见微生物的胃肠道装置
公开(公告)号：EP3185816A1
公开(公告)日：2017-07-05
申请号：EP15835975.2
申请日：2015-08-25
申请人： Elwha LLC
发明人： BANGERA, Mahalaxmi Gita , DUNCAN, William David , HYDE, Roderick A. , KINDSVOGEL, Wayne R. , SWEENEY, Elizabeth A.
IPC分类号： A61F2/00 , A61F2/04
CPC分类号： A61F5/0076 , A61F2/04 , A61F2002/045 , A61F2210/0004 , A61F2210/0057 , A61F2210/0076 , A61F2220/0016 , A61F2240/001 , A61K35/74 , A61K35/741 , A61K35/745 , A61K35/747 , A61K38/168 , A61K2035/115 , A61L27/54 , A61L29/08 , A61L29/148 , A61L29/16 , A61L31/005 , A61L31/048 , A61L31/06 , A61L31/10 , A61L31/145 , A61L31/148 , A61L31/16 , A61L2300/252 , A61L2300/604 , A61L2300/62 , A61L2420/02 , A61L2420/06
摘要： A gastrointestinal device and methods of manufacturing said gastrointestinal device are described and include a flexible tubular structure including an inner surface and an outer surface, a plurality of at least one type of commensal microbe associated with at least a portion of at least one of the inner surface and the outer surface, and a proximal end and a distal end, the proximal end and the distal end forming a flow conduit through the flexible tubular structure; and at least one anchor structure including one or more gastric wall-engaging components configured to engage a wall of the gastrointestinal tract of the subject.
摘要翻译：描述了一种胃肠设备和制造所述胃肠设备的方法，其包括柔性管状结构，该柔性管状结构包括内表面和外表面，至少一种与内表面和外表面中的至少一个相关联的微生物促进剂，至少一种微生物促进剂，其被配置为促进至少一种共生微生物以及近端和远端的吸引，集群和生长，所述近端和所述远端形成通过所述柔性管状结构的流动导管; 以及至少一个锚定结构，其包括一个或多个胃壁接合部件，所述一个或多个胃壁接合部件被配置成接合所述对象的胃肠道壁。

7. 发明申请

WO2016033011A1 GASTROINTESTINAL DEVICE WITH ASSOCIATED COMMENSAL MICROBES 审中-公开
标题翻译：具有相关联的通用微波的气体装置
公开(公告)号：WO2016033011A1
公开(公告)日：2016-03-03
申请号：PCT/US2015/046650
申请日：2015-08-25
申请人： ELWHA LLC
发明人： BANGERA, Mahalaxmi Gita , DUNCAN, William David , HYDE, Roderick A. , KINDSVOGEL, Wayne R. , SWEENEY, Elizabeth A.
IPC分类号： A61F2/00 , A61F2/04
CPC分类号： A61F5/0076 , A61F2/04 , A61F2002/045 , A61F2210/0004 , A61F2210/0057 , A61F2210/0076 , A61F2220/0016 , A61F2240/001 , A61K35/74 , A61K35/741 , A61K35/745 , A61K35/747 , A61K38/168 , A61K2035/115 , A61L27/54 , A61L29/08 , A61L29/148 , A61L29/16 , A61L31/005 , A61L31/048 , A61L31/06 , A61L31/10 , A61L31/145 , A61L31/148 , A61L31/16 , A61L2300/252 , A61L2300/604 , A61L2300/62 , A61L2420/02 , A61L2420/06
摘要： A gastrointestinal device and methods of manufacturing said gastrointestinal device are described and include a flexible tubular structure including an inner surface and an outer surface, a plurality of at least one type of commensal microbe associated with at least a portion of at least one of the inner surface and the outer surface, and a proximal end and a distal end, the proximal end and the distal end forming a flow conduit through the flexible tubular structure; and at least one anchor structure including one or more gastric wall-engaging components configured to engage a wall of the gastrointestinal tract of the subject.S
摘要翻译：描述了胃肠装置和制造所述胃肠装置的方法，并且包括包括内表面和外表面的柔性管状结构，多个至少一种类型的共生微生物，其与至少一个内部表面和外表面，以及近端和远端，近端和远端形成通过柔性管状结构的流动管道; 以及包括一个或多个胃壁接合部件的至少一个锚结构，所述胃壁接合部件配置成接合受试者的胃肠道的壁。

8. 发明申请

WO2013166241A1 FLUID SPRAYING APPARATUSES, AND RELATED SYSTEMS AND METHODS 审中-公开
标题翻译：流体喷雾装置及相关系统和方法
公开(公告)号：WO2013166241A1
公开(公告)日：2013-11-07
申请号：PCT/US2013/039198
申请日：2013-05-02
申请人： ELWHA LLC
发明人： BANGERA, Mahalaxmi Gita , HYDE, Roderick A. , KARE, Jordin T. , LEUTHARDT, Eric C. , WOOD, JR., Lowell L.
IPC分类号： A61B1/015 , A61B18/02
CPC分类号： A61M35/00 , A61B18/0218 , A61B18/04 , A61B2018/00642 , A61B2018/00702 , A61B2018/0212 , A61B2018/046 , A61B2090/061 , B05B1/32 , B05B12/124
摘要： Embodiments disclosed herein are directed to fluid spraying apparatuses, and related systems and methods. The disclosed fluid spraying apparatuses may be used, for example, to spray a medically suitable fluid on a target region of a subject, such as for treating or removing tissue of the subject. In an embodiment, a fluid spraying apparatus includes a spray mechanism including at least one reservoir, and a spraying device operably coupled to the at least one reservoir which has an adjustable spray nozzle. The fluid spraying apparatus includes a distance sensor configured to sense information at least related to a distance to a target region of a subject and output one or more signals encoding the information, and control electrical circuitry operably coupled to the spray mechanism and the distance sensor. The control electrical circuitry is configured to activate the spray mechanism responsive to receiving the one or more signals.
摘要翻译：本文公开的实施例涉及流体喷射装置，以及相关系统和方法。所公开的流体喷射装置可以用于例如将医学上合适的流体喷射到受试者的靶区域上，例如用于治疗或去除受试者的组织。在一个实施例中，流体喷射装置包括喷射机构，其包括至少一个储存器，以及可操作地联接到具有可调节喷嘴的至少一个储存器的喷洒装置。流体喷射装置包括距离传感器，该距离传感器被配置为感测至少与到达对象的目标区域的距离相关的信息，并且输出编码该信息的一个或多个信号，以及控制可操作地耦合到喷雾机构和距离传感器的电路。控制电路被配置为响应于接收到一个或多个信号来激活喷射机构。

9. 发明公开

EP3478212A1 ROBOTIC DEBRIDEMENT APPARATUSES, AND RELATED SYSTEMS AND METHODS 审中-公开
公开(公告)号：EP3478212A1
公开(公告)日：2019-05-08
申请号：EP17821059.7
申请日：2017-06-27
申请人： ELWHA LLC
发明人： BANGERA, Mahalaxmi Gita , BAYM, Michael H. , CHIN, Hon Wah , HYDE, Roderick A. , KARE, Jordin T. , MYHRVOLD, Nathan P. , SWEENEY, Elizabeth A.
IPC分类号： A61B34/30 , A61B17/50 , A61B17/3205 , A61B18/00

10. 发明申请

WO2018005449A1 ROBOTIC DEBRIDEMENT APPARATUSES, AND RELATED SYSTEMS AND METHODS 审中-公开
标题翻译：机器人装饰设备，以及相关的系统和方法
公开(公告)号：WO2018005449A1
公开(公告)日：2018-01-04
申请号：PCT/US2017/039440
申请日：2017-06-27
申请人： ELWHA LLC
发明人： BANGERA, Mahalaxmi Gita , BAYM, Michael H. , CHIN, Hon Wah , HYDE, Roderick A. , KARE, Jordin T. , MYHRVOLD, Nathan P. , SWEENEY, Elizabeth A.
IPC分类号： A61B34/30 , A61B17/50 , A61B17/3205 , A61B18/00
摘要： Robotic debridement apparatuses, related systems, and methods of using the same are disclosed herein. The robotic debridement apparatuses are configured to facilitate debridement of tissue from a body region. For example, the robotic debridement apparatuses can include one or more of at least one debriding tool configured to debride tissue, at least one debris disposal device configured to capture substances in the body region. The systems disclosed herein can include a plurality of robotic debridement apparatuses. The systems disclosed herein can include a dressing associated with the plurality of robotic debridement apparatuses. The dressing can be associated with the robotic debridement apparatuses in a manner that facilitates operations of the robotic debridement apparatuses.
摘要翻译：本文公开了机器人清创术装置，相关系统及其使用方法。机器人清创术装置被配置为促进来自身体区域的组织清创术。例如，机器人清创术装置可以包括以下中的一个或多个：至少一个清理工具，其被配置为清理组织;至少一个碎片清理设备，其被配置为捕捉身体区域中的物质。这里公开的系统可以包括多个机器人清创术装置。本文公开的系统可以包括与多个机器人清创术装置相关联的敷料。敷料可以以便于机器人清创术装置的操作的方式与机器人清创术装置相关联。

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