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1. 发明授权

EP3036339B1 SYSTEMS, METHODS AND DEVICES FOR ASSESSING MICROBIOTA OF SKIN 失效
公开(公告)号：EP3036339B1
公开(公告)日：2018-07-11
申请号：EP14837854.0
申请日：2014-08-20
申请人： ELWHA, LLC
发明人： BANGERA, Mahalaxmi Gita , BAYM, Michael H. , HYDE, Roderick A. , KARE, Jordin T. , LEUTHARDT, Eric C. , MCKNIGHT, Gary L. , PAN, Tony S. , SHARADIN, Katherine E. , SWEENEY, Elizabeth A. , TEGREENE, Clarence T. , WOOD, Lowell L. Jr.
IPC分类号： G01N33/569 , C12Q1/04 , G01N33/52 , H04N5/232 , A61B10/02 , A61F13/15
CPC分类号： A61B10/02 , A61F13/15 , G01N33/56911 , G01N33/56938 , H04N5/23229
摘要： Devices, systems, and methods for assessing microbiota of skin are described, including: a skin-covering material including an inner surface and an outer surface, the inner surface substantially conforming to a topography of a skin surface of an individual and including a plurality of signal-generating complexes, one or more of the plurality of signal-generating complexes configured to emit one or more signals in response to at least one type of microbe; an image capture device to capture an image of the inner surface of the skin-covering material, the image including one or more signals emitted from the plurality of signal-generating complexes, and to transform the image into a digital output; and a computing device including circuitry configured to receive the digital output, compare the properties of the imaged one or more signals with a database of reference signal-generating complexes, and generate a digital spatial profile of microbes on the skin-covering material.

2. 发明申请

WO2017214376A1 COMPOSITIONS AND METHODS INCLUDING B LYMPHOCYTE CELL LINE EXPRESSING MEMBRANE IMMUNOGLOBULIN DIFFERENT FROM SECRETED IMMUNOGLOBULIN AND CYTOLYTIC FUNCTION 审中-公开
标题翻译：包含B淋巴细胞系的表达膜免疫球蛋白的组合物和方法不同于分泌的免疫球蛋白和细胞功能
公开(公告)号：WO2017214376A1
公开(公告)日：2017-12-14
申请号：PCT/US2017/036521
申请日：2017-06-08
申请人： ELWHA LLC
发明人： HYDE, Roderick A. , KINDSVOGEL, Wayne R. , MCKNIGHT, Gary L.
IPC分类号： C12N5/0781 , C12N15/85 , A61K35/17 , A61K35/12
摘要： Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated cytotoxic B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin reactive to a first antigen and at least one endogenous secreted immunoglobulin reactive to a second antigen, and further capable of expressing at least one exogenously incorporated recombinant B cell receptor that signals for expression of cytotoxic effector molecules.
摘要翻译：本文公开了用于在分离的细胞毒性B淋巴细胞系中产生一种或多种免疫球蛋白的组合物和方法。分离的细胞系包括能够表达至少一种对第一抗原具有反应性的外源掺入的膜免疫球蛋白和至少一种对第二抗原具有反应性的内源性分泌的免疫球蛋白的分离的B淋巴细胞系，并且还能够表达至少一种外源掺入的重组体 B细胞受体，其表达细胞毒性效应分子。

3. 发明申请

WO2017214090A1 SYSTEMS AND METHODS FOR MONITORING COMPRESSION WITH COMPRESSION BANDAGES HAVING STRETCHABLE ELECTRONICS 审中-公开
标题翻译：用具有可伸缩电子装置的压缩带监测压缩的系统和方法
公开(公告)号：WO2017214090A1
公开(公告)日：2017-12-14
申请号：PCT/US2017/036072
申请日：2017-06-06
申请人： ELWHA LLC
发明人： DUESTERHOFT, Paul , HYDE, Roderick A. , MCKNIGHT, Gary L. , SWEENEY, Elizabeth A.
IPC分类号： A61F13/08 , A61F13/06 , A61B5/00
摘要： Systems and methods are described for monitoring compression applied by a compression bandage to a body portion of an individual. A system embodiment includes, but is not limited to, a deformable substrate integrated with a textile configured to conform to a body portion of an individual subject; one or more strain gauges integrated with; an optional sensor assembly coupled to the textile, the optional sensor assembly including one or more strain gauges configured to generate one or more sense signals associated with a strain of the textile; circuitry operably coupled to the one or more strain gauges of the sensor assembly and configured to receive the one or more sense signals associated with the strain of the textile; and a reporter operably coupled to the circuitry and configured to generate one or more communication signals associated with the strain of the textile responsive to instruction by the circuitry when the strain of the textile is less than, or greater than a threshold strain value.
摘要翻译：描述了用于监测由压迫绷带施加到个体的身体部分的压缩的系统和方法。系统实施例包括但不限于与织物一体化的可变形基底，该织物被配置成符合个体对象的身体部分; 一个或多个应变仪集成在一起; 耦合到织物的可选传感器组件，所述可选传感器组件包括一个或多个应变仪，所述应变仪被配置成生成与所述织物的应变相关联的一个或多个感测信号; 电路，所述电路可操作地耦合到所述传感器组件的所述一个或多个应变仪，并且被配置为接收与所述纺织品的所述应变相关联的所述一个或多个感测信号; 以及报告器，其可操作地耦合到所述电路并且被配置为响应于所述电路的指令在所述织物的应变小于或大于阈值应变值时产生与所述织物的应变相关联的一个或多个通信信号。 p>

4. 发明申请

WO2014179194A1 MULTI-PARAMETER TEST UNITS FOR INITIAL INDICATION OF MEDICAL SYMPTOMS 审中-公开
标题翻译：多参数测试单位，用于初步诊断医学症状
公开(公告)号：WO2014179194A1
公开(公告)日：2014-11-06
申请号：PCT/US2014/035630
申请日：2014-04-28
申请人： ELWHA LLC
发明人： HYDE, Roderick A. , KINDSVOGEL, Wayne R. , MCKNIGHT, Gary L.
IPC分类号： G01N33/50 , G01N33/53 , G01N33/573 , A61B5/00 , A61B5/01
CPC分类号： A61B5/682 , A61B5/01 , A61B10/0051 , A61B2010/0003 , A61B2562/0295
摘要： Disposable test units to assist medical personnel are described. In some embodiments, a test unit includes: a solid support; a cavity in the solid support; a reaction chamber internal to the solid support, including a plurality of biochemical reagents; a first internal channel in the solid support, connected at a first end to the cavity, connected at a second end to the reaction chamber; at least one pathogen detection region internal to the solid support; a second internal channel in the solid support, connected at a first end to the reaction chamber, connected at a second end to the at least one pathogen detection region; a temperature detector; and a persistent visible temperature indicator attached to the temperature detector.
摘要翻译：描述了一些辅助医务人员的一次性测试单元。在一些实施方案中，测试单元包括：固体支持物; 固体支撑体中的空腔; 固体支持物内部的反应室，包括多个生化试剂; 固体支撑件中的第一内部通道，在第一端连接到空腔，在第二端连接到反应室; 固体支持物内部的至少一个病原体检测区域; 所述固体支持物中的第二内部通道在第一端连接到所述反应室，在第二端连接到所述至少一个病原体检测区域; 温度检测器; 以及连接到温度检测器的持续可见温度指示器。

5. 发明申请

WO2020009905A1 SYSTEMS AND METHODS FOR INDIVIDUAL IDENTIFICATION AND AUTHORIZATION UTILIZING CONFORMABLE ELECTRONICS 审中-公开
公开(公告)号：WO2020009905A1
公开(公告)日：2020-01-09
申请号：PCT/US2019/039589
申请日：2019-06-27
申请人： ELWHA LLC
发明人： HYDE, Roderick A. , MCKNIGHT, Gary L. , PETROSKI, Robert C. , SWEENEY, Elizabeth A.
IPC分类号： G16H10/65 , G16H40/67 , G16H40/20 , G16H80/00
摘要： An identification device includes, but is not limited to, a deformable substrate configured to conform to a skin surface of a body portion of a healthcare provider; a sensor assembly coupled to the deformable substrate, the sensor assembly including one or more identity sensors configured to generate one or more identity sense signals associated with at least one physical characteristic of an individual subject other than the healthcare provider; circuitry configured to compare the one or more identity sense signals generated by the sensor assembly to reference data indicative of one or more physical characteristics associated with an identity; and a reporter configured to generate one or more communication signals associated with a comparison of the one or more identity sense signals generated by the sensor assembly to reference data indicative of one or more physical characteristics associated with an identity of at least one individual.

6. 发明申请

WO2014124086A1 BLOOD PRESSURE CUFF 审中-公开
标题翻译：血压计
公开(公告)号：WO2014124086A1
公开(公告)日：2014-08-14
申请号：PCT/US2014/015018
申请日：2014-02-06
申请人： ELWHA LLC
发明人： HYDE, Roderick A. , KARE, Jordin T. , MCKNIGHT, Gary L. , WOOD, Lowell L., Jr.
IPC分类号： A61B5/022
CPC分类号： A61B5/0205 , A61B5/02208 , A61B5/026 , A61B5/1118 , A61B5/14542 , A61B5/6824 , A61B5/6826 , A61B5/6828 , A61B5/6829 , A61B5/6885 , A61B5/7475 , A61B2562/0219
摘要： A device may include a vibration sensor configured to sense blood flow in a lumen of a person; a cuff coupled to the vibration sensor and configured to contact a limb of the person; a cuff pressurizer coupled to the cuff, the cuff pressurizer configured to adjust a compressive force of the cuff on the lumen; and an energy-generating apparatus coupled to the cuff, the energy-generating apparatus configured to generate energy from a depressurization of the cuff.
摘要翻译：设备可以包括被配置为感测人的内腔中的血流的振动传感器; 袖带，其耦合到所述振动传感器并且被配置为接触所述人的肢体; 袖带加压器，其联接到所述袖带，所述袖带加压器被配置为调节所述袖带在所述内腔上的压缩力; 以及耦合到所述袖带的能量产生装置，所述能量产生装置被配置为从所述袖带的减压产生能量。

7. 发明申请

WO2019055285A1 SYSTEMS, COMPOSITIONS, AND METHODS FOR TARGETED CHALLENGE AND IDENTIFICATION OF GUT MICROBIOTA 审中-公开
公开(公告)号：WO2019055285A1
公开(公告)日：2019-03-21
申请号：PCT/US2018/049763
申请日：2018-09-06
申请人： ELWHA LLC
发明人： HYDE, Roderick A. , MCKNIGHT, Gary L. , SWEENEY, Elizabeth A.
IPC分类号： A61K49/00 , A61B5/00 , A61B5/145
摘要： Identifying gut microbiota in a specific site of the gut through production of a measurable response following introduction of a challenge agent to the specific site of the gut is disclosed. A system embodiment includes, but is not limited to, a composition including the challenge agent; and an emissions analysis device including a body structure defining an orifice configured to receive a biofluid; a sensor operably coupled to the orifice and configured to detect at least one analyte from the biofluid and generate one or more sense signals, the one or more sense signals associated with the measurable response; circuitry operably coupled to the sensor and configured to receive the one or more sense signals associated with the measurable response; and a reporter operably coupled to the circuitry and configured to generate one or more communication signals associated with at least one targeted microbe.

8. 发明申请

WO2015073375A1 DEVICES, SYSTEMS, AND METHODS FOR AUTOMATED MEDICAL PRODUCT OR SERVICE DELIVERY 审中-公开
标题翻译：用于自动化医疗产品或服务交付的设备，系统和方法
公开(公告)号：WO2015073375A1
公开(公告)日：2015-05-21
申请号：PCT/US2014/064848
申请日：2014-11-10
申请人： ELWHA LLC
发明人： HYDE, Roderick A. , ISHIKAWA, Muriel Y. , KARE, Jordin T. , MCKNIGHT, Gary L. , PETROSKI, Robert C.
IPC分类号： G06Q50/22 , G06Q50/24 , A61J3/00
CPC分类号： G06Q50/24 , G06F19/00 , G06Q50/22 , G07F17/0092 , Y02A90/22
摘要： Various embodiments disclosed herein include systems, methods, and devices for automated delivery of medical services and products. The systems and/or methods are configured for receiving at least one input from a subject, comparing the at least one input with one or more verification datasets, generating a verification value, reinitiating receiving at least one additional input from the subject and comparing the at least one additional input with the one or more verification datasets, and communicating an output. In an embodiment, the systems and/or methods include a kiosk including at least one computing device including circuitry. Another embodiment, the systems and/or methods include a pillbox device with at least one compartment operably coupled to circuity configured for sending a signal, and with at least one port configured for transferring data with the at least one computing device of the kiosk.
摘要翻译：本文公开的各种实施例包括用于医疗服务和产品的自动递送的系统，方法和装置。所述系统和/或方法被配置用于从主体接收至少一个输入，将所述至少一个输入与一个或多个验证数据集进行比较，产生验证值，重新开始从所述对象接收至少一个附加输入，至少一个额外的输入与一个或多个验证数据集，并传达输出。在一个实施例中，系统和/或方法包括包括至少一个包括电路的计算设备的信息亭。另一个实施例中，所述系统和/或方法包括具有至少一个隔室的药盒装置，所述至少一个隔室可操作地耦合到被配置用于发送信号的电路，以及配置成用于与所述信息亭的所述至少一个计算设备传送数据的至少一个端口。

9. 发明申请

WO2015027057A1 SELECTING AND DELIVERING TREATMENT AGENTS BASED ON A MICROBE PROFILE 审中-公开
标题翻译：基于MICROBE配置文件选择和传送治疗药剂
公开(公告)号：WO2015027057A1
公开(公告)日：2015-02-26
申请号：PCT/US2014/052081
申请日：2014-08-21
申请人： ELWHA LLC , BAYM, Michael H. , LEUTHARDT, Eric C. , WOOD, Lowell L., Jr.
发明人： BAYM, Michael H. , LEUTHARDT, Eric C. , WOOD, Lowell L., Jr. , HYDE, Roderick A. , KARE, Jordin T. , MCKNIGHT, Gary L. , PAN, Tony S. , SWEENEY, Elizabeth A. , TEGREENE, Clarence T.
IPC分类号： A61M35/00 , A61B10/00 , C12Q1/04 , G06Q50/22
CPC分类号： A61B10/00 , G06F19/00 , G06F19/34
摘要： Kits, devices, methods, and systems for assessing microbiota of a body surface and selecting treatment agents to apply to the body surface to modulate one or more types of microbes are described which include a kit including a plurality of treatment agents, a microbe sampling unit including a microbe-capture region, and an analyzer including a user interface, at least one sensor component, and a computing component with a processor and circuitry.
摘要翻译：描述了用于评估体表的微生物群并选择施用于身体表面以调节一种或多种类型的微生物的试剂盒，装置，方法和系统，其包括包含多种处理剂的试剂盒，微生物采样单元包括微生物捕获区域，以及包括用户接口，至少一个传感器部件以及具有处理器和电路的计算部件的分析器。

10. 发明公开

EP3544681A1 MONITORING AND TREATING PAIN WITH EPIDERMAL ELECTRONICS 无效
公开(公告)号：EP3544681A1
公开(公告)日：2019-10-02
申请号：EP17875036.0
申请日：2017-11-27
申请人： Elwha LLC
发明人： HYDE, Roderick A. , LEUTHARDT, Eric C. , MALAMUD, Mark A. , MCKNIGHT, Gary L. , PAN, Tony S. , SHARADIN, Katherine E. , SWEENEY, Elizabeth A. , TEGREENE, Clarence T. , WHITMER, Charles , WOOD, Lowell L., Jr.
IPC分类号： A61N7/00 , A61N1/36 , A61N1/04 , A61N5/06 , A61B5/00 , A61N5/067

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