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1. 发明申请

WO2009148278A2 CHANNEL ESTIMATION AND EQUALIZATION METHOD AND SYSTEM 审中-公开
标题翻译：渠道估算和均衡方法与系统
公开(公告)号：WO2009148278A2
公开(公告)日：2009-12-10
申请号：PCT/KR2009/002991
申请日：2009-06-04
申请人： ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE , SUNGKYUNKWAN UNIVERSITY , PARK, So Ra , IM, Se Bin , CHOI, Hyung Jin , PARK, Sung Ik , LEE, Yong Tae , LIM, Jong Soo , LEE, Soo In
发明人： PARK, So Ra , IM, Se Bin , CHOI, Hyung Jin , PARK, Sung Ik , LEE, Yong Tae , LIM, Jong Soo , LEE, Soo In
IPC分类号： H04J11/00 , H04N5/44
CPC分类号： H04J13/00 , H04L25/0206 , H04L25/0212 , H04L25/022 , H04L25/0228 , H04L25/03159 , H04L25/03292 , H04L27/2602 , H04L27/2607 , H04L27/2613 , H04L27/265 , H04L2025/03414
摘要： Disclosed is a channel estimation and equalization method and system. The method inserts a pilot signal in the time domain into a guard interval, uses a hard decision signal in the frequency domain to estimate a frequency response of the channel, and equalizes a radio channel distortion through the estimated channel value.
摘要翻译：公开了一种信道估计和均衡方法及系统。该方法将时域中的导频信号插入保护间隔，使用频域中的硬判决信号来估计信道的频率响应，并通过估计的信道值来平衡无线信道失真。

2. 发明申请

WO2008147004A1 MANUFACTURING METHOD OF FULLERENE MANIFOLD 审中-公开
标题翻译：富勒曼的制造方法
公开(公告)号：WO2008147004A1
公开(公告)日：2008-12-04
申请号：PCT/KR2007/006107
申请日：2007-11-29
申请人： INDUSTRY ACADEMIC COOPERATION FOUNDATION OF KYUNGHEE UNIVERSITY , AHN, Jung Sun , YEO, Seung Jun , SHIN, Chin Ho , JO, Jung Yun , PARK, So Ra
发明人： AHN, Jung Sun , YEO, Seung Jun , SHIN, Chin Ho , JO, Jung Yun , PARK, So Ra
IPC分类号： C01B31/02
CPC分类号： B82Y40/00 , B82Y30/00 , C01B32/15 , C01B32/152
摘要： The present invention relates to a manufacturing method of fullerene manifold and more particularly, provides the method comprising generating solution droplets of micrometer size from fullerene monomers and making fullerene assembly through condensation process of fullerene monomers due to concentration of solute by natural evaporation of solvent in a vacuum and progressing photo-polymerization reaction by irradiating UV and the like to the fullerene assembly.
摘要翻译：富勒烯歧管的制造方法技术领域本发明涉及富勒烯歧管的制造方法，更具体地说，提供了从富勒烯单体生成微米尺寸的溶液液滴的方法，并且通过在溶剂中自然蒸发溶剂浓缩而使富勒烯单体的缩合通过将紫外线等照射到富勒烯组件上进行真空和进行光聚合反应。

3. 发明申请

WO2008126952A1 METHOD FOR PREPARING A CELL-ERIVED EXTRACELLULAR MATRIX SCAFFOLD 审中-公开
标题翻译：制备细胞外细胞基质SCAFFOLD的方法
公开(公告)号：WO2008126952A1
公开(公告)日：2008-10-23
申请号：PCT/KR2007/001873
申请日：2007-04-17
申请人： MIN, Byoung-Hyun , PARK, So Ra , JIN, Cheng Zhe , PARK, Kwideok
发明人： MIN, Byoung-Hyun , PARK, So Ra , JIN, Cheng Zhe , PARK, Kwideok
IPC分类号： C12N5/06 , C12N5/02 , C12N5/00
CPC分类号： C12N5/0655 , A61L27/3633 , A61L27/3817 , A61L27/48 , A61L27/56 , C12N2533/54 , C12N2533/90 , C08L67/04
摘要： The present invention relates to a method for fabricating a cell-derived extracellular matrix scaffold, more particularly, to a method for fabricating a cell- derived extracellular matrix scaffold, the method comprising the steps of obtaining a chondrocyte/extracellular matrix (ECM) membrane from chondrocytes derived from animal cartilage, obtaining a pellet-type scaffold-free construct by culturing after centrifuging the obtained chondrocytes/extracellular matrix (ECM) membrane and freeze-drying the obtained pellet-type construct. The cell-derived ECM scaffold according to the invention is a porous scaffold fabricated using cartilage tissue engineered by culturing chondrocytes in an in vitro scaffold-free system, which is not reduced in size during the cultivation and thus useful for cartilage regeneration.
摘要翻译：本发明涉及一种制备细胞衍生的细胞外基质支架的方法，更具体地说，涉及一种制备细胞衍生的细胞外基质支架的方法，所述方法包括以下步骤：从软骨细胞/细胞外基质（ECM）从动物软骨衍生的软骨细胞，通过在离心获得的软骨细胞/细胞外基质（ECM）膜并冷冻干燥获得的颗粒型构建体之后培养获得颗粒型无支架构建体。根据本发明的细胞衍生的ECM支架是使用在体外无支架体系中培养软骨细胞工程化的软骨组织制造的多孔支架，其在培养期间尺寸不减小，因此可用于软骨再生。

4. 发明申请

WO2009017264A1 AN ULTRASOUND EQUIPMENT FOR TREATING OF EDEMA AND USE THEREOF 审中-公开
标题翻译：一种超声波处理设备及其应用
公开(公告)号：WO2009017264A1
公开(公告)日：2009-02-05
申请号：PCT/KR2007/003653
申请日：2007-07-30
申请人： REGENPRIME CO., LTD. , MIN, Byoung-Hyun , PARK, So Ra , KWON, Soon Keun
发明人： MIN, Byoung-Hyun , PARK, So Ra , KWON, Soon Keun
IPC分类号： A61N7/00
CPC分类号： A61N7/00
摘要： The present invention relates to an ultrasound equipment for treating edema, and more particularly, to an ultrasound equipment to relieve symptoms of edema or repair cellular and tissue edemas by generating 20-400 mW/cm of low intensity ultrasound and use thereof. The ultrasound equipment according to the present invention comprises a main control unit equipped with a control unit for ultrasound generation for generating a 20~400mW/cm2 of low intensity ultrasound, an ultrasound generator for generating ultrasound according to the operating state of the main control unit, an ultrasound vibrator vibrating according to the value of ultrasound data inputted from the ultrasound generator, and a probe for delivering ultrasound energy to a treatment site, and when the ultrasound equipment is used, it is possible to treat edema by increasing permeability in blood vessels.
摘要翻译：本发明涉及一种用于治疗水肿的超声设备，更具体地，涉及一种通过产生20-400mW / cm的低强度超声波及其应用来减轻水肿症状或修复细胞和组织水肿的超声设备。根据本发明的超声波设备包括主控制单元，其配备有用于产生20〜400mW / cm 2的低强度超声波的超声波发生用控制单元，根据主控制单元的动作状态生成超声波的超声波发生器，根据从超声波发生器输入的超声波数据的振动振动的超声波振动器，以及用于将超声波能量输送到治疗部位的探针，当使用超声波设备时，可以通过增加血管的渗透性来治疗水肿。

5. 发明申请

WO2005045008A1 METHOD FOR INDUCING CHONDROGENESIS ON MESENCHYMAL STEM CELLS 审中-公开
标题翻译：诱导细胞干细胞成纤维细胞生长的方法
公开(公告)号：WO2005045008A1
公开(公告)日：2005-05-19
申请号：PCT/KR2004/002879
申请日：2004-11-08
申请人： INHA UNIVERSITY , PARK, So Ra , MIN, Byoung Hyun , LEE, Hyun Jung
发明人： PARK, So Ra , MIN, Byoung Hyun , LEE, Hyun Jung
IPC分类号： C12N5/06
CPC分类号： C12N5/0654 , A61K35/12 , A61K41/0028 , A61K2035/124 , C12N5/0655 , C12N13/00 , C12N2533/74
摘要： The present invention relates to a method for inducing chondrogenesis on mesenchymal stem cells, more particularly, it relates to a method for inducing chondrogenesis by employing treatment with low intensity ultrasound on the mesenchymal stem cells and a therapeutic composition comprising chondrocytes differentiated by said method. According to the present invention, it is possible to induce effectively chondrogenic differentiation of the mesenchymal stem cells without using conventional expensive growth factors, thereby making it possible to prepare economically artificial cartilage and therapeutic compositions comprising chondrocytes.
摘要翻译：本发明涉及一种用于诱导间充质干细胞的软骨形成的方法，更具体地说，涉及通过在间充质干细胞上使用低强度超声波治疗来诱导软骨形成的方法以及包含通过所述方法分化的软骨细胞的治疗组合物的方法。根据本发明，可以在不使用常规昂贵的生长因子的情况下有效诱导间充质干细胞的软骨形成分化，从而可以制备经济上人造软骨和包含软骨细胞的治疗组合物。

6. 发明申请

WO2009017267A1 METHOD FOR DIFFERENCIATING MESENCHYMAL STEM CELL AND CULTURING CHONDROCYTES USING ALGINATE COATED FIBRIN/HA COMPOSITE SCAFFOLD 审中-公开
标题翻译：使用ALGINATE涂层FIBRIN / HA复合材料SCAFF的差异化MESENCHYMAL STEM CELL和培养CHONDROCYTES的方法
公开(公告)号：WO2009017267A1
公开(公告)日：2009-02-05
申请号：PCT/KR2007/003710
申请日：2007-08-01
申请人： REGENPRIME CO., LTD. , MIN, Byoung-Hyun , PARK, So Ra , PARK, Sang-Hyug
发明人： MIN, Byoung-Hyun , PARK, So Ra , PARK, Sang-Hyug
IPC分类号： C12N5/06 , C12N5/08 , C12N5/02 , C12N5/00
CPC分类号： C12N5/0655 , C12N2533/56 , C12N2533/80
摘要： The present invention relates to a method for differentiating mesenchymal stem cells and culturing chondrocytes using a fibrin/HA(hyaluronate) composite whose biocompatibility and durability are enhanced, and a therapeutic composition containing the fibrin/HA composite, and more particularly, to a method for culturing chondrocytes and differentiating mesenchymal stem cells into chondrocytes using an alginate-coated fibrin/HA composite gel and a composition for treating a cartilage disease and a composition for treating a disc disease using a fibrin/HA composite scaffold containing a fibrin degradation inhibitor. According to the present invention, disadvantages of the traditional fibrin/HA composite being reduced in size and easily degraded in a short time period during culture were overcome, so that cells can be cultured in a more stable environment. The treatment composition according to the present invention has superior biocompatibility and biodegradability and thus it can be used for effective treatment for cartilage diseases, and it can regenerate the nuclei pulposi of a new intervertebral disk unlike currently used surgical treatment of degenerative intervertebral disk disease, so that it is expected that fundamental treatment of disc diseases can be achieved.
摘要翻译：本发明涉及使用生物相容性和耐久性增强的纤维蛋白/ HA（透明质酸盐）复合物和包含纤维蛋白/ HA复合物的治疗组合物来分化间充质干细胞和培养软骨细胞的方法，更具体地说，涉及一种用于培养软骨细胞并使用藻酸盐包被的纤维蛋白/ HA复合凝胶和用于治疗软骨疾病的组合物和使用含有纤维蛋白降解抑制剂的纤维蛋白/ HA复合支架治疗椎间盘疾病的组合物将间充质干细胞分化成软骨细胞。根据本发明，克服了传统纤维蛋白/ HA复合物在培养过程中尺寸减小并且在短时间内容易降解的缺点，使得细胞可以在更稳定的环境中培养。根据本发明的治疗组合物具有优异的生物相容性和生物降解性，因此可用于软骨疾病的有效治疗，并且可以再生新型椎间盘的髓核，与目前使用的退行性椎间盘疾病的手术治疗不同，因此预期可以实现椎间盘疾病的根本治疗。

7. 发明申请

WO2008035843A1 METHOD FOR PREPARING A CELL-DERIVED EXTRACELLULAR MATRIX MEMBRANE 审中-公开
标题翻译：制备细胞衍生的细胞外基质膜的方法
公开(公告)号：WO2008035843A1
公开(公告)日：2008-03-27
申请号：PCT/KR2007/002033
申请日：2007-04-25
申请人： Filmiagen Co., Ltd , PARK, So Ra , MIN, Byoung-Hyun , CHOI, Byung Hyune
发明人： PARK, So Ra , MIN, Byoung-Hyun , CHOI, Byung Hyune
IPC分类号： C12N5/08 , A61L27/60
CPC分类号： A61L27/3633 , A61L27/3683 , A61L27/3817 , A61L27/60 , C12N5/0655 , C12N2533/90
摘要： The present invention relates to a method for preparing a cell-derived extracellular matrix membrane, more particularly, to a method for preparing a chondrocyte-derived ECM membrane, the method comprising the steps of forming a suitable thickness of ECM membrane by culturing chondrocytes derived from animal cartilage at a high concentration in vitro , and drying it after decellularization process. The cell-derived ECM membrane scaffold according to the present invention is composed of extracellular matrix secreted by chondrocytes so that the membrane has excellent biocompatibility as well as an immune-previlage effect specific to cartilage. Since the membrane also has a suitable compressive strength, it can be used to replace periosteum for cartilage regeneration or artificial collagen membrane and used as dura mater transplant material, a natural ECM membrane for treating skin loss, materials for cell transplantation and a growth factor delivery vehicle.
摘要翻译：本发明涉及一种制备细胞衍生的细胞外基质膜的方法，更具体地说涉及一种制备软骨细胞衍生的ECM膜的方法，所述方法包括以下步骤：通过培养衍生自软骨细胞的ECM软骨细胞形成适当厚度的ECM膜体外高浓度的动物软骨，脱细胞后进行干燥。根据本发明的细胞衍生的ECM膜支架由软骨细胞分泌的细胞外基质组成，使得膜具有优异的生物相容性以及对软骨特异性的免疫预先作用。由于膜也具有合适的抗压强度，可用于替代软骨再生或人造胶原膜的骨膜，并用作硬膜移植材料，用于治疗皮肤损失的天然ECM膜，用于细胞移植的材料和生长因子递送车辆。

8. 发明申请

WO2008146956A1 THERAPEUTIC COMPOSITE FOR CARTILAGE DISORDER USING EXTRACELLULAR MATRIX (ECM) SCAFFOLD 审中-公开
标题翻译：使用细胞基质（ECM）SCAFFOLD的治疗疾病的治疗复合物
公开(公告)号：WO2008146956A1
公开(公告)日：2008-12-04
申请号：PCT/KR2007/002215
申请日：2007-05-06
申请人： MIN, Byoung-Hyun , PARK, So Ra , JIN, Cheng Zhe , CHOI, Byung Hyune
发明人： MIN, Byoung-Hyun , PARK, So Ra , JIN, Cheng Zhe , CHOI, Byung Hyune
IPC分类号： A61L27/56
CPC分类号： A61L27/56 , A61L27/3633 , A61L27/3817 , A61L27/3834 , A61L27/3852 , A61L2430/06
摘要： The present invention relates to a method for preparing a cell-derived ECM scaffold to which chondrocytes or stem cells are attached, a method for cartilage regeneration by tissue engineering, which comprises using the cell-derived ECM scaffold, and a therapeutic composition for treating cartilage disorder, which contains the ECM scaffold as an effective component. More specifically, the present invention relates to a method for cartilage regeneration by tissue engineering, which comprises transplanting ECM scaffold, having chondrocytes or stem cells attached thereto, into cartilage defects, and a therapeutic composition for treating cartilage disorder, which contains the ECM scaffold, having chondrocytes or stem cells attached thereto, as an effective component. According to the present invention, when the inventive ECM scaffold having chondrocytes or stem cells attached thereto is transplanted into a cartilage defect, mature articular cartilage having the same appearance and characteristics as those of natural cartilage tissue, can be regenerated without side effects such as inflammatory responses.
摘要翻译：本发明涉及一种制备软骨细胞或干细胞连接的细胞衍生的ECM支架的方法，一种通过组织工程软骨再生的方法，其包括使用细胞衍生的ECM支架和用于治疗软骨的治疗组合物其包含ECM支架作为有效成分。更具体地说，本发明涉及通过组织工程软骨再生的方法，其包括将附着有软骨细胞或干细胞的ECM支架移植到软骨缺损中，以及用于治疗软骨病症的治疗组合物，其含有ECM支架，具有附着于其上的软骨细胞或干细胞作为有效成分。根据本发明，当将附着有软骨细胞或干细胞的本发明的ECM支架移植到软骨缺损中时，具有与天然软骨组织相同的外观和特征的成熟关节软骨可以再生而无副作用，例如炎性响应。

9. 发明申请

WO2008004752A1 METHOD FOR PREPARING MESENCHYMAL STEM CELLS BY ULTRASONIC TREATMENT 审中-公开
标题翻译：通过超声处理制备骨髓干细胞的方法
公开(公告)号：WO2008004752A1
公开(公告)日：2008-01-10
申请号：PCT/KR2007/002031
申请日：2007-04-25
申请人： MIN, Byoung-Hyun , PARK, So Ra , CHOI, Woo-Hee
发明人： MIN, Byoung-Hyun , PARK, So Ra , CHOI, Woo-Hee
IPC分类号： C12N5/06 , C12N13/00 , C12N15/06
CPC分类号： C12N5/0663 , C12N2521/10
摘要： The present invention relates to a method for improving the efficiency of obtaining mesenchymal stem cells (MSCs), more particularly, a method for obtaining bone marrow-derived mesenchymal stem cells, the method comprising enhancing cell adhesion capacity and proliferation of mesenchymal stem cells (MSCs) by treating MSC-containing cells isolated from MSC-containing tissues with ultrasound. According to the present invention, a great amount of pure MSCs having a normal differentiation capacity can be easily obtained from a group of cells containing MSCs, compared to the existing methods.
摘要翻译：本发明涉及提高获得间充质干细胞（MSC）的效率的方法，更具体地说，涉及一种获得骨髓间充质干细胞的方法，该方法包括增强间充质干细胞（MSC）的细胞粘附能力和增殖）通过用超声波处理从含MSC组织分离的含MSC细胞。根据本发明，与现有方法相比，可以容易地从含有MSC的细胞群中获得大量具有正分化能力的纯MSC。

10. 发明公开

EP2289183A2 CHANNEL ESTIMATION AND EQUALIZATION METHOD AND SYSTEM 审中-公开
标题翻译：方法和系统的信道估计与均衡
公开(公告)号：EP2289183A2
公开(公告)日：2011-03-02
申请号：EP09758531.9
申请日：2009-06-04
申请人： Electronics and Telecommunications Research Institute
发明人： PARK, So Ra , IM, Se Bin , CHOI, Hyung Jin , PARK, Sung Ik , LEE, Yong Tae , LIM, Jong Soo , LEE, Soo In
IPC分类号： H04J11/00 , H04N5/44
CPC分类号： H04J13/00 , H04L25/0206 , H04L25/0212 , H04L25/022 , H04L25/0228 , H04L25/03159 , H04L25/03292 , H04L27/2602 , H04L27/2607 , H04L27/2613 , H04L27/265 , H04L2025/03414
摘要： Disclosed is a channel estimation and equalization method and system. The method inserts a pilot signal in the time domain into a guard interval, uses a hard decision signal in the frequency domain to estimate a frequency response of the channel, and equalizes a radio channel distortion through the estimated channel value.

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