专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009017267A1 METHOD FOR DIFFERENCIATING MESENCHYMAL STEM CELL AND CULTURING CHONDROCYTES USING ALGINATE COATED FIBRIN/HA COMPOSITE SCAFFOLD 审中-公开
标题翻译：使用ALGINATE涂层FIBRIN / HA复合材料SCAFF的差异化MESENCHYMAL STEM CELL和培养CHONDROCYTES的方法
公开(公告)号：WO2009017267A1
公开(公告)日：2009-02-05
申请号：PCT/KR2007/003710
申请日：2007-08-01
申请人： REGENPRIME CO., LTD. , MIN, Byoung-Hyun , PARK, So Ra , PARK, Sang-Hyug
发明人： MIN, Byoung-Hyun , PARK, So Ra , PARK, Sang-Hyug
IPC分类号： C12N5/06 , C12N5/08 , C12N5/02 , C12N5/00
CPC分类号： C12N5/0655 , C12N2533/56 , C12N2533/80
摘要： The present invention relates to a method for differentiating mesenchymal stem cells and culturing chondrocytes using a fibrin/HA(hyaluronate) composite whose biocompatibility and durability are enhanced, and a therapeutic composition containing the fibrin/HA composite, and more particularly, to a method for culturing chondrocytes and differentiating mesenchymal stem cells into chondrocytes using an alginate-coated fibrin/HA composite gel and a composition for treating a cartilage disease and a composition for treating a disc disease using a fibrin/HA composite scaffold containing a fibrin degradation inhibitor. According to the present invention, disadvantages of the traditional fibrin/HA composite being reduced in size and easily degraded in a short time period during culture were overcome, so that cells can be cultured in a more stable environment. The treatment composition according to the present invention has superior biocompatibility and biodegradability and thus it can be used for effective treatment for cartilage diseases, and it can regenerate the nuclei pulposi of a new intervertebral disk unlike currently used surgical treatment of degenerative intervertebral disk disease, so that it is expected that fundamental treatment of disc diseases can be achieved.
摘要翻译：本发明涉及使用生物相容性和耐久性增强的纤维蛋白/ HA（透明质酸盐）复合物和包含纤维蛋白/ HA复合物的治疗组合物来分化间充质干细胞和培养软骨细胞的方法，更具体地说，涉及一种用于培养软骨细胞并使用藻酸盐包被的纤维蛋白/ HA复合凝胶和用于治疗软骨疾病的组合物和使用含有纤维蛋白降解抑制剂的纤维蛋白/ HA复合支架治疗椎间盘疾病的组合物将间充质干细胞分化成软骨细胞。根据本发明，克服了传统纤维蛋白/ HA复合物在培养过程中尺寸减小并且在短时间内容易降解的缺点，使得细胞可以在更稳定的环境中培养。根据本发明的治疗组合物具有优异的生物相容性和生物降解性，因此可用于软骨疾病的有效治疗，并且可以再生新型椎间盘的髓核，与目前使用的退行性椎间盘疾病的手术治疗不同，因此预期可以实现椎间盘疾病的根本治疗。

2. 发明申请

WO2008035843A1 METHOD FOR PREPARING A CELL-DERIVED EXTRACELLULAR MATRIX MEMBRANE 审中-公开
标题翻译：制备细胞衍生的细胞外基质膜的方法
公开(公告)号：WO2008035843A1
公开(公告)日：2008-03-27
申请号：PCT/KR2007/002033
申请日：2007-04-25
申请人： Filmiagen Co., Ltd , PARK, So Ra , MIN, Byoung-Hyun , CHOI, Byung Hyune
发明人： PARK, So Ra , MIN, Byoung-Hyun , CHOI, Byung Hyune
IPC分类号： C12N5/08 , A61L27/60
CPC分类号： A61L27/3633 , A61L27/3683 , A61L27/3817 , A61L27/60 , C12N5/0655 , C12N2533/90
摘要： The present invention relates to a method for preparing a cell-derived extracellular matrix membrane, more particularly, to a method for preparing a chondrocyte-derived ECM membrane, the method comprising the steps of forming a suitable thickness of ECM membrane by culturing chondrocytes derived from animal cartilage at a high concentration in vitro , and drying it after decellularization process. The cell-derived ECM membrane scaffold according to the present invention is composed of extracellular matrix secreted by chondrocytes so that the membrane has excellent biocompatibility as well as an immune-previlage effect specific to cartilage. Since the membrane also has a suitable compressive strength, it can be used to replace periosteum for cartilage regeneration or artificial collagen membrane and used as dura mater transplant material, a natural ECM membrane for treating skin loss, materials for cell transplantation and a growth factor delivery vehicle.
摘要翻译：本发明涉及一种制备细胞衍生的细胞外基质膜的方法，更具体地说涉及一种制备软骨细胞衍生的ECM膜的方法，所述方法包括以下步骤：通过培养衍生自软骨细胞的ECM软骨细胞形成适当厚度的ECM膜体外高浓度的动物软骨，脱细胞后进行干燥。根据本发明的细胞衍生的ECM膜支架由软骨细胞分泌的细胞外基质组成，使得膜具有优异的生物相容性以及对软骨特异性的免疫预先作用。由于膜也具有合适的抗压强度，可用于替代软骨再生或人造胶原膜的骨膜，并用作硬膜移植材料，用于治疗皮肤损失的天然ECM膜，用于细胞移植的材料和生长因子递送车辆。

3. 发明申请

WO2006038780A1 AN ULTRASONIC EQUIPMENT FOR TREATMENT OF OSTEOARTHRITIS 审中-公开
标题翻译：用于治疗OSTEOARTHRITIS的超声设备
公开(公告)号：WO2006038780A1
公开(公告)日：2006-04-13
申请号：PCT/KR2005/003254
申请日：2005-09-30
申请人： DUPLOGEN, INC. , MIN, Byoung-Hyun , PARK, So-Ra
发明人： MIN, Byoung-Hyun , PARK, So-Ra
IPC分类号： A61N7/00
CPC分类号： A61N7/00
摘要： The present invention relates to an ultrasonic device for the treatment o arthritis, and more particularly, to an ultrasonic device for the treatment or prevention of degenerative arthritis, which is so structured that it generates ultrasonic waves with an intensity of 200-800 mW/cm2 and applies low-intensity ultrasonic energy of 100-400 mW/cm2 to cartilage cells deep in the skin's dermis. The inventive ultrasonic device comprises: a main control unit including an ultrasonic oscillation control unit allowing the generation of ultrasonic waves with a frequency of 0.1-5 MHz and low intensity of 200-800 mW/cm2; an ultrasonic generator for generating ultrasonic waves according to the control state of the main control unit; an ultrasonic vibrator that vibrates according to ultrasonic waves inputted from the ultrasonic generator; and a probe for transferring ultrasonic vibration to a joint to be treated. The ultrasonic device can induce the regeneration of cartilage tissue by the activation of cartilage tissue, and thus, can fundamentally treat degenerative arthritis.
摘要翻译：本发明涉及一种用于治疗关节炎的超声波装置，更具体地，涉及一种用于治疗或预防退行性关节炎的超声波装置，其结构为使其产生强度为200-800mW / cm2的超声波并将100-400 mW / cm2的低强度超声能量应用于皮肤真皮深层的软骨细胞。本发明的超声波装置包括：主控制单元，包括超声波振荡控制单元，其允许产生频率为0.1-5MHz，低强度为200-800mW / cm 2的超声波; 超声波发生器，用于根据主控制单元的控制状态产生超声波; 超声波振动器，其根据从超声波发生器输入的超声波振动; 以及用于将超声波振动传递到待处理接头的探针。超声波装置可以通过软骨组织的激活来诱导软骨组织的再生，从而可以从根本上治疗退行性关节炎。

4. 发明申请

WO2008126952A1 METHOD FOR PREPARING A CELL-ERIVED EXTRACELLULAR MATRIX SCAFFOLD 审中-公开
标题翻译：制备细胞外细胞基质SCAFFOLD的方法
公开(公告)号：WO2008126952A1
公开(公告)日：2008-10-23
申请号：PCT/KR2007/001873
申请日：2007-04-17
申请人： MIN, Byoung-Hyun , PARK, So Ra , JIN, Cheng Zhe , PARK, Kwideok
发明人： MIN, Byoung-Hyun , PARK, So Ra , JIN, Cheng Zhe , PARK, Kwideok
IPC分类号： C12N5/06 , C12N5/02 , C12N5/00
CPC分类号： C12N5/0655 , A61L27/3633 , A61L27/3817 , A61L27/48 , A61L27/56 , C12N2533/54 , C12N2533/90 , C08L67/04
摘要： The present invention relates to a method for fabricating a cell-derived extracellular matrix scaffold, more particularly, to a method for fabricating a cell- derived extracellular matrix scaffold, the method comprising the steps of obtaining a chondrocyte/extracellular matrix (ECM) membrane from chondrocytes derived from animal cartilage, obtaining a pellet-type scaffold-free construct by culturing after centrifuging the obtained chondrocytes/extracellular matrix (ECM) membrane and freeze-drying the obtained pellet-type construct. The cell-derived ECM scaffold according to the invention is a porous scaffold fabricated using cartilage tissue engineered by culturing chondrocytes in an in vitro scaffold-free system, which is not reduced in size during the cultivation and thus useful for cartilage regeneration.
摘要翻译：本发明涉及一种制备细胞衍生的细胞外基质支架的方法，更具体地说，涉及一种制备细胞衍生的细胞外基质支架的方法，所述方法包括以下步骤：从软骨细胞/细胞外基质（ECM）从动物软骨衍生的软骨细胞，通过在离心获得的软骨细胞/细胞外基质（ECM）膜并冷冻干燥获得的颗粒型构建体之后培养获得颗粒型无支架构建体。根据本发明的细胞衍生的ECM支架是使用在体外无支架体系中培养软骨细胞工程化的软骨组织制造的多孔支架，其在培养期间尺寸不减小，因此可用于软骨再生。

5. 发明申请

WO2008146956A1 THERAPEUTIC COMPOSITE FOR CARTILAGE DISORDER USING EXTRACELLULAR MATRIX (ECM) SCAFFOLD 审中-公开
标题翻译：使用细胞基质（ECM）SCAFFOLD的治疗疾病的治疗复合物
公开(公告)号：WO2008146956A1
公开(公告)日：2008-12-04
申请号：PCT/KR2007/002215
申请日：2007-05-06
申请人： MIN, Byoung-Hyun , PARK, So Ra , JIN, Cheng Zhe , CHOI, Byung Hyune
发明人： MIN, Byoung-Hyun , PARK, So Ra , JIN, Cheng Zhe , CHOI, Byung Hyune
IPC分类号： A61L27/56
CPC分类号： A61L27/56 , A61L27/3633 , A61L27/3817 , A61L27/3834 , A61L27/3852 , A61L2430/06
摘要： The present invention relates to a method for preparing a cell-derived ECM scaffold to which chondrocytes or stem cells are attached, a method for cartilage regeneration by tissue engineering, which comprises using the cell-derived ECM scaffold, and a therapeutic composition for treating cartilage disorder, which contains the ECM scaffold as an effective component. More specifically, the present invention relates to a method for cartilage regeneration by tissue engineering, which comprises transplanting ECM scaffold, having chondrocytes or stem cells attached thereto, into cartilage defects, and a therapeutic composition for treating cartilage disorder, which contains the ECM scaffold, having chondrocytes or stem cells attached thereto, as an effective component. According to the present invention, when the inventive ECM scaffold having chondrocytes or stem cells attached thereto is transplanted into a cartilage defect, mature articular cartilage having the same appearance and characteristics as those of natural cartilage tissue, can be regenerated without side effects such as inflammatory responses.
摘要翻译：本发明涉及一种制备软骨细胞或干细胞连接的细胞衍生的ECM支架的方法，一种通过组织工程软骨再生的方法，其包括使用细胞衍生的ECM支架和用于治疗软骨的治疗组合物其包含ECM支架作为有效成分。更具体地说，本发明涉及通过组织工程软骨再生的方法，其包括将附着有软骨细胞或干细胞的ECM支架移植到软骨缺损中，以及用于治疗软骨病症的治疗组合物，其含有ECM支架，具有附着于其上的软骨细胞或干细胞作为有效成分。根据本发明，当将附着有软骨细胞或干细胞的本发明的ECM支架移植到软骨缺损中时，具有与天然软骨组织相同的外观和特征的成熟关节软骨可以再生而无副作用，例如炎性响应。

6. 发明申请

WO2008004752A1 METHOD FOR PREPARING MESENCHYMAL STEM CELLS BY ULTRASONIC TREATMENT 审中-公开
标题翻译：通过超声处理制备骨髓干细胞的方法
公开(公告)号：WO2008004752A1
公开(公告)日：2008-01-10
申请号：PCT/KR2007/002031
申请日：2007-04-25
申请人： MIN, Byoung-Hyun , PARK, So Ra , CHOI, Woo-Hee
发明人： MIN, Byoung-Hyun , PARK, So Ra , CHOI, Woo-Hee
IPC分类号： C12N5/06 , C12N13/00 , C12N15/06
CPC分类号： C12N5/0663 , C12N2521/10
摘要： The present invention relates to a method for improving the efficiency of obtaining mesenchymal stem cells (MSCs), more particularly, a method for obtaining bone marrow-derived mesenchymal stem cells, the method comprising enhancing cell adhesion capacity and proliferation of mesenchymal stem cells (MSCs) by treating MSC-containing cells isolated from MSC-containing tissues with ultrasound. According to the present invention, a great amount of pure MSCs having a normal differentiation capacity can be easily obtained from a group of cells containing MSCs, compared to the existing methods.
摘要翻译：本发明涉及提高获得间充质干细胞（MSC）的效率的方法，更具体地说，涉及一种获得骨髓间充质干细胞的方法，该方法包括增强间充质干细胞（MSC）的细胞粘附能力和增殖）通过用超声波处理从含MSC组织分离的含MSC细胞。根据本发明，与现有方法相比，可以容易地从含有MSC的细胞群中获得大量具有正分化能力的纯MSC。

7. 发明申请

WO2010044577A3 METHOD FOR MANUFACTURING A POROUS THREE-DIMENSIONAL SUPPORT USING POWDER FROM ANIMAL TISSUE, AND POROUS THREE-DIMENSIONAL SUPPORT MANUFACTURED BY SAME 审中-公开
标题翻译：利用动物组织制造多孔三维支撑体的方法以及由该组织制造的多孔三维支撑体的制造方法
公开(公告)号：WO2010044577A3
公开(公告)日：2010-08-19
申请号：PCT/KR2009005839
申请日：2009-10-12
申请人： AJOU UNIV IND ACAD COOP FOUND , MIN BYOUNG-HYUN , JANG JI WOOK
发明人： MIN BYOUNG-HYUN , JANG JI WOOK
IPC分类号： A61L27/38
CPC分类号： A61F2/00 , A61L27/3604 , A61L27/3612 , A61L27/3654 , A61L27/3683 , A61L27/3817 , A61L27/3852 , A61L27/56 , A61L2400/08 , A61L2400/18 , A61L2430/06 , A61L2430/40
摘要： The present invention provides a method for manufacturing a porous three-dimensional support using powder from animal tissue, comprising the steps of making a powder from animal-derived tissue, decellularizing the powder before, after, or simultaneously with the step of making the powder from the animal-derived tissue, and forming the decelluralized powder from the animal-derived tissue into a porous three-dimensional support through a particle leaching method.
摘要翻译：本发明提供了一种使用动物组织粉末制造多孔三维载体的方法，该方法包括以下步骤：由来自动物的组织制备粉末，在制备粉末的步骤之前，之后或同时将粉末去细胞化来自动物的组织，通过颗粒浸出法将来自动物的组织脱颗粒化的粉末形成多孔性的三维支撑体。

8. 发明申请

WO2009017264A1 AN ULTRASOUND EQUIPMENT FOR TREATING OF EDEMA AND USE THEREOF 审中-公开
标题翻译：一种超声波处理设备及其应用
公开(公告)号：WO2009017264A1
公开(公告)日：2009-02-05
申请号：PCT/KR2007/003653
申请日：2007-07-30
申请人： REGENPRIME CO., LTD. , MIN, Byoung-Hyun , PARK, So Ra , KWON, Soon Keun
发明人： MIN, Byoung-Hyun , PARK, So Ra , KWON, Soon Keun
IPC分类号： A61N7/00
CPC分类号： A61N7/00
摘要： The present invention relates to an ultrasound equipment for treating edema, and more particularly, to an ultrasound equipment to relieve symptoms of edema or repair cellular and tissue edemas by generating 20-400 mW/cm of low intensity ultrasound and use thereof. The ultrasound equipment according to the present invention comprises a main control unit equipped with a control unit for ultrasound generation for generating a 20~400mW/cm2 of low intensity ultrasound, an ultrasound generator for generating ultrasound according to the operating state of the main control unit, an ultrasound vibrator vibrating according to the value of ultrasound data inputted from the ultrasound generator, and a probe for delivering ultrasound energy to a treatment site, and when the ultrasound equipment is used, it is possible to treat edema by increasing permeability in blood vessels.
摘要翻译：本发明涉及一种用于治疗水肿的超声设备，更具体地，涉及一种通过产生20-400mW / cm的低强度超声波及其应用来减轻水肿症状或修复细胞和组织水肿的超声设备。根据本发明的超声波设备包括主控制单元，其配备有用于产生20〜400mW / cm 2的低强度超声波的超声波发生用控制单元，根据主控制单元的动作状态生成超声波的超声波发生器，根据从超声波发生器输入的超声波数据的振动振动的超声波振动器，以及用于将超声波能量输送到治疗部位的探针，当使用超声波设备时，可以通过增加血管的渗透性来治疗水肿。

9. 发明申请

WO2005045008A1 METHOD FOR INDUCING CHONDROGENESIS ON MESENCHYMAL STEM CELLS 审中-公开
标题翻译：诱导细胞干细胞成纤维细胞生长的方法
公开(公告)号：WO2005045008A1
公开(公告)日：2005-05-19
申请号：PCT/KR2004/002879
申请日：2004-11-08
申请人： INHA UNIVERSITY , PARK, So Ra , MIN, Byoung Hyun , LEE, Hyun Jung
发明人： PARK, So Ra , MIN, Byoung Hyun , LEE, Hyun Jung
IPC分类号： C12N5/06
CPC分类号： C12N5/0654 , A61K35/12 , A61K41/0028 , A61K2035/124 , C12N5/0655 , C12N13/00 , C12N2533/74
摘要： The present invention relates to a method for inducing chondrogenesis on mesenchymal stem cells, more particularly, it relates to a method for inducing chondrogenesis by employing treatment with low intensity ultrasound on the mesenchymal stem cells and a therapeutic composition comprising chondrocytes differentiated by said method. According to the present invention, it is possible to induce effectively chondrogenic differentiation of the mesenchymal stem cells without using conventional expensive growth factors, thereby making it possible to prepare economically artificial cartilage and therapeutic compositions comprising chondrocytes.
摘要翻译：本发明涉及一种用于诱导间充质干细胞的软骨形成的方法，更具体地说，涉及通过在间充质干细胞上使用低强度超声波治疗来诱导软骨形成的方法以及包含通过所述方法分化的软骨细胞的治疗组合物的方法。根据本发明，可以在不使用常规昂贵的生长因子的情况下有效诱导间充质干细胞的软骨形成分化，从而可以制备经济上人造软骨和包含软骨细胞的治疗组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式