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1. 发明申请

WO2009045343A1 INSTRUMENTED PIPETTE TIP 审中-公开
标题翻译：仪器仪表提示
公开(公告)号：WO2009045343A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/011205
申请日：2008-09-26
申请人： EL SPECTRA, LLC , AYLIFFE, Harold, E. , KING, Curtis, S.
发明人： AYLIFFE, Harold, E. , KING, Curtis, S.
IPC分类号： B01L3/02
CPC分类号： B01L3/0275 , B01L3/0217 , B01L3/5027 , B01L2300/0627 , B01L2300/0645 , G01N35/1016 , G01N2035/1062
摘要： An improved pipette tip (100) including an elongate body stretching between a proximal end (116) and a distal end (114). The body (112) is typically made from a plurality of layers (e.g. 130, 132, 134, 136, 138) configured and arranged to provide a fluid path extending from the distal end toward the proximal end. The improved pipette tip (100) includes a sensor component disposed to electrically interrogate fluid flowing along the fluid path. An operable sensor component includes an electrode (e.g. 154, 192) that is disposed in the fluid path to contact fluid therein. A pipette tip (100) may be embodied to: count particles, verify sample integrity (e.g. freedom from bubbles), monitor sample flow rate, and confirm an inspired volume, among other uses.
摘要翻译：一种改进的移液器吸头（100），包括在近端（116）和远端（114）之间延伸的细长体。主体（112）通常由多个层（例如，130,132,134,136,138）制成，其被构造和布置成提供从远端朝向近端延伸的流体路径。改进的移液管尖端（100）包括设置成电询问沿着流体路径流动的流体的传感器部件。可操作的传感器部件包括布置在流体路径中以接触其中的流体的电极（例如154,192）。移液管尖端（100）可以被实现为：除了其他用途之外，还可以计数颗粒，验证样品完整性（例如，不受气泡的影响），监测样品流速，以及确认启发体积。

2. 发明申请

WO2009126257A1 METHOD FOR MANUFACTIRING A MICROFLUIDIC SENSOR 审中-公开
标题翻译：微流感传感器的制造方法
公开(公告)号：WO2009126257A1
公开(公告)日：2009-10-15
申请号：PCT/US2009/002172
申请日：2009-04-07
申请人： E.I. SPECTRA, LLC , AYLIFFE, Harold, E. , KING, Curtis, S.
发明人： AYLIFFE, Harold, E. , KING, Curtis, S.
IPC分类号： G01N11/00
CPC分类号： B01L3/502707 , B01L2200/0647 , B01L2200/10 , B01L2300/0645 , B01L2300/0681 , B01L2300/0874 , B01L2300/0887 , B01L2300/123
摘要： A method to manufacture microfluidic sensors, typically including componentizing substrate layers One such method includes providing a plurality of layers of material configured to permit their stacking to form at least a first cap layer, a first channel layer, an interrogation layer, and a second channel layer During assembly, ribbon sections of substrate layers are sandwiched to cooperatively align elements through-the-thickness of the sandwich Individual sensors are then removed from the sandwich ribbon A componentizing step includes forming one or more elements for successive sensors spaced along the axial length of a ribbon Certain elements include electrically conductive patterned structures preferably printed onto a substrate using conductive ink and a printing process, sometimes placing material in operable position to conduct electricity through the thickness of at least one nbbon Other elements may include channels, tunnels, and vias that can be machined, stamped, or cut into a ribbon section.
摘要翻译：一种制造微流体传感器的方法，通常包括组分化衬底层一种这样的方法包括提供多层材料，其被配置为允许其堆叠形成至少第一覆盖层，第一沟道层，询问层和第二沟道层在组装期间，衬底层的带状部分被夹持以通过夹层的厚度协同对准元件。然后将单独的传感器从夹带中移出。组件化步骤包括形成一个或多个元件，用于沿着轴向长度丝带某些元件包括导电图案结构，优选地使用导电油墨和印刷方法印刷在基底上，有时将材料放置在可操作位置以将电穿过至少一个nbbon的厚度。其它元件可以包括通道，隧道和通孔，可加工，冲压或切割丝带部分。

3. 发明申请

WO2009070246A1 FLUORESCENCE-BASED PIPETTE INSTRUMENT 审中-公开
标题翻译：基于荧光管的仪器
公开(公告)号：WO2009070246A1
公开(公告)日：2009-06-04
申请号：PCT/US2008/013003
申请日：2008-11-21
申请人： E.I SPECTRA, LLC , AYLIFFE, Harold, E. , KING, Curtis, S.
发明人： AYLIFFE, Harold, E. , KING, Curtis, S.
IPC分类号： B01L3/02
CPC分类号： G01N15/10 , B01L3/0217 , B01L3/0275 , B01L3/50273 , B01L2200/0647 , B01L2200/0689 , B01L2300/025 , B01L2300/0645 , B01L2300/0654 , B01L2300/0874 , B01L2300/0887 , G01N21/05 , G01N21/645 , G01N21/65 , G01N35/10 , G01N2015/1062 , G01N2015/1486 , G01N2021/0346 , G01N2021/6482 , G01N2035/103 , G01N2035/1039 , G01N2035/1062
摘要： An improved pipette tip (276) including an elongate body stretching between a proximal end (277) and a distal end. The body typically includes a plurality of thin film layers (e.g. 154, 156, 102, 158, 202) configured and arranged to provide a fluid path extending from the distal end toward the proximal end (277). The improved pipette tip (276) includes an interrogation zone in which to interrogate fluid flowing along the fluid path. One operable interrogation arrangement, generally (100), includes structure configured to permit detection of radiation resulting from a Stokes-shift. Optionally, a sensor component may include one or more electrode (e.g. 248, 250) that is disposed in the fluid path to contact fluid therein for electrically-based interrogation. A pipette tip (276) may be embodied to: count particles, verify sample integrity (e.g. freedom from bubbles), monitor sample flow rate, and confirm an inspired volume, among other uses.
摘要翻译：改进的移液管尖端（276），包括在近端（277）和远端之间延伸的细长体。身体通常包括多个薄膜层（例如154,156,102,158,202），其被构造和布置成提供从远端朝向近端（277）延伸的流体路径。改进的移液管尖端（276）包括询问区域，用于询问沿着流体路径流动的流体。通常（100）的一个可操作的询问装置包括被配置为允许检测由斯托克斯转变引起的辐射的结构。可选地，传感器部件可以包括设置在流体路径中的一个或多个电极（例如248,250），以接触其中的用于基于电的询问的流体。移液管尖端（276）可以被实现为：除了其他用途之外，还可以对颗粒进行计数，验证样品完整性（例如，无气泡），监测样品流速，以及确认启发体积。

4. 发明申请

WO2010126459A1 PIPETTE INSTRUMENT 审中-公开
标题翻译：管件仪器
公开(公告)号：WO2010126459A1
公开(公告)日：2010-11-04
申请号：PCT/US2009/002564
申请日：2009-04-27
申请人： EI SPECTRA, LLC , AYLIFFE, Harold, E. , KING, Curtis, S. , MCGUINNIS, Michael, E.
发明人： AYLIFFE, Harold, E. , KING, Curtis, S. , MCGUINNIS, Michael, E.
IPC分类号： G01N1/14
CPC分类号： G01N15/12 , B01L3/021 , B01L3/0237 , B01L2200/141 , B01L2200/143 , B01L2200/146 , B01L2400/0487 , G01N2035/1062
摘要： A pipette instrument 100 carrying interrogation circuitry 132 adapted to interrogate a data signal received from a removable instrumented pipette tip 114. The pipette 100 includes a microprocessor and memory 130 that can be programmed to perform data collection procedures. User controls typically include a start button 108, and a track wheel 1 10. A display device 1 12 can present device options through one or more menu, and show data resulting from one or more test result. The pipette can interrogate particles carried by a fluid flowing through a tip 1 14 by detecting either of, or both of, Coulter principle phenomena, and Stokes-shift phenomena.
摘要翻译：携带询问电路132的移液管仪器100，用于询问从可移动的带标号的移液管尖端114接收的数据信号。移液管100包括微处理器和存储器130，其可编程为执行数据采集程序。用户控件通常包括起始按钮108和履带轮110.显示装置112可以通过一个或多个菜单呈现装置选项，并显示由一个或多个测试结果产生的数据。移液管可以通过检测库尔特原理现象和斯托克斯转移现象中的任一个或两者来询问流过尖端114的流体携带的颗粒。

5. 发明公开

EP2265923A1 METHOD FOR MANUFACTURING A MICROFLUIDIC SENSOR 审中-公开
标题翻译：用于生产微流体传感器
公开(公告)号：EP2265923A1
公开(公告)日：2010-12-29
申请号：EP09731019.7
申请日：2009-04-07
申请人： El Spectra, LLC
发明人： AYLIFFE, Harold, E. , KING, Curtis, S.
IPC分类号： G01N11/00
CPC分类号： B01L3/502707 , B01L2200/0647 , B01L2200/10 , B01L2300/0645 , B01L2300/0681 , B01L2300/0874 , B01L2300/0887 , B01L2300/123
摘要： A method to manufacture microfluidic sensors, typically including componentizing substrate layers One such method includes providing a plurality of layers of material configured to permit their stacking to form at least a first cap layer, a first channel layer, an interrogation layer, and a second channel layer During assembly, ribbon sections of substrate layers are sandwiched to cooperatively align elements through-the-thickness of the sandwich Individual sensors are then removed from the sandwich ribbon A componentizing step includes forming one or more elements for successive sensors spaced along the axial length of a ribbon Certain elements include electrically conductive patterned structures preferably printed onto a substrate using conductive ink and a printing process, sometimes placing material in operable position to conduct electricity through the thickness of at least one nbbon Other elements may include channels, tunnels, and vias that can be machined, stamped, or cut into a ribbon section.

6. 发明公开

EP2195114A1 INSTRUMENTED PIPETTE TIP 有权转让
标题翻译： INSTRUMENTIERTE PIPETTENSPITZE
公开(公告)号：EP2195114A1
公开(公告)日：2010-06-16
申请号：EP08835264.6
申请日：2008-09-26
申请人： El Spectra, LLC
发明人： AYLIFFE, Harold, E. , KING, Curtis, S.
IPC分类号： B01L3/02
CPC分类号： B01L3/0275 , B01L3/0217 , B01L3/5027 , B01L2300/0627 , B01L2300/0645 , G01N35/1016 , G01N2035/1062
摘要： An improved pipette tip (100) including an elongate body stretching between a proximal end (116) and a distal end (114). The body (112) is typically made from a plurality of layers (e.g. 130, 132, 134, 136, 138) configured and arranged to provide a fluid path extending from the distal end toward the proximal end. The improved pipette tip (100) includes a sensor component disposed to electrically interrogate fluid flowing along the fluid path. An operable sensor component includes an electrode (e.g. 154, 192) that is disposed in the fluid path to contact fluid therein. A pipette tip (100) may be embodied to: count particles, verify sample integrity (e.g. freedom from bubbles), monitor sample flow rate, and confirm an inspired volume, among other uses.

7. 发明授权

EP2425226B1 PIPETTE INSTRUMENT 有权转让
公开(公告)号：EP2425226B1
公开(公告)日：2020-10-07
申请号：EP09844122.3
申请日：2009-04-27
申请人： El Spectra, LLC
发明人： AYLIFFE, Harold, E. , KING, Curtis, S. , MCGUINNIS, Michael, E.
IPC分类号： G01N1/14 , B01L3/02 , G01N15/12

8. 发明公开

EP2425226A1 PIPETTE INSTRUMENT 有权转让
标题翻译： PIPETTENGERÄT
公开(公告)号：EP2425226A1
公开(公告)日：2012-03-07
申请号：EP09844122.3
申请日：2009-04-27
申请人： El Spectra, LLC
发明人： AYLIFFE, Harold, E. , KING, Curtis, S. , MCGUINNIS, Michael, E.
IPC分类号： G01N1/14
CPC分类号： G01N15/12 , B01L3/021 , B01L3/0237 , B01L2200/141 , B01L2200/143 , B01L2200/146 , B01L2400/0487 , G01N2035/1062
摘要： A pipette instrument 100 carrying interrogation circuitry 132 adapted to interrogate a data signal received from a removable instrumented pipette tip 114. The pipette 100 includes a microprocessor and memory 130 that can be programmed to perform data collection procedures. User controls typically include a start button 108, and a track wheel 1 10. A display device 1 12 can present device options through one or more menu, and show data resulting from one or more test result. The pipette can interrogate particles carried by a fluid flowing through a tip 1 14 by detecting either of, or both of, Coulter principle phenomena, and Stokes-shift phenomena.

9. 发明授权

EP2195114B1 INSTRUMENTED PIPETTE TIP 有权转让
标题翻译：仪表吸管尖端
公开(公告)号：EP2195114B1
公开(公告)日：2017-03-22
申请号：EP08835264.6
申请日：2008-09-26
申请人： El Spectra, LLC
发明人： AYLIFFE, Harold, E. , KING, Curtis, S.
IPC分类号： B01L3/02
CPC分类号： B01L3/0275 , B01L3/0217 , B01L3/5027 , B01L2300/0627 , B01L2300/0645 , G01N35/1016 , G01N2035/1062

10. 发明公开

EP2214833A1 FLUORESCENCE-BASED PIPETTE INSTRUMENT 审中-公开
标题翻译：移液器仪器对荧光性碱基
公开(公告)号：EP2214833A1
公开(公告)日：2010-08-11
申请号：EP08854302.0
申请日：2008-11-21
申请人： El Spectra, LLC
发明人： AYLIFFE, Harold, E. , KING, Curtis, S.
IPC分类号： B01L3/02
CPC分类号： G01N15/10 , B01L3/0217 , B01L3/0275 , B01L3/50273 , B01L2200/0647 , B01L2200/0689 , B01L2300/025 , B01L2300/0645 , B01L2300/0654 , B01L2300/0874 , B01L2300/0887 , G01N21/05 , G01N21/645 , G01N21/65 , G01N35/10 , G01N2015/1062 , G01N2015/1486 , G01N2021/0346 , G01N2021/6482 , G01N2035/103 , G01N2035/1039 , G01N2035/1062
摘要： An improved pipette tip (276) including an elongate body stretching between a proximal end (277) and a distal end. The body typically includes a plurality of thin film layers (e.g. 154, 156, 102, 158, 202) configured and arranged to provide a fluid path extending from the distal end toward the proximal end (277). The improved pipette tip (276) includes an interrogation zone in which to interrogate fluid flowing along the fluid path. One operable interrogation arrangement, generally (100), includes structure configured to permit detection of radiation resulting from a Stokes-shift. Optionally, a sensor component may include one or more electrode (e.g. 248, 250) that is disposed in the fluid path to contact fluid therein for electrically-based interrogation. A pipette tip (276) may be embodied to: count particles, verify sample integrity (e.g. freedom from bubbles), monitor sample flow rate, and confirm an inspired volume, among other uses.

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