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1. 发明申请

WO1991001718A1 METHOD OF PHOTOSTABILIZING EYEWASH AND PHOTOSTABILIZED EYEWASH 审中-公开
标题翻译：光敏化学和光致发光眼睛的方法
公开(公告)号：WO1991001718A1
公开(公告)日：1991-02-21
申请号：PCT/JP1990000950
申请日：1990-07-26
申请人： EISAI CO., LTD. , SANTEN PHARMACEUTICAL CO., LTD. , MORITA, Takakazu , MITA, Shiro , KAWASHIMA, Yoichi
发明人： EISAI CO., LTD. , SANTEN PHARMACEUTICAL CO., LTD.
IPC分类号： A61K09/08
CPC分类号： A61K33/22 , A61K9/0048 , A61K31/047 , A61K2300/00
摘要： A method of photostabilizing an eyewash containing a photo-unstable medicine as an ingredient, which comprises adding thereto boric acid and/or borax and a polyhydric alcohol.

2. 发明申请

WO1997046526A1 STABLE POLYMORPHS OF DONEPEZIL (1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON)-2-YL]METHYLPIPERIDINE) HYDROCHLORIDE AND PROCESS FOR PRODUCTION 审中-公开
标题翻译：二苯乙烯（1-苄基-4 - [（5,6-二甲氧基-1-茚满酮）-2-基]甲基哌啶）的稳定聚合物及其制备方法
公开(公告)号：WO1997046526A1
公开(公告)日：1997-12-11
申请号：PCT/JP1996003881
申请日：1996-12-27
申请人： EISAI CO., LTD. , IMAI, Akio , WATANABE, Hideaki , KAJIMA, Takashi , ISHIHAMA, Yasushi , OHTSUKA, Akiyo , TANAKA, Tomohide
发明人： EISAI CO., LTD.
IPC分类号： C07D211/32
CPC分类号： C07D211/32
摘要： Donepezil hydrochloride, 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride, is provided here in the form of four polymorphs which are stable against heat and humidity in the pharmaceutical use. They can be industrially produced. They are specified by peaks in X-ray powder diffraction pattern and absorption peaks in infrared absorption spectra in potassium bromide.
摘要翻译：盐酸多奈哌齐，1-苄基-4 - [（5,6-二甲氧基-1-茚满酮）-2-基]甲基哌啶盐酸盐，以药物用途中对热和湿度稳定的四种多晶型物的形式提供。他们可以在工业上生产。它们由X射线粉末衍射图中的峰和溴化钾红外吸收光谱中的吸收峰指定。

3. 发明申请

WO1997012872A1 ACRIDONE COMPOUNDS 审中-公开
标题翻译： ACRIDONE化合物
公开(公告)号：WO1997012872A1
公开(公告)日：1997-04-10
申请号：PCT/JP1996002880
申请日：1996-10-03
申请人： EISAI CO., LTD. , MIYAMOTO, Mitsuaki , YOSHIUCHI, Tatsuya , SATO, Keizo , KAINO, Makoto , TAKASHIMA, Yoshihiro , MORIYA, Katsuhiro , SAKUMA, Yoshinori , YAMADA, Koji , HARADA, kOkichi , NISHIZAWA, Yukio , KOBAYASHI, Seiichi , OKITA, Makoto , KATAYAMA, Koichi
发明人： EISAI CO., LTD.
IPC分类号： C07D219/14
CPC分类号： C07D219/14
摘要： Novel acridone compounds represented by general formula (I) or pharmacologically acceptable salts thereof efficacious in the prevention and treatment of diseases in which chemical transmitters (histamine, leukotriene, etc.) participate, typified by asthma, allergic rhinitis, atopic dermatitis, urticaria, hay fever, digestive tract allergy, food allergy, etc., wherein R , R , R , R , R and R are the same or different and each represents hydrogen, hydroxy, halogeno, lower alkyl, cycloalkyl, lower alkoxy, etc.; Y represents -(CH2)t-(B)m-(CH2)-Z [wherein m is 0 or 1; t and n represent each an integer of from 0 to 6; B represents lower alkylene, optionally substituted arylene, etc.; and Z represents cyano, optionally protected carboxy, acyl or -NR R (wherein R and R are the same or different and each represents hydrogen, lower alkyl, lower alkoxy, hydroxyalkyl, etc.)]; and D represents oxygen or sulfur.
摘要翻译：由通式（I）表示的新型吖啶酮化合物或其药学上可接受的盐在预防和治疗化学发射器（组胺，白三烯等）参与的疾病中有效，以哮喘，过敏性鼻炎，特应性皮炎，荨麻疹，干草为代表发热，消化道过敏，食物过敏等，其中R 1，R 2，R 3，R 4，R 5和R 6相同或不同，表示氢，羟基，卤代，低级烷基，环烷基，低级烷氧基等; Y表示 - （CH 2）t - （B）m - （CH 2）-Z [其中m为0或1; t和n表示0〜6的整数。 B表示低级亚烷基，任选取代的亚芳基等; 和Z表示氰基，任意保护的羧基，酰基或-NR 7 R 8（其中R 7和R 8相同或不同，各自代表氢，低级烷基，低级烷氧基，羟基烷基等。）]; D表示氧或硫。

4. 发明申请

WO1997012871A1 ACRIDONE DERIVATIVE 审中-公开
标题翻译：阿司匹林衍生物
公开(公告)号：WO1997012871A1
公开(公告)日：1997-04-10
申请号：PCT/JP1995002007
申请日：1995-10-02
申请人： EISAI CO., LTD. , MIYAMOTO, Mitsuaki , YOSHIUCHI, Tatsuya , ABE, Shinya , TANAKA, Masayuki , MORIYA, Katsuhiro , KATAYAMA, Satoshi , YAMANAKA, Takashi , YAMADA, Koji
发明人： EISAI CO., LTD.
IPC分类号： C07D219/06
CPC分类号： C07D219/14
摘要： An acridone derivative represented by general formula (I) and a pharmacologically acceptable salt thereof, efficacious in preventing or treating deseases wherein histamine, leucotriene and the like participate and allergic diseases such as asthma, allergic rhinitis, atopic dermatitis, urticaria, hay fever, gastrointestinal allergy, and food allergy, wherein R to R represent each hydrogen, lower alkyl, etc.; and n represents an integer of 1 to 6.
摘要翻译：由通式（I）表示的吖啶酮衍生物及其药理学上可接受的盐可有效预防或治疗组胺，白三烯等参与的过敏性疾病如哮喘，过敏性鼻炎，特应性皮炎，荨麻疹，花粉症，胃肠道过敏和食物过敏，其中R 1至R 8表示每个氢，低级烷基等; n表示1〜6的整数。

5. 发明申请

WO1996039411A1 SUBSTITUTED LIPOSACCHARIDES USEFUL IN THE TREATMENT AND PREVENTION OF ENDOTOXEMIA 审中-公开
标题翻译：用于治疗和预防内毒素的替代利妥昔单抗
公开(公告)号：WO1996039411A1
公开(公告)日：1996-12-12
申请号：PCT/US1996009578
申请日：1996-06-05
申请人： EISAI CO., LTD. , CHRIST, William, J. , ROSSIGNOL, Daniel, P. , KOBAYASHI, Seiichi , KAWATA, Tsutomu
发明人： EISAI CO., LTD.
IPC分类号： C07H05/04
CPC分类号： C07H15/04 , A61K9/0073 , C07H3/04 , C07H11/00 , C07H15/12
摘要： Novel substituted liposaccharides useful in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock and methods of using these agents are provided. Also provided are method of preparing these agents and intermediates useful therein.
摘要翻译：提供了可用于预防和肯定治疗包括败血症，败血症和各种形式的败血症休克的内毒素血症的新型取代的脂糖和使用这些药剂的方法。还提供制备这些试剂的方法和其中有用的中间体。

6. 发明申请

WO1996016170A3 PROTEINS INVOLVED IN THE REGULATION OF CELL-CELL ADHESION AND USES THEREOF 审中-公开
公开(公告)号：WO1996016170A3
公开(公告)日：1996-05-30
申请号：PCT/GB1995002686
申请日：1995-11-16
申请人： EISAI CO., LTD. , STADDON, James, Michael
发明人： EISAI CO., LTD.
IPC分类号： C12N15/12

7. 发明申请

WO1996014302A1 PYRAZOLE DERIVATIVES EXHIBITING ANTI-INFLAMMATORY AND ANALGESIC EFFECTS 审中-公开
标题翻译：展示抗炎和麻醉效应的吡唑衍生物
公开(公告)号：WO1996014302A1
公开(公告)日：1996-05-17
申请号：PCT/JP1995002250
申请日：1995-11-06
申请人： EISAI CO., LTD. , NUMATA, Hirotoshi , OKAMOTO, Yasushi , SHINODA, Masanobu , KOBAYASHI, Naoki , MIYAZAWA, Shuhei , KAWAHARA, Tetsuya , SHIROTA, Hiroshi , NAGAKURA, Naoki , HORIZOE, Tatsuo , ABE, Shinya , KOBAYASHI, Seiichi , YAMANAKA, Takashi
发明人： EISAI CO., LTD.
IPC分类号： C07D231/12
CPC分类号： C07D231/12 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/10 , C07D409/04 , C07D413/10 , C07D419/06
摘要： Pyrazole derivatives represented by formula (I) and physiologically acceptable salts thereof can suppress the production of both of prostaglandins and leukotrienes simultaneously, and, therefore, exhibit anti-inflammatory and analgesic effects.
摘要翻译：由式（I）表示的吡唑衍生物及其生理学上可接受的盐可以同时抑制前列腺素和白三烯两者的产生，因此具有抗炎和镇痛作用。

8. 发明申请

WO1996003156A1 METHOD OF STERILIZING A PREFILLED SYRINGE AND A PREFILLED SYRINGE STERILIZED BY THE SAME 审中-公开
标题翻译：杀菌预先注射的方法和由其灭菌的预先注射的方法
公开(公告)号：WO1996003156A1
公开(公告)日：1996-02-08
申请号：PCT/JP1995001459
申请日：1995-07-21
申请人： EISAI CO., LTD. , NOZU, Yukio , IKEUCHI, Takayuki , IDA, Katsumi , WATANABE, Sumio
发明人： EISAI CO., LTD.
IPC分类号： A61L02/06
CPC分类号： B65B7/2821 , A61L2/07 , B65B3/003
摘要： A prefilled syringe (1) having an outer cylindrical body (2) which includes a nozzle (6) as is integrally formed at its one end (5) and an opening (8) as is provided at its other end (7), wherein said cylindrical body is filled with a medical liquid substance (medication to be injected) (9) and said nozzle is sealed with a cap (3) while said opening (8) is sealed with a gasket (4). In the process of fabricating said prefilled syringe (1), said cap (3) is sterilized with steam after it is immersed in distilled water, but before it seals the nozzle (6) of said cylindrical body (2), and also said gasket (4) is sterilized with steam after it is immersed in distilled water, but before it seals the other end (7) of said outer cylindrical body (2).
摘要翻译：一种具有外圆柱体（2）的预充式注射器（1），其包括在其一端（5）处一体形成的喷嘴（6）和在其另一端（7）处设置的开口（8），其中所述圆柱形主体填充有医疗液体物质（待注射药物）（9），并且所述喷嘴用盖子（3）密封，而所述开口（8）用垫圈（4）密封。在制造所述预充式注射器（1）的过程中，所述盖（3）在浸入蒸馏水中之后，但在密封所述圆柱体（2）的喷嘴（6）之前，用蒸汽灭菌，并且所述垫圈（4）在将其浸入蒸馏水中之后，然后在密封所述外圆柱体（2）的另一端（7）之前用蒸汽灭菌。

9. 发明申请

WO1994027583A2 APOPTOSIS INHIBITORS FOR TREATING NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：用于治疗神经损伤性疾病的药物抑制剂
公开(公告)号：WO1994027583A2
公开(公告)日：1994-12-08
申请号：PCT/GB1994001169
申请日：1994-05-31
申请人： EISAI CO., LTD. , RUBIN, Lee, Laurence , BROOKS, Susan, Frances
发明人： EISAI CO., LTD.
IPC分类号： A61K31/00
CPC分类号： A61K31/57 , A61K31/00 , A61K31/135 , A61K31/375 , A61K31/40 , A61K31/52 , A61K31/64
摘要： Apoptotic cell death in a fully differentiated, non-dividing cell such as a neuron is caused by an abortive attempt of the cell to re-enter or pass through the mitotic cycle. Therefore, agents which prevent such entry or passage are effective in preventing, or at least delaying, apoptotic cell death and are therefore useful in the treatment of neurodegenerative diseases in general, including stroke, Alzheimer's disease, Parkinson's disease and motor-neuron disease in particular.
摘要翻译：在完全分化的非分裂细胞如神经元中的细胞凋亡细胞死亡是由于细胞重新进入或通过有丝分裂循环的堕胎尝试引起的。因此，阻止这种进入或通过的药剂有效地预防或至少延迟凋亡细胞死亡，因此可用于治疗一般的神经变性疾病，特别是中风，阿尔茨海默病，帕金森病和运动神经元疾病。

10. 发明申请

WO1994014777A1 HETEROCYCLIC CARBONIC ACID DERIVATIVES WHICH BIND TO RETINOID RECEPTORS (RAR) 审中-公开
标题翻译：杂环羧酸衍生物（RAR）
公开(公告)号：WO1994014777A1
公开(公告)日：1994-07-07
申请号：PCT/JP1993001841
申请日：1993-12-20
申请人： EISAI CO., LTD. , YOSHIMURA, Hiroyuki , NAGAI, Mitsuo , HIBI, Shigeki , KIKUCHI, Koichi , HISHINUMA, Ieharu , NAGAKAWA, Junichi , ASADA, Makoto , MIYAMOTO, Norimasa , HIDA, Takayuki , OGASAWARA, Aichi , YAMATSU, Isao
发明人： EISAI CO., LTD.
IPC分类号： C07D231/54
CPC分类号： C07D495/04 , C07D209/56 , C07D221/18 , C07D231/54 , C07D277/60 , C07D307/77 , C07D311/92 , C07D333/38 , C07D333/50 , C07D335/08 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/06 , C07D409/06 , C07D409/14 , C07D417/04 , C07D491/04
摘要： A heterocycle-containing carbonic acid derivative represented by general formula (I) or a physiologically acceptable salt thereof which exhibits an excellent preventive and therapeutic effect against various diseases linked to retinoic acid and an intermediate which is useful for the production of the heterocycle-containing carbonic acid derivative. B represents a heterocyclic group, D represents a phenyl group and A/E are as defined in the application.
摘要翻译：对通式（I）表示的含杂环的碳酸衍生物或其生理学上可接受的盐对视黄酸有相关的各种疾病具有优异的预防和治疗作用，以及可用于生产含杂环碳的中间体酸衍生物。 B表示杂环基，D表示苯基，A / E如本申请中所定义。

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