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1. 发明专利

IL158624A 3-(DISUBSTITUTED AMINO)ÔÇô7ÔÇô(SUBSTITUTED ARYL) PYRAZOLO[1,5-a]PYRIDINE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS 未知
公开(公告)号：IL158624A
公开(公告)日：2011-04-28
申请号：IL15862403
申请日：2003-10-27
申请人： HIBI SHIGEKI , KIKUCHI KOICHI , HOSHINO YORIHISA , SOEJIMA MOTOHIRO , YOSHIUCHI TATSUYA , SHIN KOGYOKU , ONO MUTSUKO , TAKAHASHI YOSHINORI , SHIBATA HISASHI , INO MITSUHIRO , EISAI R&D MAN CO LTD , HIRAKAWA TETSUYA , EISAI CO LTD
发明人： HIBI SHIGEKI , KIKUCHI KOICHI , HOSHINO YORIHISA , SOEJIMA MOTOHIRO , YOSHIUCHI TATSUYA , SHIN KOGYOKU , ONO MUTSUKO , TAKAHASHI YOSHINORI , SHIBATA HISASHI , INO MITSUHIRO , HIRAKAWA TETSUYA
IPC分类号： A61P3/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P15/00 , A61P19/00 , A61P25/08 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P37/08 , A61P43/00 , C07D471/04 , C07F5/02 , C07F7/22
摘要： Compounds represented by the general formula: Äwherein R represents methoxy, ethyl, methylthio, etc., R , R and R each represent hydrogen, a halogen, etc., R and R each represent -X -X -X (wherein X represents a single bond or -CO-, X represents a single bond, -NR , etc. and X and R each represent hydrogen, C1-10 alkyl, etc.), and Ar represents phenyl, pyridyl, etc.Ü, salts thereof and hydrates of the foregoing.

2. 发明申请

WO1997033871A1 NITROGENOUS TRICYCLIC COMPOUNDS AND DRUGS COMPRISING THE SAME 审中-公开
标题翻译：硝基三环化合物和包含其的药物
公开(公告)号：WO1997033871A1
公开(公告)日：1997-09-18
申请号：PCT/JP1997000789
申请日：1997-03-13
申请人： EISAI CO., LTD. , MIYAMOTO, Mitsuaki , YOSHIUCHI, Tatsuya , SATO, Keizo , KAINO, Makoto , TANAKA, Masayuki , SOEJIMA, Motohiro , MORIYA, Katsuhiro , SAKUMA, Yoshinori , YAMADA, Koji , HARADA, Kokichi , NISHIZAWA, Yukio , KOBAYASHI, Seiichi , OKITA, Makoto , KATAYAMA, Koichi
发明人： EISAI CO., LTD.
IPC分类号： C07D219/14
CPC分类号： C07D417/06 , C07D279/22 , C07D279/24 , C07D417/12 , C09B21/00 , C09B57/08
摘要： Novel phenothiazine, acridan, acridone oxime, acridone hydrazone, and dibenzodiazepine derivatives which are effective in the prevention and treatment of diseases in which histamine, leukotriene, etc., participate. Phenothiazine, acridan, acridone oxime, acridone hydrazone, and dibenzodiazepine derivatives represented by general formula (I) (where D represents alkylene, etc.) or pharmacologically acceptable salts thereof are effective in the prevention and treatment of diseases in which chemical transmitters such as histamine and leukotriene participate, for example, asthma, allergic rhinitis, atopic dermatitis, hives, hay fever, gastrointestinal allergy, and dietary allergy, wherein R , R , R , R , R , R , R and R are the same or different and each represents hydrogen, hydroxy, cyano, nitro, optionally substituted carbamoyl, halogeno, lower alkyl optionally substituted by hologeno, etc.; Z represents -S-, -SO-, -SO2-, =NO-substituent, -NC(O)-, or =NN-substituent; and Q represents, for example, -NR R (where R and R are the same or different and each represents hydrogen, lower alkyl optionally substituted by halogeno, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, or optionally substituted heteroarylalkyl, or R and R may be bonded to each other to thereby form a three- to eight-membered ring in cooperation with the nitrogen atom bonded thereto).
摘要翻译：新颖的吩噻嗪，吖啶酮，吖啶酮肟，吖啶酮腙和二苯并二氮杂衍生物，其有效预防和治疗组胺，白三烯等参与的疾病。吩噻嗪，吖啶酮，吖啶酮肟，吖啶酮腙和通式（I）表示的二苯并二氮杂衍生物（其中D表示亚烷基等）或其药理学上可接受的盐可有效预防和治疗化学发射体如组胺白三烯参与例如哮喘，过敏性鼻炎，特应性皮炎，荨麻疹，花粉热，胃肠过敏和饮食过敏，其中R 1，R 2，R 3，R 4，R 4， R 5，R 7和R 8相同或不同，各自表示氢，羟基，氰基，硝基，任选取代的氨基甲酰基，卤代，任选被氢原子取代的低级烷基等; Z表示-S-，-SO-，-SO 2 - ，= NO-取代基，-NC（O） - 或= N - 取代基; 并且Q表示例如-NR 20 R 21（其中R 20和R 21相同或不同，各自表示氢，任选被卤代取代的低级烷基，任选取代的芳基，任选取代的芳基烷基，任选取代的杂芳基或任选取代的杂芳基烷基，或R 20和R 21可以彼此键合，从而与键合的氮原子配合形成三元至八元环）。

3. 发明申请

WO1997012872A1 ACRIDONE COMPOUNDS 审中-公开
标题翻译： ACRIDONE化合物
公开(公告)号：WO1997012872A1
公开(公告)日：1997-04-10
申请号：PCT/JP1996002880
申请日：1996-10-03
申请人： EISAI CO., LTD. , MIYAMOTO, Mitsuaki , YOSHIUCHI, Tatsuya , SATO, Keizo , KAINO, Makoto , TAKASHIMA, Yoshihiro , MORIYA, Katsuhiro , SAKUMA, Yoshinori , YAMADA, Koji , HARADA, kOkichi , NISHIZAWA, Yukio , KOBAYASHI, Seiichi , OKITA, Makoto , KATAYAMA, Koichi
发明人： EISAI CO., LTD.
IPC分类号： C07D219/14
CPC分类号： C07D219/14
摘要： Novel acridone compounds represented by general formula (I) or pharmacologically acceptable salts thereof efficacious in the prevention and treatment of diseases in which chemical transmitters (histamine, leukotriene, etc.) participate, typified by asthma, allergic rhinitis, atopic dermatitis, urticaria, hay fever, digestive tract allergy, food allergy, etc., wherein R , R , R , R , R and R are the same or different and each represents hydrogen, hydroxy, halogeno, lower alkyl, cycloalkyl, lower alkoxy, etc.; Y represents -(CH2)t-(B)m-(CH2)-Z [wherein m is 0 or 1; t and n represent each an integer of from 0 to 6; B represents lower alkylene, optionally substituted arylene, etc.; and Z represents cyano, optionally protected carboxy, acyl or -NR R (wherein R and R are the same or different and each represents hydrogen, lower alkyl, lower alkoxy, hydroxyalkyl, etc.)]; and D represents oxygen or sulfur.
摘要翻译：由通式（I）表示的新型吖啶酮化合物或其药学上可接受的盐在预防和治疗化学发射器（组胺，白三烯等）参与的疾病中有效，以哮喘，过敏性鼻炎，特应性皮炎，荨麻疹，干草为代表发热，消化道过敏，食物过敏等，其中R 1，R 2，R 3，R 4，R 5和R 6相同或不同，表示氢，羟基，卤代，低级烷基，环烷基，低级烷氧基等; Y表示 - （CH 2）t - （B）m - （CH 2）-Z [其中m为0或1; t和n表示0〜6的整数。 B表示低级亚烷基，任选取代的亚芳基等; 和Z表示氰基，任意保护的羧基，酰基或-NR 7 R 8（其中R 7和R 8相同或不同，各自代表氢，低级烷基，低级烷氧基，羟基烷基等。）]; D表示氧或硫。

4. 发明申请

WO1997012871A1 ACRIDONE DERIVATIVE 审中-公开
标题翻译：阿司匹林衍生物
公开(公告)号：WO1997012871A1
公开(公告)日：1997-04-10
申请号：PCT/JP1995002007
申请日：1995-10-02
申请人： EISAI CO., LTD. , MIYAMOTO, Mitsuaki , YOSHIUCHI, Tatsuya , ABE, Shinya , TANAKA, Masayuki , MORIYA, Katsuhiro , KATAYAMA, Satoshi , YAMANAKA, Takashi , YAMADA, Koji
发明人： EISAI CO., LTD.
IPC分类号： C07D219/06
CPC分类号： C07D219/14
摘要： An acridone derivative represented by general formula (I) and a pharmacologically acceptable salt thereof, efficacious in preventing or treating deseases wherein histamine, leucotriene and the like participate and allergic diseases such as asthma, allergic rhinitis, atopic dermatitis, urticaria, hay fever, gastrointestinal allergy, and food allergy, wherein R to R represent each hydrogen, lower alkyl, etc.; and n represents an integer of 1 to 6.
摘要翻译：由通式（I）表示的吖啶酮衍生物及其药理学上可接受的盐可有效预防或治疗组胺，白三烯等参与的过敏性疾病如哮喘，过敏性鼻炎，特应性皮炎，荨麻疹，花粉症，胃肠道过敏和食物过敏，其中R 1至R 8表示每个氢，低级烷基等; n表示1〜6的整数。

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