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1. 发明申请

WO2006069327A9 IMPLANTABLE TRANSDUCER DEVICES 审中-公开
标题翻译：可植入式传感器装置
公开(公告)号：WO2006069327A9
公开(公告)日：2006-08-24
申请号：PCT/US2005046826
申请日：2005-12-21
申请人： EBR SYSTEMS INC , BRISKEN AXEL F , COWAN MARK W , ECHT DEBRA S , RILEY RICHARD E
发明人： BRISKEN AXEL F , COWAN MARK W , ECHT DEBRA S , RILEY RICHARD E
IPC分类号： A61N1/378
CPC分类号： A61N1/37205 , A61N1/362 , A61N1/3787
摘要： Receiver-stimulators comprise a nearly isotropic transducer assembly, demodulator circuitry, and at least two tissue contacting electrodes. Use of near isotropic transducers allows the devices to be implanted with less concern regarding the orientation relative to an acoustic energy source. Transducers or transducer elements having relatively small sizes, typically less than 1/2 the wavelength of the acoustic source, enhance isotropy. The use of single crystal piezoelectric materials enhance sensitivity.
摘要翻译：接收器 - 刺激器包括近似各向同性的换能器组件，解调器电路和至少两个组织接触电极。近似各向同性换能器的使用允许植入对于相对于声能源的取向的关注较少。具有相对较小尺寸（通常小于声源的波长的1/2）的传感器或换能器元件增强了各向同性。单晶压电材料的使用提高了灵敏度。

2. 发明申请

WO2006069215A2 LEADLESS CARDIAC SYSTEM FOR PACING AND ARRHYTHMIA TREATMENT 审中-公开
标题翻译：无铅心脑血管系统用于治疗和治疗ARRHYTHMIA治疗
公开(公告)号：WO2006069215A2
公开(公告)日：2006-06-29
申请号：PCT/US2005046532
申请日：2005-12-21
申请人： EBR SYSTEMS INC , COWAN MARK W , ECHT DEBRA S , RILEY RICHARD E , BRISKEN AXEL F
发明人： COWAN MARK W , ECHT DEBRA S , RILEY RICHARD E , BRISKEN AXEL F
IPC分类号： A61N1/378
CPC分类号： A61N1/3621 , A61N1/368 , A61N1/37205 , A61N1/37217 , A61N1/3756 , A61N1/3787
摘要： Systems including an implantable receiver-stimulator and an implantable controller-transmitter are used for leadless electrical stimulation of body tissues. Cardiac pacing and arrhythmia control is accomplished with one or more implantable receiver-stimulators and an external or implantable controller-transmitter. Systems are implanted by testing external or implantable devices at different tissue sites, observing physiologic and device responses, and selecting sites with preferred performance for implanting the systems. In these systems, a controller-transmitter is activated at a remote tissue location to transmit/deliver acoustic energy through the body to a receiver-stimulator at a target tissue location. The receiver-stimulator converts the acoustic energy to electrical energy for electrical stimulation of the body tissue. The tissue locations(s) can be optimized by moving either or both of the controller-transmitter and the receiver-stimulator to determine the best patient and device responses.
摘要翻译：包括可植入接收器刺激器和可植入控制器 - 发射器的系统用于对身体组织进行无铅电刺激。心脏起搏和心律失常控制由一个或多个可植入接收器刺激器和外部或可植入控制器发射器来实现。通过在不同组织部位测试外部或可植入装置，观察生理和装置反应以及选择具有植入系统的优选性能的部位植入系统。在这些系统中，控制器 - 发射器在远程组织位置处被激活，以将声能通过身体发射/传递到目标组织位置处的接收器 - 刺激器。接收器 - 刺激器将声能转换为电能以对身体组织进行电刺激。可以通过移动控制器 - 发射器和接收器 - 刺激器中的任一者或两者来确定最佳患者和设备响应来优化组织位置。

3. 发明申请

WO2007149936A3 SYSTEMS AND METHODS FOR IMPLANTABLE LEADLESS TISSUE STIMULATION 审中-公开
标题翻译：无侵袭性组织刺激的系统和方法
公开(公告)号：WO2007149936A3
公开(公告)日：2008-10-16
申请号：PCT/US2007071693
申请日：2007-06-20
申请人： EBR SYSTEMS INC , COWAN MARK W , RILEY RICHARD E , BRISKEN AXEL F , ECHT DEBRA S
发明人： COWAN MARK W , RILEY RICHARD E , BRISKEN AXEL F , ECHT DEBRA S
IPC分类号： A61N1/36
CPC分类号： A61N1/37217 , A61N1/0534 , A61N1/0541 , A61N1/36003 , A61N1/3756 , A61N1/3787
摘要： Systems and methods are disclosed to stimulate tissue to treat medical conditions involving tissues such as the bone, spine, stomach, nerves, brain and the cochlea The disclosed invention uses electrical stimulation of the tissue, where vibrational (or acoustic) energy from a source (10) is received by an implanted device (20) and converted to electrical energy and the converted electrical energy is used by implanted electrodes (220) to stimulate the pre-determined tissue sites The vibrational energy is generated by a controller- transmitter (160), which could be either implanted or located externally The vibrational energy is received by a receiver-stimulator (200), which could be located at or close to the stimulation site.
摘要翻译：公开了系统和方法来刺激组织以治疗涉及诸如骨骼，脊椎，胃，神经，脑和耳蜗的组织的医学状况。所公开的发明使用组织的电刺激，其中来自源的振动（或声学）能量 10）由植入装置（20）接收并转换成电能，并且所转换的电能由注入的电极（220）使用以刺激预定的组织部位。振动能量由控制器 - 发射器（160）产生，，其可以植入或位于外部。振动能量由接收器刺激器（200）接收，其可以位于或接近刺激部位。

4. 发明申请

WO2007027940A3 METHODS AND SYSTEMS FOR HEART FAILURE PREVENTION AND TREATMENTS USING ULTRASOUND AND LEADLESS IMPLANTABLE DEVICES 审中-公开
标题翻译：心脏衰竭预防和治疗的方法和系统使用超声波和无铅可植入装置
公开(公告)号：WO2007027940A3
公开(公告)日：2007-06-28
申请号：PCT/US2006034102
申请日：2006-08-30
申请人： EBR SYSTEMS INC , ECHT DEBRA S , RILEY RICHARD E , COWAN MARK W , BRISKEN AXEL F
发明人： ECHT DEBRA S , RILEY RICHARD E , COWAN MARK W , BRISKEN AXEL F
IPC分类号： A61N7/00
CPC分类号： A61N1/362 , A61N1/3627 , A61N1/37205 , A61N1/3787 , A61N7/00 , A61N2007/0004
摘要： The present invention relies on a controller-transmitter device to deliver ultrasound energy into cardiac tissue in order to directly improve cardiac function and/or to energize one or more implanted receiver-stimulator devices that transduce the ultrasound energy to electrical energy to perform excitatory and/or non-excitatory treatments for heart failure. The acoustic energy can be applied as a single burst or as multiple bursts.
摘要翻译：本发明依赖于控制器 - 发射器装置将超声能量输送到心脏组织中，以便直接改善心脏功能和/或激发一个或多个植入的接收器 - 刺激器装置，其将超声能量转换成电能以进行兴奋和/ 或心脏衰竭的非兴奋性治疗。声能可以作为单个突发或多个突发应用。

5. 发明申请

WO2006069327A3 IMPLANTABLE TRANSDUCER DEVICES 审中-公开
标题翻译：可植入传感器装置
公开(公告)号：WO2006069327A3
公开(公告)日：2006-12-21
申请号：PCT/US2005046826
申请日：2005-12-21
申请人： EBR SYSTEMS INC , BRISKEN AXEL F , COWAN MARK W , ECHT DEBRA S , RILEY RICHARD E
发明人： BRISKEN AXEL F , COWAN MARK W , ECHT DEBRA S , RILEY RICHARD E
IPC分类号： A61N1/18
CPC分类号： A61N1/37205 , A61N1/362 , A61N1/3787
摘要： Receiver-stimulators comprise a nearly isotropic transducer assembly, demodulator circuitry, and at least two tissue contacting electrodes. Use of near isotropic transducers allows the devices to be implanted with less concern regarding the orientation relative to an acoustic energy source. Transducers or transducer elements having relatively small sizes, typically less than 1/2 the wavelength of the acoustic source, enhance isotropy. The use of single crystal piezoelectric materials enhance sensitivity.
摘要翻译：接收器 - 刺激器包括几乎各向同性的换能器组件，解调器电路和至少两个组织接触电极。近乎各向同性的换能器的使用允许对器件进行植入，而不关心与声能源相关的取向。尺寸相对较小的换能器或换能器元件，通常小于声源波长的1/2，增强了各向同性。单晶压电材料的使用提高了灵敏度。

6. 发明申请

WO2007033094A3 METHODS AND APPARATUS FOR DETERMINING CARDIAC STIMULATION SITES USING HEMODYNAMIC DATA 审中-公开
标题翻译：使用血液动力学数据确定心脏刺激位点的方法和装置
公开(公告)号：WO2007033094A3
公开(公告)日：2007-10-04
申请号：PCT/US2006035346
申请日：2006-09-11
申请人： EBR SYSTEMS , ECHT DEBRA S , RILEY RICHARD E , COWAN MARK W , BRISKEN AXEL F
发明人： ECHT DEBRA S , RILEY RICHARD E , COWAN MARK W , BRISKEN AXEL F
IPC分类号： A61N1/00
CPC分类号： A61N1/36514 , A61N1/36564
摘要： Methods and apparatus for determining an endocardial implantation site for implanting an electrode, such as a leadless stimulation electrode. An embodiment of one method in accordance with the invention includes delivering sufficient electrical energy for initiation of cardiac activation to a plurality of different test locations at the heart of a patient, and determining hemodynamic responses in reaction to that the stimulus delivered to the different test locations. This method further includes identifying an implantation site for implanting the electrode by selecting at least one of the test locations corresponding to a favorable hemodynamic response.
摘要翻译：用于确定用于植入诸如无引线电极的电极的心内膜植入部位的方法和装置。根据本发明的一种方法的一个实施方案包括将足够的电能用于引发心脏激活到患者心脏的多个不同的测试位置，以及确定血液动力学反应，以反映输送到不同测试位置的刺激。该方法还包括通过选择对应于有利的血液动力学响应的至少一个测试位置来识别用于植入电极的植入部位。

7. 发明申请

WO2009086405A3 OPTIMIZING SIZE OF IMPLANTABLE MEDICAL DEVICES BY ISOLATING THE POWER SOURCE 审中-公开
标题翻译：通过隔离电源优化可植入医疗设备的尺寸
公开(公告)号：WO2009086405A3
公开(公告)日：2009-12-30
申请号：PCT/US2008088207
申请日：2008-12-23
申请人： EBR SYSTEMS INC , FOWLER ROBERT , COWAN MARK W , WILLIS N PARKER , BRISKEN AXEL F , ECHT DEBRA S
发明人： FOWLER ROBERT , COWAN MARK W , WILLIS N PARKER , BRISKEN AXEL F , ECHT DEBRA S
IPC分类号： A61N1/00
CPC分类号： A61N1/378 , A61N1/37217 , A61N1/37288
摘要： A wireless cardiac stimulation device comprising an implantable transmitter module housing a transmitter and a separately implantable battery module housing a battery for powering the transmitter and other device electronics via a subcutaneously routable electrical cable connecting the module is disclosed. The transmitter module contains a transmitter enclosure which comprises one or more ultrasound transducers. Having separate transmitter and battery modules allows implantation of the transmitter module closer to the target receiver implanted in tissue. A discrete battery module also enables easy replacement of the battery without disturbing the transmitter, which is highly desirable.
摘要翻译：公开了一种无线心脏刺激设备，其包括容纳发射器的可植入发射器模块和容纳电池的单独植入式电池模块，所述电池用于通过连接模块的皮下可路由电缆为发射器和其他设备电子器件供电。发射器模块包含发射器外壳，其包括一个或多个超声波换能器。使独立的发射器和电池模块允许将发射器模块植入更靠近植入组织中的目标接收器。独立的电池模块还可以在不干扰发射机的情况下轻松更换电池，这非常理想。

8. 发明申请

WO2008039619A3 TEMPORARY LEADLESS PACING SYSTEMS AND METHODS 审中-公开
标题翻译：临时无铅PACING系统和方法
公开(公告)号：WO2008039619A3
公开(公告)日：2009-04-16
申请号：PCT/US2007076812
申请日：2007-08-24
申请人： EBR SYSTEMS INC , RILEY RICHARD E , ECHT DEBRA S , COWAN MARK W , BRISKEN AXEL R
发明人： RILEY RICHARD E , ECHT DEBRA S , COWAN MARK W , BRISKEN AXEL R
IPC分类号： A61N1/378
CPC分类号： A61N1/37205 , A61N1/362 , A61N1/3756 , A61N1/3787
摘要： Systems including an implantable receiver-stimulator and an external controller-transmitter system are used for leadless acute stimulation of the heart, particularly after heart surgery. Cardiac pacing and arrhythmia control is accomplished with one or more implantable receiver-stimulators and an external system that alternatively includes the use of an external pacemaker. Receiver-stimulators are implanted in the heart during surgery or during an acute interventional procedure and then a triggered for stimulation by using the external system. In one embodiment of these systems, a controller-transmitter is activated by an external pacemaker to time the delivery of acoustic energy transmission through the body to a receiver-stimulator at a target tissue location. The receiver-stimulator converts the acoustic energy to electrical energy for electrical stimulation of the heart tissue.
摘要翻译：包括可植入接收器刺激器和外部控制器 - 发射器系统的系统用于心脏的无引线急性刺激，特别是在心脏手术之后。心脏起搏和心律失常控制通过一个或多个可植入接收器刺激器和外部系统来实现，该系统可选地包括使用外部起搏器。接收器刺激器在手术期间或在急性介入手术期间植入心脏，然后通过使用外部系统触发刺激。在这些系统的一个实施例中，控制器 - 发射器由外部起搏器激活以将通过身体的声能传输的传递时间传递到目标组织位置处的接收器 - 刺激器。接收器 - 刺激器将声能转换为电能，用于电刺激心脏组织。

9. 发明专利

JP2012196485A Leadless cardiac system for pacing and arrhythmia treatment 审中-公开
标题翻译：无铅心脑血管系统用于治疗和治疗ARRHYTHMIA治疗
公开(公告)号：JP2012196485A
公开(公告)日：2012-10-18
申请号：JP2012128159
申请日：2012-06-05
申请人： Ebr Systems Inc , イービーアールシステムズ, インコーポレイテッド
发明人： COWAN MARK W , ECHT DEBRA S , RILEY RICHARD E , BRISKEN AXEL F
IPC分类号： A61N1/368 , A61B5/0245 , A61B5/0402 , A61N1/375
CPC分类号： A61N1/3621 , A61N1/368 , A61N1/37205 , A61N1/37217 , A61N1/3756 , A61N1/3787
摘要： PROBLEM TO BE SOLVED: To provide systems including an implantable receiver-stimulator and an implantable controller-transmitter used for leadless electrical stimulation of body tissues.SOLUTION: Cardiac pacing and arrhythmia control is accomplished with one or more implantable receiver-stimulators 2 and an external or implantable controller-transmitter 1. The systems are implanted by testing external or implantable devices at different tissue sites, observing physiologic and device responses, and selecting sites with preferred performance for implanting the systems. In these systems, the controller-transmitter is activated at a remote tissue location to transmit/deliver acoustic energy through the body to a receiver-stimulator at a target tissue location. The receiver-stimulator converts the acoustic energy to electrical energy for electrical stimulation of the body tissue.
摘要翻译：要解决的问题：提供包括植入式接收器刺激器和用于身体组织的无引线电刺激的可植入控制器 - 发射器的系统。解决方案：心脏起搏和心律失常控制由一个或多个可植入接收器刺激器2和外部或可植入的控制器 - 发射器1完成。通过在不同组织位置测试外部或可植入装置植入系统，观察生理和装置响应和选择具有植入系统的首选性能的站点。在这些系统中，控制器 - 发射器在远程组织位置处被激活，以将声能通过身体发射/传递到目标组织位置处的接收器 - 刺激器。接收器 - 刺激器将声能转换为电能以对身体组织进行电刺激。版权所有（C）2013，JPO＆INPIT

10. 发明专利

JP2012011232A Leadless cardiac system for pacing and arrhythmia treatment 有权
标题翻译：无铅心脑血管系统用于治疗和治疗ARRHYTHMIA治疗
公开(公告)号：JP2012011232A
公开(公告)日：2012-01-19
申请号：JP2011226036
申请日：2011-10-13
申请人： Ebr Systems Inc , イービーアールシステムズ, インコーポレイテッド
发明人： COWAN MARK W , ECHT DEBRA S , RILEY RICHARD E , BRISKEN AXEL F
IPC分类号： A61N1/372
CPC分类号： A61N1/3621 , A61N1/368 , A61N1/37205 , A61N1/37217 , A61N1/3756 , A61N1/3787
摘要： PROBLEM TO BE SOLVED: To provide a system including an implantable receiver-stimulator device and an implantable controller-transmitter device used for leadless electrical stimulation of body tissues.SOLUTION: Cardiac pacing and arrhythmia control is accomplished with one or more implantable receiver-stimulators and an external or implantable controller-transmitter. Systems are implanted by testing external or implantable devices at different tissue sites, observing physiologic and device responses, and selecting sites with preferred performance for implanting the systems. In these systems, a controller-transmitter is activated at a remote tissue location to transmit/deliver acoustic energy through the body to a receiver-stimulator at a target tissue location. The receiver-stimulator converts the acoustic energy to electrical energy for electrical stimulation of the body tissue. The tissue locations can be optimized by moving either or both of the controller-transmitter and the receiver-stimulator to determine the best patient and device responses.
摘要翻译：要解决的问题：提供一种包括可植入接收器刺激器装置和用于身体组织的无引线电刺激的可植入控制器 - 发射器装置的系统。解决方案：心脏起搏和心律失常控制由一个或多个可植入接收器刺激器和外部或可植入控制器发射器完成。通过在不同组织部位测试外部或可植入装置，观察生理和装置反应以及选择具有植入系统的优选性能的部位植入系统。在这些系统中，控制器 - 发射器在远程组织位置处被激活，以将声能通过身体发射/传递到目标组织位置处的接收器 - 刺激器。接收器 - 刺激器将声能转换为电能以对身体组织进行电刺激。可以通过移动控制器 - 发射器和接收器 - 刺激器之一或两者来确定最佳患者和设备响应来优化组织位置。版权所有（C）2012，JPO＆INPIT

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