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1. 发明专利

JP2012196485A Leadless cardiac system for pacing and arrhythmia treatment 审中-公开
标题翻译：无铅心脑血管系统用于治疗和治疗ARRHYTHMIA治疗
公开(公告)号：JP2012196485A
公开(公告)日：2012-10-18
申请号：JP2012128159
申请日：2012-06-05
申请人： Ebr Systems Inc , イービーアールシステムズ, インコーポレイテッド
发明人： COWAN MARK W , ECHT DEBRA S , RILEY RICHARD E , BRISKEN AXEL F
IPC分类号： A61N1/368 , A61B5/0245 , A61B5/0402 , A61N1/375
CPC分类号： A61N1/3621 , A61N1/368 , A61N1/37205 , A61N1/37217 , A61N1/3756 , A61N1/3787
摘要： PROBLEM TO BE SOLVED: To provide systems including an implantable receiver-stimulator and an implantable controller-transmitter used for leadless electrical stimulation of body tissues.SOLUTION: Cardiac pacing and arrhythmia control is accomplished with one or more implantable receiver-stimulators 2 and an external or implantable controller-transmitter 1. The systems are implanted by testing external or implantable devices at different tissue sites, observing physiologic and device responses, and selecting sites with preferred performance for implanting the systems. In these systems, the controller-transmitter is activated at a remote tissue location to transmit/deliver acoustic energy through the body to a receiver-stimulator at a target tissue location. The receiver-stimulator converts the acoustic energy to electrical energy for electrical stimulation of the body tissue.
摘要翻译：要解决的问题：提供包括植入式接收器刺激器和用于身体组织的无引线电刺激的可植入控制器 - 发射器的系统。解决方案：心脏起搏和心律失常控制由一个或多个可植入接收器刺激器2和外部或可植入的控制器 - 发射器1完成。通过在不同组织位置测试外部或可植入装置植入系统，观察生理和装置响应和选择具有植入系统的首选性能的站点。在这些系统中，控制器 - 发射器在远程组织位置处被激活，以将声能通过身体发射/传递到目标组织位置处的接收器 - 刺激器。接收器 - 刺激器将声能转换为电能以对身体组织进行电刺激。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2012011232A Leadless cardiac system for pacing and arrhythmia treatment 有权
标题翻译：无铅心脑血管系统用于治疗和治疗ARRHYTHMIA治疗
公开(公告)号：JP2012011232A
公开(公告)日：2012-01-19
申请号：JP2011226036
申请日：2011-10-13
申请人： Ebr Systems Inc , イービーアールシステムズ, インコーポレイテッド
发明人： COWAN MARK W , ECHT DEBRA S , RILEY RICHARD E , BRISKEN AXEL F
IPC分类号： A61N1/372
CPC分类号： A61N1/3621 , A61N1/368 , A61N1/37205 , A61N1/37217 , A61N1/3756 , A61N1/3787
摘要： PROBLEM TO BE SOLVED: To provide a system including an implantable receiver-stimulator device and an implantable controller-transmitter device used for leadless electrical stimulation of body tissues.SOLUTION: Cardiac pacing and arrhythmia control is accomplished with one or more implantable receiver-stimulators and an external or implantable controller-transmitter. Systems are implanted by testing external or implantable devices at different tissue sites, observing physiologic and device responses, and selecting sites with preferred performance for implanting the systems. In these systems, a controller-transmitter is activated at a remote tissue location to transmit/deliver acoustic energy through the body to a receiver-stimulator at a target tissue location. The receiver-stimulator converts the acoustic energy to electrical energy for electrical stimulation of the body tissue. The tissue locations can be optimized by moving either or both of the controller-transmitter and the receiver-stimulator to determine the best patient and device responses.
摘要翻译：要解决的问题：提供一种包括可植入接收器刺激器装置和用于身体组织的无引线电刺激的可植入控制器 - 发射器装置的系统。解决方案：心脏起搏和心律失常控制由一个或多个可植入接收器刺激器和外部或可植入控制器发射器完成。通过在不同组织部位测试外部或可植入装置，观察生理和装置反应以及选择具有植入系统的优选性能的部位植入系统。在这些系统中，控制器 - 发射器在远程组织位置处被激活，以将声能通过身体发射/传递到目标组织位置处的接收器 - 刺激器。接收器 - 刺激器将声能转换为电能以对身体组织进行电刺激。可以通过移动控制器 - 发射器和接收器 - 刺激器之一或两者来确定最佳患者和设备响应来优化组织位置。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2013165983A Optimizing energy transmission in leadless tissue stimulation system 有权
标题翻译：无铅组织刺激系统优化能量传递
公开(公告)号：JP2013165983A
公开(公告)日：2013-08-29
申请号：JP2013087244
申请日：2013-04-18
申请人： Ebr Systems Inc , イービーアールシステムズ, インコーポレイテッド
发明人： N PARKER WILLIS , BRISKEN AXEL F , COWAN MARK W , PARE MICHAEL , FOWLER ROBERT , BRENNAN JAMES
IPC分类号： A61N1/372
CPC分类号： A61N1/3787 , A61N1/37217 , A61N1/37235 , A61N1/3756
摘要： PROBLEM TO BE SOLVED: To provide methods and systems for optimizing acoustic energy transmission in implantable devices.SOLUTION: Transducer elements 110 transmit acoustic locator signals 120 towards a receiver assembly 150, and the receiver responds with a location signal. The location signal can reveal information related to the location of the receiver and the efficiency of the transmitted acoustic beam received by the receiver. This information enables the transmitter to target the receiver and optimize the acoustic energy transfer between the transmitter and the receiver. The energy can be used for therapeutic purposes, for example, stimulating tissue or for diagnostic purposes.
摘要翻译：要解决的问题：提供用于优化可植入装置中的声能传输的方法和系统。解决方案：传感器元件110向接收器组件150传输声学定位器信号120，并且接收机响应位置信号。位置信号可以显示与接收机的位置有关的信息和由接收机接收的所发送的声波的效率。该信息使发射机能够瞄准接收机并优化发射机和接收机之间的声能传输。能量可用于治疗目的，例如刺激组织或用于诊断目的。

4. 发明专利

DE602004026308D1 未知
公开(公告)号：DE602004026308D1
公开(公告)日：2010-05-12
申请号：DE602004026308
申请日：2004-06-15
申请人： EBR SYSTEMS INC
发明人： ECHT DEBRA S , BRISKEN AXEL F , RILEY RICHARD E , COWAN MARK W
IPC分类号： A61N1/362 , A61H1/00 , A61H1/02 , A61H5/00 , A61H23/02 , A61H31/00 , A61N20060101 , A61N1/00 , A61N1/18 , A61N1/20 , A61N1/22 , A61N1/24 , A61N1/26 , A61N1/36 , A61N1/39 , A61N7/00

5. 发明专利

AU2020216305A1 Devices, systems, and methods for cardiac resynchronization therapy 未知
公开(公告)号：AU2020216305A1
公开(公告)日：2021-08-26
申请号：AU2020216305
申请日：2020-01-27
申请人： EBR SYSTEMS INC
发明人： KIM STEVEN , WILLIS PARKER
IPC分类号： H04B11/00 , A61N1/36 , A61N1/362 , A61N1/365
摘要： The present technology generally includes devices, systems, and methods for providing electrical stimulation to the left ventricle of a human heart in a patient suffering from Left Bundle Branch Block (LBBB). In particular, the present technology includes an implantable receiver-stimulator and an implantable controller-transmitter for leadless electrical stimulation of the heart. The receiver-stimulator can include one or more sensors capable of detecting the electrical conduction of the heart and the receiver-stimulator can be configured to pace the stimulation of the left ventricle based off the sensed electrical conduction to achieve synchronization of the left and right ventricles.

6. 发明专利

AT462471T 未知
公开(公告)号：AT462471T
公开(公告)日：2010-04-15
申请号：AT04755266
申请日：2004-06-15
申请人： EBR SYSTEMS INC
发明人： ECHT DEBRA , BRISKEN AXEL , RILEY RICHARD , COWAN MARK
IPC分类号： A61N1/362 , A61H1/00 , A61H1/02 , A61H5/00 , A61H23/02 , A61H31/00 , A61N20060101 , A61N1/00 , A61N1/18 , A61N1/20 , A61N1/22 , A61N1/24 , A61N1/26 , A61N1/36 , A61N1/39 , A61N7/00

7. 发明申请

WO2007016581A3 EFFICIENTLY DELIVERING ACOUSTIC STIMULATION ENERGY TO TISSUE 审中-公开
公开(公告)号：WO2007016581A3
公开(公告)日：2007-02-08
申请号：PCT/US2006/029971
申请日：2006-07-31
申请人： EBR SYSTEMS, INC. , COWAN, Mark, W.
发明人： COWAN, Mark, W.
IPC分类号： A61N1/00
摘要： A system for delivering an electrical stimulation pulse to tissue comprises a controller-transmitter and a receiver-stimulator. The controller-transmitter includes circuitry having an energy storage capacitor. The capacitance of the energy storage capacitor is adjusted to improve the efficiency of energy delivered from the receiver-stimulator to tissue by modifying the geometry of an acoustic drive burst from the controller-transmitter.

8. 发明申请

WO2007016581A2 EFFICIENTLY DELIVERING ACOUSTIC STIMULATION ENERGY TO TISSUE 审中-公开
标题翻译：有效地将声学刺激能量输送到组织
公开(公告)号：WO2007016581A2
公开(公告)日：2007-02-08
申请号：PCT/US2006029971
申请日：2006-07-31
申请人： EBR SYSTEMS INC , COWAN MARK W
发明人： COWAN MARK W
IPC分类号： A61N1/18
CPC分类号： A61N1/362 , A61N1/37217 , A61N1/3787
摘要： A system for delivering an electrical stimulation pulse to tissue comprises a controller-transmitter and a receiver-stimulator. The controller-transmitter includes circuitry having an energy storage capacitor. The capacitance of the energy storage capacitor is adjusted to improve the efficiency of energy delivered from the receiver-stimulator to tissue by modifying the geometry of an acoustic drive burst from the controller-transmitter.
摘要翻译：用于向组织输送电刺激脉冲的系统包括控制器 - 发射器和接收器 - 刺激器。控制器 - 变送器包括具有能量存储电容器的电路。通过修改来自控制器 - 发射器的声学驱动脉冲串的几何结构，能量存储电容器的电容被调整以提高从接收器 - 刺激器传递到组织的能量的效率。

9. 发明申请

WO2006069327A9 IMPLANTABLE TRANSDUCER DEVICES 审中-公开
标题翻译：可植入式传感器装置
公开(公告)号：WO2006069327A9
公开(公告)日：2006-08-24
申请号：PCT/US2005046826
申请日：2005-12-21
申请人： EBR SYSTEMS INC , BRISKEN AXEL F , COWAN MARK W , ECHT DEBRA S , RILEY RICHARD E
发明人： BRISKEN AXEL F , COWAN MARK W , ECHT DEBRA S , RILEY RICHARD E
IPC分类号： A61N1/378
CPC分类号： A61N1/37205 , A61N1/362 , A61N1/3787
摘要： Receiver-stimulators comprise a nearly isotropic transducer assembly, demodulator circuitry, and at least two tissue contacting electrodes. Use of near isotropic transducers allows the devices to be implanted with less concern regarding the orientation relative to an acoustic energy source. Transducers or transducer elements having relatively small sizes, typically less than 1/2 the wavelength of the acoustic source, enhance isotropy. The use of single crystal piezoelectric materials enhance sensitivity.
摘要翻译：接收器 - 刺激器包括近似各向同性的换能器组件，解调器电路和至少两个组织接触电极。近似各向同性换能器的使用允许植入对于相对于声能源的取向的关注较少。具有相对较小尺寸（通常小于声源的波长的1/2）的传感器或换能器元件增强了各向同性。单晶压电材料的使用提高了灵敏度。

10. 发明公开

US20240139523A9 SYSTEMS, DEVICES, AND METHODS FOR ELECTROMECHANICAL SENSING AND MAPPING 有权
公开(公告)号：US20240139523A9
公开(公告)日：2024-05-02
申请号：US17863735
申请日：2022-07-13
申请人： EBR Systems, Inc.
发明人： N. Parker Willis
IPC分类号： A61N1/365 , A61N1/02 , A61N1/372
CPC分类号： A61N1/36578 , A61N1/025 , A61N1/37217 , A61B5/1102
摘要： Systems, devices, and methods for tracking and determining the motion of a cardiac implant is disclosed. The motion of the implant is determined by transmitting acoustic energy to a tissue location using an acoustic controller-transmitter comprising an array of acoustic transducers; wherein the implant is configured to convert the transmitted acoustic energy to electrical energy; and the tracking is achieved by determining the electrical energy delivered to the tissue throughout one or more cardiac cycles in order to create a motion profile of the cardiac implant.

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