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1. 发明申请

WO2007016581A3 EFFICIENTLY DELIVERING ACOUSTIC STIMULATION ENERGY TO TISSUE 审中-公开
公开(公告)号：WO2007016581A3
公开(公告)日：2007-02-08
申请号：PCT/US2006/029971
申请日：2006-07-31
申请人： EBR SYSTEMS, INC. , COWAN, Mark, W.
发明人： COWAN, Mark, W.
IPC分类号： A61N1/00
摘要： A system for delivering an electrical stimulation pulse to tissue comprises a controller-transmitter and a receiver-stimulator. The controller-transmitter includes circuitry having an energy storage capacitor. The capacitance of the energy storage capacitor is adjusted to improve the efficiency of energy delivered from the receiver-stimulator to tissue by modifying the geometry of an acoustic drive burst from the controller-transmitter.

2. 发明申请

WO2007027940A2 METHODS AND SYSTEMS FOR HEART FAILURE PREVENTION AND TREATMENTS USING ULTRASOUND AND LEADLESS IMPLANTABLE DEVICES 审中-公开
标题翻译：使用超声和无铅可植入器械治疗心脏衰竭和治疗的方法和系统
公开(公告)号：WO2007027940A2
公开(公告)日：2007-03-08
申请号：PCT/US2006/034102
申请日：2006-08-30
申请人： EBR SYSTEMS, INC. , ECHT, Debra, S. , RILEY, Richard, E. , COWAN, Mark, W. , BRISKEN, Axel, F.
发明人： ECHT, Debra, S. , RILEY, Richard, E. , COWAN, Mark, W. , BRISKEN, Axel, F.
IPC分类号： A61H1/00
CPC分类号： A61N1/362 , A61N1/3627 , A61N1/37205 , A61N1/3787 , A61N7/00 , A61N2007/0004
摘要： The present invention relies on a controller-transmitter device to deliver ultrasound energy into cardiac tissue in order to directly improve cardiac function and/or to energize one or more implanted receiver-stimulator devices that transduce the ultrasound energy to electrical energy to perform excitatory and/or non-excitatory treatments for heart failure. The acoustic energy can be applied as a single burst or as multiple bursts.
摘要翻译：本发明依赖于控制器 - 发射器设备来将超声能量递送到心脏组织中以便直接改善心脏功能和/或激励一个或多个植入的接收器 - 刺激器设备，其转换超声能量到电能来执行心力衰竭的兴奋性和/或非兴奋性治疗。声能可以作为单个突发或多个突发应用。

3. 发明申请

WO2004112895A1 VIBRATIONAL PACING THERAPY DEVICE 审中-公开
标题翻译：振动治疗装置
公开(公告)号：WO2004112895A1
公开(公告)日：2004-12-29
申请号：PCT/US2004/018987
申请日：2004-06-15
申请人： EBR SYSTEMS, INC. , ECHT, Debra, S. , BRISKEN, Axel, F. , RILEY, Richard, E. , COWAN, Mark, W.
发明人： ECHT, Debra, S. , BRISKEN, Axel, F. , RILEY, Richard, E. , COWAN, Mark, W.
IPC分类号： A61N1/362
CPC分类号： A61N1/362 , A61H23/0245 , A61H31/006 , A61N1/3627 , A61N1/3962 , A61N7/00 , A61N2007/0026
摘要： Methods and systems for pacing the heart include a vibrational transducer (14), which directs vibrational energy at the heart, usually including at least one ventricle, to pace the heart to promote synchronized contraction of the ventricles. Optionally, additional vibrational and/or electrical stimulation (12) may be provided.
摘要翻译：用于起搏心脏的方法和系统包括振动换能器（14），其引导通常包括至少一个心室的心脏的振动能量以调节心脏以促进心室的同步收缩。可选地，可以提供额外的振动和/或电刺激（12）。

4. 发明申请

WO2004112887A3 METHODS AND SYSTEMS FOR TREATING HEART FAILURE WITH VIBRATIONAL ENERGY 审中-公开
公开(公告)号：WO2004112887A3
公开(公告)日：2004-12-29
申请号：PCT/US2004/019084
申请日：2004-06-15
申请人： EBR SYSTEMS, INC. , ECHT, Debra, S. , BRISKEN, Axel, F. , RILEY, Richard, E. , COWAN, Mark, W.
发明人： ECHT, Debra, S. , BRISKEN, Axel, F. , RILEY, Richard, E. , COWAN, Mark, W.
IPC分类号： A61N1/36
摘要： Methods and apparatus (10) for treating heart failure rely on delivering ultrasonic or other vibrational energy to the heart. The energy may be delivered acutely or chronically, in response to detected cardiac events, in response to manual actuation and/or in response to operation of an implantable defibrillator. The vibrational transducer is implanted so that the vibrational energy can be directed toward at least a portion of the heart in order to increase contractility, vasodilation, tissue perfusion, and/or cardiac output.

5. 发明申请

WO2009120636A1 TEMPORARY ELECTRODE CONNECTION FOR WIRELESS PACING SYSTEMS 审中-公开
标题翻译：用于无线PACING系统的临时电极连接
公开(公告)号：WO2009120636A1
公开(公告)日：2009-10-01
申请号：PCT/US2009/037978
申请日：2009-03-23
申请人： EBR SYSTEMS, INC. , MOORE, David, F. , COWAN, Mark, W. , WILLIS, N., Parker
发明人： MOORE, David, F. , COWAN, Mark, W. , WILLIS, N., Parker
IPC分类号： A61B5/00
CPC分类号： A61N1/3787 , A61B5/042 , A61B17/3468 , A61N1/362 , A61N1/3702 , A61N1/37205 , A61N1/37223 , A61N1/3756
摘要： Delivery of an implantable wireless receiver-stimulator (R-S) into the heart using delivery catheter is described. R-S comprises a cathode and an anode and wirelessly receives and converts energy, such as acoustic ultrasound energy, to electrical energy to stimulate the heart. Conductive wires routed through the delivery system temporarily connect R-S electrodes to external monitor and pacing controller. R-S comprises a first temporary electrical connection from the catheter to the cathode, and a second temporary electrical connection from the catheter to the anode. Temporary electrical connections allow external monitoring of heart's electrical activity as sensed by R-S electrodes to determine tissue viability for excitation as well as to assess energy conversion efficiency.
摘要翻译：描述了使用输送导管将植入式无线接收器刺激器（R-S）递送到心脏中。 R-S包括阴极和阳极，并且将诸如声学超声能量的能量无线地接收并转换成电能以刺激心脏。通过传送系统布线的导线将R-S电极临时连接到外部监护仪和起搏控制器。 R-S包括从导管到阴极的第一临时电连接以及从导管到阳极的第二临时电连接。临时电气连接允许外部监测由R-S电极感测的心脏电活动，以确定激发的组织活力以及评估能量转换效率。

6. 发明申请

WO2008147703A1 OPTIMIZING ENERGY TRANSMISSION IN A LEADLESS TISSUE STIMULATION SYSTEM 审中-公开
标题翻译：无铅组织刺激系统优化能量传递
公开(公告)号：WO2008147703A1
公开(公告)日：2008-12-04
申请号：PCT/US2008/063669
申请日：2008-05-15
申请人： EBR SYSTEMS, INC. , WILLIS, N. Parker , BRISKEN, Axel, F. , COWAN, Mark, W. , PARE, Michael , FOWLER, Robert , BRENNAN, James
发明人： WILLIS, N. Parker , BRISKEN, Axel, F. , COWAN, Mark, W. , PARE, Michael , FOWLER, Robert , BRENNAN, James
IPC分类号： A61H1/00
CPC分类号： A61N1/3787 , A61N1/37217 , A61N1/37235 , A61N1/3756
摘要： Method and systems for optimizing acoustic energy transmission in implantable devices are disclosed. Transducer elements transmit acoustic locator signals towards a receiver assembly, and the receiver responds with a location signal. The location signal can reveal information related to the location of the receiver and the efficiency of the transmitted acoustic beam received by the receiver. This information enables the transmitter to target the receiver and optimize the acoustic energy transfer between the transmitter and the receiver. The energy can be used for therapeutic purposes, for example, stimulating tissue or for diagnostic purposes.
摘要翻译：公开了用于优化可植入装置中的声能传输的方法和系统。传感器元件将声学定位器信号传送到接收器组件，并且接收器用位置信号进行响应。位置信号可以显示与接收机的位置有关的信息和由接收机接收的所发送的声波的效率。该信息使发射机能够瞄准接收机并优化发射机和接收机之间的声能传输。能量可用于治疗目的，例如刺激组织或用于诊断目的。

7. 发明申请

WO2007149931A2 ACOUSTICALLY-POWERED WIRELESS DEFIBRILLATOR 审中-公开
标题翻译：有声功率的无线解调器
公开(公告)号：WO2007149931A2
公开(公告)日：2007-12-27
申请号：PCT/US2007/071687
申请日：2007-06-20
申请人： EBR SYSTEMS, INC. , COWAN, Mark, W. , BRISKEN, Axel, R.
发明人： COWAN, Mark, W. , BRISKEN, Axel, R.
IPC分类号： A61N1/39
CPC分类号： A61N1/3968 , A61N1/3787 , A61N1/3962 , A61N1/3975
摘要： An acoustic transmitter produces a pulsed ultrasound waveform which is transmitted through body tissues to an implanted receiver-stimulator device. The waveform has an acoustic amplitude, pulse width, and pulse repetition period, which corresponds to a pacing pulse electrical amplitude, pacing pulse width, and pacing cycle length, respectively. The receiver-stimulator device intercepts at least a portion of the transmitted acoustic energy and coverts that acoustic energy into electrical energy using piezoelectric or other devices. This electrical energy is applied to circuitry, which produces a desired stimulating pulse waveform, which is then applied to tissue-contacting electrodes.
摘要翻译：声发射器产生脉冲超声波，其通过身体组织传输到植入的接收器 - 刺激器装置。该波形具有分别对应于起搏脉冲电幅度，起搏脉冲宽度和起搏周期长度的声振幅，脉冲宽度和脉冲重复周期。接收器 - 刺激器装置拦截至少一部分透射声能，并使用压电或其它装置将该声能覆盖成电能。该电能被施加到产生期望的刺激脉冲波形的电路，然后将其施加到组织接触电极。

8. 发明申请

WO2008039619A2 TEMPORARY LEADLESS PACING SYSTEMS AND METHODS 审中-公开
标题翻译：临时无铅PACING系统和方法
公开(公告)号：WO2008039619A2
公开(公告)日：2008-04-03
申请号：PCT/US2007/076812
申请日：2007-08-24
申请人： EBR SYSTEMS, INC. , RILEY, Richard, E. , ECHT, Debra, S. , COWAN, Mark, W. , BRISKEN, Axel, R.
发明人： RILEY, Richard, E. , ECHT, Debra, S. , COWAN, Mark, W. , BRISKEN, Axel, R.
IPC分类号： A61N1/00
CPC分类号： A61N1/37205 , A61N1/362 , A61N1/3756 , A61N1/3787
摘要： Systems including an implantable receiver-stimulator and an external controller-transmitter system are used for leadless acute stimulation of the heart, particularly after heart surgery. Cardiac pacing and arrhythmia control is accomplished with one or more implantable receiver-stimulators and an external system that alternatively includes the use of an external pacemaker. Receiver-stimulators are implanted in the heart during surgery or during an acute interventional procedure and then a triggered for stimulation by using the external system. In one embodiment of these systems, a controller-transmitter is activated by an external pacemaker to time the delivery of acoustic energy transmission through the body to a receiver-stimulator at a target tissue location. The receiver-stimulator converts the acoustic energy to electrical energy for electrical stimulation of the heart tissue.
摘要翻译：包括可植入接收器刺激器和外部控制器 - 发射器系统的系统用于心脏的无引线急性刺激，特别是在心脏手术之后。心脏起搏和心律失常控制通过一个或多个可植入接收器刺激器和外部系统来实现，该系统可选地包括使用外部起搏器。接收器刺激器在手术期间或在急性介入手术期间植入心脏，然后通过使用外部系统触发刺激。在这些系统的一个实施例中，控制器 - 发射器由外部起搏器激活以将通过身体的声能传输的传递时间传递到目标组织位置处的接收器 - 刺激器。接收器 - 刺激器将声能转换为电能，用于电刺激心脏组织。

9. 发明申请

WO2007149936A2 SYSTEMS AND METHODS FOR IMPLANTABLE LEADLESS TISSUE STIMULATION 审中-公开
标题翻译：无牵引组织刺激的系统和方法
公开(公告)号：WO2007149936A2
公开(公告)日：2007-12-27
申请号：PCT/US2007/071693
申请日：2007-06-20
申请人： EBR SYSTEMS, INC. , COWAN, Mark, W. , RILEY, Richard, E. , BRISKEN, Axel, F. , ECHT, Debra, S.
发明人： COWAN, Mark, W. , RILEY, Richard, E. , BRISKEN, Axel, F. , ECHT, Debra, S.
IPC分类号： A61N1/36
CPC分类号： A61N1/37217 , A61N1/0534 , A61N1/0541 , A61N1/36003 , A61N1/3756 , A61N1/3787
摘要： Systems and methods are disclosed to stimulate tissue to treat medical conditions involving tissues such as the bone, spine, stomach, nerves, brain and the cochlea. The disclosed invention uses electrical stimulation of the tissue, where vibrational (or acoustic) energy from a source is received by an implanted device and converted to electrical energy and the converted electrical energy is used by implanted electrodes to stimulate the pre-determined tissue sites. The vibrational energy is generated by a controller-transmitter, which could be either implanted or located externally. The vibrational energy is received by a receiver-stimulator, which could be located at or close to the stimulation site.
摘要翻译：公开了系统和方法来刺激组织以治疗涉及诸如骨骼，脊椎，胃，神经，脑和耳蜗的组织的医学状况。所公开的发明使用组织的电刺激，其中来自源的振动（或声学）能量被注入的装置接收并转换成电能，并且转换的电能被注入的电极用于刺激预定的组织部位。振动能量由控制器 - 发射器产生，其可以被植入或位于外部。振动能量由接收器刺激器接收，其可以位于或靠近刺激部位。

10. 发明申请

WO2006069327A2 IMPLANTABLE TRANSDUCER DEVICES 审中-公开
标题翻译：可植入传感器装置
公开(公告)号：WO2006069327A2
公开(公告)日：2006-06-29
申请号：PCT/US2005/046826
申请日：2005-12-21
申请人： EBR SYSTEMS, INC. , BRISKEN, Axel, F. , COWAN, Mark, W. , ECHT, Debra, S. , RILEY, Richard, E.
发明人： BRISKEN, Axel, F. , COWAN, Mark, W. , ECHT, Debra, S. , RILEY, Richard, E.
IPC分类号： A61N1/378
CPC分类号： A61N1/37205 , A61N1/362 , A61N1/3787
摘要： Receiver-stimulators comprise a nearly isotropic transducer assembly, demodulator circuitry, and at least two tissue contacting electrodes. Use of near isotropic transducers allows the devices to be implanted with less concern regarding the orientation relative to an acoustic energy source. Transducers or transducer elements having relatively small sizes, typically less than 1/2 the wavelength of the acoustic source, enhance isotropy. The use of single crystal piezoelectric materials enhance sensitivity.
摘要翻译：接收器 - 刺激器包括几乎各向同性的换能器组件，解调器电路和至少两个组织接触电极。近乎各向同性的换能器的使用允许对器件进行植入，而不关心与声能源相关的取向。尺寸相对较小的换能器或换能器元件，通常小于声源波长的1/2，增强了各向同性。单晶压电材料的使用提高了灵敏度。

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