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1. 发明公开

EP2900318A1 SYSTEMS. DEVICES, AND METHODS FOR SELECTIVELY LOCATING IMPLANTABLE DEVICES 有权转让
标题翻译：系统的设备和方法选择性检测装置植入
公开(公告)号：EP2900318A1
公开(公告)日：2015-08-05
申请号：EP13842369.4
申请日：2013-09-30
申请人： Pare, Mike , Moore, David , Willis, N., Parker
发明人： PARE, Mike , MOORE, David , WILLIS, N., Parker
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/37 , A61N1/37205 , A61N1/37217 , A61N1/37229 , A61N1/37252 , A61N1/3756
摘要： Method and systems for determining the location or identify of implantable devices are disclosed. An implantable device generates an electrical output and then modifies the output at a pre-configured interval for a pre-configured period. A sensor detects the modified output and locates or identifies the implantable device based on the modified output.

2. 发明申请

WO2009086405A3 OPTIMIZING SIZE OF IMPLANTABLE MEDICAL DEVICES BY ISOLATING THE POWER SOURCE 审中-公开
标题翻译：通过隔离电源优化可植入医疗设备的尺寸
公开(公告)号：WO2009086405A3
公开(公告)日：2009-12-30
申请号：PCT/US2008088207
申请日：2008-12-23
申请人： EBR SYSTEMS INC , FOWLER ROBERT , COWAN MARK W , WILLIS N PARKER , BRISKEN AXEL F , ECHT DEBRA S
发明人： FOWLER ROBERT , COWAN MARK W , WILLIS N PARKER , BRISKEN AXEL F , ECHT DEBRA S
IPC分类号： A61N1/00
CPC分类号： A61N1/378 , A61N1/37217 , A61N1/37288
摘要： A wireless cardiac stimulation device comprising an implantable transmitter module housing a transmitter and a separately implantable battery module housing a battery for powering the transmitter and other device electronics via a subcutaneously routable electrical cable connecting the module is disclosed. The transmitter module contains a transmitter enclosure which comprises one or more ultrasound transducers. Having separate transmitter and battery modules allows implantation of the transmitter module closer to the target receiver implanted in tissue. A discrete battery module also enables easy replacement of the battery without disturbing the transmitter, which is highly desirable.
摘要翻译：公开了一种无线心脏刺激设备，其包括容纳发射器的可植入发射器模块和容纳电池的单独植入式电池模块，所述电池用于通过连接模块的皮下可路由电缆为发射器和其他设备电子器件供电。发射器模块包含发射器外壳，其包括一个或多个超声波换能器。使独立的发射器和电池模块允许将发射器模块植入更靠近植入组织中的目标接收器。独立的电池模块还可以在不干扰发射机的情况下轻松更换电池，这非常理想。

3. 发明申请

WO2006060421A3 SYSTEM FOR REGISTERING AN IMAGE WITH A NAVIGATIONAL REFERENCE CATHETER 审中-公开
标题翻译：用导航参考导管注册图像的系统
公开(公告)号：WO2006060421A3
公开(公告)日：2006-11-09
申请号：PCT/US2005043186
申请日：2005-11-30
申请人： BOSTON SCIENT SCIMED INC , WILLIS N PARKER
发明人： WILLIS N PARKER
IPC分类号： A61B5/06 , A61B6/12 , A61B8/08
CPC分类号： A61B8/0833 , A61B5/0422 , A61B5/743 , A61B6/12 , A61B6/503 , A61B6/5247 , A61B8/0841 , A61B8/0883 , A61B8/463 , A61B8/5238 , A61B90/36 , A61B2090/364 , A61B2090/3929
摘要： Systems for processing and/or superimposing a medical image of an anatomical body (e.g., a heart) with graphical information are provided. Reference elements and/or reference catheter are placed in contact with the anatomical body. A physical structure within a navigational coordinate system is located using the reference elements and/or reference catheter. An image reference within an image coordinate corresponding to the physical structure is located. Location of the image reference can be accomplished, e.g., by displaying the medical image and electronically marking the displayed image reference, or by automatically locating image data corresponding to the image reference. The navigational and image coordinate systems are then registered based on the location of the physical structure within the navigational coordinate system and the location of the image reference within the image coordinate system, which allows graphical information to be accurately merged with the medical image data.
摘要翻译：提供了用于利用图形信息处理和/或叠加解剖身体（例如，心脏）的医学图像的系统。将参考元件和/或参考导管放置成与解剖体接触。使用参考元件和/或参考导管定位导航坐标系内的物理结构。定位与物理结构对应的图像坐标内的图像参考。图像参考的位置可以例如通过显示医学图像并以电子方式标记所显示的图像参考或通过自动定位与图像参考对应的图像数据来完成。然后基于导航坐标系内的物理结构的位置和图像坐标系内的图像参考的位置来配准导航和图像坐标系，这允许将图形信息与医学图像数据准确合并。

4. 发明申请

WO2005038481A1 SYSTEM FOR DETERMINING THE LOCATION OF A MEDICAL PROBE USING A REFERENCE TRANSDUCER ARRAY 审中-公开
标题翻译：使用参考传感器阵列确定医疗探头的位置的系统
公开(公告)号：WO2005038481A1
公开(公告)日：2005-04-28
申请号：PCT/US2004/031476
申请日：2004-09-24
申请人： SCIMED LIFE SYSTEMS, INC. , WILLIS, N, Parker
发明人： WILLIS, N, Parker
IPC分类号： G01S5/22
CPC分类号： G01S5/22 , A61B18/1492 , A61B34/20 , A61B90/36 , A61B2017/00044 , A61B2018/00839 , A61B2034/2063 , A61B2034/2072 , A61B2090/365 , A61B2090/378
摘要： Systems for determining the coordinates of a location element mounted on a medical probe. First and second signals are transmitted between the location element and a first and second reference transducers, which may be arranged in a reference array that can be attached to a patient's skin. A transit time difference between the first and second signals is determined, e.g., using a thresholding or correlation technique. A distance difference between a first distance extending from the location element to the first reference element and a second distance extending from the location element to the second reference element is then determined based on the transit time difference. An angle between the reference array and the location element can then be determined based on the determined distance difference and a known distance between the first and second reference transducers.
摘要翻译：用于确定安装在医疗探头上的定位元件的坐标的系统。第一和第二信号在位置元件和第一和第二参考换能器之间传递，第一和第二参考换能器可以布置在可附接到患者皮肤的参考阵列中。确定第一和第二信号之间的传输时间差，例如使用阈值或相关技术。然后，基于通过时间差来确定从位置元件延伸到第一参考元件的第一距离与从位置元件延伸到第二参考元件的第二距离之间的距离差。然后可以基于所确定的距离差和第一和第二参考换能器之间的已知距离来确定参考阵列和位置元件之间的角度。

5. 发明申请

WO2004105616A1 SYSTEMS FOR REGISTERING ULTRASOUND IMAGE IN THREE-DIMENSIONAL COORDINATE SYSTEM 审中-公开
标题翻译：用于在三维坐标系中记录超声图像的系统
公开(公告)号：WO2004105616A1
公开(公告)日：2004-12-09
申请号：PCT/US2004/010896
申请日：2004-04-09
申请人： SCIMED LIFE SYSTEMS, INC. , WILLIS, N., Parker
发明人： WILLIS, N., Parker
IPC分类号： A61B8/08
CPC分类号： A61B8/0841 , A61B8/0833
摘要： Ultrasound image data of an anatomical structure is acquired within a first coordinate system, and graphical data (e.g., sites of interest) is acquired in a second coordinate system. The location of an ultrasound transducer within the first coordinate system and a second coordinate system is determined, and a transformation between the first and second coordinate systems is performed based on the location of the ultrasound transducer within the first and second coordinate systems. Using this transformation, the ultrasound image data, which has previously been acquired in the first coordinate system, can be registered and displayed within the second coordinate system, along with graphical data.
摘要翻译：在第一坐标系中获取解剖结构的超声图像数据，并且在第二坐标系中获取图形数据（例如，感兴趣的位点）。确定超声换能器在第一坐标系和第二坐标系内的位置，并且基于超声波换能器在第一和第二坐标系内的位置来执行第一和第二坐标系之间的变换。使用该变换，先前已经在第一坐标系中获取的超声图像数据可以与图形数据一起登记并显示在第二坐标系统内。

6. 发明申请

WO2011112865A1 OPERATION AND ESTIMATION OF OUTPUT VOLTAGE OF WIRELESS STIMULATORS 审中-公开
标题翻译：无线刺激器输出电压的运算和估计
公开(公告)号：WO2011112865A1
公开(公告)日：2011-09-15
申请号：PCT/US2011/027985
申请日：2011-03-10
申请人： EBR SYSTEMS, INC , WILLIS, N., Parker
发明人： WILLIS, N., Parker
IPC分类号： A61N1/18
CPC分类号： A61N1/3787 , A61N1/362 , A61N1/37205 , A61N1/3756
摘要： A controller-transmitter transmits acoustic energy through the body to an implanted acoustic receiver-stimulator. The receiver-stimulator converts the acoustic energy into electrical energy and delivers the electrical energy to tissue using an electrode assembly. The receiver-stimulator limits the output voltage delivered to the tissue to a predetermined maximum output voltage. In the presence of interfering acoustic energy sources output voltages are thereby limited prior to being delivered to the tissue. Furthermore, the controller-transmitter estimates the output voltage that is delivered to the tissue by the implanted receiver-stimulator. The controller-transmitter measures a query spike voltage resulting from the electrical energy delivered to the tissue by the receiver-stimulator, and computes a ratio of the predetermined maximum output voltage and a maximum query spike voltage. The maximum query spike voltage is computed by detecting a query spike voltage plateau.
摘要翻译：控制器 - 发射器通过身体将声能传递到植入的声学接收器 - 刺激器。接收器 - 刺激器将声能转换成电能，并使用电极组件将电能传递到组织。接收器 - 刺激器将输送到组织的输出电压限制在预定的最大输出电压。在存在干扰声能源的情况下，输出电压在被传送到组织之前被限制。此外，控制器 - 发射器估计由植入的接收器 - 刺激器传送到组织的输出电压。控制器 - 发射器测量由接收器 - 刺激器传送到组织的电能产生的查询尖峰电压，并且计算预定的最大输出电压和最大查询尖峰电压的比率。通过检测查询尖峰电压平台来计算最大查询尖峰电压。

7. 发明申请

WO2009120785A3 IMPLANTABLE WIRELESS ACOUSTIC STIMULATORS WITH HIGH ENERGY CONVERSION EFFICIENCIES 审中-公开
标题翻译：具有高能量转换效率的可伸缩无线耳鸣刺激器
公开(公告)号：WO2009120785A3
公开(公告)日：2009-12-30
申请号：PCT/US2009038258
申请日：2009-03-25
申请人： EBR SYSTEMS INC , MOORE DAVID F , MOHR PAUL , WILLIS N PARKER , BRISKEN AXEL F
发明人： MOORE DAVID F , MOHR PAUL , WILLIS N PARKER , BRISKEN AXEL F
IPC分类号： A61N1/00
CPC分类号： H02N2/186 , A61N1/362 , A61N1/37205 , A61N1/3756 , A61N1/3787
摘要： Receiver-stimulator with folded or rolled up assembly of piezoelectric components, causing the receiver-stimulator to operate with a high degree of isotropy are disclosed. The receiver-stimulator comprises piezoelectric components, rectifier circuitry, and at least two stimulation electrodes. Isotropy allows the receiver-stimulator to be implanted with less concern regarding the orientation relative the transmitted acoustic field from an acoustic energy source.
摘要翻译：具有压电元件的折叠或卷起组件的接收器 - 刺激器，使得接收器 - 刺激器以高度的各向同性运行。接收器 - 刺激器包括压电元件，整流电路和至少两个刺激电极。各向同性允许接收器 - 刺激器被植入，而不考虑相对于来自声能源的传输声场的取向。

8. 发明申请

WO2005112750A1 SYSTEM FOR GRAPHICALLY REPRESENTING ANATOMICAL ORIFICES AND LUMENS 审中-公开
标题翻译：用于图形表示解剖学和光学的系统
公开(公告)号：WO2005112750A1
公开(公告)日：2005-12-01
申请号：PCT/US2005/017422
申请日：2005-05-18
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WILLIS, N, Parker , HWANG, Ren-Her , ZENG, Jinglin
发明人： WILLIS, N, Parker , HWANG, Ren-Her , ZENG, Jinglin
IPC分类号： A61B5/042
CPC分类号： A61B5/0422 , A61B5/06 , A61B5/064 , A61B8/0833 , A61B8/0883 , A61B8/0891 , A61B18/1492 , A61B34/20 , A61B90/36 , A61B2017/00053 , A61B2018/00839 , A61B2034/102 , A61B2034/105 , A61B2034/2063 , G06T17/00 , G06T2210/41
摘要： Systems are provided for generating graphical representations of orifices and lumens. One system comprises a probe, such as a catheter (108), and a processor that generates a representation of the surface (e.g., an endocardial surface) within a coordinate system, and defines line segments within the coordinate system while the probe distal end is laterally moved within an orifice (e.g., a valve or a lumen ostium) associated with the surface, wherein each of the line segments represents the probe distal end. The processor further defines intersection points within the coordinate system, wherein each of the points represents an intersection of one of the line segments and the surface representation. Lastly, the processor graphically generates a representation of the orifice based on the intersection points, e.g., by forming the orifice representation around the intersection points.
摘要翻译：提供了用于产生孔和流明的图形表示的系统。一个系统包括诸如导管（108）的探针和在坐标系内产生表面（例如，心内膜表面）的表示的处理器，并且在探针远端是在与表面相关联的孔（例如，阀或管腔）中横向移动，其中每个线段表示探针远端。处理器进一步定义坐标系中的交点，其中每个点表示线段和表面表示之一的交点。最后，处理器基于交点图形地生成孔口的表示，例如通过在交点附近形成孔口表示。

9. 发明申请

WO2014052985A1 SYSTEMS. DEVICES, AND METHODS FOR SELECTIVELY LOCATING IMPLANTABLE DEVICES 审中-公开
标题翻译：系统。用于选择性地定位可植入设备的设备和方法
公开(公告)号：WO2014052985A1
公开(公告)日：2014-04-03
申请号：PCT/US2013/062766
申请日：2013-09-30
申请人： PARE, Mike , MOORE, David , WILLIS, N., Parker
发明人： PARE, Mike , MOORE, David , WILLIS, N., Parker
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/37 , A61N1/37205 , A61N1/37217 , A61N1/37229 , A61N1/37252 , A61N1/3756
摘要： Method and systems for determining the location or identify of implantable devices are disclosed. An implantable device generates an electrical output and then modifies the output at a pre-configured interval for a pre-configured period. A sensor detects the modified output and locates or identifies the implantable device based on the modified output.
摘要翻译：公开了用于确定可植入装置的位置或识别的方法和系统。可植入装置产生电输出，然后以预配置的时间间隔修改输出以进行预配置的周期。传感器检测修改的输出，并根据修改的输出定位或识别可植入设备。

10. 发明申请

WO2009120636A1 TEMPORARY ELECTRODE CONNECTION FOR WIRELESS PACING SYSTEMS 审中-公开
标题翻译：用于无线PACING系统的临时电极连接
公开(公告)号：WO2009120636A1
公开(公告)日：2009-10-01
申请号：PCT/US2009/037978
申请日：2009-03-23
申请人： EBR SYSTEMS, INC. , MOORE, David, F. , COWAN, Mark, W. , WILLIS, N., Parker
发明人： MOORE, David, F. , COWAN, Mark, W. , WILLIS, N., Parker
IPC分类号： A61B5/00
CPC分类号： A61N1/3787 , A61B5/042 , A61B17/3468 , A61N1/362 , A61N1/3702 , A61N1/37205 , A61N1/37223 , A61N1/3756
摘要： Delivery of an implantable wireless receiver-stimulator (R-S) into the heart using delivery catheter is described. R-S comprises a cathode and an anode and wirelessly receives and converts energy, such as acoustic ultrasound energy, to electrical energy to stimulate the heart. Conductive wires routed through the delivery system temporarily connect R-S electrodes to external monitor and pacing controller. R-S comprises a first temporary electrical connection from the catheter to the cathode, and a second temporary electrical connection from the catheter to the anode. Temporary electrical connections allow external monitoring of heart's electrical activity as sensed by R-S electrodes to determine tissue viability for excitation as well as to assess energy conversion efficiency.
摘要翻译：描述了使用输送导管将植入式无线接收器刺激器（R-S）递送到心脏中。 R-S包括阴极和阳极，并且将诸如声学超声能量的能量无线地接收并转换成电能以刺激心脏。通过传送系统布线的导线将R-S电极临时连接到外部监护仪和起搏控制器。 R-S包括从导管到阴极的第一临时电连接以及从导管到阳极的第二临时电连接。临时电气连接允许外部监测由R-S电极感测的心脏电活动，以确定激发的组织活力以及评估能量转换效率。

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