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1. 发明申请

US20070166676A1 COGNITIVE TRAINING USING GUIDED EYE MOVEMENTS 审中-公开
标题翻译：使用指导眼睛运动的认知训练
公开(公告)号：US20070166676A1
公开(公告)日：2007-07-19
申请号：US11611329
申请日：2006-12-15
申请人： Dylan Bird , Samuel Chan , Peter Delahunt , Joseph Hardy , Stephen Lisberger , Henry Mahncke , Michael Merzenich
发明人： Dylan Bird , Samuel Chan , Peter Delahunt , Joseph Hardy , Stephen Lisberger , Henry Mahncke , Michael Merzenich
IPC分类号： G09B19/00
CPC分类号： G09B7/04
摘要： Computer-implemented method for enhancing cognitive ability of a participant using guided eye movements. Multiple graphical elements are provided for visual presentation to the participant, each having a value. A temporal sequence of at least two of the graphical elements are visually presented at a specified stimulus intensity, e.g., duration or presentation time, including displaying the value of each graphical element at a respective position in a visual field for a specified duration, then ceasing to display the value. The participant is required to respond to the displayed values. A determination is made as to whether the participant responded correctly, and the stimulus intensity modified in response, e.g., using a maximum likelihood procedure. The visually presenting, requiring, determining, and modifying are repeated in an iterative manner to improve the participant's cognitive skills. Periodically, assessments of the participant's progress are performed, e.g., using the maximum likelihood procedure.
摘要翻译：使用引导眼动作提高参与者认知能力的计算机实现方法。提供了多个图形元素用于视觉呈现给参与者，每个具有值。至少两个图形元素的时间序列以指定的刺激强度例如持续时间或呈现时间以视觉方式呈现，包括在视野中的相应位置显示指定持续时间的每个图形元素的值，然后停止显示值。参与者需要响应显示的值。确定参与者是否正确响应，以及响应中修改的刺激强度，例如使用最大似然程序。以迭代的方式重复视觉呈现，要求，确定和修改，以提高参与者的认知技能。定期对参与者的进度进行评估，例如使用最大似然程序。

2. 发明申请

US20070166675A1 COGNITIVE TRAINING USING VISUAL STIMULI 审中-公开
标题翻译：使用VISUAL STIMULI的认知训练
公开(公告)号：US20070166675A1
公开(公告)日：2007-07-19
申请号：US11611291
申请日：2006-12-15
申请人： Sharona Atkins , Dylan Bird , Samuel Chan , Peter Delahunt , Shruti Gangadhar , Joseph Hardy , Stephen Lisberger , Henry Mahncke , Michael Merzenich , Donald Richards
发明人： Sharona Atkins , Dylan Bird , Samuel Chan , Peter Delahunt , Shruti Gangadhar , Joseph Hardy , Stephen Lisberger , Henry Mahncke , Michael Merzenich , Donald Richards
IPC分类号： G09B19/00
CPC分类号： G09B5/06 , G09B7/00 , G09B7/04
摘要： A computer-implemented method for enhancing cognition, e.g., for improving cognitive ability of a participant using visual stimuli. A set (or sets) of visual stimuli is provided for visual presentation to the participant. A visual stimulus from the set is visually presented to the participant. The participant is required to respond to the visual stimulus. A determination is made regarding whether the participant responded correctly. The stimulus intensity of the visual stimuli presented may be adjusted based on the correctness/incorrectness of the participant's response according to a single-stair maximum likelihood (e.g., ZEST) or N-up/M-down procedure. The visually presenting, requiring, and determining are repeated one or more times in an iterative manner to improve the participant's cognition, e.g., ability to process visual information, memory, etc. Assessments may be performed during the repeating according to a dual-stair maximum likelihood (e.g., ZEST) or N-up/M-down procedure. The repeating may include performing multiple exercises using visual stimuli.
摘要翻译：一种用于增强认知的计算机实现的方法，例如用于提高参与者使用视觉刺激的认知能力。提供视觉刺激的一套（或多组）视觉呈现给参与者。来自该组的视觉刺激被视觉呈现给参与者。参与者需要对视觉刺激作出反应。确定参与者是否正确回应。所提供的视觉刺激的刺激强度可以根据参与者的响应的正确性/不正确性来调整，这是由于单步最大似然（例如，ZEST）或N-up / M-down过程。视觉呈现，要求和确定以迭代的方式重复一次或多次，以改善参与者的认知，例如处理视觉信息，记忆等的能力。评估可以在根据双重阶段最大值的重复期间执行可能性（例如，ZEST）或N-up / M-down过程。重复的可能包括使用视觉刺激进行多次练习。

3. 发明申请

US20070134632A1 Assessment in cognitive training exercises 审中-公开
标题翻译：认知训练中的评估
公开(公告)号：US20070134632A1
公开(公告)日：2007-06-14
申请号：US11465313
申请日：2006-08-17
申请人： Samuel Chan , Joseph Hardy , Henry Mahncke
发明人： Samuel Chan , Joseph Hardy , Henry Mahncke
IPC分类号： G09B19/00
CPC分类号： G09B7/02
摘要： A computer-implemented method is described for assessing an aging adult's ability to integrate visual-spatial and auditory memory by requiring the adult to spatially match pairs of graphically presented response buttons that are associated with aurally presented stimuli which is processed by a computing device. The adult is presented with a grid of response buttons, each associated with an aural stimulus. When the adult selects a response button, its aural stimulus is presented. The adult is required to consecutively select a response button having the same aural stimulus. As the adult sequentially selects response buttons having the same aural stimuli, the button pair is removed. First assessment trials are performed for a first plurality of grids, training trials are performed for a second plurality of grids, then second assessment trials performed for the first plurality of grids. The adult's performances in the two assessments are compared to determine the adult's improvement.
摘要翻译：描述了一种计算机实现的方法，用于通过要求成年人空间匹配由计算设备处理的与听觉呈现的刺激相关联的图形呈现的响应按钮对，来评估老化成年人整合视觉空间和听觉记忆的能力。成年人呈现出一个响应按钮网格，每个都与听觉刺激相关联。当成年人选择响应按钮时，会显示其听觉刺激。成人需要连续选择具有相同听觉刺激的响应按钮。随着成人依次选择具有相同听觉刺激的响应按钮，则移除按钮对。对于第一组多个网格进行第一次评估试验，对第二组网格进行训练试验，然后对第一组多个网格进行第二次评估试验。比较成人在两项评估中的表现，以确定成人的改善。

4. 发明申请

US20070141541A1 ASSESSMENT IN COGNITIVE TRAINING EXERCISES 审中-公开
标题翻译：评估在认知训练中的运动
公开(公告)号：US20070141541A1
公开(公告)日：2007-06-21
申请号：US11465290
申请日：2006-08-17
申请人： Samuel Chan , Joseph Hardy , Henry Mahncke
发明人： Samuel Chan , Joseph Hardy , Henry Mahncke
IPC分类号： G09B19/00
CPC分类号： G09B19/00 , G09B5/06 , G09B7/02
摘要： A method on a computing device is provided for assessing a stimulus threshold of an older adult by requiring the adult to differentiate between rapidly presented stimuli. The method trains the time order judgment of the adult by presenting upward and downward frequency sweeps, in random order, separated by an inter-stimulus interval (ISI). Icons associated with the upward and downward frequency sweeps allow the adult to indicate an order in which the frequency sweeps are presented (i.e., UP-UP, UP-DOWN, DOWN-UP, and DOWN-DOWN). Correct/incorrect selection of an order causes the inter-stimulus interval and/or the duration of the frequency sweeps to be adaptively reduced/increased, using a maximum likelihood procedure, such as ZEST or QUEST, where two tracks, each with a respective duration and ISI, are adjusted until their values substantially converge, or a specified number of trials is performed. The threshold is determined by averaging the final values of the two tracks.
摘要翻译：提供了一种计算设备上的方法，用于通过要求成年人区分快速呈现的刺激来评估老年人的刺激阈值。该方法通过以随机顺序呈现上下频率扫描，通过刺激间间隔（ISI）分开来训练成人的时间顺序判断。与向上和向下频率扫描相关联的图标允许成人指示呈现频率扫描的顺序（即，UP-UP，UP-DOWN，DOWN-UP和DOWN-DOWN）。使用诸如ZEST或QUEST之类的最大似然程序自适应地减小/增加频率扫描的间隔和/或频率扫描的持续时间，其中两个轨道（每个具有相应的持续时间）和ISI，直到它们的值基本上收敛，或者进行了特定数量的试验。通过对两个轨道的最终值进行平均来确定阈值。

5. 发明申请

US20070134634A1 ASSESSMENT IN COGNITIVE TRAINING EXERCISES 审中-公开
标题翻译：评估在认知训练中的运动
公开(公告)号：US20070134634A1
公开(公告)日：2007-06-14
申请号：US11465333
申请日：2006-08-17
申请人： Samuel Chan , Joseph Hardy , Henry Mahncke
发明人： Samuel Chan , Joseph Hardy , Henry Mahncke
IPC分类号： G09B19/00
CPC分类号： G09B19/00
摘要： Computer-implemented method for determining a threshold regarding an aging adult's ability to remember and perform sequences of auditory instructions. A stage specifies a set of stimulus attributes. First and second tracks are respectively initialized to stage values below and above an initial anticipated threshold specifying an initial estimate of stimulus attributes corresponding to a specified performance level of the adult. A sequence of auditory instructions is presented indicating respective manipulations of graphical objects in accordance with the stage value of a specified one of either the first or second track. Input manipulating the graphical objects is received from the adult, and the stage value of the track modified in response. This is performed with respect to each of a plurality of sequences to determine final stage values for the tracks, and a threshold comprising the stage value associated with the specified performance level determined based on the final stage values.
摘要翻译：用于确定关于老化成年人记忆和执行听觉指示序列的能力的阈值的计算机实现的方法。舞台指定一组刺激属性。分别将第一和第二轨道初始化为低于和高于初始预期阈值的阶段值，其指定对应于成人的指定性能水平的刺激属性的初始估计。呈现听觉指令序列，其指示根据第一或第二轨迹中指定的一个的阶段值对图形对象的相应操作。从成人接收到操作图形对象的输入，并且响应中修改了轨道的阶段值。这相对于多个序列中的每一个执行以确定轨道的最终级值，以及包括与基于最终级值确定的指定性能级别相关联的级值的阈值。

6. 发明申请

US20070134633A1 Assessment in cognitive training exercises 审中-公开
标题翻译：认知训练中的评估
公开(公告)号：US20070134633A1
公开(公告)日：2007-06-14
申请号：US11465322
申请日：2006-08-17
申请人： Samuel Chan , Joseph Hardy , Henry Mahncke
发明人： Samuel Chan , Joseph Hardy , Henry Mahncke
IPC分类号： G09B19/00
CPC分类号： G09B7/02
摘要： A method on a computing device for determining a psychophysical threshold regarding an aging adult's ability to temporarily store and retrieve an order of the syllables by requiring the adult to listen to two or more aurally processed syllables, presented serially, view the syllables graphically, and designate the order in which the syllables were presented. Two tracks are initialized to respective stage values, each corresponding to attributes of the presented syllables. A number of trials are performed according to each of the two tracks. As the adult attempts to determine the syllable order in trials, correct/incorrect selection of an order causes the stage value of a track to be adaptively reduced/increased, using a maximum likelihood procedure, e.g., ZEST, where the two tracks are adjusted until their values substantially converge, or a specified number of trials is performed. The final stage values of the tracks are averaged to determine the threshold.
摘要翻译：一种计算设备上的方法，用于通过要求成年人听取两个或更多个听觉上被处理的音节，以连续呈现的方式，以图形方式查看音节并指定了音节，来确定关于老化成年人暂时存储和检索音节的顺序的能力的心理物理阈值提供音节的顺序。两个轨道被初始化为相应的阶段值，每一个对应于所呈现的音节的属性。根据两个轨道中的每一个进行许多试验。当成年人尝试确定试验中的音节顺序时，使用最大似然程序（例如ZEST）自动减少/增加一个音阶的正确/不正确选择导致音轨的舞台值，其中调整两首曲目直到它们的值基本上收敛，或者进行了特定数量的试验。轨道的最后阶段值被平均以确定阈值。

7. 发明申请

US20080003558A1 Cognitive Training Using Multiple Stimulus Streams With Response Inhibition 审中-公开
标题翻译：使用响应抑制的多个激励流的认知训练
公开(公告)号：US20080003558A1
公开(公告)日：2008-01-03
申请号：US11760500
申请日：2007-06-08
申请人： Samuel Chan , Joseph Hardy , Michael Merzenich
发明人： Samuel Chan , Joseph Hardy , Michael Merzenich
IPC分类号： G09B7/00
CPC分类号： G09B5/00
摘要： System and method for enhancing cognition using continuous performance with multiple stimulus streams. A target correspondence is presented. A continuous sequence of stimulus groups is presented one stimulus group at a time, where each stimulus group includes at least two stimuli, and where each stimulus group is presented for a specified duration, and separated by a specified inter-stimulus-interval (ISI). For each stimulus group in the sequence: the subject is required to respond to the group, indicating when all the stimuli in the group correspond in accordance with the target correspondence, and refraining from indicating when the stimuli do not correspond, correctness/incorrectness of the response is determined, and the duration and/or the ISI adjusted accordingly, using an adaptive procedure, e.g., a continuous performance maximum likelihood procedure. The presenting the target correspondence, presenting the sequence of stimulus groups, and the requiring/determining/adjusting for each group, are iterated to improve cognition of the subject.
摘要翻译：用多个刺激流连续表现增强认知的系统和方法。提出目标信函。刺激组的连续序列每次呈现一个刺激组，其中每个刺激组包括至少两个刺激，并且其中每个刺激组呈现指定持续时间，并且通过指定的刺激间隔（ISI）分开，。对于序列中的每个刺激组：受试者需要对组进行响应，指示组中的所有刺激根据目标对应关系何时对应，并且避免指示何时刺激不对应，正确性/不正确性确定响应，并且使用自适应过程（例如连续性能最大似然程序）相应地调整持续时间和/或ISI。提出目标对应，呈现刺激组的顺序，以及每个组的要求/确定/调整，以改善对主体的认知。

8. 发明申请

US20070293735A1 COGNITIVE TRAINING USING ONE OR MORE STIMULUS STREAMS AND TARGET ATTRIBUTE MATCHING 审中-公开
标题翻译：使用一个或多个STIMULUS STREAMS和目标属性匹配的认知训练
公开(公告)号：US20070293735A1
公开(公告)日：2007-12-20
申请号：US11760435
申请日：2007-06-08
申请人： Samuel Chan , Joseph Hardy , Michael Merzenich
发明人： Samuel Chan , Joseph Hardy , Michael Merzenich
IPC分类号： A61B5/00
CPC分类号： A61B5/16
摘要： System and method for enhancing cognition using continuous performance with respect to one or more stimulus streams. At least one target attribute is presented to the subject after which a continuous sequence of stimulus groups from a stimulus set is presented one stimulus group at a time, each group including one or more stimuli, presented for a specified duration, and separated by a specified inter-stimulus-interval (ISI). For each stimulus group in the sequence: the subject is required to respond to the group, indicating when all the stimuli in the group correspond to the target attribute(s); correctness/incorrectness of the response is determined, and the duration and/or the ISI adjusted based on the determining using an adaptive procedure, e.g., a continuous performance maximum likelihood procedure. The presenting the target attribute(s), presenting the continuous sequence, and requiring/determining/adjusting for each group, are repeated iteratively to improve the cognition of the subject.
摘要翻译：用于使用针对一个或多个刺激流的连续性能增强认知的系统和方法。向对象呈现至少一个目标属性，在此之后，来自刺激组的刺激组的连续序列一次呈现一个刺激组，每个组包括一个或多个刺激，呈现持续指定的持续时间，并被指定的刺激间期（ISI）。对于序列中的每个刺激组：要求对象对组进行响应，指示组中的所有刺激何时对应于目标属性; 确定响应的正确性/不正确性，并且基于使用自适应过程（例如连续性能最大似然性过程）的确定来调整持续时间和/或ISI。呈现目标属性，呈现连续序列，以及需要/确定/调整每个组，重复地重复以改善对象的认知。

9. 发明申请

US20070299319A1 Cognitive Training Using A Continuous Performance Adaptive Procedure 审中-公开
标题翻译：使用连续性能自适应过程的认知训练
公开(公告)号：US20070299319A1
公开(公告)日：2007-12-27
申请号：US11760413
申请日：2007-06-08
申请人： Samuel Chan , Joseph Hardy
发明人： Samuel Chan , Joseph Hardy
IPC分类号： A61B5/00
CPC分类号： A61B5/16 , A61B5/486 , G09B7/00
摘要： A computer-implemented method for enhancing cognition, e.g., for improving cognitive ability and memory of a subject using continuous performance with respect to a stimulus stream. A target descriptor is presented to the subject after which, a continuous sequence of stimulus groups from a stimulus set is presented one stimulus at a time, each stimulus presented for a specified duration, and separated by a specified inter-stimulus-interval (ISI). For each stimulus in the sequence: the subject is required to respond to the stimulus, indicating when the stimulus corresponds to the target descriptor, and the duration and/or the ISI adjusted accordingly, using an adaptive procedure. The presenting the target descriptor(s), presenting the continuous sequence, and requiring/determining/adjusting for each stimulus, are repeated iteratively to improve the cognition of the subject.
摘要翻译：一种用于增强认知的计算机实现的方法，例如用于使用针对刺激流的连续性能来改善受试者的认知能力和记忆。目标描述符被呈现给受试者，在此之后，来自刺激组的刺激组的连续序列一次呈现一个刺激，每个刺激呈现指定的持续时间，并被指定的刺激间隔（ISI）分开，。对于序列中的每个刺激：受试者需要响应刺激，指示刺激何时对应于目标描述符，并且使用自适应过程相应地调整持续时间和/或ISI。呈现呈现连续序列的目标描述符，以及需要/确定/调整每种刺激的方法被重复地重复以改善对象的认知。

10. 发明授权

US09410975B2 Pressure manifold to equalize pressure in integration PCR-CE microfluidic devices 有权
标题翻译：集成PCR-CE微流体装置的压力歧管以均衡压力
公开(公告)号：US09410975B2
公开(公告)日：2016-08-09
申请号：US12600171
申请日：2008-05-15
申请人： Chen Li , Samuel Chan , Jian Ping Zhang
发明人： Chen Li , Samuel Chan , Jian Ping Zhang
IPC分类号： B01L3/00 , G01N27/26 , G01N35/10 , C12P19/34 , G01N35/00
CPC分类号： G01N35/1095 , B01L3/502707 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L2200/027 , B01L2200/0684 , B01L2300/0645 , B01L2300/0819 , B01L2400/0487 , B01L2400/049 , G01N2035/00158 , G01N2035/00237
摘要： A device is presented that includes a chip having a plurality of wells that are optionally connected by capillary channels, and a manifold member configured to be disposed over the chip for equalizing pressure over the wells and capillary channels.
摘要翻译：提出了一种装置，其包括具有可选地通过毛细管通道连接的多个阱的芯片，以及配置成设置在芯片上方以均衡孔和毛细通道上的压力的歧管构件。

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