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1. 发明申请

US20140088937A1 Methods of Predicting The Probability of Modulation of Transcript Levels By RNAI Compounds 审中-公开
标题翻译：通过RNAI化合物预测转录水平调节概率的方法
公开(公告)号：US20140088937A1
公开(公告)日：2014-03-27
申请号：US14091459
申请日：2013-11-27
申请人： Duncan Brown , Julja Burchard , Eugen C. Buehler
发明人： Duncan Brown , Julja Burchard , Eugen C. Buehler
IPC分类号： G06F19/12
CPC分类号： G16B5/00 , G16B20/00
摘要： The present invention provides a method for determining the probability that an RNAi compound modulates the expression level of a gene using a linear regression model. The present invention also provides a method for determining the probabilities that an RNAi compound modulates the expression levels of each gene in a set of genes of interest using the linear regression model. The present invention provides a method for determining the seed-sequence-dependent signature size of an RNAi compound using the linear regression model. The invention provides a method for identifying genes having seed-sequence-dependent silencing effect by an siRNA using the linear regression model. The invention further provides a method for selecting from a plurality of siRNAs one or more siRNAs with higher silencing efficacy, specificity and diversity in silencing a target gene in an organism. The invention also provides a method for determining the coefficients of the above linear regression model.
摘要翻译：本发明提供了使用线性回归模型确定RNAi化合物调节基因表达水平的可能性的方法。本发明还提供了使用线性回归模型确定RNAi化合物调节一组感兴趣基因中的每个基因的表达水平的概率的方法。本发明提供了使用线性回归模型确定RNAi化合物的种子序列依赖性特征大小的方法。本发明提供一种使用线性回归模型鉴定siRNA的具有种子序列依赖性沉默效应的基因的方法。本发明还提供了从多个siRNA中选择一种或多种沉默效力，特异性和沉默生物体中靶基因多样性的siRNA的方法。本发明还提供了一种用于确定上述线性回归模型的系数的方法。

2. 发明申请

US20120072123A1 Methods of Predicting The Probability of Modulation of Transcript Levels By RNAI Compounds 审中-公开
标题翻译：通过RNAI化合物预测转录水平调节概率的方法
公开(公告)号：US20120072123A1
公开(公告)日：2012-03-22
申请号：US13322931
申请日：2010-05-27
申请人： Duncan Brown , Julja Burchard , Eugen C. Buehler
发明人： Duncan Brown , Julja Burchard , Eugen C. Buehler
IPC分类号： G06F19/20
CPC分类号： G16B5/00 , G16B20/00
摘要： The present invention provides a method for determining the probability that an RNAi compound modulates the expression level of a gene using a linear regression model. The present invention also provides a method for determining the probabilities that an RNAi compound modulates the expression levels of each gene in a set of genes of interest using the linear regression model. The present invention provides a method for determining the seed-sequence-dependent signature size of an RNAi compound using the linear regression model. The invention provides a method for identifying genes having seed-sequence-dependent silencing effect by an siRNA using the linear regression model. The invention further provides a method for selecting from a plurality of siRNAs one or more siRNAs with higher silencing efficacy, specificity and diversity in silencing a target gene in an organism. The invention also provides a method for determining the coefficients of the above linear regression model.
摘要翻译：本发明提供了使用线性回归模型确定RNAi化合物调节基因表达水平的可能性的方法。本发明还提供了使用线性回归模型确定RNAi化合物调节一组感兴趣基因中的每个基因的表达水平的概率的方法。本发明提供了使用线性回归模型确定RNAi化合物的种子序列依赖性特征大小的方法。本发明提供一种使用线性回归模型鉴定siRNA的具有种子序列依赖性沉默效应的基因的方法。本发明还提供了从多个siRNA中选择一种或多种沉默效力，特异性和沉默生物体中靶基因多样性的siRNA的方法。本发明还提供了一种用于确定上述线性回归模型的系数的方法。

3. 发明申请

US20140094503A1 RNA INTERFERENCE MEDIATED INHIBITION OF ISOCITRATE DEHYDROGENASE (IDH1) GENE EXPRESSION 有权
标题翻译： RNA干扰介导的异烟肼脱氢酶（IDH1）基因表达的抑制
公开(公告)号：US20140094503A1
公开(公告)日：2014-04-03
申请号：US14123822
申请日：2012-06-01
申请人： Yong Ma , Duncan Brown , Steven Bartz
发明人： Yong Ma , Duncan Brown , Steven Bartz
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , C07H21/02 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/332 , C12N2310/3521 , C12N2310/3533 , C12Y101/01042 , C12N2310/322
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of IDH1 and mutant IDH1 gene expression and/or activity, and/or modulate an IDH1 or mutant IDH1 gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules, including small nucleic acid molecules such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules, that are capable of mediating or that mediate RNA interference (RNAi) against IDH1 or mutant IDH1 gene expression.
摘要翻译：本发明涉及用于研究，诊断和治疗响应于IDH1和突变体IDH1基因表达和/或活性的调节和/或调节IDH1或突变体的性状，疾病和病症的化合物，组合物和方法 IDH1基因表达途径。具体地说，本发明涉及双链核酸分子，包括小核酸分子，如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA）分子，其能够介导或介导针对IDH1或突变体IDH1基因表达的RNA干扰（RNAi）。

4. 发明申请

US20130165500A1 RNA Interference Mediated Inhibition of Prolyl Hydroxylase Domain 2 (PHD2) Gene Expression Using Short Interfering Nucleic Acid (siNA) 有权
标题翻译： RNA干扰介导的脯氨酰羟化酶域2（PHD2）基因表达的抑制使用短干扰核酸（siNA）
公开(公告)号：US20130165500A1
公开(公告)日：2013-06-27
申请号：US13818310
申请日：2011-08-24
申请人： Brandon Ason , Duncan Brown , Walter Strapps
发明人： Brandon Ason , Duncan Brown , Walter Strapps
IPC分类号： C07H21/02 , A61K45/06 , A61K31/713
CPC分类号： C12N15/1137 , A61K31/713 , A61K45/06 , C07H21/00 , C07H21/02 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/3525 , C12N2310/3533
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond expressed/synthetic to the modulation of PHD2 gene expression and/or activity, and/or modulate a beta-catenin gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short inter-fering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsR-NA), micro-RNA (miRNA), and short hair-pin RNA (shRNA) molecules that are capa-ble of mediating or that mediate RNA inter-ference (RNAi) against PHD2 gene expres-sion.
摘要翻译：本发明涉及用于研究，诊断和治疗对调节PHD2基因表达和/或活性表达/合成的性状，疾病和病症的化合物，组合物和方法，和/或调节β-连环蛋白基因表达途径。具体地说，本发明涉及包括小核酸分子的双链核酸分子，如短核酸核酸（siNA），短干扰RNA（siRNA），双链RNA（dsR-NA），微RNA （miRNA）和短发夹RNA（shRNA）分子，其可介导或介导针对PHD2基因表达的RNA干扰（RNAi）。

5. 发明授权

US07761258B2 Method of monitoring a load condition of a vehicle 有权
标题翻译：监测车辆负载状况的方法
公开(公告)号：US07761258B2
公开(公告)日：2010-07-20
申请号：US11717332
申请日：2007-03-13
申请人： Duncan Brown
发明人： Duncan Brown
IPC分类号： G01G19/08
CPC分类号： B60G17/01908 , B60G17/017 , B60G2200/142 , B60G2204/11 , B60G2204/1162 , B60G2400/0511 , B60G2400/0512 , B60G2400/60 , B60G2600/02 , B60G2600/042 , B60G2600/044 , B60G2600/202 , B60G2800/70 , G01G19/08 , G01G23/3735
摘要： A system for indicating the state of load of a vehicle having suspension components comprising: at least one transducer mountable on a single suspension component such that a signal relating to the angular deflection of the suspension component can be generated; and a controller configured to receive the signal and generate an output representative of the state of load of the vehicle.
摘要翻译：一种用于指示具有悬挂部件的车辆的负载状态的系统，包括：可安装在单个悬架部件上的至少一个换能器，使得可以产生与悬架部件的角度偏转有关的信号; 以及控制器，被配置为接收所述信号并产生代表所述车辆的负载状态的输出。

6. 发明授权

US08412485B2 System and method of monitoring a load condition of a vehicle 有权
标题翻译：监测车辆负载状况的系统和方法
公开(公告)号：US08412485B2
公开(公告)日：2013-04-02
申请号：US12797968
申请日：2010-06-10
申请人： Duncan Brown
发明人： Duncan Brown
IPC分类号： G01G19/14 , G01M1/00
CPC分类号： B60G17/01908 , B60G17/017 , B60G2200/142 , B60G2204/11 , B60G2204/1162 , B60G2400/0511 , B60G2400/0512 , B60G2400/60 , B60G2600/02 , B60G2600/042 , B60G2600/044 , B60G2600/202 , B60G2800/70 , G01G19/08 , G01G23/3735
摘要： A system and method for indicating the load condition of a vehicle having suspension components comprising: at least one of an inclinometer or an accelerometer mounted on at least one suspension component to measure the deflection angle of the suspension component; and a controller configured to use deflection angle and generate an output representative of the load condition of the vehicle.
摘要翻译：一种用于指示具有悬挂部件的车辆的载荷状态的系统和方法，包括：安装在至少一个悬架部件上的倾斜计或加速度计中的至少一个，以测量悬架部件的偏转角; 以及控制器，被配置为使用偏转角度并产生表示车辆的负载状况的输出。

7. 发明申请

US20080121438A1 System 有权
标题翻译：系统
公开(公告)号：US20080121438A1
公开(公告)日：2008-05-29
申请号：US11717332
申请日：2007-03-13
申请人： Duncan Brown
发明人： Duncan Brown
IPC分类号： G01G19/08
CPC分类号： B60G17/01908 , B60G17/017 , B60G2200/142 , B60G2204/11 , B60G2204/1162 , B60G2400/0511 , B60G2400/0512 , B60G2400/60 , B60G2600/02 , B60G2600/042 , B60G2600/044 , B60G2600/202 , B60G2800/70 , G01G19/08 , G01G23/3735
摘要： A system for indicating the state of load of a vehicle having suspension components comprising: at least one transducer mountable on a single suspension component such that a signal relating to the angular deflection of the suspension component can be generated; and a controller configured to receive the signal and generate an output representative of the state of load of the vehicle.
摘要翻译：一种用于指示具有悬挂部件的车辆的负载状态的系统，包括：可安装在单个悬架部件上的至少一个换能器，使得可以产生与悬架部件的角度偏转有关的信号; 以及控制器，被配置为接收所述信号并产生代表所述车辆的负载状态的输出。

8. 发明申请

US20080039171A1 Computerized game with cascading strategy and full information 有权
标题翻译：具有级联策略和完整信息的电脑游戏
公开(公告)号：US20080039171A1
公开(公告)日：2008-02-14
申请号：US11973098
申请日：2007-10-05
申请人： Scott Slomiany , Lawrence DeMar , Duncan Brown
发明人： Scott Slomiany , Lawrence DeMar , Duncan Brown
IPC分类号： A63F9/24
CPC分类号： G07F17/32 , G07F17/3293 , G07F17/3295
摘要： A gaming machine and method for operating the same has gameplay elements provided in a manner that can be visualized, with the gameplay elements having a specific nature which is revealed to the player at a beginning to the game. That is, the player knows the value, or ranking, or position, etc., of the gameplay elements upon inception of the game. In a base level for the game of the gaming machine, no unknown gameplay element or random event is injected into the gameplay elements. This is a full information format for the gaming machine and method, and success is measured by the player's ability to manipulate the gameplay elements presented. A gaming machine and a method for operating the same is also provided with the gameplay elements once again having a specific nature which is known to the player at a start to game play, and in a preferred embodiment not subject thereafter to a random or unknown event, with the gameplay elements being arranged in one of a variety of different arrangements presenting a plurality of choices to a player for subsequent play of the elements. Outcome of the game is dependent upon the choices made by the player, with a given choice potentially influencing the next choice that may be available. Embodiments of the invention in the form of a checkers game and in the form of a poker-type game are disclosed, among others.
摘要翻译：用于操作该游戏机的游戏机和方法具有以可视化的方式提供的游戏元素，游戏元素具有特定的性质，游戏开始时向玩家显露。也就是说，玩家知道游戏开始时游戏元素的价值，排名或位置等。在游戏机游戏的基础水平中，没有未知的游戏元素或随机事件被注入游戏元素中。这是游戏机和方法的完整信息格式，成功通过玩家操纵游戏元素的能力来衡量。游戏机和操作该游戏机的方法还具有游戏元素，其再次具有游戏开始时游戏玩家已知的特定性质，并且在优选实施例中不受随机或未知事件影响游戏元素以各种不同的布置方式布置成向播放器呈现多个选择以便随后播放元素。游戏的结果取决于玩家的选择，给定的选择潜在地影响可能可用的下一个选择。本发明的实施例以跳棋游戏的形式并以扑克式游戏的形式进行了公开。

9. 发明申请

US20070269987A1 Polishing Liquid for Cmp Process and Polishing Method 审中-公开
标题翻译：抛光液用于Cmp工艺和抛光方法
公开(公告)号：US20070269987A1
公开(公告)日：2007-11-22
申请号：US10552606
申请日：2004-05-07
申请人： Tomoharu Nakano , Fumihiro Nakajima , Tadakazu Miyazaki , Duncan Brown , Matthew Healy
发明人： Tomoharu Nakano , Fumihiro Nakajima , Tadakazu Miyazaki , Duncan Brown , Matthew Healy
IPC分类号： H01L21/321
CPC分类号： C09G1/02 , H01L21/31053
摘要： An abrasive liquid for CMP process characterized by comprising an abrasive material, an aqueous solvent and an addition agent, and containing abrasive particles having a particle diameter of 20 to 80 nm by 15 weight % or more on the basis of the weight of the abrasive liquid; and a method of polishing by using the abrasive liquid are appropriate for the processing of flattening the surface of a device wafer on which at least a silicon oxide film is formed, and take effect of being capable of stably performing superior abrasive properties such as flattening properties, low flaw properties and high washing properties, and then are the most appropriate for the processing of flattening the surface of a semiconductor device comprising a layer insulation film or an element separation film, a magnetic head and a substrate for a liquid crystal display in the semiconductor industry.
摘要翻译：一种用于CMP工艺的磨料液体，其特征在于包括研磨材料，水性溶剂和添加剂，并且基于研磨液的重量，包含粒径为20至80nm至15重量％或更多的磨料颗粒 ; 并且通过使用研磨液的研磨方法适用于对至少形成有氧化硅膜的器件晶片的表面进行平坦化处理，并且能够稳定地进行优异的研磨性能如扁平化性能低缺陷特性和高洗涤性，最适合用于对包含层间绝缘膜或元件分离膜，磁头和液晶显示器用基板的半导体器件的表面进行平坦化处理半导体行业。

10. 发明申请

US20060121971A1 System and method of an interactive multiple participant game 审中-公开
标题翻译：交互式多参与游戏的系统和方法
公开(公告)号：US20060121971A1
公开(公告)日：2006-06-08
申请号：US11296840
申请日：2005-12-06
申请人： Scott Slomiany , Lawrence DeMar , Duncan Brown , Steven Katz
发明人： Scott Slomiany , Lawrence DeMar , Duncan Brown , Steven Katz
IPC分类号： A63F9/24
CPC分类号： G07F17/3276 , G07F17/32 , G07F17/3288 , G07F17/3293 , G07F17/3295 , G07F17/34
摘要： A plurality of linked gaming machines are disclosed that enhance the community participation and enjoyment of a game on multiple gaming machines. Players participate in an interactive game, either simultaneously, alternatively or in a systematic sequence, as a group or community. The participating players compete in the game such that the actions and results of each player affect the other players in the community. The interactive game combines skill and luck to improve play of the game. The interactive game could be a bonus game which players need to qualify in order to participate. If a player does not qualify, a wager can be placed to participate in the game. Players with different wagers can participate in the same game and players can wager on the outcomes of other players.
摘要翻译：公开了多个连接的游戏机，其增强了在多个游戏机上的游戏的社区参与和享受。作为一个团体或社区，玩家可以同时或以系统的顺序参与互动游戏。参赛者参加比赛，每个选手的动作和结果都会影响社区其他玩家。互动游戏结合了技能和运气来改善游戏的玩法。互动游戏可能是玩家需要参加资格的奖金游戏。如果玩家不符合资格，可以投注一下参与比赛。不同赌注的玩家可以参加同一场比赛，玩家可以对其他玩家的成果投下赌注。

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