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1. 发明申请

US20110181410A1 MONITORING OR FEEDBACK SYSTEMS AND METHODS 有权
标题翻译：监控或反馈系统和方法
公开(公告)号：US20110181410A1
公开(公告)日：2011-07-28
申请号：US13016575
申请日：2011-01-28
申请人： Douglas A. Levinson , Howard Bernstein , Donald E. Chickering, III
发明人： Douglas A. Levinson , Howard Bernstein , Donald E. Chickering, III
IPC分类号： G08B21/00
CPC分类号： G06F19/3456 , G06F19/00 , Y02A90/26
摘要： The present invention generally relates to systems and methods for monitoring and/or providing feedback for drugs or other pharmaceuticals taken by a subject. In one aspect, the present invention is directed to devices and methods for determining a species within the skin of a subject; and producing feedback to a subject based on the determination of the species. The feedback may be, for example, visual, audible, tactile, a change in temperature, etc. In some cases, information regarding the determination of the species may be transmitted to another entity, e.g., a health care provider, a computer, a relative, etc., which may then provide feedback to the subject in some fashion. In some cases, the feedback may be directly indicative of the species, e.g., whether the species is present, the concentration of the species, whether a by-product of a reaction involving the species is present, whether a compound affected by the species is present, etc. However, the feedback may also be indirect in some embodiments. For example, the subject may be presented with an external reward, e.g., based on the determination of the species within the skin. For instance, a reward such as cash, coupons, songs, discounts, personal items, etc., may be offered based on the level of compliance of the subject. Still other aspects of the invention are generally directed to kits involving such devices (with or without the drug to be monitored), methods of promoting such systems, or the like.
摘要翻译：本发明一般涉及用于监测和/或提供受试者所采取的药物或其他药物的反馈的系统和方法。一方面，本发明涉及用于确定受试者皮肤内物种的装置和方法; 并根据物种的确定向对象产生反馈。反馈可以是例如视觉，听觉，触觉，温度变化等。在一些情况下，关于物种的确定的信息可以被传输到另一个实体，例如医疗保健提供者，计算机，相对等，其然后可以以某种方式向受试者提供反馈。在一些情况下，反馈可以直接指示物种，例如物种是否存在，物种的浓度，是否存在涉及物种的反应的副产物，受物种影响的化合物是否为存在等。然而，在一些实施例中，反馈也可以是间接的。例如，受试者可以例如基于皮肤内物种的确定来呈现外部奖励。例如，可以基于主体的合规级别来提供诸如现金，优惠券，歌曲，折扣，个人物品等的奖励。本发明的其它方面通常涉及涉及这种装置的试剂盒（有或没有待监测的药物），促进这种系统的方法等。

2. 发明申请

US20100256465A1 DEVICES AND TECHNIQUES ASSOCIATED WITH DIAGNOSTICS, THERAPIES, AND OTHER APPLICATIONS, INCLUDING SKIN-ASSOCIATED APPLICATIONS 有权
标题翻译：与诊断，治疗和其他应用相关的设备和技术，包括皮肤相关应用
公开(公告)号：US20100256465A1
公开(公告)日：2010-10-07
申请号：US12716229
申请日：2010-03-02
申请人： Howard Bernstein , Donald E. Chickering, III , Douglas A. Levinson , David R. Walt , Shawn Davis , Ramin Haghgooie , Robert S. Langer , Timothy M. Blicharz
发明人： Howard Bernstein , Donald E. Chickering, III , Douglas A. Levinson , David R. Walt , Shawn Davis , Ramin Haghgooie , Robert S. Langer , Timothy M. Blicharz
IPC分类号： A61B5/00 , A61B5/145 , G01N21/00
CPC分类号： A61B5/150099 , A61B5/0013 , A61B5/0022 , A61B5/0077 , A61B5/1438 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61B5/150022 , A61B5/150221 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/150969 , A61B5/150984 , A61B5/151 , A61B5/15125 , A61B5/157 , A61B5/411 , A61B5/4839 , A61B5/4845 , A61B5/486 , A61B5/685 , A61B5/6898 , A61B5/743
摘要： The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.
摘要翻译：本发明一般涉及与诊断，治疗和其它应用相关联的装置和技术，包括皮肤相关应用，例如用于递送和/或从主体（例如通过皮肤）排出流体的装置。在一些实施例中，所述装置包括用于在进入位置从所述受试者的皮肤和/或穿过所述受试者的皮肤接入可提取介质的系统，以及由支撑结构支撑的压力调节器，所述压力调节器能够至少在所述皮肤上形成压差访问站点的一部分。在一些情况下，该装置还可以包括由支撑结构支持的传感器，用于确定来自主体的可提取介质的至少一个状况，以及可选地由支撑结构支撑的信号发生器，用于产生与介质由传感器确定。

3. 发明授权

US09113836B2 Devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications 有权
标题翻译：与诊断，治疗和其他应用相关的设备和技术，包括皮肤相关应用
公开(公告)号：US09113836B2
公开(公告)日：2015-08-25
申请号：US12716229
申请日：2010-03-02
申请人： Howard Bernstein , Donald E. Chickering, III , Douglas A. Levinson , David R. Walt , Shawn Davis , Ramin Haghgooie
发明人： Howard Bernstein , Donald E. Chickering, III , Douglas A. Levinson , David R. Walt , Shawn Davis , Ramin Haghgooie
IPC分类号： A61B5/00 , A61B5/145 , G01N21/00 , A61B5/15 , A61B5/151 , A61B5/157 , A61B5/1459 , A61B5/1486
CPC分类号： A61B5/150099 , A61B5/0013 , A61B5/0022 , A61B5/0077 , A61B5/1438 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61B5/150022 , A61B5/150221 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/150969 , A61B5/150984 , A61B5/151 , A61B5/15125 , A61B5/157 , A61B5/411 , A61B5/4839 , A61B5/4845 , A61B5/486 , A61B5/685 , A61B5/6898 , A61B5/743
摘要： The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.
摘要翻译：本发明一般涉及与诊断，治疗和其它应用相关联的装置和技术，包括皮肤相关应用，例如用于递送和/或从主体（例如通过皮肤）排出流体的装置。在一些实施例中，所述装置包括用于在进入位置从所述受试者的皮肤和/或穿过所述受试者的皮肤接入可提取介质的系统，以及由支撑结构支撑的压力调节器，所述压力调节器能够至少在所述皮肤上形成压差访问站点的一部分。在一些情况下，该装置还可以包括由支撑结构支持的传感器，用于确定来自主体的可提取介质的至少一个状况，以及可选地由支撑结构支撑的信号发生器，用于产生与介质由传感器确定。

4. 发明授权

US08821412B2 Delivering and/or receiving fluids 有权
标题翻译：输送和/或接收流体
公开(公告)号：US08821412B2
公开(公告)日：2014-09-02
申请号：US13680351
申请日：2012-11-19
申请人： Javier Gonzalez-Zugasti , A. David Boccuti , Donald E. Chickering, III , Mark Michelman , Ramin Haghgooie , Shawn Davis , Scott James , Maisam Dadgar , Greg Fisher , Richard L. Miller , Christopher J. Morse , Howard Bernstein , Douglas A. Levinson
发明人： Javier Gonzalez-Zugasti , A. David Boccuti , Donald E. Chickering, III , Mark Michelman , Ramin Haghgooie , Shawn Davis , Scott James , Maisam Dadgar , Greg Fisher , Richard L. Miller , Christopher J. Morse , Howard Bernstein , Douglas A. Levinson
IPC分类号： A61B5/00
CPC分类号： A61B5/150374 , A61B5/1411 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/151 , A61B5/15113 , A61B5/15117 , A61B5/15144 , A61B5/154 , A61B5/411 , A61B5/685 , A61B10/0045 , A61B10/0051 , A61B10/007 , A61B2010/008 , A61M37/0015 , G06F19/00 , G16H10/40
摘要： The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.
摘要翻译：本发明一般涉及通过装置开口接收体液。在一个方面，该装置包括流动活化器，其布置成使流体从受试者释放。部署致动器可以在展开方向上致动流动活化器，这又可导致流体从受试者释放。流动活化剂也可以通过回缩致动器在回缩方向上移动。在一个方面，设备可以包括真空源，其可以帮助促进流体流入设备的开口中和/或可以帮助促进流体从开口流到储存室。在一个方面，设备致动器可以实现开口和真空源之间的流体连通，并且在启用流体连通之后可以启动流动活化器。

5. 发明申请

US20120041338A1 CLINICAL AND/OR CONSUMER TECHNIQUES AND DEVICES 审中-公开
标题翻译：临床和/或消费者技术和设备
公开(公告)号：US20120041338A1
公开(公告)日：2012-02-16
申请号：US13208770
申请日：2011-08-12
申请人： Donald E. Chickering, III , Douglas A. Levinson , Shawn Davis , Ramin Haghgooie , Howard Bernstein , David R. Walt
发明人： Donald E. Chickering, III , Douglas A. Levinson , Shawn Davis , Ramin Haghgooie , Howard Bernstein , David R. Walt
IPC分类号： A61B5/15 , A61M5/00
CPC分类号： A61M37/0015 , A61B5/117 , A61B5/14514 , A61B5/150984 , A61B5/415 , A61B5/417 , A61B5/418 , A61B90/96 , A61B90/98 , A61B2560/0412 , A61M5/14248 , A61M37/00 , A61M2037/0023 , A61M2037/0061 , A61M2205/3576 , A61M2205/6009 , A61M2205/6072 , A61N1/30 , A61N1/325
摘要： The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from other tissues of the body. In some cases, the device may contain a substance transfer component such as needles or microneedles, which can be inserted into the skin or another organ to deliver and/or receiving fluid or other substances from the subject. In some embodiments, the device may include an activator constructed and arranged to insert one or more substance transfer components into the skin or other organ. In certain cases, the device may also include a storage chamber for receiving a fluid received from the subject.
摘要翻译：本发明一般涉及用于递送和/或接受来自受试者，例如来自皮肤和/或来自身体的其它组织的物质或物质例如血液的系统和方法。在一些情况下，该装置可以包含诸如针或微针的物质转移组件，其可以插入到皮肤或另一个器官中以从受试者输送和/或接收流体或其他物质。在一些实施方案中，该装置可以包括构造和布置成将一种或多种物质转移组分插入皮肤或其它器官中的活化剂。在某些情况下，该装置还可以包括用于接收从受试者接收的流体的储存室。

6. 发明申请

US20110125058A1 PATIENT-ENACTED SAMPLING TECHNIQUE 审中-公开
标题翻译：患者采集采样技术
公开(公告)号：US20110125058A1
公开(公告)日：2011-05-26
申请号：US12953744
申请日：2010-11-24
申请人： Douglas A. Levinson , Howard Bernstein , Donald E. Chickering, III , Shawn Davis , Ramin Haghgooie
发明人： Douglas A. Levinson , Howard Bernstein , Donald E. Chickering, III , Shawn Davis , Ramin Haghgooie
IPC分类号： A61B5/15 , G09B19/00
CPC分类号： A61B5/150984 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150305 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/74 , A61B10/0045 , A61B2010/008
摘要： The present invention is generally directed to systems and methods for sampling fluids from subjects. The fluid may be any suitable bodily fluid, e.g., blood or interstitial fluid. In some cases, the subject is a patient. The subject may have a device that can be applied to the skin of the subject (e.g., by the subject, or another person), and the device is able to obtain a sample of fluid. The fluid may be stored within a reservoir in the device, and the fluid may be obtained from the subject at any convenient time, e.g., at home, away from a healthcare setting, etc. In some embodiments, the device, or a portion thereof, may be returned to a clinical and/or laboratory setting to analyze the fluid stored within the device.
摘要翻译：本发明总体上涉及用于从主体取样流体的系统和方法。流体可以是任何合适的体液，例如血液或间质液。在某些情况下，受试者是患者。受试者可以具有可以应用于受试者的皮肤（例如受试者或其他人）的装置，并且该装置能够获得流体样本。流体可以存储在装置中的储存器中，并且可以在任何方便的时间（例如在家中，远离保健设置等）从受试者获得流体。在一些实施例中，装置或其一部分，可以返回到临床和/或实验室设置以分析存储在装置内的流体。

7. 发明申请

US20110105872A1 SYSTEMS AND METHODS FOR APPLICATION TO SKIN AND CONTROL OF ACTUATION, DELIVERY, AND/OR PERCEPTION THEREOF 审中-公开
标题翻译：适用于皮肤的系统和方法及其致动，输送和/或认知的控制
公开(公告)号：US20110105872A1
公开(公告)日：2011-05-05
申请号：US12915735
申请日：2010-10-29
申请人： Donald E. Chickering, III , Douglas A. Levinson , Shawn Davis , Ramin Haghgooie , Howard Bernstein , David R. Walt
发明人： Donald E. Chickering, III , Douglas A. Levinson , Shawn Davis , Ramin Haghgooie , Howard Bernstein , David R. Walt
IPC分类号： A61B5/157 , A61B5/15
CPC分类号： A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150106 , A61B5/150122 , A61B5/150129 , A61B5/150137 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150305 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150809 , A61B5/150824 , A61B5/150893 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15109 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685 , A61B2560/0412 , A61B2560/0443 , A61M5/425 , A61M35/00 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/588
摘要： The present invention generally relates, in certain aspects, to systems and methods for application to the skin, and control of actuation, delivery, and/or perception thereof. For example, certain aspects of the invention are generally directed to devices for delivering to and/or withdrawing fluid or from subjects, e.g., to or from the skin and/or beneath the skin. In one aspect, the delivery and/or withdrawal of fluid is at least partially obscured. For example, the obscuration may be by time, and/or by sensory obscuration (e.g., by providing tactile, olfactory, auditory, and/or visual sensations). Certain aspects of the invention are generally directed to devices able to automatically deliver to and/or withdraw fluid from the skin and/or beneath the skin after activation, e.g., where the fluid is delivered and/or withdrawn without the need for any additional intervention. The devices may be activated by any suitable technique. In other aspects, a device may be contained in a package, and when removed from the package, the device may be constructed and arranged to be able to deliver and/or withdraw fluid when the device is applied to the skin, and in some cases, automatically and/or without any further intervention by the subject or another person.
摘要翻译：本发明在某些方面一般涉及用于皮肤的系统和方法，以及对其致动，传递和/或感知的控制。例如，本发明的某些方面通常涉及用于递送到和/或从流体或从受试者递送到皮肤和/或从皮肤下方的装置。在一个方面，流体的递送和/或排出至少部分地模糊。例如，遮蔽可以是时间，和/或通过感觉遮蔽（例如，通过提供触觉，嗅觉，听觉和/或视觉感觉）。本发明的某些方面通常涉及能够在活化后自动递送至皮肤和/或皮下的流体的装置，例如在流体被输送和/或取出而不需要任何额外干预的情况下。可以通过任何合适的技术来激活装置。在其他方面，装置可以包含在包装中，并且当从包装中取出时，可以构造和布置该装置，以便当该装置应用于皮肤时能够输送和/或抽出流体，并且在某些情况下，自动地和/或没有受试者或另一个人的进一步干预。

8. 发明申请

US20110251562A1 RAPID DELIVERY AND/OR WITHDRAWAL OF FLUIDS 审中-公开
标题翻译：快速交付和/或取消流体
公开(公告)号：US20110251562A1
公开(公告)日：2011-10-13
申请号：US13166611
申请日：2011-06-22
申请人： Donald E. Chickering, III , Shawn Davis , Ramin Haghgooie , Howard Bernstein , Douglas A. Levinson , Mark Michelman
发明人： Donald E. Chickering, III , Shawn Davis , Ramin Haghgooie , Howard Bernstein , Douglas A. Levinson , Mark Michelman
IPC分类号： A61M5/00
CPC分类号： A61B5/6849 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685
摘要： The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.
摘要翻译：本发明一般涉及用于递送和/或从皮肤和/或皮肤下方的受试者递送和/或从物质或诸如血液或间质液体中取出物质的方法。一方面，本发明一般涉及使用包含流体转运器（例如，一个或多个微针）的装置从例如皮肤和/或从皮肤下面抽取或提取血液的装置和方法）和在接收血液之前具有小于大气压的内部压力的储存室。在一些情况下，该装置可以是独立的，并且在某些情况下，可以将该装置应用于皮肤并被激活以从受试者中抽出血液。然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液内的分析物。例如，血液可以从装置中取出，和/或该装置可以包含能够确定血液和/或怀疑含在血液中的分析物的传感器或试剂。本发明的其它方面涉及用于抽出血液（或其他体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。

9. 发明授权

US09041541B2 Monitoring or feedback systems and methods 有权
标题翻译：监控或反馈系统和方法
公开(公告)号：US09041541B2
公开(公告)日：2015-05-26
申请号：US13016575
申请日：2011-01-28
申请人： Douglas A. Levinson , Howard Bernstein , Donald E. Chickering, III
发明人： Douglas A. Levinson , Howard Bernstein , Donald E. Chickering, III
IPC分类号： G08B23/00 , G06F19/00
CPC分类号： G06F19/3456 , G06F19/00 , Y02A90/26
摘要： The present invention generally relates to systems and methods for monitoring and/or providing feedback for drugs or other pharmaceuticals taken by a subject. In one aspect, the present invention is directed to devices and methods for determining a species within the skin of a subject; and producing feedback to a subject based on the determination of the species. The feedback may be, for example, visual, audible, tactile, a change in temperature, etc. In some cases, information regarding the determination of the species may be transmitted to another entity, e.g., a health care provider, a computer, a relative, etc., which may then provide feedback to the subject in some fashion. In some cases, the feedback may be directly indicative of the species, e.g., whether the species is present, the concentration of the species, whether a by-product of a reaction involving the species is present, whether a compound affected by the species is present, etc. However, the feedback may also be indirect in some embodiments. For example, the subject may be presented with an external reward, e.g., based on the determination of the species within the skin. For instance, a reward such as cash, coupons, songs, discounts, personal items, etc., may be offered based on the level of compliance of the subject. Still other aspects of the invention are generally directed to kits involving such devices (with or without the drug to be monitored), methods of promoting such systems, or the like.
摘要翻译：本发明一般涉及用于监测和/或提供受试者所采取的药物或其他药物的反馈的系统和方法。一方面，本发明涉及用于确定受试者皮肤内物种的装置和方法; 并根据物种的确定向对象产生反馈。反馈可以是例如视觉，听觉，触觉，温度变化等。在一些情况下，关于物种的确定的信息可以被传输到另一个实体，例如医疗保健提供者，计算机，相对等，其然后可以以某种方式向受试者提供反馈。在一些情况下，反馈可以直接指示物种，例如物种是否存在，物种的浓度，是否存在涉及物种的反应的副产物，受物种影响的化合物是否为存在等。然而，在一些实施例中，反馈也可以是间接的。例如，受试者可以例如基于皮肤内物种的确定来呈现外部奖励。例如，可以基于主体的合规级别来提供诸如现金，优惠券，歌曲，折扣，个人物品等的奖励。本发明的其它方面通常涉及涉及这种装置的试剂盒（有或没有待监测的药物），促进这种系统的方法等。

10. 发明授权

US09033898B2 Sampling devices and methods involving relatively little pain 有权
标题翻译：抽样装置和方法相对较少疼痛
公开(公告)号：US09033898B2
公开(公告)日：2015-05-19
申请号：US13166451
申请日：2011-06-22
申请人： Donald E. Chickering, III , Howard Bernstein , Shawn Davis , Ramin Haghgooie , Douglas A. Levinson , Mark Michelman , Ping Gong
发明人： Donald E. Chickering, III , Howard Bernstein , Shawn Davis , Ramin Haghgooie , Douglas A. Levinson , Mark Michelman , Ping Gong
IPC分类号： A61B5/00 , A61B17/14 , A61B17/32 , A61M37/00 , A61B5/15 , A61B5/151 , A61B5/157 , A61B10/02 , A61B17/00 , A61B5/145 , A61B5/1455 , A61B5/1468 , A61B5/154
CPC分类号： A61B5/150984 , A61B5/1411 , A61B5/14514 , A61B5/14546 , A61B5/1455 , A61B5/1468 , A61B5/150022 , A61B5/150091 , A61B5/150099 , A61B5/150106 , A61B5/150129 , A61B5/150145 , A61B5/15016 , A61B5/150229 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150969 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15119 , A61B5/15125 , A61B5/15134 , A61B5/15136 , A61B5/1514 , A61B5/15186 , A61B5/1519 , A61B5/15194 , A61B5/154 , A61B5/157 , A61B17/00234 , A61B2010/0225 , A61B2562/0238 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046
摘要： Systems and methods for delivering and/or receiving a substance or substances, such as blood, from subjects. In one embodiment, devices and methods for receiving blood from a subject employ devices including a substance transfer component (such as one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In certain embodiments, substances may be received from and/or delivered to the subject with relatively little pain. The pain may be assessed, for example, using pain scales such as the WONG BAKER FACES Pain Scale. The device may be self-contained, applied to the skin, and activated to receive blood from the subject. The device, or a portion thereof, may be processed to determine the blood and/or an analyte within the blood using sensors or agents in the device or an external apparatus. Other aspects of the present invention are directed at other devices for receiving bodily fluids kits involving such devices, methods of making such devices, methods of using such devices, and the like.
摘要翻译：用于从受试者传送和/或接收物质或物质如血液的系统和方法。在一个实施例中，用于从受试者接收血液的装置和方法使用包括物质转移组分（例如一个或多个微针）的装置和在接收血液之前具有小于大气压的内部压力的储存室。在某些实施方案中，可以相对较少的疼痛从受试者接受和/或递送物质。可以评估疼痛，例如，使用诸如黄巴克面霜疼痛量表的疼痛量表。该装置可以是独立的，应用于皮肤，并被激活以从受试者接收血液。可以使用装置或外部装置中的传感器或试剂处理装置或其一部分，以确定血液和/或血液内的分析物。本发明的其它方面涉及用于接收涉及这种装置的体液套件的其他装置，制造这种装置的方法，使用这种装置的方法等。

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