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1. 发明授权

US09113836B2 Devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications 有权
标题翻译：与诊断，治疗和其他应用相关的设备和技术，包括皮肤相关应用
公开(公告)号：US09113836B2
公开(公告)日：2015-08-25
申请号：US12716229
申请日：2010-03-02
申请人： Howard Bernstein , Donald E. Chickering, III , Douglas A. Levinson , David R. Walt , Shawn Davis , Ramin Haghgooie
发明人： Howard Bernstein , Donald E. Chickering, III , Douglas A. Levinson , David R. Walt , Shawn Davis , Ramin Haghgooie
IPC分类号： A61B5/00 , A61B5/145 , G01N21/00 , A61B5/15 , A61B5/151 , A61B5/157 , A61B5/1459 , A61B5/1486
CPC分类号： A61B5/150099 , A61B5/0013 , A61B5/0022 , A61B5/0077 , A61B5/1438 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61B5/150022 , A61B5/150221 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/150969 , A61B5/150984 , A61B5/151 , A61B5/15125 , A61B5/157 , A61B5/411 , A61B5/4839 , A61B5/4845 , A61B5/486 , A61B5/685 , A61B5/6898 , A61B5/743
摘要： The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.
摘要翻译：本发明一般涉及与诊断，治疗和其它应用相关联的装置和技术，包括皮肤相关应用，例如用于递送和/或从主体（例如通过皮肤）排出流体的装置。在一些实施例中，所述装置包括用于在进入位置从所述受试者的皮肤和/或穿过所述受试者的皮肤接入可提取介质的系统，以及由支撑结构支撑的压力调节器，所述压力调节器能够至少在所述皮肤上形成压差访问站点的一部分。在一些情况下，该装置还可以包括由支撑结构支持的传感器，用于确定来自主体的可提取介质的至少一个状况，以及可选地由支撑结构支撑的信号发生器，用于产生与介质由传感器确定。

2. 发明授权

US08821938B2 Porous drug matrices and methods of manufacture thereof 有权
标题翻译：多孔药物基质及其制造方法
公开(公告)号：US08821938B2
公开(公告)日：2014-09-02
申请号：US13022776
申请日：2011-02-08
申请人： Julie Straub , David Altreuter , Howard Bernstein , Donald E. Chickering, III , Sarwat Khattak , Greg Randall
发明人： Julie Straub , David Altreuter , Howard Bernstein , Donald E. Chickering, III , Sarwat Khattak , Greg Randall
IPC分类号： A61K9/14 , A61K9/00 , A61K31/335 , A01N43/02
CPC分类号： A61K9/1635 , A61K9/1611 , A61K9/1623 , A61K9/1688 , A61K9/1694
摘要： Drugs, especially low aqueous solubility drugs, are provided in a porous matrix form, preferably microparticles, which enhances dissolution of the drug in aqueous media. The drug matrices preferably are made using a process that includes (i) dissolving a drug, preferably a drug having low aqueous solubility, in a volatile solvent to form a drug solution, (ii) combining at least one pore forming agent with the drug solution to form an emulsion, suspension, or second solution and hydrophilic or hydrophobic excipients that stabilize the drug and inhibit crystallization, and (iii) removing the volatile solvent and pore forming agent from the emulsion, suspension, or second solution to yield the porous matrix of drug. Hydrophobic or hydrophilic excipients may be selected to stabilize the drug in crystalline form by inhibiting crystal growth or to stabilize the drug in amorphous form by preventing crystallization. The pore forming agent can be either a volatile liquid that is immiscible with the drug solvent or a volatile solid compound, preferably a volatile salt. In a preferred embodiment, spray drying is used to remove the solvents and the pore forming agent. The resulting porous matrix has a faster rate of dissolution following administration to a patient, as compared to non-porous matrix forms of the drug. In a preferred embodiment, microparticles of the porous drug matrix are reconstituted with an aqueous medium and administered parenterally, or processed using standard techniques into tablets or capsules for oral administration.
摘要翻译：药物，特别是低含水溶性药物以多孔基质形式提供，优选微粒，其增强药物在水性介质中的溶解。药物基质优选使用以下方法制备，所述方法包括（i）将挥发性溶剂中的药物（优选为低溶解度的药物）溶解以形成药物溶液，（ii）将至少一种成孔剂与药物溶液以形成稳定药物并抑制结晶的乳液，悬浮液或第二溶液和亲水或疏水赋形剂，和（iii）从乳液，悬浮液或第二溶液中除去挥发性溶剂和成孔剂以产生多孔基质药物。可以选择疏水性或亲水性赋形剂，以通过抑制晶体生长来稳定药物的结晶形式，或者通过防止结晶来稳定药物的无定形形式。成孔剂可以是与药物溶剂或挥发性固体化合物，优选挥发性盐不混溶的挥发性液体。在优选的实施方案中，使用喷雾干燥来除去溶剂和成孔剂。与药物的无孔基质形式相比，得到的多孔基质在给予患者后具有更快的溶解速率。在优选的实施方案中，多孔药物基质的微粒用水性介质重新配制，并肠胃外给药，或使用标准技术加工成用于口服给药的片剂或胶囊。

3. 发明授权

US08821412B2 Delivering and/or receiving fluids 有权
标题翻译：输送和/或接收流体
公开(公告)号：US08821412B2
公开(公告)日：2014-09-02
申请号：US13680351
申请日：2012-11-19
申请人： Javier Gonzalez-Zugasti , A. David Boccuti , Donald E. Chickering, III , Mark Michelman , Ramin Haghgooie , Shawn Davis , Scott James , Maisam Dadgar , Greg Fisher , Richard L. Miller , Christopher J. Morse , Howard Bernstein , Douglas A. Levinson
发明人： Javier Gonzalez-Zugasti , A. David Boccuti , Donald E. Chickering, III , Mark Michelman , Ramin Haghgooie , Shawn Davis , Scott James , Maisam Dadgar , Greg Fisher , Richard L. Miller , Christopher J. Morse , Howard Bernstein , Douglas A. Levinson
IPC分类号： A61B5/00
CPC分类号： A61B5/150374 , A61B5/1411 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/151 , A61B5/15113 , A61B5/15117 , A61B5/15144 , A61B5/154 , A61B5/411 , A61B5/685 , A61B10/0045 , A61B10/0051 , A61B10/007 , A61B2010/008 , A61M37/0015 , G06F19/00 , G16H10/40
摘要： The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.
摘要翻译：本发明一般涉及通过装置开口接收体液。在一个方面，该装置包括流动活化器，其布置成使流体从受试者释放。部署致动器可以在展开方向上致动流动活化器，这又可导致流体从受试者释放。流动活化剂也可以通过回缩致动器在回缩方向上移动。在一个方面，设备可以包括真空源，其可以帮助促进流体流入设备的开口中和/或可以帮助促进流体从开口流到储存室。在一个方面，设备致动器可以实现开口和真空源之间的流体连通，并且在启用流体连通之后可以启动流动活化器。

4. 发明申请

US20120275955A1 PLASMA OR SERUM PRODUCTION AND REMOVAL OF FLUIDS UNDER REDUCED PRESSURE 有权
标题翻译：等离子体或血清生产和减少压力下的流体
公开(公告)号：US20120275955A1
公开(公告)日：2012-11-01
申请号：US13456505
申请日：2012-04-26
申请人： Ramin Haghgooie , Donald E. Chickering, III , Shawn Davis , Mark Michelman , Howard Bernstein , Kristin Horton
发明人： Ramin Haghgooie , Donald E. Chickering, III , Shawn Davis , Mark Michelman , Howard Bernstein , Kristin Horton
IPC分类号： B01D71/68 , B01D71/10 , A61M1/34 , B01D63/00
CPC分类号： A61B5/150099 , A61B5/1411 , A61B5/1438 , A61B5/14514 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1455 , A61B5/1486 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150343 , A61B5/150358 , A61B5/150412 , A61B5/150419 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150984 , A61B5/151 , A61B5/15105 , A61B5/15142 , A61B5/154 , A61B10/0045 , A61B2562/0295 , A61M1/34 , A61M1/3486 , A61M1/3687 , A61M2202/0415 , A61M2205/3334 , B01L3/502753 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2400/049 , B01L2400/0655 , B01L2400/0688 , G01N33/18 , G01N33/1826
摘要： In some embodiments, the present invention generally relates to the separation of blood within a device to form plasma or serum. In some embodiments, the present invention generally relates to the removal of fluids, such as blood, contained within a device. For example, a device may be applied to the skin of a subject to receive blood from the subject and pass the blood through a separation membrane, which separates the blood into plasma and a portion concentrated in blood cells. As another example, blood or plasma may be allowed to clot within the device and serum (the unclotted portion of the blood) may be withdrawn from the device. The device may contain, in some cases, a vacuum source such as a pre-packaged vacuum to facilitate receiving of blood and/or passage of the blood through the separation membrane to produce plasma or serum.
摘要翻译：在一些实施方案中，本发明一般涉及在装置内分离血液以形成血浆或血清。在一些实施方案中，本发明一般涉及去除包含在装置内的流体，例如血液。例如，可以将装置施加到受试者的皮肤以从受试者接收血液，并将血液通过分离膜，该分离膜将血液分离成血浆，并将部分浓缩在血细胞中。作为另一个例子，血液或血浆可能被允许在装置内凝结，血清（未经切开的血液部分）可以从装置中取出。在一些情况下，该装置可以包含诸如预包装真空的真空源，以便于接收血液和/或使血液通过分离膜以产生血浆或血清。

5. 发明申请

US20120041338A1 CLINICAL AND/OR CONSUMER TECHNIQUES AND DEVICES 审中-公开
标题翻译：临床和/或消费者技术和设备
公开(公告)号：US20120041338A1
公开(公告)日：2012-02-16
申请号：US13208770
申请日：2011-08-12
申请人： Donald E. Chickering, III , Douglas A. Levinson , Shawn Davis , Ramin Haghgooie , Howard Bernstein , David R. Walt
发明人： Donald E. Chickering, III , Douglas A. Levinson , Shawn Davis , Ramin Haghgooie , Howard Bernstein , David R. Walt
IPC分类号： A61B5/15 , A61M5/00
CPC分类号： A61M37/0015 , A61B5/117 , A61B5/14514 , A61B5/150984 , A61B5/415 , A61B5/417 , A61B5/418 , A61B90/96 , A61B90/98 , A61B2560/0412 , A61M5/14248 , A61M37/00 , A61M2037/0023 , A61M2037/0061 , A61M2205/3576 , A61M2205/6009 , A61M2205/6072 , A61N1/30 , A61N1/325
摘要： The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from other tissues of the body. In some cases, the device may contain a substance transfer component such as needles or microneedles, which can be inserted into the skin or another organ to deliver and/or receiving fluid or other substances from the subject. In some embodiments, the device may include an activator constructed and arranged to insert one or more substance transfer components into the skin or other organ. In certain cases, the device may also include a storage chamber for receiving a fluid received from the subject.
摘要翻译：本发明一般涉及用于递送和/或接受来自受试者，例如来自皮肤和/或来自身体的其它组织的物质或物质例如血液的系统和方法。在一些情况下，该装置可以包含诸如针或微针的物质转移组件，其可以插入到皮肤或另一个器官中以从受试者输送和/或接收流体或其他物质。在一些实施方案中，该装置可以包括构造和布置成将一种或多种物质转移组分插入皮肤或其它器官中的活化剂。在某些情况下，该装置还可以包括用于接收从受试者接收的流体的储存室。

6. 发明申请

US20110125058A1 PATIENT-ENACTED SAMPLING TECHNIQUE 审中-公开
标题翻译：患者采集采样技术
公开(公告)号：US20110125058A1
公开(公告)日：2011-05-26
申请号：US12953744
申请日：2010-11-24
申请人： Douglas A. Levinson , Howard Bernstein , Donald E. Chickering, III , Shawn Davis , Ramin Haghgooie
发明人： Douglas A. Levinson , Howard Bernstein , Donald E. Chickering, III , Shawn Davis , Ramin Haghgooie
IPC分类号： A61B5/15 , G09B19/00
CPC分类号： A61B5/150984 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150305 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/74 , A61B10/0045 , A61B2010/008
摘要： The present invention is generally directed to systems and methods for sampling fluids from subjects. The fluid may be any suitable bodily fluid, e.g., blood or interstitial fluid. In some cases, the subject is a patient. The subject may have a device that can be applied to the skin of the subject (e.g., by the subject, or another person), and the device is able to obtain a sample of fluid. The fluid may be stored within a reservoir in the device, and the fluid may be obtained from the subject at any convenient time, e.g., at home, away from a healthcare setting, etc. In some embodiments, the device, or a portion thereof, may be returned to a clinical and/or laboratory setting to analyze the fluid stored within the device.
摘要翻译：本发明总体上涉及用于从主体取样流体的系统和方法。流体可以是任何合适的体液，例如血液或间质液。在某些情况下，受试者是患者。受试者可以具有可以应用于受试者的皮肤（例如受试者或其他人）的装置，并且该装置能够获得流体样本。流体可以存储在装置中的储存器中，并且可以在任何方便的时间（例如在家中，远离保健设置等）从受试者获得流体。在一些实施例中，装置或其一部分，可以返回到临床和/或实验室设置以分析存储在装置内的流体。

7. 发明申请

US20110105872A1 SYSTEMS AND METHODS FOR APPLICATION TO SKIN AND CONTROL OF ACTUATION, DELIVERY, AND/OR PERCEPTION THEREOF 审中-公开
标题翻译：适用于皮肤的系统和方法及其致动，输送和/或认知的控制
公开(公告)号：US20110105872A1
公开(公告)日：2011-05-05
申请号：US12915735
申请日：2010-10-29
申请人： Donald E. Chickering, III , Douglas A. Levinson , Shawn Davis , Ramin Haghgooie , Howard Bernstein , David R. Walt
发明人： Donald E. Chickering, III , Douglas A. Levinson , Shawn Davis , Ramin Haghgooie , Howard Bernstein , David R. Walt
IPC分类号： A61B5/157 , A61B5/15
CPC分类号： A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150106 , A61B5/150122 , A61B5/150129 , A61B5/150137 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150305 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150809 , A61B5/150824 , A61B5/150893 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15109 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685 , A61B2560/0412 , A61B2560/0443 , A61M5/425 , A61M35/00 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/588
摘要： The present invention generally relates, in certain aspects, to systems and methods for application to the skin, and control of actuation, delivery, and/or perception thereof. For example, certain aspects of the invention are generally directed to devices for delivering to and/or withdrawing fluid or from subjects, e.g., to or from the skin and/or beneath the skin. In one aspect, the delivery and/or withdrawal of fluid is at least partially obscured. For example, the obscuration may be by time, and/or by sensory obscuration (e.g., by providing tactile, olfactory, auditory, and/or visual sensations). Certain aspects of the invention are generally directed to devices able to automatically deliver to and/or withdraw fluid from the skin and/or beneath the skin after activation, e.g., where the fluid is delivered and/or withdrawn without the need for any additional intervention. The devices may be activated by any suitable technique. In other aspects, a device may be contained in a package, and when removed from the package, the device may be constructed and arranged to be able to deliver and/or withdraw fluid when the device is applied to the skin, and in some cases, automatically and/or without any further intervention by the subject or another person.
摘要翻译：本发明在某些方面一般涉及用于皮肤的系统和方法，以及对其致动，传递和/或感知的控制。例如，本发明的某些方面通常涉及用于递送到和/或从流体或从受试者递送到皮肤和/或从皮肤下方的装置。在一个方面，流体的递送和/或排出至少部分地模糊。例如，遮蔽可以是时间，和/或通过感觉遮蔽（例如，通过提供触觉，嗅觉，听觉和/或视觉感觉）。本发明的某些方面通常涉及能够在活化后自动递送至皮肤和/或皮下的流体的装置，例如在流体被输送和/或取出而不需要任何额外干预的情况下。可以通过任何合适的技术来激活装置。在其他方面，装置可以包含在包装中，并且当从包装中取出时，可以构造和布置该装置，以便当该装置应用于皮肤时能够输送和/或抽出流体，并且在某些情况下，自动地和/或没有受试者或另一个人的进一步干预。

8. 发明申请

US20110009847A1 SYSTEMS AND METHODS FOR CREATING AND USING SUCTION BLISTERS OR OTHER POOLED REGIONS OF FLUID WITHIN THE SKIN 审中-公开
标题翻译：用于在皮肤中创建和使用吸液泡沫或其他液体区域的系统和方法
公开(公告)号：US20110009847A1
公开(公告)日：2011-01-13
申请号：US12716233
申请日：2010-03-02
申请人： Douglas A. Levinson , Howard Bernstein , Richard Rox Anderson
发明人： Douglas A. Levinson , Howard Bernstein , Richard Rox Anderson
IPC分类号： A61M31/00
CPC分类号： A61B5/150099 , A61B5/0013 , A61B5/0022 , A61B5/0077 , A61B5/1438 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61B5/150022 , A61B5/150221 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/150969 , A61B5/150984 , A61B5/151 , A61B5/15125 , A61B5/157 , A61B5/411 , A61B5/4839 , A61B5/4845 , A61B5/486 , A61B5/685 , A61B5/6898 , A61B5/743
摘要： The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.
摘要翻译：本发明一般涉及与诊断，治疗和其它应用相关联的装置和技术，包括皮肤相关应用，例如用于递送和/或从主体（例如通过皮肤）排出流体的装置。在一些实施例中，所述装置包括用于在进入位置从所述受试者的皮肤和/或穿过所述受试者的皮肤接入可提取介质的系统，以及由支撑结构支撑的压力调节器，所述压力调节器能够至少在所述皮肤上形成压差访问站点的一部分。在一些情况下，该装置还可以包括由支撑结构支持的传感器，用于确定来自主体的可提取介质的至少一个状况，以及可选地由支撑结构支撑的信号发生器，用于产生与介质由传感器确定。

9. 发明申请

US20100249560A1 OXYGEN SENSOR 审中-公开
标题翻译：氧传感器
公开(公告)号：US20100249560A1
公开(公告)日：2010-09-30
申请号：US12716222
申请日：2010-03-02
申请人： Douglas A. Levinson , Howard Bernstein
发明人： Douglas A. Levinson , Howard Bernstein
IPC分类号： A61B5/145
CPC分类号： G01N33/84 , A61B5/021 , A61B5/14532 , A61B5/14542 , A61B5/411 , A61B2560/0412 , A61M5/14244 , G01N33/54366 , G01N33/72
摘要： The present invention generally relates to systems and methods for determining oxygen in a sample, or in a subject. In one aspect, the present invention is generally directed to an article exhibiting a determinable feature responsive to oxygen, such as oxygen-sensitive particles. The particles may exhibit a determinable change with a change in oxygen concentration, and such particles can accordingly be used to determine oxygen. For example, in one set of embodiments, the particles may be at least partially coated with a protein, such as hemoglobin, that is able to interact with oxygen. In some cases, the protein may aggregate under certain conditions (e.g., under relatively low oxygen concentrations), and such protein aggregation may be used, for example, to cause the particles to become aggregated, which can be determined in some way. In some cases, such aggregation may be irreversible; i.e., the degree of aggregation corresponds to the most extreme oxygen concentrations that the proteins were exposed to. Such articles may be used, for example, to determine oxygen within a sample, or within a subject, such as a human subject. For instance, the article may be formed as a skin patch, or administered to the skin of a subject, e.g., on the surface of the skin, within the dermis or epidermis, etc., to determine oxygen within the subject.
摘要翻译：本发明一般涉及用于测定样品或受试者中的氧的系统和方法。一方面，本发明一般涉及一种表现出对氧敏感的颗粒有氧的可确定特征的物品。颗粒可以随着氧浓度的变化而呈现可确定的变化，因此可以使用这样的颗粒来确定氧气。例如，在一组实施方案中，颗粒可以至少部分地涂覆有能够与氧相互作用的蛋白质，例如血红蛋白。在一些情况下，蛋白质可以在某些条件下（例如，在相对低的氧浓度下）聚集，并且可以使用这种蛋白质聚集，例如使颗粒变得聚集，这可以以某种方式确定。在某些情况下，这种聚合可能是不可逆的; 即聚集度对应于蛋白质暴露于最极端的氧浓度。例如，这样的制品可用于测定样品内或受试者（例如人类受试者）内的氧。例如，制品可以形成为皮肤贴片，或者施用于受试者的皮肤，例如皮肤表面，真皮或表皮等内，以确定受试者内的氧。

10. 发明申请

US20070148211A1 PROCESSES FOR MAKING PARTICLE-BASED PHARMACEUTICAL FORMULATIONS FOR ORAL ADMINISTRATION 审中-公开
标题翻译：制造基于粒子的药物制剂进行口腔管理的方法
公开(公告)号：US20070148211A1
公开(公告)日：2007-06-28
申请号：US11610802
申请日：2006-12-14
申请人： David Altreuter , Howard Bernstein , Luis Brito , Shaina Brito , Donald Chickering , Eric Huang , Rajeev Jain , Sridhar Narasimhan , Julie Straub
发明人： David Altreuter , Howard Bernstein , Luis Brito , Shaina Brito , Donald Chickering , Eric Huang , Rajeev Jain , Sridhar Narasimhan , Julie Straub
IPC分类号： A61K9/28 , A61K9/48 , A61K9/20 , A61K9/14
CPC分类号： A61K9/145 , A61K9/0056 , A61K9/0095 , A61K9/2072 , A61K9/2077 , A61K9/2095
摘要： A method is provided for making an oral dosage form of a pharmaceutical agent which includes the steps of (a) providing particles which include a pharmaceutical agent; (b) blending the particles with particles of a pre-processed excipient to form a primary blend, wherein the pre-processed excipient is prepared by (i) dissolving a bulking agent (e.g., a sugar) and at least one non-friable excipient (e.g., a waxy or liquid surfactant) in a solvent to form an excipient solution, and (ii) removing the solvent from the excipient solution to form the pre-processed excipient in dry powder form; (c) milling the primary blend to form a milled pharmaceutical formulation blend that includes microparticles or nanoparticles of the pharmaceutical agent; and (d) processing the milled pharmaceutical formulation blend into a solid oral dosage form or liquid suspension for oral administration. The process yields formulations having improved wettability or dispersibility.
摘要翻译：提供了制备药剂口服剂型的方法，其包括以下步骤：（a）提供包含药剂的颗粒; （b）将颗粒与预处理的赋形剂的颗粒混合以形成初级共混物，其中预处理的赋形剂通过以下步骤制备：（i）将填充剂（例如糖）和至少一种不易碎的赋形剂（例如，蜡状或液体表面活性剂）在溶剂中形成赋形剂溶液，和（ii）从赋形剂溶液中除去溶剂以形成干粉末形式的预处理赋形剂; （c）研磨初级共混物以形成包含药剂的微粒或纳米颗粒的研磨的药物配制物混合物; 和（d）将经研磨的药物制剂混合物加工成固体口服剂型或用于口服给药的液体悬浮液。该方法产生具有改善的润湿性或分散性的制剂。

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