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1. 发明授权

US06752765B1 Method and apparatus for monitoring heart rate and abnormal respiration 有权
标题翻译：用于监测心率和异常呼吸的方法和装置
公开(公告)号：US06752765B1
公开(公告)日：2004-06-22
申请号：US09715637
申请日：2000-11-17
申请人： Donald N. Jensen , Linda L. Ruetz , Catherine R. Condie , Yong Kyun Cho , Ulla Strobel , Scott Davie
发明人： Donald N. Jensen , Linda L. Ruetz , Catherine R. Condie , Yong Kyun Cho , Ulla Strobel , Scott Davie
IPC分类号： A61N1365
CPC分类号： A61N1/36521
摘要： An implantable device having enhanced capabilities for monitoring a patient's heart rate and respiration trends over extended periods of time is disclosed. The information collected by the implantable device may be stored and telemetered to an associated external device such as a device programmer for display and analysis. Heart rates are measured by measuring the time intervals between sensed depolarizations of a chamber of the patient's heart and preceding sensed depolarizations or delivered pacing pulses. Intervals may be measured in the ventricle and/or atrium of the patient's heart. According to another aspect of the invention, an implanted impedance sensor is employed to monitor minute ventilation. The heart rate and minute ventilation data is used to develop long-term trend data used for diagnostic purposes. In one embodiment of the invention, heart interval and minute ventilation measurements are taken only during defined time periods of the night and/or day when the patient is at rest. A sensor such as an activity sensor or metabolic rate sensor may be used to confirm patient inactivity.
摘要翻译：公开了一种具有增强的用于监测患者的心率和延长的时间段的呼吸趋势的能力的可植入装置。由可植入装置收集的信息可以存储和遥测到相关联的外部设备，例如用于显示和分析的设备编程器。通过测量感觉到的患者心脏的室的去极化和之前感测到的去极化或发出的起搏脉冲之间的时间间隔来测量心率。间隔可以在患者心脏的心室和/或心房中测量。根据本发明的另一方面，采用植入式阻抗传感器来监测分钟通气。心率和分钟通气数据用于开发用于诊断目的的长期趋势数据。在本发明的一个实施例中，心脏间隔和分钟通气测量仅在患者休息的夜晚和/或天的限定时间段期间进行。可以使用诸如活性传感器或代谢率传感器的传感器来确认患者不活动。

2. 发明授权

US08187200B2 Method and apparatus to detect and monitor the frequency of obstructive sleep apnea 有权
标题翻译：检测和监测阻塞性睡眠呼吸暂停频率的方法和装置
公开(公告)号：US08187200B2
公开(公告)日：2012-05-29
申请号：US12369899
申请日：2009-02-12
申请人： Donald N. Jensen , Catherine R. Condie , Yong Kyun Cho
发明人： Donald N. Jensen , Catherine R. Condie , Yong Kyun Cho
IPC分类号： A61B5/085
CPC分类号： A61B5/0538 , A61B5/04 , A61B5/0809 , A61B5/1118 , A61B5/4818
摘要： The present invention provides a method and apparatus for detecting and monitoring obstructive sleep apnea. The apparatus includes an intracardiac impedance sensor to measure intracardiac impedance, a movement sensor to measure an amount of movement of a patient, and a controller operatively coupled to said intracardiac impedance sensor and said movement sensor, said controller adapted to receive at least one of an intracardiac impedance and the amount of movement of the patient and detect obstructive sleep apnea based upon said intracardiac impedance and said movement.
摘要翻译：本发明提供一种用于检测和监测阻塞性睡眠呼吸暂停的方法和装置。该装置包括用于测量心内阻抗的心内阻抗传感器，用于测量患者的移动量的运动传感器以及可操作地耦合到所述心内阻抗传感器和所述运动传感器的控制器，所述控制器适于接收至少一个心内阻抗和患者的运动量，并且基于所述心内阻塞和所述移动来检测阻塞性睡眠呼吸暂停。

3. 发明授权

US07123965B2 Method and apparatus for injection of external data within an implantable medical device 有权
公开(公告)号：US07123965B2
公开(公告)日：2006-10-17
申请号：US10137171
申请日：2002-04-30
申请人： Catherine R. Condie , Gerald A. Portzline , Yong Kyun Cho , John S. Brandstetter , Luc R. Mongeon , Lucy M. Nichols , Steve R Hornberger
发明人： Catherine R. Condie , Gerald A. Portzline , Yong Kyun Cho , John S. Brandstetter , Luc R. Mongeon , Lucy M. Nichols , Steve R Hornberger
IPC分类号： A61N1/365
CPC分类号： A61N1/37252 , A61N1/36514 , A61N1/37264 , G06F19/00
摘要： A method and an apparatus for performing implementing external data into an implantable medical device. A first stress test is performed using an external sensor. External data resulting from the initial stress test is acquired. An external data injection process is performed. The external data injection process includes providing the external data to the implantable medical device. A second stress test is performed, the second stress test being substantially similar to the first stress test. Internal data resulting from the second stress test is acquired. Internal data resulting from the second stress test along with the external data resulting from the first stress test, are processed.

4. 发明授权

US06885891B2 Automatic rate response sensor mode switch 有权
标题翻译：自动速率响应传感器模式开关
公开(公告)号：US06885891B2
公开(公告)日：2005-04-26
申请号：US10040120
申请日：2001-12-31
申请人： Yong Kyun Cho , Catherine R. Condie
发明人： Yong Kyun Cho , Catherine R. Condie
IPC分类号： A61B5/00 , A61N1/365
CPC分类号： A61N1/36585
摘要： An automatic rate response sensor mode switch is implemented in an implantable medical device to monitor and isolate any sensor in an integrated sensor scheme. The isolated sensor is based on identification of problems associated with the sensor. The implantable medical device will switch to operate with the remainder sensor(s). Specifically, an algorithm tests and determines sensor status to initiate and operate the sensor mode switch. The software continuously monitors, isolates or qualifies a sensor to come back on-line automatically.
摘要翻译：在可植入医疗设备中实现自动速率响应传感器模式开关，以监测和隔离集成传感器方案中的任何传感器。隔离传感器基于与传感器相关的问题的识别。可植入医疗设备将切换到与其余传感器一起操作。具体来说，算法测试并确定传感器状态以启动和操作传感器模式开关。该软件可以连续监测，隔离或限定传感器自动返回在线。

5. 发明授权

US07031772B2 Method and apparatus for rate responsive adjustments in an implantable medical device 有权
公开(公告)号：US07031772B2
公开(公告)日：2006-04-18
申请号：US10134560
申请日：2002-04-29
申请人： Catherine R. Condie , John D. Wahlstrand , Gerald A. Portzline , Yong Kyun Cho , John S. Brandstetter , Luc R. Mongeon
发明人： Catherine R. Condie , John D. Wahlstrand , Gerald A. Portzline , Yong Kyun Cho , John S. Brandstetter , Luc R. Mongeon
IPC分类号： A61N1/365
CPC分类号： A61N1/36542 , A61N1/36521 , G06F19/00 , G06F19/3456 , G16H40/63
摘要： A method and an apparatus for performing rate responsive control in an implantable medical device using a scaling factor. Sensor data is acquired using a sensor operatively coupled with the implantable medical device. At least one setpoint for controlling a rate of therapy is generated, the setpoint being based upon the sensor data. A scaling factor adjustment process is performed for scaling the internal sensor data to correlate the sensor data to the setpoint. The rate of therapy is adjusted based upon the scaling factor adjustment.

6. 发明授权

US07206635B2 Method and apparatus for modifying delivery of a therapy in response to onset of sleep 有权
标题翻译：响应睡眠发作改变治疗递送的方法和装置
公开(公告)号：US07206635B2
公开(公告)日：2007-04-17
申请号：US10736370
申请日：2003-12-15
申请人： Yong Kyun Cho , Donald N. Jensen , Luc R. Mongeon
发明人： Yong Kyun Cho , Donald N. Jensen , Luc R. Mongeon
IPC分类号： A61F1/365
CPC分类号： A61N1/36521 , A61N1/36542 , A61N1/3702
摘要： A method and apparatus for providing a therapy to the patient that includes a therapy component configured to provide the therapy to the patient, sensing circuitry sensing a parameter of the patient, and a microprocessor coupled to the therapy component and the sensing circuitry to determine onset of a first state of the patient in response to the sensed physiologic parameter, and to determine whether the onset of the first state is detected for a predetermined time period.
摘要翻译：一种用于向患者提供治疗的方法和装置，包括治疗组件，其被配置为向患者提供治疗，感测电路感测患者的参数，以及耦合到治疗组件和感测电路的微处理器，以确定响应于感测到的生理参数的患者的第一状态，并且确定在预定时间段内是否检测到第一状态的开始。

7. 发明授权

US06731984B2 Method for providing a therapy to a patient involving modifying the therapy after detecting an onset of sleep in the patient, and implantable medical device embodying same 有权
标题翻译：用于在检测到患者的睡眠发作之后对涉及修改治疗的患者提供治疗的方法以及体内相同的可植入医疗装置
公开(公告)号：US06731984B2
公开(公告)日：2004-05-04
申请号：US09876528
申请日：2001-06-07
申请人： Yong Kyun Cho , Donald N. Jensen , Luc R. Mongeon
发明人： Yong Kyun Cho , Donald N. Jensen , Luc R. Mongeon
IPC分类号： A61N1365
CPC分类号： A61N1/36521 , A61N1/36542
摘要： An implantable medical device system is described including an implantable medical device for implantation in a patient. One embodiment of the implantable medical device includes a therapy component for providing a therapy to the patient, a minute ventilation (MV) sensing circuit producing MV values indicative of a MV of the patient at time intervals, and computational circuitry. The computational circuitry receives a number of the MV values over a period of time, calculates a statistical parameter (e.g., a mean) of the MV values, and calculates a deviation of the MV values from the statistical parameter (e.g., a standard deviation of the MV values). The computational circuitry detects an onset of sleep in the patient when the deviation of the MV values from the statistical parameter is less than a predetermined MV threshold value, and signals the therapy component to modify the therapy when the onset of sleep is detected in the patient. A method is disclosed for providing therapy to a patient, including detecting an onset of sleep in the patient, and modifying the therapy following the detecting the onset of sleep in the patient.
摘要翻译：描述了一种植入式医疗装置系统，其包括用于植入患者体内的可植入医疗装置。可植入医疗装置的一个实施例包括用于向患者提供治疗的治疗部件，以及以计算电路产生指示患者的MV的MV值的分钟通气（MV）感测电路。计算电路在一段时间内接收多个MV值，计算MV值的统计参数（例如，平均值），并计算MV值与统计参数的偏差（例如，标准偏差 MV值）。当MV值与统计参数的偏差小于预定的MV阈值时，计算电路检测患者的睡眠开始，并且当在患者中检测到睡眠发作时发出信号，以修改治疗组件。公开了一种用于向患者提供治疗的方法，包括检测患者的睡眠发作，以及在检测到患者的睡眠发作之后修改治疗。

8. 发明授权

US08332045B2 System and method for cardiac lead switching 有权
标题翻译：心脏导联切换的系统和方法
公开(公告)号：US08332045B2
公开(公告)日：2012-12-11
申请号：US12363327
申请日：2009-01-30
申请人： John Louis Sommer , Michael William Kimmel , Yong Kyun Cho
发明人： John Louis Sommer , Michael William Kimmel , Yong Kyun Cho
IPC分类号： A61N1/00
CPC分类号： A61N1/37 , A61N1/056 , A61N1/086 , A61N1/3718
摘要： An implantable medical device (IMD) can include an implantable pulse generator (IPG), such as a cardiac pacemaker or an implantable cardioverter-defibrillator (ICD). Various portions of the IMD, such as a device body, a lead body, or a lead tip, can be provided to reduce or dissipate a current and heat induced by various external environmental factors. According to various embodiments, features can be incorporated into the lead body, the lead tip, or the IMD body to reduce the creation of an induced current, or dissipate the induced current and heat created due to an induced current in the lead.
摘要翻译：可植入医疗装置（IMD）可以包括可植入脉冲发生器（IPG），例如心脏起搏器或植入式心律转复除颤器（ICD）。可以提供IMD的各个部分，例如装置主体，引线主体或引线头，以减少或消散由各种外部环境因素引起的电流和热量。根据各种实施例，可以将特征结合到引线体，引线尖端或IMD体中，以减少感应电流的产生，或者消散由于引线中的感应电流而产生的感应电流和热量。

9. 发明申请

US20120108984A1 INTEGRATED PATIENT CARE 有权
标题翻译：一体化患者护理
公开(公告)号：US20120108984A1
公开(公告)日：2012-05-03
申请号：US12915992
申请日：2010-10-29
申请人： Tommy D. Bennett , Yong Kyun Cho , Randolph M. Biallas
发明人： Tommy D. Bennett , Yong Kyun Cho , Randolph M. Biallas
IPC分类号： G06Q50/00 , A61B5/021
CPC分类号： G06F19/3481 , A61B5/0022 , A61B5/021 , A61B5/0215 , A61B5/0537 , A61B5/11 , A61B5/4836 , A61B5/4878 , A61B5/743 , A61B5/7435 , A61N1/37247 , G06F19/00 , G06F19/3456 , G06Q50/22 , G16H40/63 , G16H50/20
摘要： A therapy regimen, e.g., a contingent medication prescription, may be created and automatically distributed to a patient via an integrated patient care system. A clinician may create therapy instructions by at least associating patient conditions with one or more therapy regimens, e.g., medication prescriptions. In some examples, the integrated patient care system may present historical condition data to the clinician to aid the clinician with creating and/or updating the therapy instructions specific to the patient. A therapy module of the integrated patient care system may use the therapy instructions to automatically select a therapy regimen from the therapy instructions based on a patient condition detected based on a sensed physiological parameter. The physiological parameter of the patient may be sensed by an implanted or external sensor. In some examples, the therapy regimen can be presented to the patient according to a predetermined schedule or in response to the detected condition.
摘要翻译：可以创建治疗方案，例如或有药物处方，并通过综合的患者护理系统自动分配给患者。临床医生可以通过至少将患者状况与一种或多种治疗方案（例如药物处方）相关联来产生治疗指导。在一些示例中，综合的患者护理系统可向临床医生呈现历史状态数据，以帮助临床医生创建和/或更新患者特有的治疗指导。综合患者护理系统的治疗模块可以使用治疗指令根据基于检测到的生理参数检测到的患者状况从治疗指令中自动选择治疗方案。患者的生理参数可以通过植入或外部传感器来感测。在一些实例中，治疗方案可以根据预定的时间表或响应于检测到的病症呈现给患者。

10. 发明授权

US06964641B2 Implantable medical device with sleep disordered breathing monitoring 有权
公开(公告)号：US06964641B2
公开(公告)日：2005-11-15
申请号：US10746814
申请日：2003-12-24
申请人： Yong Kyun Cho , Eduardo N. Warman , Todd J. Sheldon
发明人： Yong Kyun Cho , Eduardo N. Warman , Todd J. Sheldon
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/0215 , A61B5/022 , A61B5/0245 , A61B5/0456 , A61B5/0464 , A61B5/0476 , A61B5/08 , A61B5/083 , A61B5/087 , A61B5/11 , A61B5/113 , A61B7/00 , A61N1/36 , A61N1/365
CPC分类号： A61N1/3601 , A61B5/0031 , A61B5/01 , A61B5/0205 , A61B5/0215 , A61B5/022 , A61B5/0245 , A61B5/0456 , A61B5/0464 , A61B5/0476 , A61B5/0809 , A61B5/0816 , A61B5/0833 , A61B5/0836 , A61B5/087 , A61B5/0878 , A61B5/1116 , A61B5/1118 , A61B5/1135 , A61B5/4818 , A61B7/003 , A61N1/36521 , A61N1/36557
摘要： An implantable medical device (IMD) includes a sensor for monitoring parameters indicative of sleep disordered breathing. The IMD also includes a position sensor that indicates the relative position and/or activity level of the patient. The position sensor data is used in one or more ways in conjunction with the SDB sensing. The position data is used to confirm that such sensed data is likely indicative of SDB or to select the appropriate criteria for comparison.

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