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1. 发明授权

US5177221A Chromogenic hemispherands and their preparation 失效
标题翻译：显色半球及其制备
公开(公告)号：US5177221A
公开(公告)日：1993-01-05
申请号：US564203
申请日：1990-08-08
申请人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
发明人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
IPC分类号： C07D323/00 , C07D493/08 , C07D498/08 , G01N27/333
CPC分类号： C07D493/08 , C07D323/00 , G01N27/3335
摘要： The present invention resides in the discovery of a new class of compounds defined herein as "chromogenic hemispherands" useful for the measurement of ions, in particular, ions in aqueous solution, which have the structure ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R', same or different, is lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R", same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;Q is a chromogenic moiety capable of providing the appearance of or change in color, or which is otherwise capable of providing a detectable response in the presence of a particular cation;m is 1 to about 3;n is 0 to about 3;A is an aliphatic or aromatic subunit, e.g., ##STR2##
摘要翻译：本发明在于发现本文中定义的可用于测量离子，特别是水溶液中的离子的“显色半球”，其具有以下结构：其中：R相同或不同，是氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; R'相同或不同，为低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; R“相同或不同，为氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; Q是能够提供颜色出现或变化的发色部分，或者否则能够在特定阳离子存在下提供可检测的响应; m为1〜3; n为0至约3; A是脂肪族或芳香族亚基，例如

2. 发明授权

US5011924A Chromogenic cryptahemispherands and their preparation 失效
标题翻译：显色隐窝和它们的制备
公开(公告)号：US5011924A
公开(公告)日：1991-04-30
申请号：US349465
申请日：1989-05-09
申请人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
发明人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
IPC分类号： C07D498/08 , G01N33/84
CPC分类号： C07D498/08 , G01N33/84
摘要： The present invention resides in the discovery of a new class of compounds defined herein as "chromogenic cryptahemispherands" useful for the measurement of ions, in particular, ions in aqueous solution, which have the structure ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R', same or different, is lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R", same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;Q is a chromogenic moiety capable of providing the appearance of or change in color, or which is otherwise capable of providing a detectable response in the presence of a particular cation;a, b, m and n, same or different, are 1 to about 3; and x, y, same or different, are 1 to about 4.A test device utilizing one or more of the compounds for performing such measurements is also disclosed.
摘要翻译：本发明在于在本文定义的一类新的化合物的发现，其可用于测量离子，特别是水溶液中的离子，其具有以下结构：其中：R相同或不同，是氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; R'相同或不同，为低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; R“相同或不同，为氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; Q是能够提供颜色出现或变化的发色部分，或者否则能够在特定阳离子存在下提供可检测的响应; a，b，m和n相同或不同，为1〜3; x，y相同或不同，为1至约4.还公开了利用一种或多种化合物进行这种测量的测试装置。

3. 发明授权

US4992381A Method of detecting electrolytes in an aqueous test sample using chromogenic hemispherands and test device therefor 失效
标题翻译：使用显色半球及其测试装置检测含水测试样品中的电解质的方法
公开(公告)号：US4992381A
公开(公告)日：1991-02-12
申请号：US38679
申请日：1987-04-15
申请人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
发明人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
IPC分类号： C07D323/00 , C07D493/08 , C07D498/08 , C09B57/00 , G01N27/333 , G01N31/00 , G01N31/22
CPC分类号： C07D493/08 , C07D323/00 , G01N27/3335
摘要： The present invention resides in the discovery of a new class of compounds defined herein as "chromogenic hemispherands" useful for the measurement of ions, in particular, ions in aqueous solution, methods of using the chromogenic hemispherands and test devices containing the chromogenic hemispherands. The chromogenic hemispherands of the invention have the structure ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R', same or different, is lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R", same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;Q is a chromogenic moiety capable of providing the appearance of or change in color, or which is otherwise capable of providing a detectable response in the presence of a particular cation;m is 1 to about 3;n is 0 to about 3;P is an aliphatic or aromatic subunit, e.g., --CR.sub.2 CR.sub.2 OCR.sub.2 CR.sub.2 --, ##STR2##

4. 发明授权

US4859606A Method for detecting cations in a test sample utilizing chromogenic cryptahemispherands 失效
标题翻译：使用显色隐孢子虫检测试样中阳离子的方法
公开(公告)号：US4859606A
公开(公告)日：1989-08-22
申请号：US38681
申请日：1987-04-15
申请人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
发明人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
IPC分类号： G01N27/333 , C07D498/08 , C09B57/00 , G01N27/416 , G01N31/00 , G01N31/22 , G01N33/84
CPC分类号： C07D498/08 , G01N33/84
摘要： The present invention resides in the discovery of a class of compounds defined herein as "chromogenic cryptahemispherands" useful for the measurement of ions, in particular, ions in aqueous solution, which have the structure ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R', same or different, is lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R", same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;Q is a chromogenic moiety capable of providing the appearance of or change in color, or which is otherwise capable of providing a detectable response in the presence of a particular cation;a, b, m and n, same or different, are 1 to about 3; and x, y, same or different, are 1 to about 4.A test device utilizing one or more of the compounds for performing such measurements is also disclosed.

5. 发明授权

US5145787A Method for determining the concentration of cations in a sample 失效
标题翻译：确定样品中阳离子浓度的方法
公开(公告)号：US5145787A
公开(公告)日：1992-09-08
申请号：US803134
申请日：1991-12-05
申请人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
发明人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
IPC分类号： C07D498/08 , C07D498/18 , G01N33/52 , G01N33/84
CPC分类号： C07D498/08 , C07D498/18 , G01N33/521 , G01N33/84
摘要： The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic crypt and compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;m and n, either same or different, are equal to 0 to about 4;a and e, either same or different, are equal to 0 to about 2;b and d, either same or different, are equal to 0 to about 5;R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and--Q-- is ##STR2## wherein X is CH, N, or COH; and Y includes ##STR3## except that when Q is ##STR4## wherein Y is p-nitrophenylazo, 3-phenylisothiazolyl-5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino or bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 to 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2.
摘要翻译：本发明是用于确定样品中存在的阳离子量的试剂和方法，试剂包括一个或多个显色隐窝和式I（I）的化合物，其中相同或不同的k和j等于1 至约5; m和n相同或不同，等于0至约4; a和e相同或不同，等于0至约2; b和d相同或不同，等于0至约5; R，相同或不同，为氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; 和-Q-是，其中X是CH，N或COH; 并且Y包括，不同之处在于Q是，其中Y是对硝基苯基偶氮，3-苯基异噻唑-5-偶氮，异噻唑-5-偶氮，噻唑基-5 （2,4,6-三硝基苯基偶氮），对硝基苯乙烯基，对苯醌二亚氨基亚氨基或双 - （对二甲基氨基苯基）羟甲基，则不能存在以下条件：同时b等于0至1，d等于 0或1，j等于1，n等于1或2，a等于1，e等于1，k等于1，m等于2。

6. 发明授权

US5045475A Reagent for determining cations 失效
标题翻译：用于确定阳离子的试剂
公开(公告)号：US5045475A
公开(公告)日：1991-09-03
申请号：US201576
申请日：1988-06-01
申请人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
发明人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
IPC分类号： C07D498/08 , C07D498/18 , G01N33/52 , G01N33/84
CPC分类号： C07D498/08 , C07D498/18 , G01N33/521 , G01N33/84
摘要： The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;m and n, either same or different, are equal to 0 to about 4;a and e, either same or different, are equal to 0 to about 2;b and d, either same or different, are equal to 0 to about 5;R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and--Q-- is ##STR2## wherein X and CH, N, or COH; and Y includes ##STR3## except that when Q is ##STR4## wherein Y is p-nitrophenylazo, 3-phenylisothiazolyl-5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino or bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 or 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2.
摘要翻译：本发明是用于测定样品中存在的阳离子量的试剂和方法，该试剂包括一种或多种式I（I）的显色隐窝化合物，其中相同或不同的k和j相同或不同，约5; m和n相同或不同，等于0至约4; a和e相同或不同，等于0至约2; b和d相同或不同，等于0至约5; R，相同或不同，为氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; 和-Q-是，其中X和CH，N或COH; 并且Y包括，不同之处在于Q是，其中Y是对硝基苯基偶氮，3-苯基异噻唑-5-偶氮，异噻唑-5-偶氮，噻唑基-5 （2,4,6-三硝基苯基偶氮），对硝基苯乙烯基，对苯醌二亚氨基亚氨基或双 - （对二甲基氨基苯基）羟甲基，则不能存在以下条件：同时b等于0或1，d等于 0或1，j等于1，n等于1或2，a等于1，e等于1，k等于1，m等于2。

7. 发明授权

US5073501A Method for determining the concentration of cations in a sample 失效
标题翻译：确定样品中阳离子浓度的方法
公开(公告)号：US5073501A
公开(公告)日：1991-12-17
申请号：US304356
申请日：1989-01-30
申请人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
发明人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
IPC分类号： C07D498/08 , C07D498/18 , G01N33/52 , G01N33/84
CPC分类号： C07D498/08 , C07D498/18 , G01N33/521 , G01N33/84
摘要： The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;m and n, either same or different, are equal to 0 to about 4;a and e, either same or different, are equal to 0 to about 2;b and d, either same or different, are equal to 0 to about 5;R, either same or different, is hydrogen.lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and-Q- is ##STR2## wherein X is CH, N, or COH; and Y includes ##STR3## except that when Q is ##STR4## wherein Y is p-nitrophenylazo, 3-phenylisothiazolyl-5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino or bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 or 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2.
摘要翻译：本发明是用于测定样品中存在的阳离子量的试剂和方法，该试剂包括一种或多种式I（I）的显色隐窝化合物，其中相同或不同的k和j相同或不同，约5; m和n相同或不同，等于0至约4; a和e相同或不同，等于0至约2; b和d相同或不同，等于0至约5; R相同或不同，是氢。低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; 和-Q-是，其中X是CH，N或COH; 并且Y包括，不同之处在于Q是，其中Y是对硝基苯基偶氮，3-苯基异噻唑-5-偶氮，异噻唑-5-偶氮，噻唑基-5 （2,4,6-三硝基苯基偶氮），对硝基苯乙烯基，对苯醌二亚氨基亚氨基或双 - （对二甲基氨基苯基）羟甲基，则不能存在以下条件：同时b等于0或1，d等于 0或1，j等于1，n等于1或2，a等于1，e等于1，k等于1，m等于2。

8. 发明授权

US4994395A Chromogenic cryptand reagents and methods for determining cation concentrations in test samples containing interfering cations 失效
标题翻译：显色穴位试剂和测定含有干扰阳离子的试样中的阳离子浓度的方法
公开(公告)号：US4994395A
公开(公告)日：1991-02-19
申请号：US038741
申请日：1987-04-15
申请人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
发明人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
IPC分类号： G01N31/00 , C07D498/08 , C07D498/18 , G01N33/52 , G01N33/84
CPC分类号： C07D498/08 , G01N33/525 , G01N33/84 , Y10S436/805
摘要： The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent comprising(a) one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;m and n, either same or different, are equal to 0 to about 4;a and e, either same or different, are equal to 0 to about 2;b and d, either same or different, are equal to 0 to about 5;R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and--Q-- is ##STR2## wherein X is CH, N, or COH; andY includes ##STR3## and (b) one or more interfering cation complexing compound masks.

9. 发明授权

US4808539A Compounds, reagents and procedures for determining cations 失效
标题翻译：用于确定阳离子的化合物，试剂和程序
公开(公告)号：US4808539A
公开(公告)日：1989-02-28
申请号：US38843
申请日：1987-04-15
申请人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
发明人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
IPC分类号： G01N31/00 , C07D498/08 , C07D498/18 , G01N33/52 , G01N33/84 , G01N33/20
CPC分类号： C07D498/08 , C07D498/18 , G01N33/521 , G01N33/84
摘要： The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent comprising one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;m and n, either same or different, are equal to 0 to about 4;a and e, either same or different, are equal to 0 to about 2;b and d, either same or different, are equal to 0 to about 5;R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and-Q- is ##STR2## wherein X is CH, N, or COH; andY includes ##STR3## except that when Q is ##STR4## wherein Y is selected from the group consisting of p-nitrophenylazo, 3-phenylisothiazalyl -5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino and bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 or 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2.

10. 发明授权

US5096831A Reagents for determining cations 失效
标题翻译：用于确定阳离子的试剂
公开(公告)号：US5096831A
公开(公告)日：1992-03-17
申请号：US699188
申请日：1991-05-13
申请人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
发明人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
IPC分类号： C07D498/08 , C07D498/18 , G01N33/52 , G01N33/84
CPC分类号： C07D498/08 , C07D498/18 , G01N33/521 , G01N33/84
摘要： The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;m and n, either same or different, are equal to 0 to about 4;a and e, either same or different, are equal to 0 to about 2;b and d, either same or different, are equal to 0 to about 5;R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and ##STR2## wherein X is CH, N or COH; andY includes ##STR3## except that when Q is ##STR4## wherein Y is p-nitrophenylazo, 3-phenylisothiazolyl-5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino or bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 or 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2.
摘要翻译：本发明是用于测定样品中存在的阳离子量的试剂和方法，该试剂包括一种或多种式I（I）的显色隐窝化合物，其中相同或不同的k和j相同或不同，约5; m和n相同或不同，等于0至约4; a和e相同或不同，等于0至约2; b和d相同或不同，等于0至约5; R，相同或不同，为氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; 和，其中X是CH，N或COH; 并且Y包括，不同之处在于Q是，其中Y是对硝基苯基偶氮，3-苯基异噻唑-5-偶氮，异噻唑-5-偶氮，噻唑基-5 （2,4,6-三硝基苯基偶氮），对硝基苯乙烯基，对苯醌二亚氨基亚氨基或双 - （对二甲基氨基苯基）羟甲基，则不能存在以下条件：同时b等于0或1，d等于 0或1，j等于1，n等于1或2，a等于1，e等于1，k等于1，m等于2。

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