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1. 发明授权

US06635720B1 Core-shell tectodendrimers 失效
标题翻译：核壳结构树枝状聚合物
公开(公告)号：US06635720B1
公开(公告)日：2003-10-21
申请号：US09913050
申请日：2002-01-24
申请人： Donald A. Tomalia , Srinivas Uppuluri , Douglas R. Swanson , Herbert M. Brothers, II
发明人： Donald A. Tomalia , Srinivas Uppuluri , Douglas R. Swanson , Herbert M. Brothers, II
IPC分类号： C08L7700
CPC分类号： C08G83/003 , C08G69/02 , C08G69/04 , C08G69/48 , Y10S424/16 , Y10S977/754 , Y10S977/788 , Y10S977/835
摘要： Core-shell tecto(dendrimers) useful in biomedicine, pharmaceuticals, personal care products, and in other ways analogous to the known uses for dendrimers, hypercomb branched polymers, and other dendritic polymers are the reaction product of a core dendritic polymer molecule having a plurality of terminal functional groups of a first type which are not reactive with each other, and a plurality of shell dendritic polymer molecules having a plurality of terminal functional groups of a second type which are not reactive with each other, but which are reactive with the terminal functional groups of the first type. Each of the shell dendritic polymer molecules is chemically bonded to the core dendritic polymer molecule by a reaction of at least one of the terminal functional groups of the second type with at least one of the terminal functional groups of the first type.
摘要翻译：可用于生物医学，药物，个人护理产品的核壳结构（树枝状大分子），以及类似于已知用于树枝状大分子，超支化支化聚合物和其它树枝状聚合物的其它方式是具有多个核心树枝状聚合物分子的反应产物不具有反应性的第一种类型的末端官能团，以及具有多个彼此不反应但与末端反应的第二类型的末端官能团的多个壳状树枝状聚合物分子第一类功能组。每个壳树枝状聚合物分子通过第二类型的至少一个末端官能团与至少一个第一类型的末端官能团的反应与核心树枝状聚合物分子化学键合。

2. 发明授权

US6020457A Disulfide-containing dendritic polymers 失效
标题翻译：含二硫化物的树枝状聚合物
公开(公告)号：US6020457A
公开(公告)日：2000-02-01
申请号：US941527
申请日：1997-09-30
申请人： June W. Klimash , Herbert M. Brothers, II , Douglas R. Swanson , Rui Yin , Ralph Spindler , Donald A. Tomalia , Yong Hsu , Roberta C. Cheng
发明人： June W. Klimash , Herbert M. Brothers, II , Douglas R. Swanson , Rui Yin , Ralph Spindler , Donald A. Tomalia , Yong Hsu , Roberta C. Cheng
IPC分类号： C08G83/00 , C08G69/00 , C08G73/00
CPC分类号： C08G83/003 , B82Y30/00 , B82Y40/00 , Y10S424/16
摘要： Dendritic polymers containing disulfide functional groups which are essentially inert under non-reducing conditions, but which form sulfhydryl groups upon being subjected to a reducing agent are prepared by synthesizing dendritic polymers having a core with a disulfide linkage or by reacting a dendritic polymer with a molecule containing a disulfide linkage and reactive terminal groups. In one aspect of the invention, dendritic polymers having a single disulfide functional group at the core are provided. The single disulfide group at the core can be reduced to form two sulfhydryl groups to which other molecules, such as proteins, oligonucleotides, peptides, hormones, other dendritic polymers, non-dendritic polymers, etc., can be bound. Applications for the disulfide functionalized dendritic polymers include formation of differentiated dendrimers, formation of binding reagents for diagnostics, drug delivery, gene therapy and magnetic resins imaging, and in the preparation of self-assembled dendrimer monolayers on a quartz crystal resonators to provide dendrimer-modified electrodes which are useful for detecting various ions or molecules. In another aspect of the invention, dendritic polymers having sulfhydryl terminals are provided. The sulfhydryl terminated dendritic polymers can be used to prepare stable, curable resins composition which can undergo cross linking when subjected to a reducing agent.
摘要翻译：通过合成具有核心与二硫键的树枝状聚合物或通过使树枝状聚合物与分子反应而制备的含二硫键官能团的树枝状聚合物在非还原条件下基本上为惰性但在形成巯基后形成巯基的树枝状聚合物含有二硫键和反应性末端基团。在本发明的一个方面，提供了在核心具有单个二硫键官能团的树枝状聚合物。可以将核心上的单个二硫基团还原形成两个巯基，其中可以结合其它分子，例如蛋白质，寡核苷酸，肽，激素，其他树状聚合物，非树枝状聚合物等。用于二硫化物官能化树枝状聚合物的应用包括形成分化的树枝状大分子，形成用于诊断的结合试剂，药物递送，基因治疗和磁性树脂成像，以及在石英晶体共振器上制备自组装树枝状聚合物单层以提供树枝状聚合物修饰用于检测各种离子或分子的电极。在本发明的另一方面，提供了具有巯基末端的树枝状聚合物。巯基封端的树枝状聚合物可用于制备当经受还原剂时可以进行交联的稳定的可固化树脂组合物。

3. 发明授权

US5714166A Bioactive and/or targeted dendrimer conjugates 失效
标题翻译：生物活性和/或靶向树枝状大分子缀合物
公开(公告)号：US5714166A
公开(公告)日：1998-02-03
申请号：US400203
申请日：1995-03-07
申请人： Donald A. Tomalia , James R. Baker , Roberta C. Cheng , Anna U. Bielinska , Michael J. Fazio , David M. Hedstrand , Jennifer A. Johnson , Donald A. Kaplan, deceased , Scott L. Klakamp , William J. Kruper, Jr. , Jolanta Kukowska-Latallo , Bartley D. Maxon , Lars T. Piehler , Ian A. Tomlinson , Larry R. Wilson , Rui Yin , Herbert M. Brothers, II
发明人： Donald A. Tomalia , James R. Baker , Roberta C. Cheng , Anna U. Bielinska , Michael J. Fazio , David M. Hedstrand , Jennifer A. Johnson , Donald A. Kaplan, deceased , Scott L. Klakamp , William J. Kruper, Jr. , Jolanta Kukowska-Latallo , Bartley D. Maxon , Lars T. Piehler , Ian A. Tomlinson , Larry R. Wilson , Rui Yin , Herbert M. Brothers, II
IPC分类号： C12N15/02 , A01N25/10 , A61K20060101 , A61K31/70 , A61K38/00 , A61K39/385 , A61K39/44 , A61K45/00 , A61K47/34 , A61K47/48 , A61K48/00 , A61K49/00 , A61K51/00 , C07C211/29 , C07C233/11 , C07C237/20 , C07K20060101 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/555 , C07K17/06 , C07K17/08 , C08G73/00 , C08G83/00 , C08L101/00 , C12N20060101 , C12N5/10 , C12N15/09 , C12N15/57 , C12N15/87 , C12P21/02 , C12P21/08 , C12R1/91 , A61K31/74 , A61K9/14 , A61K31/785
CPC分类号： A01N25/10 , A61K47/48192 , A61K47/48207 , A61K47/4823 , A61K47/48961 , A61K49/085 , A61K49/124 , B82Y5/00 , C07C211/29 , C07C233/11 , C07C237/20 , C08G83/003 , C08L101/005 , C12N15/87 , Y10S424/16
摘要： Dendritic polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried material, where the carrier material can be a biological response modifier, have been prepared. The conjugate can also have a target director present, and when it is present then the carried material may be a bioactive agent. Preferred dendritic polymers are dense star polymers, which have been complexed with biological response modifiers. These conjugates and complexes have particularly advantageous properties due to their unique characteristics.
摘要翻译：已经制备了由载体材料可以是生物反应调节剂的至少一种携带材料的至少一个单元组成的树枝状聚合物共轭物。缀合物还可以存在目标导向剂，并且当其存在时，所携带的材料可以是生物活性剂。优选的树枝状聚合物是与生物反应调节剂复合的致密星形聚合物。这些共轭物和配合物由于其独特的特性而具有特别有利的性质。

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