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1. 发明授权

US07166709B2 Haemostatically active preparation containing vWF and method for the production thereof 有权
标题翻译：含有vWF的止血活性制剂及其制备方法
公开(公告)号：US07166709B2
公开(公告)日：2007-01-23
申请号：US10257375
申请日：2001-04-04
申请人： Djuro Josic , Monika Stadler , Gerhard Gruber
发明人： Djuro Josic , Monika Stadler , Gerhard Gruber
IPC分类号： A23J1/00 , A61K35/14 , C07K1/00
CPC分类号： C07K14/755
摘要： A process for preparing a hemostatically active preparation containing von Willebrand factor (vWF) from a fraction of human plasma by chromatographic purification of a vWF-containing plasma fraction on an anion-exchange material which has the anion-exchanging groups on grafted polymeric structures (tentacle materials), collecting a vWF-containing fraction, followed by purification of said fraction using gel permeation to prepare a purified thermally stable vWF-containing preparation; and heating the preparation for inactivating viruses.
摘要翻译：通过在具有接枝聚合物结构上的阴离子交换基团的阴离子交换材料上层析纯化含vWF的血浆级分，从一部分人血浆中制备含有血管性血友病因子（vWF）的止血活性制剂的方法材料），收集含vWF的级分，然后使用凝胶渗透纯化所述级分以制备纯化的热稳定的含vWF的制剂; 并加热灭活病毒的制剂。

2. 发明授权

US07985846B2 Hemostatically active vWF-containing preparation and process for the preparation thereof 有权
标题翻译：含血液活性的含vWF的制剂及其制备方法
公开(公告)号：US07985846B2
公开(公告)日：2011-07-26
申请号：US11649357
申请日：2007-01-04
申请人： Djuro Josic , Monika Stadler , Gerhard Gruber
发明人： Djuro Josic , Monika Stadler , Gerhard Gruber
IPC分类号： A23J1/00
CPC分类号： C07K14/755
摘要： A process for preparing a hemostatically active preparation containing von Willebrand factor (vWF) from a fraction of human plasma by chromatographic purification of a vWF-containing plasma fraction on an anion-exchange material which has the anion-exchanging groups on grafted polymeric structures (tentacle materials), collecting a vWF-containing fraction, followed by purification of said fraction using gel permeation to prepare a purified thermally stable vWF-containing preparation; and heating the preparation for inactivating viruses.
摘要翻译：通过在具有接枝聚合物结构上的阴离子交换基团的阴离子交换材料上层析纯化含vWF的血浆级分，从一部分人血浆中制备含有血管性血友病因子（vWF）的止血活性制剂的方法材料），收集含vWF的级分，然后使用凝胶渗透纯化所述级分以制备纯化的热稳定的含vWF的制剂; 并加热灭活病毒的制剂。

3. 发明申请

US20070232791A1 Hemostatically active vWF-containing preparation and process for the preparation thereof 有权
标题翻译：含血液活性的含vWF的制剂及其制备方法
公开(公告)号：US20070232791A1
公开(公告)日：2007-10-04
申请号：US11649357
申请日：2007-01-04
申请人： Djuro Josic , Monika Stadler , Gerhard Gruber
发明人： Djuro Josic , Monika Stadler , Gerhard Gruber
IPC分类号： C07K14/745 , C07K1/22
CPC分类号： C07K14/755
摘要： A process for preparing a hemostatically active preparation containing von Willebrand factor (vWF) from a fraction of human plasma by chromatographic purification of a vWF-containing plasma fraction on an anion-exchange material which has the anion-exchanging groups on grafted polymeric structures (tentacle materials), collecting a vWF-containing fraction, followed by purification of said fraction using gel permeation to prepare a purified thermally stable vWF-containing preparation; and heating the preparation for inactivating viruses.
摘要翻译：通过在具有接枝聚合物结构上的阴离子交换基团的阴离子交换材料上层析纯化含vWF的血浆级分，从一部分人血浆中制备含有血管性血友病因子（vWF）的止血活性制剂的方法材料），收集含vWF的级分，然后使用凝胶渗透纯化所述级分以制备纯化的热稳定的含vWF的制剂; 并加热灭活病毒的制剂。

4. 发明授权

US06528246B2 Method for the inactivation of non-lipid-coated viruses 失效
标题翻译：灭活非脂质包被病毒的方法
公开(公告)号：US06528246B2
公开(公告)日：2003-03-04
申请号：US08501034
申请日：1995-09-28
申请人： Monika Stadler , Horst Schwinn , Djuro Josic , Werner Gehringer , Frederic Bal
发明人： Monika Stadler , Horst Schwinn , Djuro Josic , Werner Gehringer , Frederic Bal
IPC分类号： A01N102
CPC分类号： C07K14/755 , A61L2/0088
摘要： A method for the inactivation of viruses, in particular those having no lipid coats, in protein-containing compositions from blood, blood plasma or similar natural sources by treating said source, simultaneously or succesively, with an effective amount of dialkyl or trialkyl phosphates and optionally surfactants at an elevated temperature in the range of from 55° C. to 67° C. for five hours to 30 hours.
摘要翻译：一种通过用有效量的磷酸二烷基酯或三烷基酯同时或连续地处理所述来源，从血液，血浆或类似天然来源的含蛋白质组合物中灭活病毒，特别是没有脂质涂层的方法，表面活性剂在升高的温度范围为55℃至67℃，持续5小时至30小时。

5. 发明授权

US07932365B2 Preparation and composition of inter-alpha inhibitor proteins from human plasma for therapeutic use 有权
标题翻译：来自人血浆的α型间抑制蛋白的制备和组成用于治疗用途
公开(公告)号：US07932365B2
公开(公告)日：2011-04-26
申请号：US10578449
申请日：2004-11-05
申请人： Yow-Pin Lim , Djuro Josic , Douglas C. Hixson
发明人： Yow-Pin Lim , Djuro Josic , Douglas C. Hixson
IPC分类号： A23J1/00 , C07K14/435 , C12Q1/00
CPC分类号： C07K14/811 , A61K38/00 , B01D15/363 , B01D15/3804 , G01N30/96 , G01N33/566 , G01N2030/009 , G01N2333/81 , G01N2800/52
摘要： The invention relates to Inter-alpha inhibitor proteins (IαIp). The invention further relates to processes for purification of IαIp compositions and their use for treatment of human diseases such as sepsis and septic shock, rheumatoid arthritis, cancer and infectious diseases.
摘要翻译：本发明涉及α间抗体蛋白（IαIp）。本发明还涉及纯化IαIp组合物的方法及其用于治疗人类疾病如败血症和败血性休克，类风湿性关节炎，癌症和感染性疾病的用途。

6. 发明授权

US06736973B1 Chromatographic device 有权
标题翻译：色谱装置
公开(公告)号：US06736973B1
公开(公告)日：2004-05-18
申请号：US09601037
申请日：2000-07-26
申请人： Ales Podgornik , Milos Barut , Ales Strancar , Djuro Josic
发明人： Ales Podgornik , Milos Barut , Ales Strancar , Djuro Josic
IPC分类号： B01D1508
CPC分类号： G01N30/482 , B01D15/325 , B01D15/327 , B01D15/363 , B01J20/261 , B01J20/28042 , B01J20/28092 , B01J20/28097 , B01J20/285 , B01J20/287 , B01J2220/54 , B01J2220/82 , G01N30/56 , G01N30/6004 , G01N30/6069 , G01N30/6091 , G01N2030/525 , G01N2030/528
摘要： A porous self-supporting structure comprising at least two porous components A and B and the porous component B embraces the porous component A, wherein (i) surfaces of pores of the at least two porous components A and B are provided with chemical moieties for interaction with substances passing the pores and (ii) the pores of the porous components comprise a uniform multimodal pore size distribution through the entire polymeric structure.
摘要翻译：包含至少两个多孔组分A和B以及多孔组分B的多孔自支撑结构包括多孔组分A，其中（i）至少两个多孔组分A和B的孔表面设置有用于相互作用的化学部分通过孔的物质和（ii）多孔组分的孔包含通过整个聚合物结构的均匀的多峰孔径分布。

7. 发明授权

US06893856B2 Process for preparing virus-inactivated factors 1X and X by membrane chromatography 失效
标题翻译：通过膜层析法制备病毒灭活因子1X和X的方法
公开(公告)号：US06893856B2
公开(公告)日：2005-05-17
申请号：US10136468
申请日：2002-05-02
申请人： Djuro Josic , Ales Strancar
发明人： Djuro Josic , Ales Strancar
IPC分类号： A61K35/16 , A61K38/43 , A61K38/46 , A61P7/04 , C07K1/16 , C07K1/18 , C07K1/22 , C07K1/34 , C07K14/745 , C12N9/64 , C02F1/28 , C12N7/06
CPC分类号： C12N9/647 , C07K14/745
摘要： Disclosed is a process for preparing agents containing virus-inactivated vitamin K-dependent plasma components as well as protein C, protein S, factors II, VII, IX and/or X as well as combinations thereof, such as, for example, PPSB preparations, wherein a source containing these components is subjected to a appropriate separation procedures, especially by using membrane-chromatographic methods.
摘要翻译：公开了一种制备含有病毒灭活的维生素K依赖性血浆成分以及蛋白C，蛋白S，因子II，VII，IX和/或X及其组合的药剂的方法，例如PPSB制剂其中含有这些组分的源经受适当的分离程序，特别是通过使用膜 - 色谱法。

8. 发明授权

US06319401B1 Device for the rapid separation and/or conversion of substrates 有权
标题翻译：用于快速分离和/或转换基材的装置
公开(公告)号：US06319401B1
公开(公告)日：2001-11-20
申请号：US09276711
申请日：1999-03-26
申请人： Djuro Josic , Primoz Koselj , Ales Podgronik , Ales Strancar
发明人： Djuro Josic , Primoz Koselj , Ales Podgronik , Ales Strancar
IPC分类号： B01D6500
CPC分类号： B01J20/3242 , B01D15/1821 , B01D15/1892 , B01D15/22 , B01J20/28014 , B01J20/28042 , G01N30/02 , G01N30/6017 , G01N30/6069 , G01N2030/324 , G01N2030/386 , G01N2030/527 , B01D2015/389
摘要： A device for the rapid separation and/or conversion of substrates is disclosed herein. The device include a porous tube (2) disposed inside a tubular sample distributor (3). The tubular sample distributor (3) includes channel structures on its inner surface and is disposed inside a tubular body (4). A tubular sample collector (1) having channel structures on its outer surface is disposed inside the porous tube (2). A circular sample distributor (7) is provided having a circumferential portion and radially extending grooves in conjunction with the channel structures of the tubular sample distributor (3). A circular sample collector (8) is also provided having a circumferential portion and radially extending grooves in conjunction with the channel structures of the tubular sample collector (1). The hollow body (4) is arranged between securing means (5) that provide a sample inlet and outlet in communication with the circular sample distributor (7) and circular sample collector (8), respectively.
摘要翻译：本文公开了用于快速分离和/或转换基底的装置。该装置包括设置在管状样品分配器（3）内的多孔管（2）。管状样品分配器（3）在其内表面上包括通道结构，并且设置在管状体（4）的内部。在其外表面上具有通道结构的管状样品收集器（1）设置在多孔管（2）的内部。圆形样品分配器（7）设置有与管状样品分配器（3）的通道结构相结合的周向部分和径向延伸的凹槽。还提供了圆形样品收集器（8），其具有与管状样品收集器（1）的通道结构相结合的圆周部分和径向延伸的凹槽。中空体（4）分别设置在提供与圆形样品分配器（7）和圆形样品收集器（8）连通的样品入口和出口的固定装置（5）之间。

9. 发明授权

US5972218A Porous tube filter 失效
标题翻译：多孔管过滤器
公开(公告)号：US5972218A
公开(公告)日：1999-10-26
申请号：US518511
申请日：1995-08-23
申请人： Djuro Josic , Primoz Koselj , Ales Podgronik , Ales Strancar
发明人： Djuro Josic , Primoz Koselj , Ales Podgronik , Ales Strancar
IPC分类号： B01D15/18 , B01D15/22 , B01J20/32 , C12M1/12 , C12M1/34 , C12M1/40 , C12M3/06 , G01N30/02 , G01N30/32 , G01N30/38 , G01N30/52 , G01N30/60 , B01D65/00
CPC分类号： B01J20/3242 , B01D15/22 , B01J20/28014 , B01J20/28042 , G01N30/6017 , G01N30/6069 , B01D15/1821 , B01D15/1892 , G01N2030/324 , G01N2030/386 , G01N2030/527 , G01N30/02
摘要： An apparatus for the conversion of substrates both for analytical and preparative purposes in a flow-through and cross-flow reactor having compact porous discs and/or compact porous tubes as carrier for conversion reaction or preparative separations which compact porous discs and/or compact porous tubes are modified with substances being capable of specifically binding and/or converting said substrates by distributing the samples to be converted and/or preparatively separated and collecting the converted and/or separated substrates preferably in a low volume, wherein the distribution of the sample does not affect the carrier adversely.
摘要翻译：用于在具有紧凑多孔盘的流通和交叉流动反应器中转化用于分析和制备目的的底物的装置和/或紧凑多孔管作为用于转化反应或制备分离的载体，其将多孔盘和/或紧密多孔用能够通过分配要转化和/或制备分离的样品来特异性结合和/或转化所述底物的管子进行改性，优选以低体积收集经转化和/或分离的底物，其中样品的分布不会对运营商造成不利影响。

10. 发明授权

US5919909A Process for the preparation of factor IX from biological sources 失效
标题翻译：从生物来源制备因子IX的过程
公开(公告)号：US5919909A
公开(公告)日：1999-07-06
申请号：US894654
申请日：1997-11-26
申请人： Djuro Josic , Lutz Hoffer , Frank Morfeld
发明人： Djuro Josic , Lutz Hoffer , Frank Morfeld
IPC分类号： C07K1/16 , C07K1/30 , C07K14/745 , C12N9/64 , A61K35/14 , C12N7/04
CPC分类号： C12N9/644 , C12Y304/21022
摘要： A process for the preparation of factor IX from a biological source by chromatography involves prior treatment with ammonium sulfate as a protein precipitant at a concentration of from 1.5-2.3 mol/l.
摘要翻译： PCT No.PCT / EP96 / 00636 Sec。 371日期：1997年11月26日 102（e）日期1997年11月26日PCT提交1996年2月14日PCT公布。 WO96 / 27003 PCT出版物日期1996年9月6日通过色谱法从生物来源制备因子IX的方法涉及以硫酸铵作为蛋白质沉淀剂的前处理，浓度为1.5-2.3mol / l。

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