专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07932365B2 Preparation and composition of inter-alpha inhibitor proteins from human plasma for therapeutic use 有权
标题翻译：来自人血浆的α型间抑制蛋白的制备和组成用于治疗用途
公开(公告)号：US07932365B2
公开(公告)日：2011-04-26
申请号：US10578449
申请日：2004-11-05
申请人： Yow-Pin Lim , Djuro Josic , Douglas C. Hixson
发明人： Yow-Pin Lim , Djuro Josic , Douglas C. Hixson
IPC分类号： A23J1/00 , C07K14/435 , C12Q1/00
CPC分类号： C07K14/811 , A61K38/00 , B01D15/363 , B01D15/3804 , G01N30/96 , G01N33/566 , G01N2030/009 , G01N2333/81 , G01N2800/52
摘要： The invention relates to Inter-alpha inhibitor proteins (IαIp). The invention further relates to processes for purification of IαIp compositions and their use for treatment of human diseases such as sepsis and septic shock, rheumatoid arthritis, cancer and infectious diseases.
摘要翻译：本发明涉及α间抗体蛋白（IαIp）。本发明还涉及纯化IαIp组合物的方法及其用于治疗人类疾病如败血症和败血性休克，类风湿性关节炎，癌症和感染性疾病的用途。

2. 发明授权

US06660482B1 Inter-alpha-trypsin inhibitor as a marker for sepsis 有权
标题翻译： α型胰蛋白酶抑制剂作为败血症的标志物
公开(公告)号：US06660482B1
公开(公告)日：2003-12-09
申请号：US09514450
申请日：2000-02-28
申请人： Yow-Pin Lim , Douglas C. Hixson
发明人： Yow-Pin Lim , Douglas C. Hixson
IPC分类号： G01N3353
CPC分类号： G01N33/573 , C12Q1/37
摘要： The invention provides a method of diagnosing sepsis in a mammal by contacting a bodily fluid from the mammal with a ligand which binds to an inter-alpha trypsin inhibitor (ITI) polypeptide under conditions sufficient to form an ITI-ligand complex and detecting the complex.
摘要翻译：本发明提供了一种通过使来自哺乳动物的身体液体与足以形成ITI-配体复合物并检测该复合物的条件与α间胰蛋白酶抑制剂（ITI）多肽结合的配体接触来诊断哺乳动物的败血症的方法。

3. 发明授权

US06489128B1 Methods for detecting cancer of the central nervous system 失效
标题翻译：检测中枢神经系统癌症的方法
公开(公告)号：US06489128B1
公开(公告)日：2002-12-03
申请号：US09491479
申请日：2000-01-24
申请人： Yow-Pin Lim , Douglas C. Hixson
发明人： Yow-Pin Lim , Douglas C. Hixson
IPC分类号： G01N33574
CPC分类号： G01N33/57407 , A61K38/57 , C07K16/38
摘要： A method for diagnosing a tumor in the central nervous system of a mammal is carried out by contacting a bodily fluid from the mammal with a ligand which binds to inter-alpha trypsin inhibitor.
摘要翻译：通过使来自哺乳动物的体液与与α间胰蛋白酶抑制剂结合的配体接触来进行哺乳动物的中枢神经系统中的肿瘤的诊断方法。

4. 发明授权

US5284559A Preparative electrophoresis device and method 失效
标题翻译：制备型电泳装置及方法
公开(公告)号：US5284559A
公开(公告)日：1994-02-08
申请号：US899460
申请日：1992-06-16
申请人： Yow-Pin Lim , Douglas C. Hixson
发明人： Yow-Pin Lim , Douglas C. Hixson
IPC分类号： G01N27/447 , B01D57/02 , G01N27/26
CPC分类号： B01D57/02
摘要： A preparative electrophoresis device having a pair of spaced apart plates, a pre-cast electrophoretic gel between the plates, and a semipermeable membrane sealably connected to ends of the plates to define with the plates a collection channel for receiving molecules that have traveled through the gel. Also disclosed are close spacing (less than 2.0 mm) of the plates, an inlet tube and an outlet tube connected to the two plates and communicating with opposite ends of the collection channel, an elongated divider between the plates to divide the gel into a purification region and an indicating region that is not as wide as the purification region and receives marker molecules of known molecular weight to indicate the location in the indicating region of molecules of interest, and pumping electrophoretic buffer into the collection channel at the same rate that it is pumped out.
摘要翻译：一种制备型电泳装置，其具有一对间隔开的板，在板之间的预制电泳凝胶，以及半透膜，其可密封地连接到板的端部，以与板一起限定用于接收已经穿过凝胶的分子的收集通道。还公开了板的紧密间距（小于2.0mm），连接到两个板并与收集通道的相对端连通的入口管和出口管，在板之间的细长分隔器，以将凝胶分成纯化区域和指示区域，其不如纯化区域那么宽，并且接收已知分子量的标记分子以指示感兴趣的分子的指示区域中的位置，并以相同的速率将电泳缓冲液泵送到收集通道中抽出来

5. 发明申请

US20110236381A1 INHIBITION OF INTER-ALPHA TRYPSIN INHIBITOR FOR THE TREATMENT OF AIRWAY DISEASE 审中-公开
标题翻译：用于治疗气道疾病的ALPHA TRYPSIN抑制剂的抑制
公开(公告)号：US20110236381A1
公开(公告)日：2011-09-29
申请号：US13133000
申请日：2009-04-01
申请人： Stavros Garantziotis , Yow-Pin Lim , John W. Hollingsworth , W. Michael Foster
发明人： Stavros Garantziotis , Yow-Pin Lim , John W. Hollingsworth , W. Michael Foster
IPC分类号： A61K39/395 , A61K31/7088 , A61K38/02 , A61P11/06 , A61P11/00 , A61K31/7105 , A61P11/08
CPC分类号： C07K16/38 , A61K9/0075 , A61K9/0078 , A61K31/726 , A61K31/727 , A61K31/728 , A61K39/395 , A61K2039/505 , C07K2317/76
摘要： It is disclosed herein that blockade of inter-alpha-trypsin inhibitor (IaI) prevents the development of airway hyperresponsiveness in animal models of asthma and chronic obstructive pulmonary disease. Provided herein are methods of treating an airway disease or disorder in a subject by administering to the subject a therapeutically effective amount of an inhibitor of IaI. Also provided is a method of preventing or reducing airway hyperresponsiveness in a subject by administering to the subject a therapeutically effective amount of an inhibitor of IaI. The IaI inhibitor can be any compound that inhibits the expression or activity of IaI or a gene encoding an IaI polypeptide. In some embodiments, the IaI inhibitor is administered locally to the airway of the subject in need of treatment. For example, the inhibitor can be administered by aerosol delivery, such as by using an inhaler or nebulizer.
摘要翻译：本文公开了阻断α间胰蛋白酶抑制剂（IaI）的阻断，阻止哮喘和慢性阻塞性肺疾病的动物模型中气道高反应性的发展。本文提供了通过向受试者施用治疗有效量的IaI抑制剂来治疗受试者的气道疾病或病症的方法。还提供了通过向受试者施用治疗有效量的IaI抑制剂来预防或减少受试者的气道高反应性的方法。 IaI抑制剂可以是任何抑制IaI或编码IaI多肽的基因的表达或活性的化合物。在一些实施方案中，将IaI抑制剂局部施用于需要治疗的受试者的气道。例如，抑制剂可以通过气溶胶递送来施用，例如通过使用吸入器或喷雾器。

6. 发明授权

US09139641B2 Preparation and composition of inter-alpha proteins from blood 有权
标题翻译：来自血液的α型蛋白质的制备和组成
公开(公告)号：US09139641B2
公开(公告)日：2015-09-22
申请号：US12995141
申请日：2009-05-28
申请人： Yow-Pin Lim , Edward S. Sirya , Peter Brne
发明人： Yow-Pin Lim , Edward S. Sirya , Peter Brne
IPC分类号： A23J1/00 , C07K14/81 , A61K38/00
CPC分类号： A61K38/57 , A61K38/00 , C07K14/811
摘要： The present invention generally provides processes for purification of Inter-alpha inhibitor proteins (IαIp) and compositions thereof from blood.
摘要翻译：本发明通常提供从血液中纯化α间抗体蛋白（IαIp）及其组合物的方法。

7. 发明申请

US20060110774A1 Methods for detecting sepsis 有权
标题翻译：检测败血症的方法
公开(公告)号：US20060110774A1
公开(公告)日：2006-05-25
申请号：US11255634
申请日：2005-10-20
申请人： Loren Fast , Yow-Pin Lim
发明人： Loren Fast , Yow-Pin Lim
IPC分类号： G01N33/53 , C12P21/04 , C07K16/40
CPC分类号： G01N33/6893 , C07K16/40 , G01N2333/96436 , G01N2800/26
摘要： Compositions and methods for detecting sepsis by contacting a subject-derived sample with a ligand that binds to GRK and determining the concentration of GRK in the sample. An increase in the concentration of GRK compared to that of a normal, healthy control sample indicates that the subject from which the sample is obtained is suffering from or at risk of developing sepsis.
摘要翻译：通过使受试者衍生的样品与与GRK结合的配体接触并测定样品中的GRK的浓度来检测败血症的组合物和方法。与正常健康对照样品相比，GRK浓度的增加表明获得样品的受试者患有或有发展为败血症的风险。

8. 发明申请

US20070297982A1 Preparation And Composition Of Inter-Alpha Inhibitor Proteins From Human Plasma For Therapeutic Use 有权
标题翻译：用于治疗用途的人血浆中α-α抑制蛋白的制备和组成
公开(公告)号：US20070297982A1
公开(公告)日：2007-12-27
申请号：US10578449
申请日：2004-11-05
申请人： Yow-Pin Lim , Josic Djuro , Douglas Hixson
发明人： Yow-Pin Lim , Josic Djuro , Douglas Hixson
IPC分类号： A61K35/16 , A61K38/36 , A61P29/00 , A61P31/00 , A61P35/00 , C07K1/16 , C07K1/22 , C07K1/30 , C07K14/745 , C07K14/76 , C07K14/81
CPC分类号： C07K14/811 , A61K38/00 , B01D15/363 , B01D15/3804 , G01N30/96 , G01N33/566 , G01N2030/009 , G01N2333/81 , G01N2800/52
摘要： The invention relates to Inter-alpha inhibitor proteins (IαIp). The invention further relates to processes for purification of IαIp compositions and their use for treatment of human diseases such as sepsis and septic shock, rheumatoid arthritis, cancer and infectious diseases.
摘要翻译：本发明涉及α间抗体抑制蛋白（IalphaIp）。本发明还涉及纯化IalphaIp组合物的方法及其用于治疗人类疾病如败血症和败血性休克，类风湿性关节炎，癌症和感染性疾病的用途。

9. 发明申请

US20110190194A1 PREPARATION AND COMPOSITION OF INTER-ALPHA PROTEINS FROM BLOOD 有权
标题翻译：血液中ALPHA蛋白的制备和组成
公开(公告)号：US20110190194A1
公开(公告)日：2011-08-04
申请号：US12995141
申请日：2009-05-28
申请人： Yow-Pin Lim , Edward S. Sirya , Peter Brne
发明人： Yow-Pin Lim , Edward S. Sirya , Peter Brne
IPC分类号： A61K38/57 , C07K14/81 , A61P31/00 , A61P19/02 , A61P35/00 , A61P35/04 , A61P15/06
CPC分类号： A61K38/57 , A61K38/00 , C07K14/811
摘要： The present invention generally provides processes for purification of Inter-alpha inhibitor proteins (IαIp) and compositions thereof from blood.
摘要翻译：本发明通常提供从血液中纯化α间抗体蛋白（IαIp）及其组合物的方法。

10. 发明授权

US07939282B2 Methods for detecting sepsis 有权
标题翻译：检测败血症的方法
公开(公告)号：US07939282B2
公开(公告)日：2011-05-10
申请号：US11255634
申请日：2005-10-20
申请人： Loren D. Fast , Yow-Pin Lim
发明人： Loren D. Fast , Yow-Pin Lim
IPC分类号： G01N33/53 , G01N33/543 , G01N33/563 , G01N33/573 , G01N33/577 , C07K16/18 , C07K16/40
CPC分类号： G01N33/6893 , C07K16/40 , G01N2333/96436 , G01N2800/26
摘要： Compositions and methods for detecting sepsis by contacting a subject-derived sample with a ligand that binds to GRK and determining the concentration of GRK in the sample. An increase in the concentration of GRK compared to that of a normal, healthy control sample indicates that the subject from which the sample is obtained is suffering from or at risk of developing sepsis.
摘要翻译：通过使受试者衍生的样品与与GRK结合的配体接触并测定样品中的GRK的浓度来检测败血症的组合物和方法。与正常健康对照样品相比，GRK浓度的增加表明获得样品的受试者患有或有发展为败血症的风险。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式