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1. 发明申请

US20120189699A1 POLYSACCHARIDE GEL FORMULATION HAVING MULTI-STAGE BIOACTIVE AGENT DELIVERY 有权
标题翻译：具有多阶段生物交换剂的多糖凝胶配方
公开(公告)号：US20120189699A1
公开(公告)日：2012-07-26
申请号：US13439566
申请日：2012-04-04
申请人： Dimitrios Stroumpoulis , Dustin B. Leslie , Christopher S. Mudd , Ahmet Tezel
发明人： Dimitrios Stroumpoulis , Dustin B. Leslie , Christopher S. Mudd , Ahmet Tezel
IPC分类号： A61K9/14 , A61P23/00 , A61K31/737
CPC分类号： A61K8/042 , A61K8/492 , A61K8/60 , A61K8/602 , A61K8/676 , A61K8/678 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/736 , A61K9/0024 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/727 , A61K31/728 , A61K31/737 , A61K31/738 , A61K47/12 , A61K47/36 , A61K2800/522 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J3/12 , C08J3/128 , C08J3/24 , C08J2351/02 , C08K5/0025 , C08L1/02 , C08L5/04 , C08L5/08 , C08L5/10
摘要： Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of providing at least one polysaccharide and incorporating at least one inhibitor of degradation into the polysaccharide.
摘要翻译：本文描述的是多糖凝胶制剂，其包括至少一种多糖降解抑制剂及其制备方法。本文描述的方法包括提供至少一种多糖并将至少一种降解抑制剂并入多糖中的步骤。

2. 发明申请

US20100098764A1 POLYSACCHARIDE GEL FORMULATION HAVING MULTI-STAGE BIOACTIVE AGENT DELIVERY 有权
标题翻译：具有多阶段生物交换剂的多糖凝胶配方
公开(公告)号：US20100098764A1
公开(公告)日：2010-04-22
申请号：US12616020
申请日：2009-11-10
申请人： Dimitrios STROUMPOULIS , Dustin B. Leslie , Christopher S. Mudd , Ahmet Tezel
发明人： Dimitrios STROUMPOULIS , Dustin B. Leslie , Christopher S. Mudd , Ahmet Tezel
IPC分类号： A61K31/726 , A61K9/14 , A61K31/235 , A61K31/165
CPC分类号： A61K8/042 , A61K8/492 , A61K8/60 , A61K8/602 , A61K8/676 , A61K8/678 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/736 , A61K9/0024 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/727 , A61K31/728 , A61K31/737 , A61K31/738 , A61K47/12 , A61K47/36 , A61K2800/522 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J3/12 , C08J3/128 , C08J3/24 , C08J2351/02 , C08K5/0025 , C08L1/02 , C08L5/04 , C08L5/08 , C08L5/10
摘要： Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of providing at least one polysaccharide and incorporating at least one inhibitor of degradation into the polysaccharide.
摘要翻译：本文描述的是多糖凝胶制剂，其包括至少一种多糖降解抑制剂及其制备方法。本文描述的方法包括提供至少一种多糖并将至少一种降解抑制剂并入多糖中的步骤。

3. 发明授权

US08394784B2 Polysaccharide gel formulation having multi-stage bioactive agent delivery 有权
标题翻译：具有多级生物活性剂递送的多糖凝胶制剂
公开(公告)号：US08394784B2
公开(公告)日：2013-03-12
申请号：US12616020
申请日：2009-11-10
申请人： Dimitrios Stroumpoulis , Dustin B. Leslie , Christopher S. Mudd , Ahmet Tezel
发明人： Dimitrios Stroumpoulis , Dustin B. Leslie , Christopher S. Mudd , Ahmet Tezel
IPC分类号： A01N43/04 , C07H1/00
CPC分类号： A61K8/042 , A61K8/492 , A61K8/60 , A61K8/602 , A61K8/676 , A61K8/678 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/736 , A61K9/0024 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/727 , A61K31/728 , A61K31/737 , A61K31/738 , A61K47/12 , A61K47/36 , A61K2800/522 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J3/12 , C08J3/128 , C08J3/24 , C08J2351/02 , C08K5/0025 , C08L1/02 , C08L5/04 , C08L5/08 , C08L5/10
摘要： Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of providing at least one polysaccharide and incorporating at least one inhibitor of degradation into the polysaccharide.
摘要翻译：本文描述的是多糖凝胶制剂，其包括至少一种多糖降解抑制剂及其制备方法。本文描述的方法包括提供至少一种多糖并将至少一种降解抑制剂并入多糖中的步骤。

4. 发明授权

US08513216B2 Polysaccharide gel formulation having increased longevity 有权
公开(公告)号：US08513216B2
公开(公告)日：2013-08-20
申请号：US12558270
申请日：2009-09-11
申请人： Dimitrios Stroumpoulis , Christopher S. Mudd , Ahmet Tezel
发明人： Dimitrios Stroumpoulis , Christopher S. Mudd , Ahmet Tezel
IPC分类号： A61K31/70
CPC分类号： A61L27/26 , A61K8/042 , A61K8/492 , A61K8/60 , A61K8/602 , A61K8/676 , A61K8/678 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/736 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/727 , A61K31/728 , A61K31/737 , A61K31/738 , A61K47/183 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/42 , A61K2800/522 , A61L27/505 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08K5/053 , C08L5/08 , C08L2205/02
摘要： Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of providing at least one polysaccharide and incorporating at least one inhibitor of degradation into the polysaccharide. In some embodiments, the incorporating step comprises 1) mixing the at least one inhibitor with the at least one polysaccharide at a highly hydrated state thereby encapsulating the at least one inhibitor in a polysaccharide network, and 2) dehydrating the polysaccharide network thereby controlling release kinetics or final swell ratio. In another embodiment, the incorporating step comprises 1) encapsulating at least one inhibitor into a biocompatible or biodegradable vessel and 2) combining the polysaccharide and the vessel into a gel formulation. The polysaccharide gel formulations described herein can be used for a variety of cosmetic applications.

5. 发明授权

US08394783B2 Polysaccharide gel formulation having multi-stage bioactive agent delivery 有权
公开(公告)号：US08394783B2
公开(公告)日：2013-03-12
申请号：US13439566
申请日：2012-04-04
申请人： Dimitrios Stroumpoulis , Dustin Leslie , Christopher S. Mudd , Ahmet Tezel
发明人： Dimitrios Stroumpoulis , Dustin Leslie , Christopher S. Mudd , Ahmet Tezel
IPC分类号： A61K31/70
CPC分类号： A61K8/042 , A61K8/492 , A61K8/60 , A61K8/602 , A61K8/676 , A61K8/678 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/736 , A61K9/0024 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/727 , A61K31/728 , A61K31/737 , A61K31/738 , A61K47/12 , A61K47/36 , A61K2800/522 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J3/12 , C08J3/128 , C08J3/24 , C08J2351/02 , C08K5/0025 , C08L1/02 , C08L5/04 , C08L5/08 , C08L5/10
摘要： Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of providing at least one polysaccharide and incorporating at least one inhibitor of degradation into the polysaccharide.

6. 发明授权

US08394782B2 Polysaccharide gel formulation having increased longevity 有权
标题翻译：多糖凝胶配方寿命延长
公开(公告)号：US08394782B2
公开(公告)日：2013-03-12
申请号：US12276167
申请日：2008-11-21
申请人： Dimitrios Stroumpoulis , Christopher S. Mudd , Ahmet Tezel
发明人： Dimitrios Stroumpoulis , Christopher S. Mudd , Ahmet Tezel
IPC分类号： A61K31/70
CPC分类号： A61L27/26 , A61K8/042 , A61K8/492 , A61K8/60 , A61K8/602 , A61K8/676 , A61K8/678 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/736 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/727 , A61K31/728 , A61K31/737 , A61K31/738 , A61K47/183 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/42 , A61K2800/522 , A61L27/505 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08K5/053 , C08L5/08 , C08L2205/02
摘要： Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of providing at least one polysaccharide and incorporating at least one inhibitor of degradation into the polysaccharide. In some embodiments, the incorporating step comprises 1) mixing the at least one inhibitor with the at least one polysaccharide at a highly hydrated state thereby encapsulating the at least one inhibitor in a polysaccharide network, and 2) dehydrating the polysaccharide network thereby controlling release kinetics or final swell ratio. In another embodiment, the incorporating step comprises 1) encapsulating at least one inhibitor into a biocompatible or biodegradable vessel and 2) combining the polysaccharide and the vessel into a gel formulation. The polysaccharide gel formulations described herein can be used for a variety of cosmetic applications.
摘要翻译：本文描述的是多糖凝胶制剂，其包括至少一种多糖降解抑制剂及其制备方法。本文描述的方法包括提供至少一种多糖并将至少一种降解抑制剂并入多糖中的步骤。在一些实施方案中，掺入步骤包括：1）以高水合状态将至少一种抑制剂与至少一种多糖混合，从而将至少一种抑制剂包封在多糖网络中，和2）使多糖网络脱水从而控制释放动力学或最终膨胀比。在另一个实施方案中，掺入步骤包括：1）将至少一种抑制剂包封在生物相容性或可生物降解的容器中，和2）将多糖和血管结合成凝胶制剂。本文所述的多糖凝胶制剂可用于各种化妆品应用。

7. 发明申请

US20100004198A1 POLYSACCHARIDE GEL FORMULATION HAVING INCREASED LONGEVITY 有权
标题翻译：多糖凝胶配方具有增加的长度
公开(公告)号：US20100004198A1
公开(公告)日：2010-01-07
申请号：US12558270
申请日：2009-09-11
申请人： Dimitrios STROUMPOULIS , Christopher S. Mudd , Ahmet Tezel
发明人： Dimitrios STROUMPOULIS , Christopher S. Mudd , Ahmet Tezel
IPC分类号： A61K31/715 , A61K31/717 , A61K31/722 , A61K31/721 , A61K31/727 , A61K31/728
CPC分类号： A61L27/26 , A61K8/042 , A61K8/492 , A61K8/60 , A61K8/602 , A61K8/676 , A61K8/678 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/736 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/727 , A61K31/728 , A61K31/737 , A61K31/738 , A61K47/183 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/42 , A61K2800/522 , A61L27/505 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08K5/053 , C08L5/08 , C08L2205/02
摘要： Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of providing at least one polysaccharide and incorporating at least one inhibitor of degradation into the polysaccharide. In some embodiments, the incorporating step comprises 1) mixing the at least one inhibitor with the at least one polysaccharide at a highly hydrated state thereby encapsulating the at least one inhibitor in a polysaccharide network, and 2) dehydrating the polysaccharide network thereby controlling release kinetics or final swell ratio. In another embodiment, the incorporating step comprises 1) encapsulating at least one inhibitor into a biocompatible or biodegradable vessel and 2) combining the polysaccharide and the vessel into a gel formulation. The polysaccharide gel formulations described herein can be used for a variety of cosmetic applications.
摘要翻译：本文描述的是多糖凝胶制剂，其包括至少一种多糖降解抑制剂及其制备方法。本文描述的方法包括提供至少一种多糖并将至少一种降解抑制剂并入多糖中的步骤。在一些实施方案中，掺入步骤包括：1）以高水合状态将至少一种抑制剂与至少一种多糖混合，从而将至少一种抑制剂包封在多糖网络中，和2）使多糖网络脱水从而控制释放动力学或最终膨胀比。在另一个实施方案中，掺入步骤包括：1）将至少一种抑制剂包封在生物相容性或可生物降解的容器中，和2）将多糖和血管结合成凝胶制剂。本文所述的多糖凝胶制剂可用于各种化妆品应用。

8. 发明申请

US20090143331A1 POLYSACCHARIDE GEL FORMULATION HAVING INCREASED LONGEVITY 有权
标题翻译：多糖凝胶配方具有增加的长度
公开(公告)号：US20090143331A1
公开(公告)日：2009-06-04
申请号：US12276167
申请日：2008-11-21
申请人： Dimitrios Stroumpoulis , Christopher S. Mudd , Ahmet Tezel
发明人： Dimitrios Stroumpoulis , Christopher S. Mudd , Ahmet Tezel
IPC分类号： A61K31/715 , A61K31/717 , A61K31/721 , A61K31/727 , A61K31/728 , A61K31/737
CPC分类号： A61L27/26 , A61K8/042 , A61K8/492 , A61K8/60 , A61K8/602 , A61K8/676 , A61K8/678 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/736 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/727 , A61K31/728 , A61K31/737 , A61K31/738 , A61K47/183 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/42 , A61K2800/522 , A61L27/505 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08K5/053 , C08L5/08 , C08L2205/02
摘要： Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of providing at least one polysaccharide and incorporating at least one inhibitor of degradation into the polysaccharide. In some embodiments, the incorporating step comprises 1) mixing the at least one inhibitor with the at least one polysaccharide at a highly hydrated state thereby encapsulating the at least one inhibitor in a polysaccharide network, and 2) dehydrating the polysaccharide network thereby controlling release kinetics or final swell ratio. In another embodiment, the incorporating step comprises 1) encapsulating at least one inhibitor into a biocompatible or biodegradable vessel and 2) combining the polysaccharide and the vessel into a gel formulation. The polysaccharide gel formulations described herein can be used for a variety of cosmetic applications.
摘要翻译：本文描述的是多糖凝胶制剂，其包括至少一种多糖降解抑制剂及其制备方法。本文描述的方法包括提供至少一种多糖并将至少一种降解抑制剂并入多糖中的步骤。在一些实施方案中，掺入步骤包括：1）以高水合状态将至少一种抑制剂与至少一种多糖混合，从而将至少一种抑制剂包封在多糖网络中，以及2）使多糖网络脱水从而控制释放动力学或最终膨胀比。在另一个实施方案中，掺入步骤包括：1）将至少一种抑制剂包封在生物相容性或可生物降解的容器中，和2）将多糖和血管结合成凝胶制剂。本文所述的多糖凝胶制剂可用于各种化妆品应用。

9. 发明授权

US08961474B2 Syringe 有权
标题翻译：注射器
公开(公告)号：US08961474B2
公开(公告)日：2015-02-24
申请号：US12968576
申请日：2010-12-15
申请人： Dimitrios Stroumpoulis , Christopher S. Mudd
发明人： Dimitrios Stroumpoulis , Christopher S. Mudd
IPC分类号： A61M5/315 , A61M5/19
CPC分类号： A61M5/31501 , A61M5/19 , A61M5/31511 , A61M5/3158 , A61M5/31596 , A61M2005/31508 , A61M2005/31598
摘要： A syringe is disclosed. The syringe may include a syringe body with a fluid chamber, the syringe body having a distal end and a proximal end, with an extrusion opening at the proximal end; a dividing wall disposed within the fluid chamber, defining a first fluid chamber and a second fluid chamber, the first fluid chamber and the second fluid chamber in communication with the extrusion opening; a first plunger disposed in a distal end of the first chamber, the first plunger including a first locking mechanism configured to prevent the first plunger from sliding away from the proximal end of the syringe body, when the first plunger is in a first initial position and the second plunger is being depressed; and a second plunger disposed in a distal end of the second chamber, the second plunger including a second locking mechanism configured to prevent the second plunger from sliding away from the proximal end of the syringe body when the second plunger is in a second initial position and the first plunger is being depressed.
摘要翻译：公开了一种注射器。注射器可以包括具有流体室的注射器主体，注射器主体具有远端和近端，在近端具有挤出开口; 分隔壁，其设置在所述流体室内，限定第一流体室和第二流体室，所述第一流体室和所述第二流体室与所述挤出开口连通; 第一柱塞，其设置在所述第一室的远端中，所述第一柱塞包括第一锁定机构，所述第一锁定机构构造成当所述第一柱塞处于第一初始位置时防止所述第一柱塞从所述注射器主体的近端滑离; 第二柱塞被压下; 以及第二柱塞，其设置在所述第二室的远端中，所述第二柱塞包括第二锁定机构，所述第二锁定机构构造成当所述第二柱塞处于第二初始位置时防止所述第二柱塞从所述注射器主体的近端滑离，第一柱塞被压下。

10. 发明申请

US20110166531A1 SYRINGE 有权
标题翻译：注射器
公开(公告)号：US20110166531A1
公开(公告)日：2011-07-07
申请号：US12968576
申请日：2010-12-15
申请人： Dimitrios Stroumpoulis , Christopher S. Mudd
发明人： Dimitrios Stroumpoulis , Christopher S. Mudd
IPC分类号： A61M5/31
CPC分类号： A61M5/31501 , A61M5/19 , A61M5/31511 , A61M5/3158 , A61M5/31596 , A61M2005/31508 , A61M2005/31598
摘要： A syringe is disclosed. The syringe may include a syringe body with a fluid chamber, the syringe body having a distal end and a proximal end, with an extrusion opening at the proximal end; a dividing wall disposed within the fluid chamber, defining a first fluid chamber and a second fluid chamber, the first fluid chamber and the second fluid chamber in communication with the extrusion opening; a first plunger disposed in a distal end of the first chamber, the first plunger including a first locking mechanism configured to prevent the first plunger from sliding away from the proximal end of the syringe body, when the first plunger is in a first initial position and the second plunger is being depressed; and a second plunger disposed in a distal end of the second chamber, the second plunger including a second locking mechanism configured to prevent the second plunger from sliding away from the proximal end of the syringe body when the second plunger is in a second initial position and the first plunger is being depressed.
摘要翻译：公开了一种注射器。注射器可以包括具有流体室的注射器主体，注射器主体具有远端和近端，在近端具有挤出开口; 分隔壁，其设置在所述流体室内，限定第一流体室和第二流体室，所述第一流体室和所述第二流体室与所述挤出开口连通; 第一柱塞，其设置在所述第一室的远端中，所述第一柱塞包括第一锁定机构，所述第一锁定机构构造成当所述第一柱塞处于第一初始位置时防止所述第一柱塞从所述注射器主体的近端滑离; 第二柱塞被压下; 以及第二柱塞，其设置在所述第二室的远端中，所述第二柱塞包括第二锁定机构，所述第二锁定机构构造成当所述第二柱塞处于第二初始位置时防止所述第二柱塞从所述注射器主体的近端滑离，第一柱塞被压下。

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