专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060078918A1 Natural ligand for orphan G protein coupled receptor GPR86 and methods of use 失效
标题翻译：孤儿G蛋白偶联受体GPR86的天然配体及其使用方法
公开(公告)号：US20060078918A1
公开(公告)日：2006-04-13
申请号：US11216987
申请日：2005-08-31
申请人： Didier Communi , Nathalie Suarez , Michel Detheux , Stephane Brezillon , Vincent Lannoy , Marc Parmentier , Jean-Marie Boeynaems
发明人： Didier Communi , Nathalie Suarez , Michel Detheux , Stephane Brezillon , Vincent Lannoy , Marc Parmentier , Jean-Marie Boeynaems
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/5008 , A61K31/7076 , C07K14/47 , C07K14/705 , G01N33/502 , G01N33/5041 , G01N33/5091 , G01N33/5735 , G01N33/68 , G01N33/6842 , G01N33/6845 , G01N2333/726 , G01N2500/00
摘要： The present invention is related to a method of detecting the dysregulation of GPR86 activity.
摘要翻译：本发明涉及检测GPR86活性失调的方法。

2. 发明授权

US07422846B2 Natural ligand for orphan G protein coupled receptor GPR86 and methods of use 失效
标题翻译：孤儿G蛋白偶联受体GPR86的天然配体及其使用方法
公开(公告)号：US07422846B2
公开(公告)日：2008-09-09
申请号：US11216987
申请日：2005-08-31
申请人： Didier Communi , Nathalie Suarez , Michel Detheux , Stephane Brezillian , Vincent Lannoy , Marc Parmentier , Jean-Marie Boeynaems
发明人： Didier Communi , Nathalie Suarez , Michel Detheux , Stephane Brezillian , Vincent Lannoy , Marc Parmentier , Jean-Marie Boeynaems
IPC分类号： C12Q1/00 , G01N33/53 , G01N35/567
CPC分类号： G01N33/5008 , A61K31/7076 , C07K14/47 , C07K14/705 , G01N33/502 , G01N33/5041 , G01N33/5091 , G01N33/5735 , G01N33/68 , G01N33/6842 , G01N33/6845 , G01N2333/726 , G01N2500/00
摘要： The present invention is related to a method of detecting the dysregulation of GPR86 activity.
摘要翻译：本发明涉及检测GPR86活性失调的方法。

3. 发明授权

US06946244B2 Methods of identifying a ligand, an agonist, and an antagonist of G protein coupled receptor GPR86 (P2Y13) 有权
标题翻译：识别G蛋白偶联受体GPR86（P2Y13）的配体，激动剂和拮抗剂的方法
公开(公告)号：US06946244B2
公开(公告)日：2005-09-20
申请号：US09924125
申请日：2001-08-07
申请人： Didier Communi , Nathalie Suarez , Michel Detheux , Stephane Brezillion , Vincent Lannoy , Marc Parmentier , Jean-Marie Boeynaems
发明人： Didier Communi , Nathalie Suarez , Michel Detheux , Stephane Brezillion , Vincent Lannoy , Marc Parmentier , Jean-Marie Boeynaems
IPC分类号： A01K67/027 , A61K31/7076 , A61K39/395 , A61K45/00 , A61P1/04 , A61P1/08 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/02 , A61P13/08 , A61P15/00 , A61P19/10 , A61P25/06 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P37/06 , A61P37/08 , C07K14/47 , C07K14/705 , C07K16/28 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/68 , G01N37/00 , C12Q1/00 , G01N35/567
CPC分类号： G01N33/5008 , A61K31/7076 , C07K14/47 , C07K14/705 , G01N33/502 , G01N33/5041 , G01N33/5091 , G01N33/5735 , G01N33/68 , G01N33/6842 , G01N33/6845 , G01N2333/726 , G01N2500/00
摘要： The present invention is related to a recombinant cell expressing a nucleotide sequence encoding a G protein coupled receptor having an amino acid sequence which presents more than 70% sequence identity with SEQ ID.NO.1 as well as to a drug screening method and kit using the orphan G protein coupled receptor GPR86, identified hereafter as receptor for ADP (P2Y13) and a homologous sequence, the corresponding polynucleotide and said recombinant cell to identify agonist, inverse agonist and antagonist compounds applicable to a diagnostic, prevention and/or treatment of various diseases and disorders.
摘要翻译：本发明涉及表达编码G蛋白偶联受体的核苷酸序列的重组细胞，其具有与SEQ ID NO.1具有超过70％序列同一性的氨基酸序列，以及使用药物筛选方法和试剂盒，其使用孤儿G蛋白偶联受体GPR86（以下称为ADP（P2Y 13 N）的受体）和同源序列，相应的多核苷酸和所述重组细胞鉴定适用于诊断的激动剂，反向激动剂和拮抗剂化合物，预防和/或治疗各种疾病和障碍。

4. 发明申请

US20080286806A1 Ligand for G-protein coupled receptor GPR43 and uses thereof 审中-公开
标题翻译： G蛋白偶联受体GPR43的配体及其用途
公开(公告)号：US20080286806A1
公开(公告)日：2008-11-20
申请号：US11986225
申请日：2007-11-20
申请人： Emmanuel LePoul , Michel Detheux , Stephane Brezillon , Vincent Lannoy , Marc Parmentier
发明人： Emmanuel LePoul , Michel Detheux , Stephane Brezillon , Vincent Lannoy , Marc Parmentier
IPC分类号： G01N33/53
CPC分类号： C07K14/70567 , A61K31/00 , A61K31/19 , C07K14/705 , G01N2333/726
摘要： The present invention is related to the G-protein coupled orphan receptor GPR43 and the identification of short chain fatty acids as natural ligands of the receptor. The invention further relates to assays for the identification of agents that modulate GPR43 ligand binding and signalling activity, as well as compositions consisting essentially of an isolated GPR43 polypeptide and an isolated short chain fatty acid. The invention also relates to diagnostic methods and kits that take advantage of the novel interaction of GPR43 with short chain fatty acids.
摘要翻译：本发明涉及G-蛋白偶联孤儿受体GPR 43和作为受体天然配体的短链脂肪酸的鉴定。本发明还涉及用于鉴定调节GPR 43配体结合和信号传导活性的试剂以及基本上由分离的GPR 43多肽和分离的短链脂肪酸组成的组合物的测定。本发明还涉及利用GPR43与短链脂肪酸的新型相互作用的诊断方法和试剂盒。

5. 发明授权

US07270966B2 Human pyrimidine receptor 有权
标题翻译：人嘧啶受体
公开(公告)号：US07270966B2
公开(公告)日：2007-09-18
申请号：US10753695
申请日：2004-01-08
申请人： Didier Communi , Marc Parmentier , Jean-Marie Boeynaems , Sabine Pirotton
发明人： Didier Communi , Marc Parmentier , Jean-Marie Boeynaems , Sabine Pirotton
IPC分类号： G01N33/53 , C12Q1/68
CPC分类号： C07K14/705 , A01K2217/05 , A01K2217/075 , C12N2310/14
摘要： This invention provides a receptor having a preference for pyrimidine nucleotides preferably uridine triphosphate over purine nucleotides. A receptor having a preference for pyrimidine nucleotides over purine nucleotides means a receptor for which pyrimidine nucleotides and purine nucleotides are not equally active and equipotent. This means that the receptor according to the invention in presence of these agonists presents a functional response (preferably the accumulation of Inositol triphosphate (IP3), diacylglycerol (DAG), or calcium ions) to lower concentration of pyrimidine nucleotides, preferably uridine triphosphate, than to purine nucleotides or a more important functional response to similar concentration of pyrimidine nucleotide than to purine nucleotide
摘要翻译：本发明提供了对嘌呤核苷酸优先选择嘧啶核苷酸优选尿苷三磷酸的受体。对嘌呤核苷酸优先选择嘧啶核苷酸的受体是指嘧啶核苷酸和嘌呤核苷酸不具有同等活性和等同性的受体。这意味着在这些激动剂存在下，根据本发明的受体具有功能性反应（优选三聚磷酸肌醇（IP3），二酰基甘油（DAG）或钙离子）的积累）以降低嘧啶核苷酸浓度，优选尿苷三磷酸嘌呤核苷酸或与嘌呤核苷酸相似浓度的嘧啶核苷酸的更重要的功能反应

6. 发明申请

US20070044166A1 P2Y4 Receptor transgenic and knockout non-human mammals 审中-公开
标题翻译： P2Y4受体转基因和敲除非人哺乳动物
公开(公告)号：US20070044166A1
公开(公告)日：2007-02-22
申请号：US11483432
申请日：2006-07-07
申请人： Didier Communi , Sabine Pirotton , Marc Parmentier , Jean-Marie Boeynaems
发明人： Didier Communi , Sabine Pirotton , Marc Parmentier , Jean-Marie Boeynaems
IPC分类号： A01K67/027
CPC分类号： C07K14/705 , A01K2217/05 , A01K2217/075 , C12N2310/14
摘要： This invention provides a receptor having a preference for pyrimidine nucleotides preferably uridine triphosphate over purine nucleotides. A receptor having a preference for pyrimidine nucleotides over purine nucleotides means a receptor for which pyrimidine nucleotides and purine nucleotides are not equally active and equipotent. This means that the receptor according to the invention in presence of these agonists presents a functional response (preferably the accumulation of Inositol triphosphate (IP3), diacylglycerol (DAG), or calcium ions) to lower concentration of pyrimidine nucleotides, preferably uridine triphosphate, than to purine nucleotides or a more important functional response to similar concentration of pyrimidine nucleotide than to purine nucleotide
摘要翻译：本发明提供了对嘌呤核苷酸优先选择嘧啶核苷酸优选尿苷三磷酸的受体。对嘌呤核苷酸优先选择嘧啶核苷酸的受体是指嘧啶核苷酸和嘌呤核苷酸不具有同等活性和等同性的受体。这意味着在这些激动剂存在下，根据本发明的受体具有功能性反应（优选三聚磷酸肌醇（IP3），二酰基甘油（DAG）或钙离子）的积累）以降低嘧啶核苷酸浓度，优选尿苷三磷酸嘌呤核苷酸或与嘌呤核苷酸相似浓度的嘧啶核苷酸的更重要的功能反应

7. 发明授权

US07312317B2 P2Y4 antibodies 有权
标题翻译： P2Y4抗体
公开(公告)号：US07312317B2
公开(公告)日：2007-12-25
申请号：US10811198
申请日：2004-03-26
申请人： Didier Communi , Jean-Marie Boeynaems , Marc Parmentier , Sabine Pirotton
发明人： Didier Communi , Jean-Marie Boeynaems , Marc Parmentier , Sabine Pirotton
IPC分类号： C07K16/18 , A61K39/395
CPC分类号： C07K14/705 , A01K2217/05 , A01K2217/075 , C12N2310/14
摘要： This invention provides a receptor having a preference for pyrimidine nucleotides preferably uridine triphosphate over purine nucleotides. A receptor having a preference for pyrimidine nucleotides over purine nucleotides means a receptor for which pyrimidine nucleotides and purine nucleotides are not equally active and equipotent. This means that the receptor according to the invention in presence of these agonists presents a functional response (preferably the accumulation of Inositol triphosphate (IP3), diacylglycerol (DAG), or calcium ions) to lower concentration of pyrimidine nucleotides, preferably uridine triphosphate, than to purine nucleotides or a more important functional response to similar concentration of pyrimidine nucleotide than to purine nucleotide.
摘要翻译：本发明提供了对嘌呤核苷酸优先选择嘧啶核苷酸优选尿苷三磷酸的受体。对嘌呤核苷酸优先选择嘧啶核苷酸的受体是指嘧啶核苷酸和嘌呤核苷酸不具有同等活性和等同性的受体。这意味着在这些激动剂存在下，根据本发明的受体具有功能性反应（优选三聚磷酸肌醇（IP3），二酰基甘油（DAG）或钙离子）的积累）以降低嘧啶核苷酸浓度，优选尿苷三磷酸嘌呤核苷酸或与嘌呤核苷酸相似浓度的嘧啶核苷酸的更重要的功能反应。

8. 发明授权

US06790626B2 Human pyrimidine receptor 有权
标题翻译：人嘧啶受体
公开(公告)号：US06790626B2
公开(公告)日：2004-09-14
申请号：US09077173
申请日：1998-11-12
申请人： Didier Communi , Sabine Pirotton , Marc Parmentier , Jean-Marie Boeynaems
发明人： Didier Communi , Sabine Pirotton , Marc Parmentier , Jean-Marie Boeynaems
IPC分类号： G01N33566
CPC分类号： C07K14/705 , A01K2217/05 , A01K2217/075 , C12N2310/14
摘要： The present invention concerns a new receptor having a preference for pyrimidine nucleotides, preferably UTP, or purine nucleotides and UDP, and which has an amino acid sequence having more than 60% homology with the amino acid sequence shown in FIG. 1.
摘要翻译：本发明涉及一种优选嘧啶核苷酸，优选UTP或嘌呤核苷酸和UDP的新受体，其具有与图1所示的氨基酸序列具有超过60％同源性的氨基酸序列。 1。

9. 发明授权

US08030453B2 Methods of making an antibody that binds a chemerin polypeptide 有权
标题翻译：制备结合凯美瑞多肽的抗体的方法
公开(公告)号：US08030453B2
公开(公告)日：2011-10-04
申请号：US12389349
申请日：2009-02-19
申请人： Valerie Wittamer , Jean-Francois Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franssen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Le Poul , Cecile Loison , Frederic Ooms
发明人： Valerie Wittamer , Jean-Francois Mirjolet , Isabelle Migeotte , David Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franssen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Le Poul , Cecile Loison , Frederic Ooms
IPC分类号： C07K16/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4702 , C07K14/575 , C07K16/18 , C07K16/28 , G01N33/74 , G01N2500/02
摘要： The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
摘要翻译：本发明涉及G蛋白偶联受体及其新型配体。本发明提供了用于鉴定调节G蛋白偶联受体活性的候选化合物的筛选试验，以及用于诊断和治疗与G蛋白偶联受体信号传导调节异常有关的疾病或病症的测定法。

10. 发明申请

US20100009345A1 Compositions and methods comprising a ligand of chemerin R 有权
标题翻译：组合物和方法，其包含凯美瑞R的配体
公开(公告)号：US20100009345A1
公开(公告)日：2010-01-14
申请号：US11977949
申请日：2007-10-26
申请人： Valeria Wittamer , J.F. Mirjolet , Isabelle Migeotte , Daivd Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franseen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Le Poul
发明人： Valeria Wittamer , J.F. Mirjolet , Isabelle Migeotte , Daivd Communi , Alberto Mantovani , Silvano Sozzani , Marisa Vulcano , Jean-Denis Franseen , Stephane Brezillon , Michel Detheux , Gilbert Vassart , Marc Parmentier , Emmanuel Le Poul
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/74 , A61K38/00 , C07K14/47 , C07K14/4702 , C07K14/575 , C07K16/18 , C07K16/28 , C07K2317/34 , G01N2500/02
摘要： The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
摘要翻译：本发明涉及G蛋白偶联受体及其新型配体。本发明提供了用于鉴定调节G蛋白偶联受体的活性的候选化合物的screeing测定法，以及可用于诊断和治疗与G蛋白偶联受体信号传导调节异常相关的疾病或病症的测定法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式